Homocysteine

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  Subject Areas on Research

  • A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. 
  • A mathematical model of the methionine cycle. 
  • A population model of folate-mediated one-carbon metabolism. 
  • Abnormalities in S-adenosylhomocysteine hydrolysis, ATP catabolism, and lymphoid differentiation in adenosine deaminase deficiency. 
  • Alterations of fibrinogen structure in human disease. 
  • An alternative pseudolikelihood method for multivariate random-effects meta-analysis. 
  • Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. 
  • Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attack. 
  • Associations between elevated homocysteine, cognitive impairment, and reduced white matter volume in healthy old adults. 
  • Authors' response. 
  • Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. 
  • Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. 
  • C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. 
  • Capgras syndrome in homocystinuria. 
  • Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Differences in the metabolic response to exogenous homocysteine in juvenile and adult rabbits. 
  • Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. 
  • Effect of glutamate analogues on brain tumor cell lines. 
  • Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial. 
  • Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia. 
  • Folate and unipolar depression. 
  • Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. 
  • Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase. 
  • Homocysteine and Cerebral Atrophy: The Epidemiology of Dementia in Singapore Study. 
  • Homocysteine and retinal emboli: the Blue Mountains Eye Study. 
  • Homocysteine and retinal vein occlusion: a population-based study. 
  • Homocysteine as a risk factor of restenosis after carotid endarterectomy. 
  • Homocysteine testing in patients with acute ischemic stroke. 
  • Homocysteinylated fibrinogen forms disulfide-linked complexes with albumin. 
  • Inflammatory, hemostatic, and other novel biomarkers for diabetic retinopathy: the multi-ethnic study of atherosclerosis. 
  • Left atrial enlargement: a cause of stroke? 
  • Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology. 
  • Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains. 
  • Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico. 
  • Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. 
  • Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs. 
  • Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia. 
  • Nitrous oxide anesthesia and plasma homocysteine in adolescents. 
  • Novel risk factors for stroke: homocysteine, inflammation, and infection. 
  • One-carbon metabolism during the menstrual cycle and pregnancy 
  • One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels. 
  • Perturbations in S-adenosylhomocysteine and S-adenosylmethionine metabolism: effects on transmethylation. 
  • Plasminogen activator inhibitor-1 (PAI-1) activity and retinal vascular calibre in type 2 diabetes. 
  • Pre-operative homocysteine levels and morbidity and mortality following cardiac surgery. 
  • Pro-thrombotic and pro-oxidant effects of diet-induced hyperhomocysteinemia. 
  • Regulation of mononuclear leukocyte function by transmethylation reactions. 
  • Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging. 
  • Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation. 
  • Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians. 
  • S-Adenosylhomocysteine metabolism in adenosine deaminase deficient cells. 
  • S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine. 
  • S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin. 
  • Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study. 
  • Serum homocysteine and stroke in atrial fibrillation. 
  • Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE). 
  • Sex differences in hepatic one-carbon metabolism. 
  • The DASH diet and blood pressure. 
  • The associations between blood levels of homocysteine, folate, vitamin B12, and retinal vascular caliber. 
  • The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. 
  • Total plasma homocysteine and primary open-angle glaucoma. 
  • Total plasmatic homocysteine and von Willebrand factor in experimental diabetes mellitus. 
  • Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates. 
  • Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants. 
  • Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. 
  • Vitamin B12 and Homocysteine Associations with Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging. 
  • Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation. 
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  Keywords of People

  • Hoffman, Maureane, Professor of Pathology, Integrative Immunobiology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics