Homeostasis

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  Subject Areas on Research

  • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. 
  • A "microRNA-like" small RNA expressed by Dengue virus? 
  • A Non-Canonical Role for β-Secretase in the Retina. 
  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A bistable Rb-E2F switch underlies the restriction point. 
  • A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells. 
  • A delicate balance: homeostatic control of copper uptake and distribution. 
  • A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. 
  • A historical perspective on the discovery of adenyl purines. 
  • A homeostatic model of oxidative damage explains paradoxes observed in earlier aging experiments: a fusion and extension of older theories of aging. 
  • A mathematical model of the folate cycle: new insights into folate homeostasis. 
  • A mathematical model of the physiological dynamics of aging and correlated mortality selection. I. Theoretical development and critiques. 
  • A new role for phytochromes in temperature-dependent germination. 
  • A noisy linear map underlies oscillations in cell size and gene expression in bacteria. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease. 
  • A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea. 
  • ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. 
  • Aberrant B-cell homeostasis in chronic GVHD. 
  • Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. 
  • Acid Load and Phosphorus Homeostasis in CKD. 
  • Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. 
  • Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. 
  • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. 
  • Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. 
  • Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease. 
  • Altered regulation of S-adenosylmethionine dependent methylation in adenosine deaminase deficiency. 
  • An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults. 
  • An auxin gradient and maximum in the Arabidopsis root apex shown by high-resolution cell-specific analysis of IAA distribution and synthesis. 
  • Analysis of Homeostatic Mechanisms in Biochemical Networks. 
  • Anesthesia in Experimental Stroke Research. 
  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. 
  • Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. 
  • Arterial homeostasis, inflammation, and erythropoietic growth factors. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Associations between purine metabolites and clinical symptoms in schizophrenia. 
  • Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. 
  • Autophagy and lymphocyte homeostasis. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Autoregulation and conduction of vasomotor responses in a mathematical model of the rat afferent arteriole. 
  • Autoregulation of Tcr V region epitopes in autoimmune disease. 
  • Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. 
  • B-cell homeostasis: digital survival or analog growth? 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • Baby, It's Cold Outside: Host-Microbiota Relationships Drive Temperature Adaptations. 
  • Bacterial conversion of folinic acid is required for antifolate resistance. 
  • Balancing acts: molecular control of mammalian iron metabolism. 
  • Basement membranes. 
  • Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis. 
  • Beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline. 
  • Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. 
  • Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. 
  • Biochemical characterization of the human copper transporter Ctr1. 
  • Biology of the natriuretic peptides. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Blood lactate: biochemistry, laboratory methods, and clinical interpretation. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule. 
  • Bone protection by inhibition of microRNA-182. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. 
  • CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? 
  • CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. 
  • CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. 
  • Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. 
  • Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function. 
  • Carnitine homeostasis in the organic acidurias. 
  • Cell biology: A guardian angel of cell integrity. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats. 
  • Cerebral autoregulation during moderate hypothermia in rats. 
  • Cerebral blood flow autoregulation during intracranial hypertension in hypoxic lambs. 
  • Cerebral blood flow autoregulation is preserved after continuous-flow left ventricular assist device implantation. 
  • Cerebral blood flow responses to inhaled carbon dioxide in schizophrenia. 
  • Changes in cerebral tissue oxygen saturation during anaesthetic-induced hypotension: an interpretation based on neurovascular coupling and cerebral autoregulation. 
  • Charting the travels of copper in eukaryotes from yeast to mammals. 
  • Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. 
  • Chemical messengers of the gut. 
  • Chondroitin sulfate glycosaminoglycans for CNS homeostasis-implications for material design. 
  • Chutes and Ladders: the search for protein kinases that act on AMPK. 
  • Cilia in vertebrate development and disease. 
  • Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. 
  • Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. 
  • Comprehensive care of the elderly patient with cancer. 
  • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. 
  • Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. 
  • Consumption of a high-fat diet alters the homeostatic regulation of energy balance. 
  • Control and modulation of fluid flow in the rat kidney. 
  • Control of Arabidopsis lateral root primordium boundaries by MYB36. 
  • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. 
  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch. 
  • Cooperation between brain and islet in glucose homeostasis and diabetes. 
  • Copper signaling axis as a target for prostate cancer therapeutics. 
  • Copper: an essential metal in biology. 
  • Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect. 
  • Cse1l is a negative regulator of CFTR-dependent fluid secretion. 
  • Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. 
  • Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. 
  • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 
  • Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Development of glucocorticoid receptor regulation in the rat forebrain: implications for adverse effects of glucocorticoids in preterm infants. 
  • Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. 
  • Dialysate Potassium, Dialysate Magnesium, and Hemodialysis Risk. 
  • Dichotomous roles of TGF-β in human cancer. 
  • Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. 
  • Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study. 
  • Disorders of phosphorus homeostasis. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Disruption of iron homeostasis in mesothelial cells after talc pleurodesis. 
  • Disruption of iron homeostasis in the lungs of transplant patients. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. 
  • Does epileptiform activity contribute to cognitive impairment in Alzheimer's disease? 
  • Does homeostasis or disturbance of homeostasis in minimum leaf water potential explain the isohydric versus anisohydric behavior of Vitis vinifera L. cultivars? 
  • Dominant factors that govern pressure natriuresis in diuresis and antidiuresis: a mathematical model. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. 
  • Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction. 
  • Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass. 
  • Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation. 
  • Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass. 
  • Effects of NKCC2 isoform regulation on NaCl transport in thick ascending limb and macula densa: a modeling study. 
  • Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. 
  • Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial. 
  • Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. 
  • Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury. 
  • Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. 
  • Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus. 
  • Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. 
  • Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1. 
  • Enhanced fitness: a randomized controlled trial of the effects of home-based physical activity counseling on glycemic control in older adults with prediabetes mellitus. 
  • Epidemiologic insights on the role of fibroblast growth factor 23 in cardiovascular disease. 
  • Epithelial progenitor cells in lung development, maintenance, repair, and disease. 
  • Escape from homeostasis. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. 
  • Estrogen-related receptor alpha as a therapeutic target in cancer. 
  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. 
  • Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Fatty acid oxidation and insulin action: when less is more. 
  • Fatty acid synthase: elementary steps in catalysis and regulation. 
  • Feedback-mediated dynamics in a model of coupled nephrons with compliant thick ascending limbs. 
  • Fgfs control homeostatic regeneration in adult zebrafish fins. 
  • Fine tuning of immunometabolism for the treatment of rheumatic diseases. 
  • Forging a field: the golden age of iron biology. 
  • Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice. 
  • From aging to virulence: forging connections through the study of copper homeostasis in eukaryotic microorganisms. 
  • From dietary glucose to liver glycogen: the full circle round. 
  • Functional analysis of two distinct bronchiolar progenitors during lung injury and repair. 
  • Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. 
  • Functions of skin-resident γδ T cells. 
  • GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. 
  • Genes determining blood cell traits. 
  • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. 
  • Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis. 
  • Genomewide search for type 2 diabetes susceptibility genes in four American populations. 
  • Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans. 
  • Glimpse of natural selection of long-lived T-cell clones in healthy life. 
  • Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. 
  • Glucose homeostasis abnormalities associated with use of gatifloxacin. 
  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. 
  • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. 
  • Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. 
  • HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use. 
  • Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells. 
  • Heme oxygenase 1 is required for mammalian iron reutilization. 
  • Hepatic β-arrestin 2 is essential for maintaining euglycemia. 
  • Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons. 
  • High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. 
  • Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. 
  • Holding the Inflammatory System in Check: TLRs and NLRs. 
  • Homeostasis and dynamic stability of the phenotype link robustness and plasticity. 
  • Homeostatic control of lymphocyte survival: potential origins and implications. 
  • Homeostatic imbalance of purine catabolism in first-episode neuroleptic-naïve patients with schizophrenia. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Homeostatic regulation of airway smooth muscle tone by catecholamine secretion in swine. 
  • How are we going to understand (dys)regulation of glucose metabolism? 
  • Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral homeostasis in 75% nephrectomized weanling rats. 
  • Hyperkalemia: a review. 
  • IL-15 regulates homeostasis and terminal maturation of NKT cells. 
  • IL-7 is essential for homeostatic control of T cell metabolism in vivo. 
  • INP51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype. 
  • Identification of a third autonomous activation domain within the human estrogen receptor. 
  • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 
  • Impact of hypocapnia and cerebral perfusion on orthostatic tolerance. 
  • Implications of Serum Chloride Homeostasis in Acute Heart Failure (from ROSE-AHF). 
  • In hypertension, the kidney breaks your heart. 
  • In hypertension, the kidney rules. 
  • Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator. 
  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. 
  • Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. 
  • Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion. 
  • Inhibitory role of the coronary arterial endothelium to alpha-adrenergic stimulation in experimental heart failure. 
  • Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. 
  • Integrating trace element metabolism from the cell to the whole organism. 
  • Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. 
  • Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese. 
  • Intrasteric regulation of myosin light chain kinase: the pseudosubstrate prototope binds to the active site. 
  • Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche. 
  • Iron and Iron-Related Proteins in Asbestosis. 
  • Iron and copper in mitochondrial diseases. 
  • Iron deprivation in cancer--potential therapeutic implications. 
  • Iron homeostasis and eye disease. 
  • Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. 
  • Iron homeostasis in the lung. 
  • Iron homeostasis. 
  • Iron homeostasis: insights from genetics and animal models. 
  • Iron metabolism: iron deficiency and iron overload. 
  • Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis. 
  • Islet α cells and glucagon--critical regulators of energy homeostasis. 
  • Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. 
  • Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. 
  • Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. 
  • Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. 
  • Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins. 
  • Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. 
  • Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus. 
  • Lung injury after ozone exposure is iron dependent. 
  • Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice. 
  • MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. 
  • MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. 
  • Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis. 
  • Magnesium neuroprotection is limited in humans with acute brain injury. 
  • Maintaining T lymphocyte homeostasis: another duty of autophagy. 
  • Maintenance of nitric oxide and redox homeostasis by the salmonella flavohemoglobin hmp. 
  • Mast cell modulation of the vascular and lymphatic endothelium. 
  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. 
  • Mechanical determinants of myocardial oxygen consumption in conscious dogs. 
  • Mechanical homeostasis is altered in uterine leiomyoma. 
  • Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1. 
  • Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. 
  • Metabolic capacity regulates iron homeostasis in endothelial cells. 
  • Metabolic engineering with recombinant adenoviruses. 
  • Metabolic factors associated with endotoxin-induced tolerance for hemorrhagic shock. 
  • Metabolic phenotype in the brothers of women with polycystic ovary syndrome. 
  • Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. 
  • Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. 
  • Metformin reverses fatty liver disease in obese, leptin-deficient mice. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. 
  • Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE. 
  • Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. 
  • Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. 
  • Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes. 
  • Mitochondrial Toxicity. 
  • Model calculations of steady state responses to binaural stimuli in the dorsal nucleus of the lateral lemniscus. 
  • Modeling the effects of positive and negative feedback in kidney blood flow control. 
  • Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis. 
  • Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. 
  • Molecular control of iron metabolism. 
  • Molecular control of steady-state dendritic cell maturation and immune homeostasis. 
  • Molecular mechanisms of beta-adrenergic receptor desensitization. 
  • Multicolor Cell Barcoding Technology for Long-Term Surveillance of Epithelial Regeneration in Zebrafish. 
  • Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice. 
  • Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis. 
  • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). 
  • Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. 
  • NADH fluorescence, [K+]0 and oxygen consumption in cat cerebral cortex during direct cortical stimulation. 
  • NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition. 
  • NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. 
  • Na channel kinetics remain stable during perforated-patch recordings. 
  • Neonates support "homeostatic" proliferation. 
  • Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala. 
  • Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress. 
  • Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium. 
  • New insights into angiotensin receptor actions: from blood pressure to aging. 
  • New light on an age-old issue. 
  • New roles for copper metabolism in cell proliferation, signaling, and disease. 
  • New ways in which GLP-1 can regulate glucose homeostasis. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse. 
  • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. 
  • Nutrition Modulation of Cardiotoxicity and Anticancer Efficacy Related to Doxorubicin Chemotherapy by Glutamine and ω-3 Polyunsaturated Fatty Acids. 
  • Obesity-related derangements in metabolic regulation. 
  • Opiates, intracranial pressure, and autoregulation. 
  • Osteoprotegerin in bone metastases: mathematical solution to the puzzle. 
  • Out of Eden: stem cells and their niches. 
  • Oxygen flux analysis to understand the biological function of sirtuins. 
  • PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling. 
  • PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. 
  • Parathyroid autotransplantation: use of cryopreserved glands in an investigation of hypocalcemia. 
  • Pathways of apoptosis in lymphocyte development, homeostasis, and disease. 
  • Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. 
  • Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. 
  • Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone. 
  • Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. 
  • Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus. 
  • Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. 
  • Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins. 
  • Plasma adiponectin increases postprandially in obese, but not in lean, subjects. 
  • Plasticity in the lung: making and breaking cell identity. 
  • Polarity and stratification of the epidermis. 
  • Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction. 
  • Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment. 
  • Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Propagation of fluctuations in biochemical systems, I: linear SSC networks. 
  • Prostaglandins in severe congestive heart failure. Relation to activation of the renin--angiotensin system and hyponatremia. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. 
  • Protein phosphorylation is a regulatory mechanism for O6-alkylguanine-DNA alkyltransferase in human brain tumor cells. 
  • Protein synthesis. The perks of balancing glucose. 
  • RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. 
  • Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. 
  • Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis. 
  • Recent advances in renal hemodynamics: insights from bench experiments and computer simulations. 
  • Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. 
  • Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis. 
  • Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy. 
  • Recombinant biologics for treatment of bleeding disorders. 
  • Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger. 
  • Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease. 
  • Redox regulation of mitochondrial biogenesis. 
  • Reduced stress defense in heme oxygenase 1-deficient cells. 
  • Regional cerebral blood flow in humans at high altitude: gradual ascent and 2 wk at 5,050 m. 
  • Regions of the 110-kDa regulatory subunit M110 required for regulation of myosin-light-chain-phosphatase activity in smooth muscle. 
  • Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. 
  • Regulating regulatory T cells. 
  • Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage. 
  • Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans. 
  • Regulation of T-cell survival and mitochondrial homeostasis by TSC1. 
  • Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. 
  • Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. 
  • Regulation of ion transport by the NHERF family of PDZ proteins. 
  • Regulation of overexpressed hexokinases in liver and islet cells. 
  • Regulation of serum 1,25-dihydroxyvitamin D3 in lactating rats. 
  • Regulation of steady-state neutrophil homeostasis by macrophages. 
  • Regulative capacity of the archenteron during gastrulation in the sea urchin. 
  • Regulatory and structural motifs of chicken gizzard myosin light chain kinase. 
  • Relationships of labyrinthine fluid pressures and blood flow. 
  • Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents. 
  • Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat. 
  • Renin-specific antibody for study of cardiovascular homeostasis. 
  • Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. 
  • Role of Acid-Base Homeostasis in Diabetic Kidney Disease. 
  • Role of aquaporin-1 in trabecular meshwork cell homeostasis during mechanical strain. 
  • Role of autophosphorylation in regulating calmodulin-dependent protein kinases. 
  • Role of fructose in the adaptation of plants to cold-induced oxidative stress. 
  • Roles of autophagy in lymphocytes: reflections and directions. 
  • SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. 
  • SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice. 
  • Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription. 
  • Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. 
  • Screening methods for thyroid hormone disruptors. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion. 
  • Serotonin synthesis, release and reuptake in terminals: a mathematical model. 
  • Serum FGF23 levels in normal and disordered phosphorus homeostasis. 
  • Sex differences in substrate metabolism and energy homeostasis. 
  • Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants. 
  • Short-term calcitriol administration improves calcium homeostasis in adults with cystic fibrosis. 
  • Sialic acid content of plasminogen 2 glycoforms as a regulator of fibrinolytic activity. Isolation, carbohydrate analysis, and kinetic characterization of six glycoforms of plasminogen. 
  • Signaling by the TNF receptor superfamily and T cell homeostasis. 
  • Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. 
  • Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome. 
  • Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. 
  • Soluble B7-H1: Differences in production between dendritic cells and T cells 
  • Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology. 
  • Stem cells and their niches: integrated units that maintain Drosophila tissues. 
  • Stem cells are dispensable for lung homeostasis but restore airways after injury. 
  • Stem cells of the adult lung: their development and role in homeostasis, regeneration, and disease. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. 
  • Sustained attention performance during sleep deprivation associates with instability in behavior and physiologic measures at baseline. 
  • T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. 
  • TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development. 
  • TRP channels in disease. 
  • Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. 
  • Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow. 
  • Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. 
  • The ABCDs of periplasmic copper trafficking. 
  • The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis. 
  • The Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action. 
  • The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. 
  • The Na-H exchanger regulatory factor. 
  • The PICALM protein plays a key role in iron homeostasis and cell proliferation. 
  • The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. 
  • The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability. 
  • The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The contribution of autophagy to lymphocyte survival and homeostasis. 
  • The dopamine transporter: a crucial component regulating dopamine transmission. 
  • The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly. 
  • The effect of depressing glial function in rat brain in situ on ion homeostasis, synaptic transmission, and neuron survival. 
  • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The functional approach to the care of the elderly: a conceptual framework. 
  • The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis. 
  • The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. 
  • The importance of LAT in the activation, homeostasis, and regulatory function of T cells. 
  • The inextricable role of the kidney in hypertension. 
  • The ins and outs of iron homeostasis. 
  • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. 
  • The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. 
  • The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. 
  • The metabolic life and times of a T-cell. 
  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. 
  • The nature and regulation of the alternative oxidase of plant mitochondria. 
  • The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. 
  • The prosurvival protein BAG3: a new participant in vascular homeostasis. 
  • The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. 
  • The renin-angiotensin system and diabetic nephropathy. 
  • The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. 
  • The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy. 
  • The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. 
  • The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. 
  • The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. 
  • The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis. 
  • The role of phosphorylation/dephosphorylation of acetyl-CoA carboxylase in the regulation of mammalian fatty acid biosynthesis. 
  • The role of proteolytic cellular systems in trabecular meshwork homeostasis. 
  • The role of sinoaortic and cardiopulmonary baroreceptor reflex arcs in nociception and stress-induced analgesia. 
  • The role of the transcription factor ETV5 in insulin exocytosis. 
  • The roles of 14-3-3 proteins in signal transduction. 
  • The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA. 
  • Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. 
  • Theoretical assessment of renal autoregulatory mechanisms. 
  • Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. 
  • Tissue renin-angiotensin system: physiologic and pharmacologic implications. Introduction. 
  • Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. 
  • Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney. 
  • Transfer function analysis of dynamic cerebral autoregulation in preeclampsia. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
  • Transient postnatal elevation of norepinephrine content and turnover in brain regions of rats exposed to terbutaline prenatally: evidence for autoregulation of noradrenergic development? 
  • Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity. 
  • Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. 
  • Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. 
  • Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. 
  • Uremic tumoral calcinosis: preliminary observations suggesting an association with aberrant vitamin D homeostasis. 
  • Using mathematical models to understand metabolism, genes, and disease. 
  • Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. 
  • Vascular angiotensin pathways: a new therapeutic target. 
  • Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. 
  • Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. 
  • Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. 
  • What does it take to make the perfect clot? 
  • What you and your patients need to know about vitamin D. 
  • While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001. 
  • c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. 
  • cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. 
  • mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. 
  • pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Chitneni, Satish K., Associate Professor in Radiology, Radiology
  • Cianciolo, George James, Associate Professor in Pathology, Pathology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hirschey, Matthew, Associate Professor in Medicine, Pharmacology & Cancer Biology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Juvvadi, Praveen Rao, Assistant Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, with tenure, School of Nursing
  • Schmid, Amy K., Associate Professor of Biology, Duke Science & Society
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology
  • Steinbach, William J., Professor of Pediatrics, Duke Innovation & Entrepreneurship
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Turi, Jennifer Lilly, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology