Histocompatibility Testing

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  Subject Areas on Research

  • 27. Transplantation immunology: organ and bone marrow. 
  • A GPS for finding the route to transplantation for the sensitized patient. 
  • A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantation. 
  • A flow cytometric crossmatch test using endothelial precursor cells isolated from peripheral blood. 
  • A retrospective analysis of the long-term effect of splenectomy on late infections, graft-versus-host disease, relapse, and survival after allogeneic marrow transplantation for chronic myelogenous leukemia. 
  • A toxicity study of trimetrexate used in combination with cyclosporine as acute graft-versus-host disease prophylaxis in HLA-mismatched, related donor bone marrow transplants. 
  • Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. 
  • Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. 
  • Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis. 
  • Allogeneic Hematopoietic Cell Transplantation for Chronic Granulomatous Disease: Controversies and State of the Art. 
  • Allogeneic bone marrow transplantation for aplastic anemia and acute leukemia. 
  • Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. 
  • Alternate donor hematopoietic cell transplantation (HCT) in non-Hodgkin lymphoma using lower intensity conditioning: a report from the CIBMTR. 
  • Alternative donors extend transplantation for patients with lymphoma who lack an HLA matched donor. 
  • Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality. 
  • Analysis of HLA-DM polymorphism in juvenile dermatomyositis (JDM) patients. 
  • Annual literature review for clinical transplants 2005. 
  • Anomalous MLR responsiveness among siblings. 
  • Anti-Angiotensin II Type 1 Receptor and Anti-Endothelial Cell Antibodies: A Cross-Sectional Analysis of Pathological Findings in Allograft Biopsies. 
  • Association of reticular dysgenesis (thymic alymphoplasia and congenital aleukocytosis) with bilateral sensorineural deafness. 
  • Barriers to bone marrow transplantation for sickle cell anemia. 
  • Bone marrow transplantation for severe aplastic anemia from genotypically HLA-nonidentical relatives. An update of the Seattle experience. 
  • Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. 
  • Busulfan/melphalan/antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: the Cord Blood Transplantation study (COBLT) experience. 
  • Cadaver renal transplantation ignoring peak-reactive sera in patients with markedly decreasing pretransplant sensitization. 
  • Casting a smaller net into a bigger donor pool: A single center's experience with the new kidney allocation system. 
  • Cellular immunology markers postransplantation predictive of long-term graft outcome. 
  • Characterization of T lymphocyte and monocyte populations in HLA B8/DRw3 normal individuals and in patients with dermatitis herpetiformis. 
  • Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood. 
  • Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation. 
  • Combined immunodeficiency due to the selective absence of CD4 inducer T lymphocytes. 
  • Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells. 
  • Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months. 
  • Comparable survival after HLA-well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis. 
  • Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency. 
  • Correction of purine nucleoside phosphorylase deficiency by transplantation of allogeneic bone marrow from a sibling. 
  • Correlations of test skin grafts and renal allograft function in human subjects genotyped for HL-A. 
  • DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. 
  • Declining influence of race on the outcome of living-donor renal transplantation. 
  • Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. 
  • Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching. 
  • Development and characterization of melanoma cell lines established by fine-needle aspiration biopsy: advances in the monitoring of patients with metastatic melanoma. 
  • Development of donor-specific and non-donor-specific HLA-DP antibodies post-transplant: the role of epitope sharing and epitope matching. 
  • Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) following both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency. 
  • Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors. 
  • Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. 
  • Donor-directed MHC class I antibody is preferentially cleared from sensitized recipients of combined liver/kidney transplants. 
  • Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia. 
  • Early acute antibody-mediated rejection of a negative flow crossmatch 3rd kidney transplant with exclusive disparity at HLA-DP. 
  • Effects of DR mismatch on long-term graft survival in simultaneous kidney-pancreas transplantation. 
  • Embryonic development of human transplantation antigens. 
  • Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids. 
  • FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors. 
  • Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance. 
  • Familial dermatomyositis. 
  • Fate of patients with newly diagnosed acute myeloid leukemia who fail primary induction therapy. 
  • Fungal infection following renal transplantation. 
  • Graft donor selection based upon single locus (haplotype) analysis within families. 
  • Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment. 
  • HL A typing, mixed leukocyte reactivity, and skin graft survival in a family with a recombinant at the HL-1 chromosomal region (major transplantation region). 
  • HLA histocompatibility affects cardiac transplant rejection and may provide one basis for organ allocation. 
  • HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. 
  • HLA-A0201 positive pancreatic cell lines: new findings and discrepancies. 
  • HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls. 
  • HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: impact of serological vs. DNA typing for HLA-A and -B loci. 
  • HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy. 
  • Haploidentical hematopoietic cell transplantation. 
  • Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups. 
  • Hematopoietic cell transplantation with cord blood for cure of HIV infections. 
  • Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. 
  • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. 
  • Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. 
  • Hereditary alterations in the immune response: coexistence of "agammaglobulinemia", acquired hypogammaglobulinemia and selective immunoglobulin deficiency in a sibship. 
  • Histocompatibility and liver transplantation. 
  • Histocompatibility testing and mixed lymphocyte culture responses in chimpanzee families. 
  • Histocompatibility testing in chimpanzee families. 
  • Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent. 
  • Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. 
  • Human renal allograft rejection despite the absence of allogeneic passenger leukocytes. 
  • Hurler syndrome: II. Outcome of HLA-genotypically identical sibling and HLA-haploidentical related donor bone marrow transplantation in fifty-four children. The Storage Disease Collaborative Study Group. 
  • Hyperbaric oxygen and cyclosporine as a combined treatment regimen to prevent skin allograft rejection in immunohistoincompatible mice. 
  • Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. 
  • Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. 
  • Immunogenetics and immunology in transplantation. 
  • Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts. 
  • Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping. 
  • Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children's Oncology Group. 
  • Impact of improving immunosuppressive treatment on outcome in cadaveric kidney transplantation. 
  • Impact of pronase on flow cytometric crossmatch outcome. 
  • Indications and Results of HLA-Identical Sibling Hematopoietic Cell Transplantation for Sickle Cell Disease. 
  • Indications and donor selections for allogeneic stem cell transplantation in children with hematologic malignancies. 
  • Influence of changes in pretransplant sensitization on patient and graft survival in cadaver renal transplantation. 
  • Intestine Transplantation Across a Positive Crossmatch With Preformed Donor-Specific Antibodies. 
  • Is it time to expand the use of cord blood donor transplantation in relapsed ALL? 
  • Kidney allograft survival of African American and Caucasian American recipients with lupus. 
  • Kidney transplant candidates' views of the transplant allocation system. 
  • Lack of isohemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation. 
  • Living unrelated kidney donation: an underutilized resource? 
  • Living-related kidney transplant or simultaneous pancreas-kidney for diabetic renal failure? 
  • Living-unrelated renal transplantation at the University of Wisconsin. 
  • Long-term results with forty-five living related renal allograft recipients genotypically identical for HLA. 
  • Lung transplantation at Duke University. 
  • Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. 
  • Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. 
  • Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. 
  • Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation. 
  • Metastable tolerance in nonhuman primates and humans. 
  • Methods to prevent rejection of homografts in man: a report on living related kidney donor selection by HL-A genotyping. 
  • Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model. 
  • Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias. 
  • Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation. 
  • Myeloablative transplantation using either cord blood or bone marrow leads to immune recovery, high long-term donor chimerism and excellent survival in chronic granulomatous disease. 
  • Myositis in children. 
  • Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. 
  • Neurologic complications after allogeneic marrow transplantation for sickle cell anemia. 
  • Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation. 
  • Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS. 
  • One-unit versus two-unit cord-blood transplantation for hematologic cancers. 
  • Outcomes among 562 recipients of placental-blood transplants from unrelated donors. 
  • Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. 
  • Outcomes of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning. 
  • Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy. 
  • Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution. 
  • Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications. 
  • Perception versus reality?: Virtual crossmatch--how to overcome some of the technical and logistic limitations. 
  • Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. 
  • Polymyositis as a manifestation of chronic graft-versus-host disease. 
  • Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome. 
  • Pre-transplant Screening for Non-HLA Antibodies: Who should be Tested? 
  • Preformed and de novo donor specific antibodies in visceral transplantation: long-term outcome with special reference to the liver. 
  • Pretransplant exposure to donor HLA-DR antigen in random transfusion units and the development of donor antigen-specific hyporeactivity. 
  • Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. 
  • Rapamycin suppression of host-versus-graft and graft-versus-host disease in MHC-mismatched rats. 
  • Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. 
  • Renal allograft cell infiltrates associated with irreversible rejection. 
  • Renal transplantation between HL-A haploidentical donor-recipient pairs: functional and morphological evaluation. 
  • Renal transplantation between HL-A identical donor-recipient pairs. Functional and morphological evaluation. 
  • Renal transplantation between histocompatible donor-recipient pairs. 
  • Renal transplantation in children. 
  • Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. 
  • Results of the South-Eastern Organ Procurement Foundation strategy for transplanting sensitized patients. 
  • Results of unrelated cord blood transplant in fanconi anemia patients: risk factor analysis for engraftment and survival. 
  • Risk factor analysis of outcomes after unrelated cord blood transplantation in patients with hurler syndrome. 
  • Risk factors for renal allograft loss in patients with systemic lupus erythematosus. 
  • Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. 
  • Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome. 
  • Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia. 
  • Selection of donors for kidney transplantation. 
  • Significance of complement split product C4d in ABO-compatible liver allograft: diagnosing utility in acute antibody mediated rejection. 
  • Simultaneous pancreas-kidney transplantation at University of Wisconsin-Madison Hospital. 
  • Simultaneous pancreas/kidney transplantation--a comparison of enteric and bladder drainage of exocrine pancreatic secretions. 
  • Skin graft rejection between subjects genotyped for HL-A. 
  • Splenic Irradiation for the Treatment of Severe Antibody-Mediated Rejection. 
  • Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors. 
  • The Incremental Cost of Incompatible Living Donor Kidney Transplantation: A National Cohort Analysis. 
  • The Virtual Crossmatch: An Essential Tool for Transplanting Sensitized Patients. 
  • The effect of natural killer cell killer Ig-like receptor alloreactivity on the outcome of bone marrow stem cell transplantation for severe combined immunodeficiency (SCID). 
  • The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients. 
  • The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles. 
  • The problem of transplanting the sensitized patient: whose problem is it? 
  • The rehabilitation of renal allograft recipients. 
  • The role of therapeutic apheresis in high immunologic risk renal transplantation: a review of current trends. 
  • Therapeutic apheresis before and after kidney transplantation. 
  • To Match or Not to Match in Cord Blood Transplantation: A Modern Look at a Recurring Question. 
  • Transmission of latent cytomegalovirus in a murine kidney tissue transplantation model. 
  • Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. 
  • Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs. 
  • Transplantation in miniature swine. III: effects of MSLA and A-O blood group matching on skin allograft survival. 
  • Transplantation of high panel-reactive antibody left ventricular assist device patients without crossmatch using on-bypass pheresis and alemtuzumab. 
  • Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose. 
  • Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease. 
  • Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories. 
  • Transplanting the highly sensitized patient: trials and tribulations. 
  • Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. 
  • Umbilical cord blood transplantation for children with thalassemia and sickle cell disease. 
  • Unrelated and HLA-nonidentical related donor marrow transplantation for thalassemia and leukemia. A combined report from the Seattle Marrow Transplant Team and the International Bone Marrow Transplant Registry. 
  • Unrelated umbilical cord blood stem cell transplant after failure of haploidentical or matched unrelated donor hematopoietic stem cell transplant. 
  • Update on umbilical cord blood transplantation. 
  • Variable HLA expression on deceased donor lymphocytes: Not all crossmatches are created equal. 
  • What role for prednisone in prevention of acute graft-versus-host disease in patients undergoing marrow transplants? 
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  Keywords of People

  • Yang, Yiping, Professor of Medicine, Immunology