Histone Deacetylases

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  Subject Areas on Research

  • A 137-kb deletion within the Potocki-Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia. 
  • A cis-regulatory map of the Drosophila genome. 
  • A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. 
  • A mechanism of COOH-terminal binding protein-mediated repression. 
  • A new (heat) shocking player in cardiac hypertrophy. 
  • A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. 
  • A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. 
  • ARID1A-mutated ovarian cancers depend on HDAC6 activity. 
  • Acetylation goes global: the emergence of acetylation biology. 
  • Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. 
  • An essential role for Mad homology domain 1 in the association of Smad3 with histone deacetylase activity*. 
  • An overview of naturally occurring histone deacetylase inhibitors. 
  • Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. 
  • Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. 
  • Antidepressant actions of histone deacetylase inhibitors. 
  • Cell cycle: Flies teach an old dogma new tricks. 
  • Chaperone-mediated 26S proteasome remodeling facilitates free K63 ubiquitin chain production and aggresome clearance. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Common non-epigenetic drugs as epigenetic modulators. 
  • Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment. 
  • Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Cholangiocarcinoma. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. 
  • Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. 
  • Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. 
  • Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells. 
  • Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection. 
  • Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. 
  • Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas. 
  • Food-Grade TiO₂ Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells. 
  • Genome-wide association study of retinopathy in individuals without diabetes. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • HDAC genes play distinct and redundant roles in Cryptococcus neoformans virulence. 
  • HDAC3 sets the timer on muscle fuel switching. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC4 regulates muscle fiber type-specific gene expression programs. 
  • HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. 
  • HDAC6 is a microtubule-associated deacetylase. 
  • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. 
  • HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. 
  • HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • HDACs in skeletal muscle remodeling and neuromuscular disease. 
  • HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. 
  • Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder. 
  • Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer. 
  • Histone Deacetylase 7 in Murine Gram-Negative Acute Lung Injury. 
  • Histone Deacetylase HDA19 Affects Root Cortical Cell Fate by Interacting with SCARECROW. 
  • Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer. 
  • Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic Role. 
  • Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. 
  • Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway. 
  • IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages. 
  • IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. 
  • Intracellular Generation of Superoxide by TiO₂ Nanoparticles Decreases Histone Deacetylase 9 (HDAC9), an Epigenetic Modifier. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. 
  • Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression. 
  • Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH. 
  • Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene. 
  • Loss of HDAC3 results in nonreceptive endometrium and female infertility. 
  • Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae. 
  • Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. 
  • Low levels of DNA polymerase alpha induce mitotic and meiotic instability in the ribosomal DNA gene cluster of Saccharomyces cerevisiae. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria. 
  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. 
  • Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production. 
  • Molecular cloning and characterization of a novel histone deacetylase HDAC10. 
  • PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. 
  • PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. 
  • Panobinostat for the management of multiple myeloma. 
  • Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. 
  • Phase 2 study of sodium phenylbutyrate in ALS. 
  • Phase II study of the histone deacetylase inhibitor Romidepsin in relapsed small cell lung cancer (Cancer and Leukemia Group B 30304). 
  • Post-transcriptional regulation of MTA family by microRNAs in the context of cancer. 
  • Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. 
  • Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity. 
  • Quality control autophagy: a joint effort of ubiquitin, protein deacetylase and actin cytoskeleton. 
  • RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression. 
  • Reduced expression of TGF beta1RII in agnogenic myeloid metaplasia is not due to mutation or methylation. 
  • Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. 
  • Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. 
  • Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. 
  • Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. 
  • Suberoylanilide hydroxamic acid represses glioma stem-like cells. 
  • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • The HDAC complex and cytoskeleton. 
  • The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer. 
  • The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. 
  • The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity. 
  • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. 
  • The discovery of histone deacetylase. 
  • The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. 
  • The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. 
  • The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. 
  • The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. 
  • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. 
  • Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. 
  • Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. 
  • Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer. 
  • Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. 
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  Keywords of People

  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics