Subject Areas on Research
- 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.
- 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells.
- 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.
- 27-Hydroxycholesterol, an Endogenous SERM, and Risk of Fracture in Postmenopausal Women: A Nested Case-Cohort Study in the Women's Health Initiative.
- 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.
- 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
- CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.
- Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1.
- Cholesterol and breast cancer pathophysiology.
- Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol.
- Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer.
- Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region.
- From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).
- Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels.
- Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.
- Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
- Obesity, cholesterol metabolism, and breast cancer pathogenesis.
- The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.
- The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.
- The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.
- The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.
- Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants.
Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology