Hyperglycemia

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  Subject Areas on Research

  • 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). 
  • A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. 
  • A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats. 
  • A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding. 
  • A survey of reports of quetiapine-associated hyperglycemia and diabetes mellitus. 
  • Acute changes in intracranial pressure and pressure-volume index after forebrain ischemia in normoglycemic and hyperglycemic rats. 
  • Age attenuates leucine oxidation after eccentric exercise. 
  • Aldose Reductase Polymorphisms, Fasting Blood Glucose, and Age-Related Cortical Cataract. 
  • Alprazolam reduces stress hyperglycemia in ob/ob mice. 
  • Astroglial acid-base dynamics in hyperglycemic and normoglycemic global ischemia. 
  • Atypical antipsychotic drugs and hyperglycemia in adolescents. 
  • Automated bolus advisor control and usability study (ABACUS): does use of an insulin bolus advisor improve glycaemic control in patients failing multiple daily insulin injection (MDI) therapy? [NCT01460446]. 
  • Baseline predictors of A1C reduction in adults using sensor-augmented pump therapy or multiple daily injection therapy: the STAR 3 experience. 
  • Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. 
  • Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. 
  • Cardiovascular Outcome Trial Update in Diabetes: New Evidence, Remaining Questions. 
  • Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats. 
  • Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics. 
  • Classically conditioned hyperglycemia in the obese mouse. 
  • Clinical pharmacology of insulin confounds stroke trials. 
  • Commentary: cardiovascular risk factors--the next epidemic in Uganda: findings from the population-based HIV/AIDS rural surveillance cohort. 
  • Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. 
  • Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. 
  • Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1. 
  • Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries. 
  • Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. 
  • Critical illness hyperglycemia in pediatric cardiac surgery. 
  • Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. 
  • Diabetes and cardiovascular disease in older adults: current status and future directions. 
  • Diabetes and the Association of Postoperative Hyperglycemia With Clinical and Economic Outcomes in Cardiac Surgery. 
  • Diabetes management and self-care education for hospitalized patients with cancer. 
  • Diabetes summer camps: history, safety, and outcomes. 
  • Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. 
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. 
  • Diabetic retinopathy. 
  • Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes. 
  • Duodenal glucagonoma: a case report. 
  • Dynamic changes in retinal vessel diameter during acute hyperglycemia in type 1 diabetes. 
  • Effect of A1C and Glucose on Postoperative Mortality in Noncardiac and Cardiac Surgeries. 
  • Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test. 
  • Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. 
  • Effectively identifying the inpatient with hyperglycemia to increase patient care and lower costs. 
  • Effects of moderate and high glycemic index meals on metabolism and exercise performance. 
  • Efficacy and safety of dapagliflozin in acute heart failure: Rationale and design of the DICTATE-AHF trial. 
  • Elevated HbA1c in donor organs from patients without a diagnosis of diabetes portends worse liver allograft survival. 
  • Ethnic variation in the impact of metabolic syndrome components and chronic kidney disease. 
  • Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage. 
  • Evaluation of alpelisib-induced hyperglycemia prophylaxis and associated risk factors in PIK3CA-mutated hormone-receptor positive, human epidermal growth factor-2 negative advanced breast cancer. 
  • Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia. 
  • Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. 
  • Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse. 
  • Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by administration of caffeine in coffee. 
  • Gamma Knife radiosurgery as a primary surgical treatment for hypersecreting pituitary adenomas. 
  • Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. 
  • Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. 
  • Glucose control in hospitalized patients. 
  • Glutamine in critical illness: the time has come, the time is now. 
  • Glutamine. 
  • Glycemic control in patients undergoing coronary artery bypass graft surgery: Clinical features, predictors, and outcomes. 
  • Glycemic index, retinal vascular caliber, and stroke mortality. 
  • Glycogenic Hepatopathy Causing Elevated Lactic Acid and Liver Enzymes. 
  • Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression. 
  • High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. 
  • Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia. 
  • Human vitamin D receptor mutations: identification of molecular defects in hypocalcemic vitamin D resistant rickets. 
  • Hyperglycaemia associated with lactic acidaemia in a renal allograft recipient with type I glycogen storage disease. 
  • Hyperglycaemia in infants with hypoxic-ischaemic encephalopathy is associated with improved outcomes after therapeutic hypothermia: a post hoc analysis of the CoolCap Study. 
  • Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse. 
  • Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells. 
  • Hyperglycemia is not associated with mortality in bacterial meningitis. 
  • Hyperglycemia, Risk of Subsequent Stroke, and Efficacy of Dual Antiplatelet Therapy: A Post Hoc Analysis of the POINT Trial. 
  • Hyperglycemia, obesity, and cancer risks on the horizon. 
  • Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. 
  • Hypertonic hyperglycemia progresses to diabetes faster than normotonic hyperglycemia. 
  • Hyponatraemia in acute heart failure is a marker of increased mortality but not when associated with hyperglycaemia. 
  • ISPAD Guidelines. Managing diabetes in preschool children. 
  • Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia. 
  • Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study. 
  • Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. 
  • Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. 
  • Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program. 
  • Improved glycemic control enhances the incretin effect in patients with type 2 diabetes. 
  • Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. 
  • Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. 
  • Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. 
  • Inhibitory effects of hyperglycemia on neural activity of the vagus in rats. 
  • Insulin or glucagon choleresis in the isolated perfused guinea pig liver. 
  • Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants. 
  • Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes. 
  • Interaction of Blood Pressure and Glycemic Status in Developing Cardiovascular Disease: Analysis of a Nationwide Real-World Database. 
  • Intraoperative hyperglycemia and cognitive decline after CABG. 
  • Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. 
  • L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. 
  • Lack of knowledge of glycosylated hemoglobin in patients with diabetic retinopathy. 
  • Letter: Glycerol, cerebral oedema, and diabetes. 
  • Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. 
  • Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). 
  • Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). 
  • Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). 
  • Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). 
  • Managing hyperglycemia and diabetes in patients receiving enteral feedings: A health system approach. 
  • Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism. 
  • Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia. 
  • Medrogestone: a prospective study in the pharmaceutical management of benign prostatic hyperplasia. 
  • Metabolic syndrome and risk of age-related macular degeneration. 
  • Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. 
  • Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging. 
  • Need for insulin therapy in type II diabetes mellitus. A randomized trial. 
  • New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. 
  • Non-ketotic hyperglycemic chorea-hemiballismus mimicking basal ganglia hemorrhage. 
  • Nonketotic hyperglycemia due to prednisone (NSC-10023) following ketotic hyperglycemia due to L-asparaginase (NSC-109229) plus prednisone. 
  • Number of children and risk of metabolic syndrome in women. 
  • Nutritional regulation of insulin-like growth factor-binding protein gene expression in the ovine fetus and pregnant ewe. 
  • Olanzapine-associated diabetes mellitus. 
  • Olanzapine-associated severe hyperglycemia, ketonuria, and acidosis: case report and review of literature. 
  • Optimizing hospital use of intravenous insulin therapy: improved management of hyperglycemia and error reduction with a new nomogram. 
  • Optimizing perioperative glycemic control. 
  • Outpatient diagnostic errors: unrecognized hyperglycemia. 
  • Path-level interpretation of Gaussian graphical models using the pair-path subscore. 
  • Patient Self-Management of Diabetes Care in the Inpatient Setting: Pro. 
  • Patients' Preferences Related to Benefits, Risks, and Formulations of Schizophrenia Treatment. 
  • Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: a longitudinal qualitative investigation. 
  • Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial: Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). 
  • Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas. 
  • Persistent perioperative hyperglycemia as an independent predictor of poor outcome after aneurysmal subarachnoid hemorrhage. 
  • Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone. 
  • Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation. 
  • Plasma glucose responses in recreational divers with insulin-requiring diabetes. 
  • Poor glycemic control is a strong predictor of postoperative morbidity and mortality in patients undergoing vascular surgery. 
  • Postoperative hyperglycemia after 4- vs 8-10-mg dexamethasone for postoperative nausea and vomiting prophylaxis in patients with type II diabetes mellitus: a retrospective database analysis. 
  • Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction. 
  • Preoperative carbohydrate loading in surgical patients with type 2 diabetes: Are concerns supported by data? 
  • Prevalence, Risk Factors, and Pathophysiology of Dysglycemia among People Living with HIV in Sub-Saharan Africa. 
  • Prognostic significance of the change in glucose level in the first 24 h after acute myocardial infarction: results from the CARDINAL study. 
  • Protein synthesis. The perks of balancing glucose. 
  • Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus. 
  • Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial. 
  • Rats! Hyperglycemia protects against glaucoma! 
  • Recall of three heart disease risk factor diagnoses among low-income women. 
  • Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia. 
  • Regulation of beta-cell glucose transporter gene expression. 
  • Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion. 
  • Reply: To PMID 22653543. 
  • Report on Racial Disparities in Hospitalized Patients with Hyperglycemia and Diabetes. 
  • Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. 
  • Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study. 
  • Risperidone-associated diabetes mellitus: a pharmacovigilance study. 
  • Role of continuous glucose monitoring in the management of glycogen storage disorders. 
  • Role of stress in the etiology and treatment of diabetes mellitus. 
  • Safely Converting an Entire Academic Medical Center From Sliding Scale to Basal Bolus Insulin via Implementation of the eGlycemic Management System. 
  • Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. 
  • Safety considerations with niacin therapy. 
  • Screening adults for pre-diabetes and diabetes may be cost-saving. 
  • Severe hyperglycemia associated with high doses of clozapine. 
  • Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. 
  • Six-month blood pressure and glucose control among HIV-infected adults with elevated blood pressure and hyperglycemia in northern Tanzania: A prospective observational study. 
  • Stress and autonomic nervous system in type II diabetes. A hypothesis. 
  • Strict glycemic targets need not be so strict: a more permissive glycemic range for critically ill children. 
  • Sulfonylurea Prescribing Patterns After the Introduction of DPP-4 Inhibitors and GLP-1 Receptor Agonists. 
  • Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia. 
  • TGF-beta: a new role for an old AktTOR. 
  • THE EFFECTS OF PERIOPERATIVE DEXAMETHASONE ON GLYCEMIC CONTROL AND POSTOPERATIVE OUTCOMES. 
  • Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups. 
  • Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia. 
  • Targeting the glucagon receptor signaling pathway as a novel strategy to counteract PI3K inhibitor induced hyperglycemia while sustaining tumor PI3K inhibition. 
  • Tetrahydroindenoindole inhibits the progression of diabetes in mice. 
  • The Burden of Hypertension and Diabetes in an Emergency Department in Northern Tanzania. 
  • The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. 
  • The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19. 
  • The clinical implications of recent studies on the structure and function of the retinal microvasculature in diabetes. 
  • The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes. 
  • The impact of hyperglycemia and obesity on hospitalization costs and clinical outcome in general surgery patients. 
  • The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial glycocalyx damage in a mouse model of type 2 diabetes. 
  • The influence of hyperglycemia on outcome of cerebral infarction. 
  • The role of dysregulated glucagon secretion in type 2 diabetes. 
  • The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. 
  • Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource. 
  • Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome. 
  • Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014. 
  • Type 1 Diabetes Mellitus. 
  • Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. 
  • Use of ECT in treatment of depression in patients with diabetes mellitus. 
  • Using insulin to prevent hyperglycemia in surgical patients. 
  • Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. 
  • Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. 
  • pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH. 
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  Keywords of People

  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology