HLA Antigens

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  Subject Areas on Research

  • A GPS for finding the route to transplantation for the sensitized patient. 
  • A Southeastern Cancer Study Group phase I/II trial with vaccinia melanoma oncolysates. 
  • A closer look at rituximab induction on HLA antibody rebound following HLA-incompatible kidney transplantation. 
  • A flow cytometric crossmatch test using endothelial precursor cells isolated from peripheral blood. 
  • A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. 
  • A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. 
  • A novel reduced-intensity conditioning regimen for unrelated umbilical cord blood transplantation in children with nonmalignant diseases. 
  • A preliminary study utilizing viable HLA mismatched cultured glioma cells as adjuvant therapy for patients with malignant gliomas. 
  • A serologic approach to the definition of human prostatic carcinoma antigens. 
  • Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset. 
  • Accelerated development of immunity following transplantation of maternal marrow stem cells into infants with severe combined immunodeficiency and transplacentally acquired lymphoid chimerism. 
  • Acute and chronic graft-versus-host disease in man. 
  • Acute cellular and antibody-mediated allograft rejection. 
  • Acute graft-vs-host disease: pathobiology and management. 
  • Acute rejection and humoral sensitization in lung transplant recipients. 
  • Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. 
  • Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning. 
  • Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens. 
  • Advances in the correction of immunodeficiency by bone marrow transplantation. 
  • Affective illness and HLA frequencies: no compelling association. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors. 
  • Alternate donor hematopoietic cell transplantation (HCT) in non-Hodgkin lymphoma using lower intensity conditioning: a report from the CIBMTR. 
  • Alternative donors extend transplantation for patients with lymphoma who lack an HLA matched donor. 
  • Analysis of regulatory CD8 T cells in Qa-1-deficient mice. 
  • Anti-Angiotensin II Type 1 Receptor and Anti-Endothelial Cell Antibodies: A Cross-Sectional Analysis of Pathological Findings in Allograft Biopsies. 
  • Anti-CD20 monoclonal antibody (rituximab) therapy for acute cardiac humoral rejection: a case report. 
  • Anti-La antibodies. 
  • Anti-self HLA may be clonally expressed. 
  • Antibody depletion strategy for the treatment of suspected antibody-mediated rejection in lung transplant recipients: Does it work? 
  • Antibody desensitization therapy in highly sensitized lung transplant candidates. 
  • Antigenic heterogeneity of human anaplastic gliomas and glioma-derived cell lines defined by monoclonal antibodies. 
  • Assembly and maturation of HLA-A and HLA-B antigens in vivo. 
  • Association of Wegener's granulomatosis with HLA-B8. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection. 
  • Bone marrow transplantation for severe aplastic anemia from genotypically HLA-nonidentical relatives. An update of the Seattle experience. 
  • Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens. 
  • CD8 CTL responses in vaccines: emerging patterns of HLA restriction and epitope recognition. 
  • Cadaveric renal transplantation in the cyclosporine and OKT3 eras: an update of the University of Wisconsin-Madison experience. 
  • Calcification of entheses associated with X-linked hypophosphatemic osteomalacia. 
  • Casting a smaller net into a bigger donor pool: A single center's experience with the new kidney allocation system. 
  • Cell lines producing human T-cell lymphoma virus show altered HLA expression. 
  • Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter. 
  • Changes in hairy cells after alpha-interferon treatment as measured by flow cytometry. 
  • Characterization of CD8(-) HLA class I/epitope tetrameric complexes binding T cells. 
  • Characterization of T cells expressing the gamma/delta antigen receptor in human renal allografts. 
  • Characterization of T lymphocyte and monocyte populations in HLA B8/DRw3 normal individuals and in patients with dermatitis herpetiformis. 
  • Characterization of a B lymphoblastoid cell line mutant that secretes HLA-A2. 
  • Characterization of a chimpanzee anti-human melanoma antiserum. 
  • Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. 
  • Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood. 
  • Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. 
  • Comparable survival after HLA-well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis. 
  • Comparative effects of pregnancy, transfusion, and prior graft rejection on sensitization and renal transplant results. 
  • Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes. II. Variant DK1: evidence for a discrete CTL recognition region. 
  • Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1. 
  • Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis. 
  • Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals. 
  • Cord blood stem cells. 
  • Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction. 
  • Current approaches in national kidney paired donation programs. 
  • Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. 
  • Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age. 
  • Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. 
  • Defective reticuloendothelial system Fc-receptor function in patients with acquired immunodeficiency syndrome. 
  • Delineation of immunologically and biochemically distinct HLA-A2 antigens. 
  • Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups. 
  • Dermatitis herpetiformis and the mucosal immune response. 
  • Dermatitis herpetiformis in two American blacks: HLA type and clinical characteristics. 
  • Dermatitis herpetiformis. 
  • Dermatitis herpetiformis: the skin and the gut. 
  • Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. 
  • Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) following both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency. 
  • Differential effects of donor-specific alloantibody. 
  • Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis? 
  • Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Donor-specific HLA-antibody-mediated humoral rejection in a liver transplant recipient fully reversed with plasmapheresis and immunoglobulin. 
  • Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring. 
  • Effect of HLA-matching recipients to donor noninherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy. 
  • Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. 
  • Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: update in a modern cohort. 
  • Endothelial cell antibodies associated with novel targets and increased rejection. 
  • Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure. 
  • Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. 
  • Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Extensive haplotype diversity in African American mothers and their cord blood units. 
  • Factors affecting success of thymus transplantation for complete DiGeorge anomaly. 
  • Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia. 
  • Factors which have a significant effect on the survival of human skin grafts. 
  • Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1. 
  • Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors. 
  • Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury. 
  • Fine mapping genetic associations between the HLA region and extremely high intelligence. 
  • Generation of autologous tumor-specific cytotoxic T-cells using HLA-A region matched allogeneic melanoma. 
  • Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. 
  • Genetic analysis of multiplex rheumatoid arthritis families. 
  • Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study. 
  • Genetic epidemiology of the susceptibility to leprosy. 
  • Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome: a review of the literature examining associations with HLA [corrected]. 
  • Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes. 
  • Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID. 
  • Giant cell interstitial pneumonia in patients without hard metal exposure: analysis of 3 cases and review of the literature. 
  • Globoid cell leukodystrophy (Krabbe disease): normal umbilical cord blood galactocerebrosidase activity and polymorphic mutations. 
  • Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. 
  • HIV vaccine development at Duke University Medical Center. 
  • HIV vaccines: where we are and where we are going. 
  • HLA and Cogan's syndrome. 
  • HLA and complement studies in Alzheimer's disease. 
  • HLA antibodies and soluble CD30 are associated with poor renal graft outcome: updated results of a single-center cross-sectional study. 
  • HLA antigen structural gene mutants selected with an allospecific monoclonal antibody. 
  • HLA antigens in primary immunodeficiency diseases. 
  • HLA histocompatibility affects cardiac transplant rejection and may provide one basis for organ allocation. 
  • HLA-A2 mutants immunoselected in vitro. Definition of residues contributing to an HLA-A2-specific serological determinant. 
  • HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients. 
  • Haploidentical transplantation for leukemia. 
  • Hematologic engraftment and reconstitution of immune function post unrelated placental cord blood transplant in an adult with acute lymphocytic leukemia. 
  • Hematopoietic cell transplantation for Chediak-Higashi syndrome. 
  • Hematopoietic cell transplantation with cord blood for cure of HIV infections. 
  • Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. 
  • Hereditary hemochromatosis: gene discovery and its implications for population-based screening. 
  • Histocompatibility and liver transplantation. 
  • Human histocompatibility antigen mutants immunoselected in vitro. Biochemical analysis of a mutant which synthesizes an altered HLA-A2 heavy chain. 
  • Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. 
  • Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research. 
  • Human melanoma and leukemia associated antigens difined by nonhuman primate antisera. 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Human umbilical cord blood: a clinically useful source of transplantable hematopoietic stem/progenitor cells. 
  • Hurler syndrome: II. Outcome of HLA-genotypically identical sibling and HLA-haploidentical related donor bone marrow transplantation in fifty-four children. The Storage Disease Collaborative Study Group. 
  • Immunization of normal human splenocytes in vitro to produce human monoclonal antibodies to cellular antigens. 
  • Immunobiology of primary intracranial tumors. Part 8: Serological responses to active immunization of patients with anaplastic gliomas. 
  • Immunogenetics and immunology in transplantation. 
  • Immunogenetics of dermatitis herpetiformis. 
  • Immunological aspects of Alzheimer disease: a review. 
  • Immunotherapy for malignant melanoma with a tumor cell vaccine. 
  • Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children's Oncology Group. 
  • Impact of prior imatinib mesylate on the outcome of hematopoietic cell transplantation for chronic myeloid leukemia. 
  • Impact of pronase on flow cytometric crossmatch outcome. 
  • Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients. 
  • Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study. 
  • Influence of host genotype on progression to acquired immunodeficiency syndrome among children infected with human immunodeficiency virus type 1. 
  • Influence of pretransplant panel-reactive antibody on outcomes in 8,160 heart transplant recipients in recent era. 
  • Inherited deficiency of C8 in a patient with recurrent meningococcal infections: further evidence for a dysfunctional C8 molecule and nonlinkage to the HLA system. 
  • Kidney transplant candidates' views of the transplant allocation system. 
  • Kinetics of TCR use in response to repeated epitope-specific immunization. 
  • Living unrelated renal donation: the University of Wisconsin experience. 
  • Long-term results with forty-five living related renal allograft recipients genotypically identical for HLA. 
  • Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide. 
  • Management of children undergoing cardiac transplantation with high Panel Reactive Antibodies. 
  • Marrow transplantation from HLA-matched unrelated donors for treatment of hematologic malignancies. 
  • Microchimerism in sensitized renal patients. 
  • Mixed leukocyte culture reactivity and graft-versus-host disease in HLA-identical marrow transplantation for leukemia. 
  • Mixed lymphocyte responses in a four-generation C2 deficiency family. 
  • Modified MHC restriction of donor-origin T cells in humans with severe combined immunodeficiency transplanted with haploidentical bone marrow stem cells. 
  • Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease. 
  • Monocyte receptors for the Fc portion of IgG studies with monomeric human IgG1: normal in vitro expression of Fc gamma receptors in HLA-B8/Drw3 subjects with defective Fc gamma-mediated in vivo clearance. 
  • Monolayer absorption of human cytotoxic T cells: evidence for clonality. 
  • Myositis in children. 
  • NIH Conference: Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases. 
  • NK susceptibility varies inversely with target cell class I HLA antigen expression. 
  • Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation. 
  • Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement. 
  • New surrogate markers for autoimmune disease activity. 
  • Non-HLA antibodies in transplantation: when do they matter? 
  • Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma. 
  • Ontogeny of the human thymus during fetal development. 
  • Pathogenesis of autoimmunity in pemphigus. 
  • Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts. 
  • Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells. 
  • Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. 
  • Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. 
  • Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. 
  • Positive relationship of clinical and serologic responses to vaccinia melanoma oncolysate. 
  • Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study. 
  • Predicting HLA genotypes using unphased and flanking single-nucleotide polymorphisms in Han Chinese population. 
  • Predictive factors in chronic graft-versus-host disease in patients with aplastic anemia treated by marrow transplantation from HLA-identical siblings. 
  • Preformed and de novo donor specific antibodies in visceral transplantation: long-term outcome with special reference to the liver. 
  • Production of a human monoclonal antibody to HLA by human-human hybridoma technology. A preliminary report. 
  • Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation. 
  • Pruritic urticarial papules and plaques of pregnancy. Clinical experience in twenty-five patients. 
  • Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. 
  • Purification and characterization of papain-solubilized HLA antigens from human platelets. 
  • Qa-1 restriction of CD8+ suppressor T cells. 
  • Quantifying the risk of incompatible kidney transplantation: a multicenter study. 
  • Recognition of HLA-A2 mutant and variant target cells by an HLA-A2 allospecific human cytotoxic T lymphocyte line. 
  • Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies. 
  • Rejection of the liver transplant. 
  • Relationship between sensitivity to natural killer cells and MHC class-I antigen expression in colon carcinoma cell lines. 
  • Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. 
  • Renal allograft cell infiltrates associated with irreversible rejection. 
  • Response and toxicity of donor lymphocyte infusions following T-cell depleted non-myeloablative allogeneic hematopoietic SCT from 3-6/6 HLA matched donors. 
  • Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. 
  • Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis. 
  • Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies. 
  • Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia. 
  • Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway. 
  • Sequential myeloablative autologous stem cell transplantation and reduced intensity allogeneic hematopoietic cell transplantation is safe and feasible in children, adolescents and young adults with poor-risk refractory or recurrent Hodgkin and non-Hodgkin lymphoma. 
  • Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. 
  • Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. 
  • Sjögren's syndrome (Sicca syndrome): current issues. 
  • Solubilization and partial isolation of human melanoma tumor-associated antigens. 
  • Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation. 
  • Status of activation of circulating vaccine-elicited CD8+ T cells. 
  • Structural analysis of HLA-A2 antigen from immunoselected mutant 8.6.1: further definition of an HLA-A2-specific serological determinant. 
  • Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes. 
  • Structural analysis of the functional sites of class I HLA antigens. 
  • Structure, function, and biosynthesis of the major human histocompatibility antigens (HLA-A and HLA-B). 
  • Studies of viral antibody responses among Amish families. 
  • Summary of FDA antibody-mediated rejection workshop. 
  • Surface antigenic characteristics of human glial brain tumor cells. 
  • Survival Benefit with Kidney Transplants from HLA-Incompatible Live Donors. 
  • Survival after HLA-identical allogeneic peripheral blood stem cell and bone marrow transplantation for hematologic malignancies: meta-analysis of randomized controlled trials. 
  • The Clinical Impact of Non-HLA Antibodies in Solid Organ Transplantation. 
  • The HLA antigens in Cogan's syndrome. 
  • The Virtual Crossmatch: An Essential Tool for Transplanting Sensitized Patients. 
  • The association between immunodeficiency and the development of autoimmune disease. 
  • The effect of donor age, recipient age, and HLA match on immunologic graft survival in cadaver renal transplant recipients. 
  • The neutral theory and natural selection in the HLA region. 
  • The pathogenesis of dermatitis herpetiformis: recent advances. 
  • The problem of transplanting the sensitized patient: whose problem is it? 
  • The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens. 
  • The role of donor-specific HLA alloantibodies in liver transplantation. 
  • The role of therapeutic apheresis in high immunologic risk renal transplantation: a review of current trends. 
  • Therapeutic apheresis before and after kidney transplantation. 
  • Transancestral mapping and genetic load in systemic lupus erythematosus. 
  • Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity. 
  • Transplantation for polycystic kidney disease. 
  • Transplanting the highly sensitized patient: trials and tribulations. 
  • Treatment of platelet alloimmunization with intravenous immunoglobulin. Two case reports and review of the literature. 
  • Two forms of HLA class I molecules in human plasma. 
  • Unique aspects of rejection and tolerance in liver transplantation. 
  • Unusual RNA splicing generates a secreted form of HLA-A2 in a mutagenized B lymphoblastoid cell line. 
  • Use of synthetic peptides in primates to induce high-titered neutralizing antibodies and MHC class I-restricted cytotoxic T cells against acquired immunodeficiency syndrome retroviruses: an HLA-based vaccine strategy. 
  • Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patients. 
  • Utility of peritransplant and rescue intravenous immunoglobulin and extracorporeal immunoadsorption in lung transplant recipients sensitized to HLA antigens. 
  • Variable HLA expression on deceased donor lymphocytes: Not all crossmatches are created equal. 
  • Virus-immune cytotoxic T cells recognize structural differences between serologically indistinguishable HLA-A2 molecules. 
  • Why do secondary cadaver renal transplants succeed? Results of the South-Eastern Organ Procurement Foundation prospective study, 1977-1982. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Parikh, Suhag H., Associate Professor of Pediatrics, Pediatrics, Blood and Marrow Transplantation
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Yang, Yiping, Professor of Medicine, Immunology