Hemolysis

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  Subject Areas on Research

  • 2,3,7,8-tetrachlorodibenzo-p-dioxin and natural immunity: lack of an effect on the complement system in a guinea pig model. 
  • A chemotactic factor for mononuclear leukocytes. 
  • A new complement-mediated cytolytic mechanism--the C1-bypass activation pathway. 
  • A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement. 
  • A retrospective study of complications of therapeutic plasma exchange in myasthenia. 
  • Activation of complement by endotoxin: a role for 2 globulin, C1, C4 and C2 in the consumption of terminal complement components by endotoxin-coated erythrocytes. 
  • Acute hemolysis in a patient with cytomegalovirus pneumonitis treated with intravenous immunoglobulin (IVIG). 
  • Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis. 
  • Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. 
  • An auto-anti-M causing hemolysis in vitro. 
  • Anti-Jka that are detected by solid-phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions. 
  • Aspirin-induced hemolysis: the role of concomitant oxidant (H2O2) challenge. 
  • Biotinylation of human C3. 
  • COMPLEMENT AND HEMOLYTIC ANTIBODY: CHANGES IN THEIR ACTIVITY INDUCED BY MERCAPTOETHANOL. 
  • Capillary blood flow. 3. Deformable model cells compared to erythrocytes in vitro. 
  • Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*. 
  • Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia. 
  • Characterization of the hematopoietic defect in paroxysmal nocturnal hemoglobinuria. 
  • Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. 
  • Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children. 
  • Cold agglutinins and cold-agglutinin disease. 
  • Complement 1 inhibitor is a regulator of the alternative complement pathway. 
  • Consumption of hamster complement by bacterial endotoxin. 
  • Cross circulation between children in hepatic coma and chimpanzees. Clinical, biochemical, and coagulation observations. 
  • Cytosolic delivery of macromolecules 4. Head group-dependent membrane permeabilization by pH-sensitive detergents. 
  • Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids. 
  • Decay-accelerating factor is present on paroxysmal nocturnal hemoglobinuria erythroid progenitors and lost during erythropoiesis in vitro. 
  • Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system. 
  • Deficiency of the homologous restriction factor in paroxysmal nocturnal hemoglobinuria. 
  • Discordant complement systems as a factor in hyperacute xenograft rejection. 
  • Disseminated intravascular coagulation and renal failure: Production in the monkey with autologous red blood cell stroma. 
  • Dysphagia in the setting of left ventricular assist device hemolysis. 
  • Effect of cortisone therapy on serum complement components. 
  • Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: membrane structure and functioning. 
  • Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity. 
  • Evidence that rabbit gamma G haemolysin in capable of utilizing guinea-pig complement more efficiently than rabbit gamma M haemolysin. 
  • Examination of Hydroxychloroquine Use and Hemolytic Anemia in G6PDH-Deficient Patients. 
  • Experimental transfusion reactions and disseminated intravascular coagulation produced by incompatible plasma in monkeys. 
  • Experimental transfusion reactions in monkeys: haemolytic, coagulant and renal effects of transfused isoimmune IgG and IgM. 
  • Factors affecting the risk of blood bank specimen hemolysis. 
  • Functional properties of the hemoglobin from the South American snake Mastigodryas bifossatus. 
  • Hematologic disorders and nonimmune hydrops fetalis. 
  • Hemocompatibility-Related Outcomes in the MOMENTUM 3 Trial at 6 Months: A Randomized Controlled Study of a Fully Magnetically Levitated Pump in Advanced Heart Failure. 
  • Hemolysis of sheep erythrocytes in guinea pig serum deficient in the fourth component of complement. I. Antibody and serum requirements. 
  • Hemolysis of sheep erythrocytes in guinea pig serum deficient in the fourth component of complement. II. Evidence for involvement of C1 and components of the alternate complement pathway. 
  • Hemolytic anemia in patients receiving sulfasalazine. 
  • Hemolytic characteristics of three commercially available centrifugal blood pumps. 
  • Hemolytic transfusion reactions caused by failure of commercial antiglobulin reagents to detect complement. 
  • Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis. 
  • Human erythrocyte catalase: an improved method of isolation and a reevaluation of reported properties. 
  • Human erythrocyte clathrin and clathrin-uncoating protein. 
  • IgG and complement-mediated tissue damage in the absence of C2: evidence of a functionally active C2-bypass pathway in a guinea pig model. 
  • Immune hemolytic transfusion reactions in monkeys: activation of the kallikrein system. 
  • Immunoradiometric assay for examination and quantitation of Brucella abortus-specific antibodies reactive with the antigen(s) used in the indirect hemolysis test. 
  • Inherited deficiency of C8 in a patient with recurrent meningococcal infections: further evidence for a dysfunctional C8 molecule and nonlinkage to the HLA system. 
  • Interaction of complex polysaccharides with the complement system: effect of calcium depletion on terminal component consumption. 
  • Lack of binding of human C3, in its native state, to C3b receptors. 
  • Lack of isohemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation. 
  • Letter: Role of calcium in paroxysmal-nocturnal-hemoglobinuria hemolysis. 
  • Leukocyte phenotypic changes in an in vitro model of ABO hemolytic transfusion reaction. 
  • Measurement of the third component of complement bound to red blood cells in patients with the cold agglutinin syndrome. 
  • Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria. 
  • Nitric Oxide-Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease. 
  • Observations on the mechanism of immune hemolysis: importance of immunoglobulin class and source of complement on the extent of damage. 
  • Paroxysmal nocturnal hemoglobinuria. Alternate-complement-pathway-mediated lysis induced by magnesium. 
  • Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. 
  • Polyimides as biomaterials: preliminary biocompatibility testing. 
  • Polymeric hemoglobins of the house mouse (Mus musculus L.): isolation of cysteinyl peptides. 
  • Prevention and diagnosis of delayed haemolytic transfusion reactions. 
  • Prospective analysis of possible myocardial damage or hemolysis occurring as a result of prolonged autoperfusion angioplasty in humans. 
  • Pulmonary hypertension and nitric oxide depletion in sickle cell disease. 
  • RBC transfusions in paroxysmal nocturnal hemoglobinuria. 
  • Randomized study of washing 40- to 42-day-stored red blood cells. 
  • Recent and innovative methods for detection of bacteremia and fungemia. 
  • Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography. 
  • Role of antibody and complement in the immune clearance and destruction of erythrocytes. II. Molecular nature of IgG and IgM complement-fixing sites and effects of their interaction with serum. 
  • STUDIES ON THE TERMINAL STEPS OF IMMUNE HEMOLYSIS. I. INHIBITION BY TRISODIUM ETHYLENEDIAMINETETRAACETATE (EDTA). 
  • STUDIES ON THE TERMINAL STEPS OF IMMUNE HEMOLYSIS. II. RESOLUTION OF THE E TRANSFORMATION REACTION INTO MULTIPLE STEPS. 
  • Separation of the acetylcholinesterase-deficient red cells in paroxysmal nocturnal hemoglobinuria. 
  • Significance of complement to the mechanism of action of endotoxin. 
  • Significance of hemolysis on extracorporeal life support after cardiac surgery in children. 
  • Spontaneous re-aggregation of IgM subunits and restoration of antibody activity after reduction and alkylation of rabbit anti-Forssman antibody. 
  • Structure-activity relationships of noreperidine congeners on cholinesterase systems in vitro and analgesia in vivo. 
  • Studies of complement-mediated membrane damage: the influence of erythrocyte storage on susceptibility to cytolysis. 
  • Surface modulation of classical pathway activation: C2 and C3 convertase formation and regulation on sheep, guinea pig, and human erythrocytes. 
  • Terminal complement components play a role in the expression of C5a. 
  • The abnormal surface characteristics of the red blood cell membrane in congenital dyserythropoietic anaemia type II (HEMPAS). 
  • The acetylcholinesterase defect in paroxysmal nocturnal hemoglobinuria: evidence that the enzyme is absent from the cell membrane. 
  • The effect of Bacillus Calmette-Guerin-induced macrophage activation on the in vivo clearance of sensitized erythrocytes. 
  • The effect of soluble complement receptor type 1 on hyperacute xenograft rejection. 
  • The effect of temperature on the reactivity of guinea-pig complement with gamma G and gamma M haemolytic antibodies. 
  • The erythrocytes in paroxysmal nocturnal haemoglobinuria of intermediate sensitivity to complement lysis. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Type II congenital dyserythropoietic anemia. 
  • Ultrastructure of hemoglobin-depleted human erythrocyte resealed ghosts. 
  • Use of a sodium polyanetholesulfonate disk for the identification of Gardnerella vaginalis. 
  • Vitamin E and total parenteral nutrition. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Mentz, Robert John, Associate Professor of Medicine, Medicine, Cardiology
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine