Hindlimb

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  Subject Areas on Research

  • A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. 
  • A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. 
  • Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. 
  • Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction. 
  • Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • An endovascular model of ischemic myopathy from peripheral arterial disease. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • Anabolic-androgenic steroid administration causes hypertrophy of immobilized and nonimmobilized skeletal muscle in a sedentary rabbit model. 
  • Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. 
  • Analysis of responses to big endothelin in the hindquarters vascular bed of the cat. 
  • Analysis of systemic and pulmonary vascular responses to PACAP and VIP: role of adrenal catecholamines. 
  • Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy. 
  • Antigen-induced arthritis. Decreased proteoglycan content and inhibition of proteoglycan synthesis in articular cartilage. 
  • Arterial intimal damage in avulsion and crush injuries in rat limbs. 
  • B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • Basal and carrageenan-induced pain behavior in Sprague-Dawley, Lewis and Fischer rats. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model. 
  • Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. 
  • Correlation of intrinsic optical signal, cerebral blood flow, and evoked potentials during activation of rat somatosensory cortex. 
  • Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model. 
  • Denatured muscle as a nerve conduit: a functional, morphologic, and electrophysiologic evaluation. 
  • Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion. 
  • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. 
  • Economy and Endurance in Human Evolution. 
  • Effects of a negative pressure venom extraction device (Extractor) on local tissue injury after artificial rattlesnake envenomation in a porcine model. 
  • Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 1): hyperalgesia, edema, and systemic cytokines. 
  • Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord. 
  • Effects of cold ischemia on reflow patterns in the rat cremaster muscle microcirculation. 
  • Effects of intranigral application of clinically-effective anticonvulsants on electroshock-induced seizures. 
  • Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model. 
  • Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. 
  • Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. 
  • Endothelium modulation of the effects of nitroglycerin on blood vessels from dogs with pacing-induced heart failure. 
  • Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia. 
  • Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes 
  • Establishment of an index with increased sensitivity for assessing murine arthritis. 
  • Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development. 
  • Force plate for measuring the ground reaction forces in small animal locomotion. 
  • Forelimb and hindlimb forces in walking and galloping primates. 
  • Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist. 
  • Gait kinetics of above- and below-branch quadrupedal locomotion in lemurid primates. 
  • Hindlimb endpoint forces predict movement direction evoked by intraspinal microstimulation in cats. 
  • Hurry Up and Get Out of the Way! Exploring the Limits of Muscle-Based Latch Systems for Power Amplification. 
  • Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents. 
  • Immobilization-induced changes in motor unit force and fatigability in the cat. 
  • Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. 
  • Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. 
  • In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia. 
  • Inducible regulation of Runx2-stimulated osteogenesis. 
  • Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation. 
  • Intermittent pneumatic compression of legs increases microcirculation in distant skeletal muscle. 
  • Investigations on spinal cord fMRI of cats under ketamine. 
  • L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. 
  • Locomotor anatomy and biomechanics of the Dmanisi hominins. 
  • Mechanisms for the functional differentiation of the propulsive and braking roles of the forelimbs and hindlimbs during quadrupedal walking in primates and felines. 
  • Mechanisms underlying cardiovascular defense reaction evoked by dorsal periaqueductal gray stimulation. 
  • Methods for Acute and Subacute Murine Hindlimb Ischemia. 
  • Micro-anastomosis of 0.3-0.4 mm vessels after cold ischemia using a rat model of toe-to-thumb transplantation. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Modality representation in the lumbar and cervical fasciculus gracilis of squirrel monkeys. 
  • Modularity of motor output evoked by intraspinal microstimulation in cats. 
  • Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. 
  • Noninvasive monitoring of muscle damage during reloading following limb disuse. 
  • Novel vascular effects of isoprenaline following pacing-induced heart failure in the dog. 
  • Ontogenetic scaling of fore limb and hind limb joint posture and limb bone cross-sectional geometry in vervets and baboons. 
  • Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model 
  • Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood. 
  • Patterns of quadrupedal locomotion in a vertical clinging and leaping primate (Propithecus coquereli) with implications for understanding the functional demands of primate quadrupedal locomotion. 
  • Poly-ADP-ribose-polymerase inhibition ameliorates hind limb ischemia reperfusion injury in a murine model of type 2 diabetes. 
  • Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. 
  • Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons. 
  • Relief of blood-induced arterial vasospasm by pharmacologic solutions. 
  • Right vs. left sensorimotor cortex suction-ablation in the rat: no difference in beam-walking recovery. 
  • Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. 
  • Role of biomechanics and muscle activation strategy in the production of endpoint force patterns in the cat hindlimb. 
  • Simultaneous photoacoustic imaging of intravascular and tissue oxygenation. 
  • Single-limb force data for two lemur species while vertically clinging. 
  • Skeletal muscle oxygen availability during respiratory acid-base disturbances in cats. 
  • Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice. 
  • Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. 
  • Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effect of exposure time on microsurgical anastomoses of experimentally crushed arteries. 
  • The effect of intrathecal neuropeptide Y on the flexor reflex in rats after carrageenan-induced inflammation. 
  • The effect of systemic acidosis on perfusion of replanted extremities. 
  • The influence of strain rate on the passive and stimulated engineering stress--large strain behavior of the rabbit tibialis anterior muscle. 
  • The use of cultured Schwann cells in nerve repair in a rabbit hind-limb model. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • Topography of spinal neurons active during hindlimb withdrawal reflexes in the decerebrate cat. 
  • Utilizing Indocyanine Green Dye Angiography to Detect Simulated Flap Venous Congestion in a Novel Experimental Rat Model. 
  • Vascularized Composite Allotransplantation: A Functional Hind Limb Model in Mice. 
  • Viscoelastic characteristics of muscle: passive stretching versus muscular contractions. 
  • [Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat. 
  • beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue. 
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  Keywords of People

  • Craciunescu, Oana, Professor of Radiation Oncology, Radiation Oncology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology