HLA-DR Antigens

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  Subject Areas on Research

  • A comparison of donor-specific and random transfusions in living-related renal transplantation and their effect on steroid withdrawal. 
  • Absolute values of dendritic cell subsets in bone marrow, cord blood, and peripheral blood enumerated by a novel method. 
  • Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. 
  • Altered lymphocyte populations in tumour invaded nodes of breast cancer patients. 
  • Amino acid residue at position 13 in HLA-DR beta chain plays a critical role in the development of Kaposi's sarcoma in AIDS patients. 
  • An HLA class II region restriction fragment length polymorphism (RFLP) in patients with dermatitis herpetiformis: association with HLA-DP phenotype. 
  • Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation. 
  • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. 
  • Circulating donor antigen and response to donor antigen as predictors of long-term lung and kidney transplant success. 
  • Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth. 
  • Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group Study. 
  • Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. 
  • DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. 
  • Decline in rates of clearance of IgG-sensitized erythrocytes with increasing age. 
  • Determinants of graft survival after renal transplantation. 
  • Development of donor-specific and non-donor-specific HLA-DP antibodies post-transplant: the role of epitope sharing and epitope matching. 
  • Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. 
  • Effect of influenza virus vaccine on the expression of human immunodeficiency virus co-receptor CCR5. 
  • Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes. 
  • Effects of DR mismatch on long-term graft survival in simultaneous kidney-pancreas transplantation. 
  • Enteral glutamine supplementation for very low birth weight infants decreases morbidity. 
  • Evidence for urothelial cell activation in interstitial cystitis. 
  • Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Flow cytometric analysis of tumour-draining lymph nodes in breast cancer patients. 
  • Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells. 
  • Genetic basis for clinical expression in multiple sclerosis. 
  • Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. 
  • HLA histocompatibility affects cardiac transplant rejection and may provide one basis for organ allocation. 
  • HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies. 
  • HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: impact of serological vs. DNA typing for HLA-A and -B loci. 
  • HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. 
  • Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups. 
  • Human leukocyte antigen class II alleles are associated with risk of alopecia areata. 
  • Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. 
  • Human splenic sinusoidal lining cells express antigens associated with monocytes, macrophages, endothelial cells, and T lymphocytes. 
  • Human thymic epithelial cells function as accessory cells for autologous mature thymocyte activation. 
  • Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression. 
  • Identification of new mamu-DRB alleles using DGGE and direct sequencing. 
  • Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. 
  • Immunoregulatory disorders associated with hereditary angioedema. II. Serologic and cellular abnormalities. 
  • In-vitro infection of chronic lymphocytic leukemia cells by Epstein-Barr virus (EBV). 
  • Interferon-beta1A-induced polyarthritis in a patient with the HLA-DRB1*0404 allele. 
  • Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. 
  • Living-related kidney transplant or simultaneous pancreas-kidney for diabetic renal failure? 
  • Living-unrelated renal donor transplantation: the UNOS experience, 1987-1991. United Network for Organ Sharing. 
  • MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain. 
  • Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. 
  • Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms. 
  • Molecular analysis of thymopentin binding to HLA-DR molecules. 
  • Molecular characterization of hypoxia-hypothermia-conditioned human endothelial cells and their interaction with human monocytes. 
  • Monocyte infiltration and kidney allograft dysfunction during acute rejection. 
  • New insights into the role of host cell proteins in antiviral vaccine protection. 
  • Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells. 
  • Pars planitis: clinical features and class II HLA associations. 
  • Predictive factors for immunologic graft failure in cadaver renal transplant recipients. 
  • Pretransplant exposure to donor HLA-DR antigen in random transfusion units and the development of donor antigen-specific hyporeactivity. 
  • Renal epithelial cell-derived monocyte colony stimulating factor as a local informant of renal injury and means of monocyte activation. 
  • Risk alleles for multiple sclerosis identified by a genomewide study. 
  • Sequential measurement of peripheral blood allogeneic microchimerism levels and association with pulmonary function. 
  • Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells. 
  • Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments. 
  • The effect of donor age, recipient age, and HLA match on immunologic graft survival in cadaver renal transplant recipients. 
  • The neutral theory and natural selection in the HLA region. 
  • The pathogenesis of dermatitis herpetiformis. 
  • The pathogenesis of dermatitis herpetiformis: recent advances. 
  • Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1. 
  • Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. 
  • Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.