Hexokinase

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  Subject Areas on Research

  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Allosteric regulation of type I hexokinase: A site-directed mutational study indicating location of the functional glucose 6-phosphate binding site in the N-terminal half of the enzyme. 
  • Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. 
  • Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. 
  • Assignment of hexokinase types 1,2,3 (Hk1,2,3) and glucokinase (Gck) to rat chromosome band 20q11, 4q34, 17q12 and 14q21 respectively, by in situ hybridization. 
  • Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. 
  • Congenital hemolytic anemias and red cell enzyme deficiencies. 
  • Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1. 
  • Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes. 
  • Differential metabolic effects of adenovirus-mediated glucokinase and hexokinase I overexpression in rat primary hepatocytes. 
  • Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease. 
  • Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. 
  • Expression of two type II-like tumor hexokinase RNA transcripts in cancer cell lines. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake. 
  • Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase. 
  • Glucose metabolism as a target of histone deacetylase inhibitors. 
  • Glucose metabolism gene variants modulate the risk of pancreatic cancer. 
  • Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. 
  • Glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntington disease fibroblasts. 
  • HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use. 
  • Handedness of crossover connections in beta sheets. 
  • Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells. 
  • LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. 
  • Oncogene pathway activation in mammary tumors dictates FDG-PET uptake. 
  • Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. 
  • Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. 
  • Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans. 
  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. 
  • Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. 
  • Regulation of overexpressed hexokinases in liver and islet cells. 
  • Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase. 
  • SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control. 
  • Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. 
  • Studies of the enzyme hexokinase. IV. The role of sulfhydryl groups. 
  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. 
  • The human gene for the type III isozyme of hexokinase: structure, basal promoter, and evolution. 
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  Keywords of People

  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship