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Subject Areas on Research
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A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine.
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Altered posttranslational modifications of collagen in keloid.
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Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity.
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Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.
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Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats.
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Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet.
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Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene.
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Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure.
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Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo.
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Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen.
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Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
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Gold(I)-catalyzed dynamic kinetic enantioselective intramolecular hydroamination of allenes.
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Gold(I)-catalyzed intramolecular enantioselective hydroalkoxylation of allenes.
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Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.
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Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol.
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Hydroxyl radical production in the brain after CO hypoxia in rats.
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Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899.
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Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
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In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)- one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites.
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Lysine hydroxylation of collagen in a fibroblast cell culture system.
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Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.
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Microbial hydroxylation and reduction of the diterpene psiadin.
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Mitochondrial generation of reactive oxygen species after brain ischemia in the rat.
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New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system.
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Nitration of tyrosine by hydrogen peroxide and nitrite.
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Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
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Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat.
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Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model.
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Prolonged production of hydroxyl radical in rat hippocampus after brain ischemia-reperfusion is decreased by 21-aminosteroids.
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Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
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Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate.
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Regio- and stereoselective synthesis of alkyl allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes with alcohols.
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Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.
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Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.
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Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.
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Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction.
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.