Mixed Function Oxygenases

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  Subject Areas on Research

  • A Pseudomonas syringae type III effector suppresses cell wall-based extracellular defense in susceptible Arabidopsis plants. 
  • A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans. 
  • A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. 
  • A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance. 
  • A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. 
  • A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans. 
  • Activation of phenylalanine hydroxylase by phenylalanine. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. 
  • Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe. 
  • Biallelic variants in AGMO with diminished enzyme activity are associated with a neurodevelopmental disorder. 
  • Biochemical and ultrastructural changes in teleost liver following subacute exposure to PCB. 
  • Biological chemistry of carbon monoxide. 
  • CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. 
  • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. 
  • Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism. 
  • Clinical application of cardiovascular pharmacogenetics. 
  • Comparison of acute response to polychlorinated biphenyl in liver of rat and channel catfish: a biochemical and morphological study. 
  • Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. 
  • Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. 
  • Dietary influences on the hepatic mixed-function oxidase system in the rat after portacaval anastomosis. 
  • Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. 
  • Distinct and overlapping roles of two gibberellin 3-oxidases in Arabidopsis development. 
  • Distinct cell-specific expression patterns of early and late gibberellin biosynthetic genes during Arabidopsis seed germination. 
  • Early de novo DNA methylation and prolonged demethylation in the muscle lineage. 
  • Ecological transition predictably associated with gene degeneration. 
  • Effect of intratracheal administration of DDT and endosulfan on cytochrome P-450 and glutathione-s-transferase in lung and liver of rats. 
  • Effect of simulated hypoxia (7620 m, 6 h) on hepatic microsomal drug metabolising enzymes activity in rats given ethanol and vitamin A. 
  • Effects of carbon tetrachloride on adrenocortical structure and function in guinea pigs. 
  • Effects of dietary pectin and cellulose on hepatic and intestinal mixed-function oxidations and hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the rat. 
  • Enantiomeric metabolic interactions and stereoselective human methadone metabolism. 
  • Enzymatically amplified voltammetric sensor for microliter sample volumes of salicylate. 
  • Estimation of the warfarin dose with clinical and pharmacogenetic data. 
  • Expression of candidate pro-GnRH processing enzymes in rat hypothalamus and an immortalized hypothalamic neuronal cell line. 
  • FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling. 
  • Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. 
  • Genetic-based dosing in orthopedic patients beginning warfarin therapy. 
  • Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. 
  • Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. 
  • Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4. 
  • Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms. 
  • Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. 
  • Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs. 
  • Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • In vitro inhibition of chick embryo lysyl hydroxylase by homogentisic acid. A proposed connective tissue defect in alkaptonuria. 
  • In vivo and in vitro analyses of amygdalar function reveal a role for copper. 
  • Induction of hepatic drug metabolizing enzymes by coal fly ash in rats. 
  • Induction of hepatic mixed function oxidase system by endosulfan in rats. 
  • Induction of pulmonary and hepatic cytochrome P-450 species by coal fly ash inhalation in rats. 
  • Induction of pulmonary drug metabolizing enzymes by coal fly ash in rats. 
  • Inhibition of coal fly ash polycyclic aromatic hydrocarbons and metals induced mixed-function oxidase activity in rat lung and liver by vitamin A and citrate. 
  • Inhibition of lysyl hydroxylase by catechol analogs. 
  • Inhibition of microsomal oxidative drug metabolism by 1,4-bis (2-[(2-hydroxyethyl)amino]-ethylamino)-9,10-anthracenedione diacetate, a new antineoplastic agent. 
  • Inter-individual differences in baseline coagulation activities and their implications for international normalized ratio control during warfarin initiation therapy. 
  • Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolising enzymes. 
  • Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. 
  • Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. 
  • Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance. 
  • Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. 
  • Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1. 
  • Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. 
  • Menstrual cycle variability in midazolam pharmacokinetics. 
  • Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Mixed function oxidases in response to quality and quantity of dietary protein. 
  • Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response. 
  • Newer knowledge of vitamin D and its metabolites in health and disease. 
  • Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. 
  • Omeprazole: a possible new candidate influencing the antiplatelet effect of clopidogrel. 
  • Oxidant, mixed-function oxidase and peroxisomal responses in channel catfish exposed to a bleached kraft mill effluent. 
  • Parallel evolution at multiple levels in the origin of hummingbird pollinated flowers in Ipomoea. 
  • Patterns of evolutionary rate variation among genes of the anthocyanin biosynthetic pathway. 
  • Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. 
  • Phenylalanine hydroxylase activity in mammalian cells. 
  • Phytochrome regulation and differential expression of gibberellin 3b-hydroxylase genes in germinating Arabidopsis seeds 
  • Potential sites of bioactive gibberellin production during reproductive growth in Arabidopsis. 
  • Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes. 
  • Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux. 
  • Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. 
  • Rat fighting behavior: serum dopamine- -hydroxylase and hypothalamic tyrosine hydroxylase. 
  • Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. 
  • Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers. 
  • Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. 
  • Single-dose disulfiram does not inhibit CYP2A6 activity. 
  • Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. 
  • Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). 
  • The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX). 
  • The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. 
  • The desirable donor pig to eliminate all xenoreactive antigens. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs. 
  • The genetic basis of a flower-color polymorphism in the common 
  • The long and winding road to warfarin pharmacogenetic testing. 
  • The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions. 
  • Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. 
  • Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. 
  • VKORC1 haplotypes in five East-Asian populations and Indians. 
  • Variability in St. John's wort formulations is an important consideration. 
  • Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like. 
  • delta-Aminolevulinic acid synthetase and heme oxygenase activity in lung and liver of rats given DDT and endosulfan intratracheally. 
  • siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth.