Histones

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  Subject Areas on Research

  • A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus. 
  • A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. 
  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A change in the structure of Vbeta chromatin associated with TCR beta allelic exclusion. 
  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. 
  • A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. 
  • A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. 
  • A phase I study of panobinostat in pediatric patients with refractory solid tumors, including CNS tumors. 
  • A role for histone acetylation in the developmental regulation of VDJ recombination. 
  • A tale of tails: how histone tails mediate chromatin compaction in different salt and linker histone environments. 
  • ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma. 
  • ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. 
  • ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. 
  • Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. 
  • Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus. 
  • Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. 
  • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. 
  • An archaeal histone-like protein regulates gene expression in response to salt stress. 
  • An integrated encyclopedia of DNA elements in the human genome. 
  • An integrative approach identified genes associated with drug response in gastric cancer. 
  • Analyzing cell cycle checkpoints after ionizing radiation. 
  • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. 
  • Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. 
  • Antidepressant actions of histone deacetylase inhibitors. 
  • Antigen receptor control of methionine metabolism in T cells. 
  • Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. 
  • Asynchronous nuclear division cycles in multinucleated cells. 
  • Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment. 
  • BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. 
  • Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases. 
  • Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics. 
  • Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. 
  • Bioactive surface modification of metal oxides via catechol-bearing modular peptides: multivalent-binding, surface retention, and peptide bioactivity. 
  • Biochemistry. A glucose-to-gene link. 
  • Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. 
  • Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. 
  • Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. 
  • CBX2 is required to stabilize the testis pathway by repressing Wnt signaling. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • Can proliferation biomarkers reliably predict recurrence in World Health Organization 2003 defined endometrial stromal sarcoma, low grade? 
  • Cell cycle control of BRCA2. 
  • Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci. 
  • Centromere identity in Drosophila is not determined in vivo by replication timing. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. 
  • Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast. 
  • Chromatin and DNA replication. 
  • Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila. 
  • Chromatin conformation of yeast centromeres 
  • Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. 
  • Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease. 
  • Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma. 
  • Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. 
  • Clustering gene expression time series data using an infinite Gaussian process mixture model. 
  • Codon usage regulates human KRAS expression at both transcriptional and translational levels. 
  • Comparative analysis of metazoan chromatin organization. 
  • Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors. 
  • Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data. 
  • Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment. 
  • Conformation-specific precipitation of human alpha 2-macroglobulin by divalent zinc or calf thymus histone H3. 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. 
  • Core and region-enriched networks of behaviorally regulated genes and the singing genome. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • DEK is required for homologous recombination repair of DNA breaks. 
  • DNA replication and transcription programs respond to the same chromatin cues. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. 
  • Developmental control of gene copy number by repression of replication initiation and fork progression. 
  • Dicentric chromosomes: unique models to study centromere function and inactivation. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. 
  • Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman. 
  • Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression. 
  • Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. 
  • Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. 
  • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. 
  • Distribution of RNA polymerase on Drosophila polytene chromosomes as studied by indirect immunofluorescence. 
  • Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. 
  • Dynamic Opposition of Histone Modifications. 
  • Dynamics of Forced Nucleosome Unraveling and Role of Nonuniform Histone-DNA Interactions 
  • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. 
  • EZH2 expression is associated with inferior overall survival in mantle cell lymphoma. 
  • Early Diverging Fungus Mucor circinelloides Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres. 
  • Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state. 
  • Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. 
  • Effects of nickel(II) on nuclear protein binding to DNA in intact mammalian cells. 
  • Engineered Fluorescent Strains of Cryptococcus neoformans: a Versatile Toolbox for Studies of Host-Pathogen Interactions and Fungal Biology, Including the Viable but Nonculturable State. 
  • Engineered human dicentric chromosomes show centromere plasticity. 
  • Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies. 
  • Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes. 
  • Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection. 
  • Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. 
  • Epigenetic regulation of male fate commitment from an initially bipotential system. 
  • Epigenetics and autism spectrum disorder: A report of an autism case with mutation in H1 linker histone HIST1H1E and literature review. 
  • Epigenetics and psychostimulant addiction. 
  • Epigenetics of chronic pain after thoracic surgery. 
  • Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. 
  • Epigenomics of centromere assembly and function. 
  • Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. 
  • Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions. 
  • Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. 
  • Expression level is a key determinant of E2F1-mediated cell fate. 
  • FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: activation is not required for repair of Cr(VI)-induced DSBs. 
  • Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. 
  • Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. 
  • Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans . 
  • Flexible histone tails in a new mesoscopic oligonucleosome model. 
  • Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis. 
  • Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. 
  • Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. 
  • Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation. 
  • Functional organization of polytene chromosomes. 
  • GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. 
  • Gene segment selection in V(D)J recombination: accessibility and beyond. 
  • Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. 
  • Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged  
  • Genome-defined African ancestry is associated with distinct mutations and worse survival in patients with diffuse large B-cell lymphoma. 
  • Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1. 
  • Genome-wide identification of regulatory elements in Sertoli cells. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. 
  • Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. 
  • Growth-Phase-Specific Modulation of Cell Morphology and Gene Expression by an Archaeal Histone Protein. 
  • H1 histone and nucleosome repeat length alterations associated with the in vitro differentiation of murine embryonal carcinoma cells to extra-embryonic endoderm. 
  • HIST1H1E heterozygous protein-truncating variants cause a recognizable syndrome with intellectual disability and distinctive facial gestalt: A study to clarify the HIST1H1E syndrome phenotype in 30 individuals. 
  • Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder. 
  • High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. 
  • High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. 
  • High-resolution mapping and characterization of open chromatin across the genome. 
  • Histone Deacetylases (HDACs) in Gastric Cancer: An Update of their Emerging Prognostic and Therapeutic Role. 
  • Histone H1 enhances the DNA binding activity of the transcription factor EmBP-1. 
  • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. 
  • Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG. 
  • Histone H3K4 methylation keeps centromeres open for business. 
  • Histone H4 acetylation by immunohistochemistry and prognosis in relapsed acute lymphocytic leukaemia (ALL). 
  • Histone Lactylation: A New Role for Glucose Metabolism. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. 
  • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. 
  • Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. 
  • Histone demethylases in neuronal differentiation, plasticity, and disease. 
  • Histone gene clusters of the newt notophthalmus are separated by long tracts of satellite DNA. 
  • Histone genes are located at the sphere loci of newt lampbrush chromosomes. 
  • Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. 
  • Histone modifications and chromatin organization in prostate cancer. 
  • Histone modifications at human enhancers reflect global cell-type-specific gene expression. 
  • Histone modifications within the human X centromere region. 
  • Histones of rat testis chromatin during early postnatal development and their interactions with DNA. 
  • IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. 
  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 
  • Identification of functional elements and regulatory circuits by Drosophila modENCODE. 
  • Immune activation by histones: plusses and minuses in inflammation. 
  • Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone. 
  • Influence of threonine metabolism on S-adenosylmethionine and histone methylation. 
  • Inhibition of Methicillin-resistant Staphylococcus aureus-induced cytokines mRNA production in human bone marrow derived mesenchymal stem cells by 1,25-dihydroxyvitamin D3. 
  • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. 
  • Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF. 
  • Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression. 
  • Intercellular trafficking of the nuclear oncoprotein DEK. 
  • KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes. 
  • KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. 
  • Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element. 
  • Linking the dynamics of chromatin occupancy and transcription with predictive models. 
  • Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. 
  • Localization of RNA polymerase in polytene chromosomes of Drosophila melanogaster. 
  • Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. 
  • Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages. 
  • Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer. 
  • Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. 
  • Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. 
  • Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors. 
  • Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. 
  • Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. 
  • Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. 
  • MATCHER: manifold alignment reveals correspondence between single cell transcriptome and epigenome dynamics. 
  • Machine Learning-Based Multiparametric Magnetic Resonance Imaging Radiomics for Prediction of H3K27M Mutation in Midline Gliomas. 
  • MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation. 
  • Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet. 
  • Mechanical regulation of nuclear structure and function. 
  • Mechanisms of specificity in neuronal activity-regulated gene transcription. 
  • Meiotic recombination hot spots and cold spots. 
  • Metabolic interactions with cancer epigenetics. 
  • Methionine metabolism in health and cancer: a nexus of diet and precision medicine. 
  • Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. 
  • Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. 
  • Methods for the analysis of histone H3 and H4 acetylation in blood. 
  • Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila. 
  • Missense variants in the chromatin remodeler CHD1 are associated with neurodevelopmental disability. 
  • Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. 
  • Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity. 
  • Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. 
  • Modulation of tissue repair by regeneration enhancer elements. 
  • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 
  • Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes. 
  • Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. 
  • Mutations of the histone linker H1-4 in neurodevelopmental disorders and functional characterization of neurons expressing C-terminus frameshift mutant H1.4. 
  • NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies. 
  • NIP45 controls the magnitude of the type 2 T helper cell response. 
  • Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors. 
  • Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. 
  • Nascent chromatin occupancy profiling reveals locus- and factor-specific chromatin maturation dynamics behind the DNA replication fork. 
  • NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. 
  • Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. 
  • Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders. 
  • Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. 
  • Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. 
  • Novel mutations target distinct subgroups of medulloblastoma. 
  • Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. 
  • Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. 
  • Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. 
  • OGP functionalized phenylalanine-based poly(ester urea) for enhancing osteoinductive potential of human mesenchymal stem cells. 
  • One-carbon metabolism and epigenetics: understanding the specificity. 
  • Osteogenic growth peptide and its use as a bio-conjugate in regenerative medicine applications. 
  • Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism. 
  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. 
  • Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. 
  • Phosphotyrosine and phosphoprotein phosphatase activity of alkaline phosphatase in mineralizing cartilage. 
  • Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498. 
  • Possible association between genetic variants in the H2AFX promoter region and risk of adult glioma in a Chinese Han population. 
  • Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. 
  • Precipitation of fibrinogen, fibrinogen degradation products and fibrin monomer by histone H3. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. 
  • Protein acetylation and histone deacetylase expression associated with malignant breast cancer progression. 
  • Protein kinase C activity, translocation, and conventional isoforms in aging rat brain. 
  • Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. 
  • Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation. 
  • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. 
  • Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo. 
  • RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. 
  • RNA polymerase B (or II) in heat induced puffs of Drosophila polytene chromosomes. 
  • Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features. 
  • Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. 
  • Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. 
  • Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters. 
  • Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. 
  • Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure. 
  • Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility. 
  • Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. 
  • Regulation of chromatin accessibility for V(D)J recombination. 
  • Regulation of mitotic chromosome cohesion by Haspin and Aurora B. 
  • Regulation of translation and transcription of messenger RNA during early embryonic development. 
  • Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease. 
  • Reprogramming after chromosome transfer into mouse blastomeres. 
  • Resolving Heart Regeneration by Replacement Histone Profiling. 
  • Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity. 
  • Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • Role of histone tails in chromatin folding revealed by a mesoscopic oligonucleosome model. 
  • SARS-CoV-2 triggers DNA damage response in Vero E6 cells. 
  • SETD2 histone modifier loss in aggressive GI stromal tumours. 
  • Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. 
  • Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. 
  • Shift in nucleosome populations during embryogenesis: microheterogeneity in nucleosomes during development of the sea urchin embryo. 
  • Silver staining of histones in Triton-acid-urea gels. 
  • Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration. 
  • Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α. 
  • Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. 
  • Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. 
  • Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. 
  • Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant. 
  • Stressed-Out T Cells Fragment the Mind. 
  • Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase. 
  • Structure and binding of the H4 histone tail and the effects of lysine 16 acetylation. 
  • Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation. 
  • Structure-guided DOT1L probe optimization by label-free ligand displacement. 
  • Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • T-cell receptor α enhancer is inactivated in αβ T lymphocytes. 
  • TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep). 
  • Targeted inhibition of V(D)J recombination by a histone methyltransferase. 
  • Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. 
  • Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. 
  • The Alarmin Properties of DNA and DNA-associated Nuclear Proteins. 
  • The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. 
  • The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration. 
  • The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia. 
  • The HDAC complex and cytoskeleton. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria. 
  • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 
  • The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE. 
  • The effect of protein synthesis inhibition on the entry of messenger RNA into the cytoplasm of sea urchin embryos. 
  • The evolving metabolic landscape of chromatin biology and epigenetics. 
  • The genetic landscape of the childhood cancer medulloblastoma. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species. 
  • The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons. 
  • The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. 
  • The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. 
  • The properties of microparticles from RAW 264.7 macrophage cells undergoing in vitro activation or apoptosis. 
  • The role of histidyl residues in zinc-induced precipitation of alpha 2-macroglobulin-proteinase complexes. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. 
  • The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. 
  • Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. 
  • Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. 
  • Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma. 
  • Unwinding the Role of FACT in Cas9-based Genome Editing. 
  • Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. 
  • X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. 
  • c-Myc Represses Transcription of Epstein-Barr Virus Latent Membrane Protein 1 Early after Primary B Cell Infection. 
  • p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Miller Jr., Francis Joseph, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society