Hydroxycholesterols

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  Subject Areas on Research

  • 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. 
  • 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. 
  • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. 
  • 27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative. 
  • 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. 
  • 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. 
  • CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. 
  • Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1. 
  • Cholesterol and breast cancer pathophysiology. 
  • Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. 
  • Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. 
  • Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. 
  • From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). 
  • Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. 
  • Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. 
  • Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 
  • Obesity, cholesterol metabolism, and breast cancer pathogenesis. 
  • The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. 
  • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 
  • The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. 
  • The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology