Hydroxylation

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  Subject Areas on Research

  • A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of L-[3,5-3H]kynurenine. 
  • Altered posttranslational modifications of collagen in keloid. 
  • Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity. 
  • Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat. 
  • Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. 
  • Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet. 
  • Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene. 
  • Determination of glucuronide conjugates of hydroxyl triphenyl phosphate (OH-TPHP) metabolites in human urine and its use as a biomarker of TPHP exposure. 
  • Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo. 
  • Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen. 
  • Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. 
  • Gold(I)-catalyzed dynamic kinetic enantioselective intramolecular hydroamination of allenes. 
  • Gold(I)-catalyzed intramolecular enantioselective hydroalkoxylation of allenes. 
  • Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. 
  • Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol. 
  • Hydroxyl radical production in the brain after CO hypoxia in rats. 
  • Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899. 
  • Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. 
  • In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)- one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites. 
  • Lysine hydroxylation of collagen in a fibroblast cell culture system. 
  • Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. 
  • Microbial hydroxylation and reduction of the diterpene psiadin. 
  • Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. 
  • New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system. 
  • Nitration of tyrosine by hydrogen peroxide and nitrite. 
  • Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. 
  • Production of hydroxyl radical in the hippocampus after CO hypoxia or hypoxic hypoxia in the rat. 
  • Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model. 
  • Prolonged production of hydroxyl radical in rat hippocampus after brain ischemia-reperfusion is decreased by 21-aminosteroids. 
  • Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. 
  • Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate. 
  • Regio- and stereoselective synthesis of alkyl allylic ethers via gold(I)-catalyzed intermolecular hydroalkoxylation of allenes with alcohols. 
  • Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2. 
  • Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs. 
  • Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. 
  • Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. 
  • Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.