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Subject Areas on Research
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16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.
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An amino-terminal fragment of LCRF, LCRF-(1-35), has the same activity as the natural peptide.
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Cigarette smoke-induced placental adrenomedullin expression and trophoblast cell invasion.
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Cycle day, estrogen level, and lead follicle size: analysis of 27,790 in vitro fertilization cycles to determine optimal start criteria for gonadotropin-releasing hormone antagonist.
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Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.
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Endocrine Screening Methods Workshop report: detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms.
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Endocrine therapy in metastatic breast cancer.
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Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis.
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Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.
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Human placental lactogen infusions into the medial preoptic area stimulate maternal behavior in steroid-primed, nulliparous female rats.
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Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.
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Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins.
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Inhibition of growth of OV-1063 human epithelial ovarian cancers and c- jun and c- fos oncogene expression by bombesin antagonists.
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International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors.
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Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
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Laboratory animal science issues in the design and conduct of studies with endocrine-active compounds.
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Luteal supplementation in in vitro fertilization: more questions than answers.
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Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs).
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Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.
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Mifepristone (RU 486) for Alzheimer's disease.
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Mild/minimal stimulation for in vitro fertilization: an old idea that needs to be revisited.
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Minimal ovarian hyperstimulation for in vitro fertilization using sequential clomiphene citrate and gonadotropin with or without the addition of a gonadotropin-releasing hormone antagonist.
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Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
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Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone.
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Prostate cancer: making the switch from LHRH antagonist to LHRH agonist.
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Purification and characterization of a luminal cholecystokinin-releasing factor from rat intestinal secretion.
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RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.
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Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells.
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Testosterone rapidly increases neural reactivity to threat in healthy men: a novel two-step pharmacological challenge paradigm.
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The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins.
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The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
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The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.
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Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium.
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Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X.
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Ventilatory and metabolic effects of hypercapnia in conscious rats: AVP V1 receptor block.
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Keywords of People
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Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Duke Innovation & Entrepreneurship
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Pastva, Amy Martha,
Associate Professor in Orthopaedic Surgery,
Cell Biology