Hydroxylation
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Subject Areas on Research
- A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine.
- Altered posttranslational modifications of collagen in keloid.
- Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.
- Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats.
- Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet.
- Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene.
- Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure.
- Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo.
- Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen.
- Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
- Gold(I)-catalyzed dynamic kinetic enantioselective intramolecular hydroamination of allenes.
- Gold(I)-catalyzed intramolecular enantioselective hydroalkoxylation of allenes.
- Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.
- Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol.
- Hydroxyl radical production in the brain after CO hypoxia in rats.
- Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
- Lysine hydroxylation of collagen in a fibroblast cell culture system.
- Mitochondrial generation of reactive oxygen species after brain ischemia in the rat.
- New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system.
- Nitration of tyrosine by hydrogen peroxide and nitrite.
- Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
- Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat.
- Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model.
- Prolonged production of hydroxyl radical in rat hippocampus after brain ischemia-reperfusion is decreased by 21-aminosteroids.
- Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
- Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate.
- Regio- and stereoselective synthesis of alkyl allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes with alcohols.
- Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
- Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction.
- The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.