Hyperplasia

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  Subject Areas on Research

  • A Quantitative Global Proteomics Approach Identifies Candidate Urinary Biomarkers That Correlate With Intraductal Papillary Mucinous Neoplasm Dysplasia. 
  • A Review of Sleeve Gastrectomy Specimen Histopathology. 
  • A case of acute onset gigantomastia in a 20-year-old woman. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A look at uterine wound healing through a histopathological study of uterine scars. 
  • A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. 
  • A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patient. 
  • A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. 
  • Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. 
  • Abnormal parathyroid glands: high-resolution MR imaging. 
  • Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. 
  • Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. 
  • Adrenocortical hyperplasia occurring with metastatic carcinoma of the prostate: report of a case exhibiting increased urinary aldosterone and glucocorticoid excretion. 
  • Adult-onset eccrine angiomatous hamartoma: report of a rare entity with unusual histological features. 
  • Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. 
  • An Extraordinary Association of Glomus Tumor and Pacinian Hyperplasia in the Hand of a Female Patient. 
  • Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants. 
  • Anterior segment optical coherence tomography features of pseudoepitheliomatous hyperplasia of the ocular surface: a study of 9 lesions. 
  • Antisense to transforming growth factor-beta(1) facilitates the apoptosis of macrophages in rat vein grafts. 
  • Association of breast cancer with the finding of atypical ductal hyperplasia at core breast biopsy. 
  • Atypical ductal hyperplasia: improved accuracy with the 11-gauge vacuum-assisted versus the 14-gauge core biopsy needle. 
  • Atypical hyperplasia: frequency and mammographic and pathologic relationships in excisional biopsies guided with mammography and clinical examination. 
  • Atypical tubule hyperplasia and renal tubule tumors in conventional rats on 90-day toxicity studies. 
  • B-cell lymphoma with hyaline vascular Castleman disease-like features: a clinicopathologic study. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • Balloon catheterization induced arterial expression of embryonic fibronectins. 
  • Basal-like cells constitute the proliferating cell population in cystic fibrosis airways. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia Necessitating Mastectomy. 
  • Borderline atypical ductal hyperplasia/low-grade ductal carcinoma in situ on breast needle core biopsy should be managed conservatively. 
  • Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • CT of the liver in patients with metastatic breast carcinoma treated by chemotherapy: findings simulating cirrhosis. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • CaN19 expression in benign and malignant hyperplasias of the skin and oral mucosa: evidence for a role in regenerative differentiation. 
  • Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility. 
  • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Case report. Atypical findings in adrenoleukodystrophy. 
  • Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. 
  • Choroid plexus hyperplasia: A possible cause of hydrocephalus in adults. 
  • Chromatophoromas and chromatophore hyperplasia in Pacific rockfish (Sebastes spp.). 
  • Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. 
  • Clinical review: irradiation for lower extremity arterial occlusive disease. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Colonic nodular lymphoid hyperplasia in a child with antibody deficiency and near-normal immunoglobulins. 
  • Compensatory renal growth after unilateral ureteral obstruction. 
  • Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. 
  • Criteria for the diagnosis of dysplasia by endoscopic optical coherence tomography. 
  • Cryosurgery for cardiac arrhythmias: acute and chronic effects on coronary arteries. 
  • Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. 
  • DEK proto-oncogene expression interferes with the normal epithelial differentiation program. 
  • Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Diagnostic criteria for degenerative, inflammatory, proliferative nonneoplastic and neoplastic liver lesions in medaka (Oryzias latipes): consensus of a National Toxicology Program Pathology Working Group. 
  • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. 
  • Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. 
  • Difficulties of parathyroidectomy after previous thyroidectomy. 
  • Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: Imaging and Clinical Features of a Frequently Delayed Diagnosis. 
  • Diffuse hyperplasia of intratarsal ectopic lacrimal gland tissue. 
  • Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. 
  • Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. 
  • Does compliance mismatch alone cause neointimal hyperplasia? 
  • Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns. 
  • Early onset of spontaneous renal preneoplastic and neoplastic lesions in young conventional rats in toxicity studies. 
  • Effect of erionite on the pleural mesothelium of the Fischer 344 rat. 
  • Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. 
  • Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. 
  • Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis. 
  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. 
  • Enlarged fetal gallbladder: prognostic importance for aneuploidy or biliary abnormality at antenatal US. 
  • Erythroleukemia: a study of 15 cases and literature review. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Estrogen receptor alpha (ESR1) mutant A908G is not a common feature in benign and malignant proliferations of the breast. 
  • Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. 
  • Experimental evaluation of microsurgical techniques in small artery anastomoses. 
  • Expression of cell adhesion molecule CD44 in primary tumors of the liver: an immunohistochemical study. 
  • Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. 
  • External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery: A Randomized Clinical Trial. 
  • Flow cytometric DNA analysis of excised breast lesions: use of fresh tissue needle aspirates obtained under guidance with mammography of the specimen. 
  • Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism. 
  • G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. 
  • Gastrin-releasing peptide gene expression in developing, hyperplastic, and neoplastic human thyroid C-cells. 
  • Gastroesophageal reflux and esophagitis in infants and children. 
  • Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia. 
  • Gene therapy and genomic strategies for cardiovascular surgery: The emerging field of surgiomics. 
  • Genetic manipulation of vein grafts. 
  • Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. 
  • Graft vascular disease after cardiac transplantation and its relationship to mean acute rejection score. 
  • Hemodynamic Parameters and Early Intimal Thickening in Branching Blood Vessels. 
  • Hemodynamic parameters and early intimal thickening in branching blood vessels. 
  • Hepatic adenoma and focal nodular hyperplasia. 
  • Hepatic adenoma: MR appearance mimicking focal nodular hyperplasia. 
  • Hepatic fibrosis associated with aging in four stocks of mice. 
  • Hepatic focal nodular hyperplasia in infant antenatally exposed to steroids. 
  • Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? 
  • Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia. 
  • Histological assessment of breast lesions identified exclusively by magnetic resonance. 
  • Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. 
  • Hypermethylation of the breast cancer-associated gene 1 promoter does not predict cytologic atypia or correlate with surrogate end points of breast cancer risk. 
  • Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging. 
  • Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. 
  • Incidental minimal atypical lobular hyperplasia on core needle biopsy: correlation with findings on follow-up excision. 
  • Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth. 
  • Increased ubiquitin immunoreactivity in hepatocellular carcinomas and precancerous lesions of the liver. 
  • Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury. 
  • Induction and spontaneous regression of pulmonary neuroendocrine cell hyperplasia in a hamster model. 
  • Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. 
  • Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling. 
  • Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury. 
  • Inhibition of intimal hyperplasia by direct thrombin inhibitors in an animal vein bypass model. 
  • Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. 
  • In Vivo Effects of Long-Term Cigarette Smoke Exposure on Mammary Tissue in Mice. 
  • Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells. 
  • Liver hypoxia as a trigger to liver regeneration: No more than another piece of the puzzle. 
  • Local ampullary resection with careful intraoperative frozen section evaluation for presumed benign ampullary neoplasms. 
  • Localization and characterization of secretin binding sites expressed by rat bile duct epithelium. 
  • Long-term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation. 
  • Lymphoid hyperplasia causing recurrent rectal prolapse. 
  • MR imaging with surface coils in primary hyperparathyroidism. 
  • MR microscopy of the rat carotid artery after balloon injury by using an implanted imaging coil. 
  • MRI with surface coils for parathyroid tumors: preliminary investigation. 
  • Massive thymic hyperplasia: characterization of a rare mediastinal mass. 
  • Masson's tumor of the pineal region: case report. 
  • Medrogestone: a prospective study in the pharmaceutical management of benign prostatic hyperplasia. 
  • Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. 
  • Microglandular hyperplasia in vaginal adenosis associated with oral contraceptives and prenatal diethylstilbestrol exposure. 
  • Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia. 
  • Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts. 
  • Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. 
  • Morphologic characterization of syndromic gastric polyps. 
  • Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. 
  • Mouse keratin 4 is necessary for internal epithelial integrity. 
  • Multidimensional Immunophenotyping of Intraductal Papillary Mucinous Neoplasms Reveals Novel T Cell and Macrophage Signature. 
  • Multilocular thymic cysts in children with human immunodeficiency virus infection: clinical and pathologic aspects. 
  • Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. 
  • Myometrial hyperplasia mimics the clinical presentation of uterine fibroids: a report of 3 cases. 
  • Myopia predicts better outcome in persistent hyperplastic primary vitreous. 
  • Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model. 
  • Nodular Regenerative Hyperplasia After Treatment With Trastuzumab Emtansine. 
  • Nodular regenerative hyperplasia in partial hepatectomy specimens. 
  • Non-Cell-Autonomous Activity of the Hemidesmosomal Protein BP180/Collagen XVII in Granulopoiesis in Humanized NC16A Mice. 
  • Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia. 
  • Parathyroid histopathology: is it of any value today? 
  • Parathyroid hormone secretion from dispersed human hyperparathyroid cells: increased secretion in cells from hyperplastic glands versus adenomas. 
  • Partial hepatectomy and bile duct ligation in rainbow trout (Oncorhynchus mykiss): histologic, immunohistochemical and enzyme histochemical characterization of hepatic regeneration and biliary hyperplasia. 
  • Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model. 
  • Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice. 
  • Peak density of immature nerve cells occurs with high-grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas. 
  • Physician Non-adherence to Colonoscopy Interval Guidelines in the Veterans Affairs Healthcare System. 
  • Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. 
  • Polyclonal polymorphic B-cell lymphoproliferative disorder with prominent pulmonary involvement in children with acquired immune deficiency syndrome. 
  • Post-obstructive diuresis: a varied syndrome. 
  • Premature sebaceous gland hyperplasia: successful treatment with isotretinoin. 
  • Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. 
  • Preoperative MR imaging in hyperparathyroidism: results and factors affecting parathyroid detection. 
  • Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases. 
  • Prevention of ischemically induced neointimal hyperplasia using ex vivo antisense oligodeoxynucleotides. 
  • Primary aldosteronism due to bilateral nodular hyperplasia: CT demonstration. 
  • Progress in the operative management of sporadic primary hyperparathyroidism over 34 years. 
  • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. 
  • Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats. 
  • Protein biosynthesis on chick oviduct polyribosomes. II. Regulation by progesterone. 
  • Proximal median neuropathy caused by surgical manipulation of Masson tumor. 
  • Pseudoangiomatous stromal hyperplasia (PASH) causing massive breast enlargement: MRI findings. 
  • Quiescent and cycling cell compartments in the senescent and Alzheimer-diseased human brain. 
  • Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling. 
  • Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish. 
  • Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. 
  • Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. 
  • Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. 
  • Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation. 
  • Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels. 
  • Role for Nox1 NADPH oxidase in atherosclerosis. 
  • Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon. 
  • Signet ring adenocarcinoma metastatic to the bronchus and mimicking goblet cell hyperplasia. A case report. 
  • Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. 
  • Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome. 
  • Spitz nevi in black children. 
  • Statin--a novel marker of nonproliferation. Expression in nonneoplastic lymphoid tissues and follicular lymphomas. 
  • TET2 Deficiency Sets the Stage for B-cell Lymphoma. 
  • TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease. 
  • Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. 
  • Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. 
  • The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions. 
  • The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics. 
  • The complementary roles of fast spin-echo MR imaging and double-phase 99m Tc-sestamibi scintigraphy for localization of hyperfunctioning parathyroid glands. 
  • The histopathology of vesical diverticula. 
  • The pathology of interstitial lung disease in nylon flock workers. 
  • The role of hyaluronic acid in atherosclerosis and intimal hyperplasia. 
  • The role of integrins in saphenous vein vascular smooth muscle cell migration. 
  • The significance of the diagnosis of atypia in breast fine-needle aspiration. 
  • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. 
  • Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation. 
  • Tracking adipogenesis during white adipose tissue development, expansion and regeneration. 
  • Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat. 
  • Transplantation of the parathyroid glands in man: clinical indications and results. 
  • Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery. 
  • USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis. 
  • Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. 
  • Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. 
  • Vegfaa instructs cardiac muscle hyperplasia in adult zebrafish. 
  • Vein graft neointimal hyperplasia is exacerbated by CXCR4 signaling in vein graft-extrinsic cells. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • Vulvar vascular tumors: a clinicopathologic study of 85 patients. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Sunday, Mary Elizabeth Anne, Professor of Pathology, Cell Biology