Hypoglycemia

• 

  Subject Areas on Research

  • 40% Glucose Gel for the Treatment of Asymptomatic Neonatal Hypoglycemia. 
  • A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial. 
  • A generic emergency protocol for patients with inborn errors of metabolism causing fasting intolerance: A retrospective, single-center study and the generation of www.emergencyprotocol.net. 
  • A primer on concentrated insulins: what an internist should know. 
  • AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. 
  • Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. 
  • Abnormal fatty acid metabolism in spinal muscular atrophy may predispose to perioperative risks. 
  • Accuracy and Longevity of an Implantable Continuous Glucose Sensor in the PRECISE Study: A 180-Day, Prospective, Multicenter, Pivotal Trial. 
  • Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia. 
  • Age-related metabolic fatigue during low glucose conditions in rat hippocampus. 
  • Algorithm to diagnose etiology of hypoglycemia after Roux-en-Y gastric bypass for morbid obesity: case series and review of the literature. 
  • Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia. 
  • Another hazard of hypertonic dextrose. 
  • Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. 
  • Assessing the Impact of an Order Panel Utilizing Weight-Based Insulin and Standardized Monitoring of Blood Glucose for Patients With Hyperkalemia. 
  • Assessing the Safety of Sitagliptin in Older Participants in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). 
  • Associations between β-blocker therapy and cardiovascular outcomes in patients with diabetes and established cardiovascular disease. 
  • Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure. 
  • Automated bolus advisor control and usability study (ABACUS): does use of an insulin bolus advisor improve glycaemic control in patients failing multiple daily insulin injection (MDI) therapy? [NCT01460446]. 
  • Avoidance of weight gain is important for oral type 2 diabetes treatments in Sweden and Germany: patient preferences. 
  • Baseline factors associated with glycaemic response to treatment with once-weekly dulaglutide in patients with type 2 diabetes. 
  • Be Careful What You Ask For: Effects of Benefit Descriptions on Diabetes Patients' Benefit-Risk Tradeoff Preferences. 
  • Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass. 
  • Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. 
  • Cardiovascular Disease Prevention: Prevention Through Control of Medical Risks. 
  • Cerebral transport and metabolism of 1-11C-D-glucose during stepped hypoglycemia. 
  • Challenges of optimizing glycaemic control in children with Type 1 diabetes: a qualitative study of parents' experiences and views. 
  • Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review. 
  • Clinical Reasoning: A 2-Day-Old Boy With Sudden Cardiac Arrest and Encephalopathy. 
  • Comment on Davis et al. Effects of Severe Hypoglycemia on Cardiovascular Outcomes and Death in the Veterans Affairs Diabetes Trial. Diabetes Care 2019;42:157-163. 
  • Comparison of an Electronic Glycemic Management System Versus Provider-Managed Subcutaneous Basal Bolus Insulin Therapy in the Hospital Setting. 
  • Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis. 
  • Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL. 
  • Day-and-Night Closed-Loop Insulin Delivery in a Broad Population of Pregnant Women With Type 1 Diabetes: A Randomized Controlled Crossover Trial. 
  • Deintensification of Treatment With Sulfonylurea and Insulin After Severe Hypoglycemia Among Older Adults With Diabetes. 
  • Diabetes and Partners. 
  • Diabetes management and self-care education for hospitalized patients with cancer. 
  • Diabetes summer camps: history, safety, and outcomes. 
  • Diagnosis and management of glycogen storage diseases type VI and IX: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). 
  • Dissociation Between Hormonal Counterregulatory Responses and Cerebral Glucose Metabolism During Hypoglycemia. 
  • Duration of type 2 diabetes does not appear to moderate hypoglycaemia rate with insulin degludec versus insulin glargine U100. 
  • Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial. 
  • Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test. 
  • Effect of predicted low suspend pump treatment on improving glycaemic control and quality of sleep in children with type 1 diabetes and their caregivers: the QUEST randomized crossover study. 
  • Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation. 
  • Effects of intensive glucose lowering in type 2 diabetes. 
  • Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. 
  • Efficacy and safety of dapagliflozin in acute heart failure: Rationale and design of the DICTATE-AHF trial. 
  • Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring system. 
  • Evaluation of Hypoglycemia in Neonates of Women at Risk for Late Preterm Delivery: An Antenatal Late Preterm Steroids Trial Cohort Study. 
  • Evaluation of the Efficacy of a Hypoglycemia Protocol to Treat Severe Hypoglycemia. 
  • Fear of hypoglycaemia in parents of young children with type 1 diabetes: a systematic review. 
  • Frequency of hypoglycemia and its significance in chronic kidney disease. 
  • Future artificial pancreas technology for type 1 diabetes: what do users want? 
  • Getting up groggy. 
  • Glucagon lowers glycemia when β-cells are active. 
  • Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus. 
  • Golden Hour Protocol for Preterm Infants: A Quality Improvement Project. 
  • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector. 
  • Home Use of an Artificial Beta Cell in Type 1 Diabetes. 
  • Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. 
  • Human brain glycogen metabolism during and after hypoglycemia. 
  • Hypoglycemia Communication in Primary Care Visits for Patients with Diabetes. 
  • Hypovitaminosis D in glycogen storage disease type I. 
  • INTRAPERITONEAL DEXTROSE ADMINISTRATION AS AN ALTERNATIVE EMERGENCY TREATMENT FOR HYPOGLYCEMIC YEARLING CALIFORNIA SEA LIONS (ZALOPHUS CALIFORNIANUS). 
  • ISPAD Guidelines. Managing diabetes in preschool children. 
  • Impact of pharmacist outreach on glucagon prescribing. 
  • Increased Risk of Severe Hypoglycemic Events Before and After Cardiovascular Outcomes in TECOS Suggests an At-Risk Type 2 Diabetes Frail Patient Phenotype. 
  • Insulin can make diabetes worse: the smoldering Somogyi effect. 
  • Intensive insulin therapy and mortality in critically ill patients. 
  • Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes. 
  • Is iatrogenic sleep disturbance worth the effort in Type 1 diabetes? 
  • Large animal models and new therapies for glycogen storage disease. 
  • Long-term complications of glycogen storage disease type Ia in the canine model treated with gene replacement therapy. 
  • Long-term efficacy following readministration of an adeno-associated virus vector in dogs with glycogen storage disease type Ia. 
  • Longitudinal Changes in Depression Symptoms and Glycemia in Adults With Type 1 Diabetes. 
  • Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism. 
  • Management of Preexisting Diabetes in Pregnancy: A Review. 
  • Managing hyperglycemia and diabetes in patients receiving enteral feedings: A health system approach. 
  • Mechanism of postgastrectomy hypoglycemia. 
  • Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe. 
  • Medium-chain acyl-coenzyme A dehydrogenase deficiency: clinical course in 120 affected children. 
  • Neurological Prognostication After Hypoglycemic Coma: Role of Clinical and EEG Findings. 
  • Nighttime blood pressure, nighttime glucose values, and target-organ damages in treated type 2 diabetes patients. 
  • Ontogeny of adrenomedullary responses to hypoxia and hypoglycemia: role of splanchnic innervation. 
  • Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate. 
  • Optimizing perioperative glycemic control. 
  • Patient-reported outcomes in patients with type 2 diabetes treated with liraglutide or glimepiride, both as add-on to metformin. 
  • Penile length of newborns in Singapore. 
  • Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: a longitudinal qualitative investigation. 
  • Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia. 
  • Plasma glucose response to recreational diving in novice teenage divers with insulin-requiring diabetes mellitus. 
  • Plasma glucose responses in recreational divers with insulin-requiring diabetes. 
  • Post-gastric bypass hypoglycaemia: a review. 
  • Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction. 
  • Prevalence and safety of diazoxide in the neonatal intensive care unit. 
  • Protein synthesis. The perks of balancing glucose. 
  • Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus. 
  • Recovery of rat adrenal amine stores after insulin administration. 
  • Regulation of beta-cell glucose transporter gene expression. 
  • Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes. 
  • Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia. 
  • Risk of hospitalized rhabdomyolysis associated with lipid-lowering drugs in a real-world clinical setting. 
  • Role of continuous glucose monitoring in the management of glycogen storage disorders. 
  • Role of stress in the etiology and treatment of diabetes mellitus. 
  • Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycaemia. 
  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. 
  • Safety of Appetite Manipulation in Children with Feeding Disorders Admitted to an Inpatient Feeding Program. 
  • Safety of octreotide in hospitalized infants. 
  • Screening for celiac disease in children with type 1 diabetes: two views of the controversy. 
  • Secretion of a large molecular-weight form of insulin-like growth factor by a primary renal tumor. 
  • Strict glycemic targets need not be so strict: a more permissive glycemic range for critically ill children. 
  • Taking a risk to save a life. 
  • Technosphere insulin: inhaled prandial insulin. 
  • The coactivator SRC-1 is an essential coordinator of hepatic glucose production. 
  • Unaltered cerebral blood flow during hypoglycemic activation of the sympathochromaffin system in humans. 
  • Unsupervised home use of an overnight closed-loop system over 3-4 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes. 
  • Use of ECT in treatment of depression in patients with diabetes mellitus. 
  • Use of an automated bolus calculator reduces fear of hypoglycemia and improves confidence in dosage accuracy in patients with type 1 diabetes mellitus treated with multiple daily insulin injections. 
  • Use of an insulin bolus advisor improves glycemic control in multiple daily insulin injection (MDI) therapy patients with suboptimal glycemic control: first results from the ABACUS trial. 
  • Utility of Continuous Glucose Monitoring vs Meal Study in Detecting Hypoglycemia After Gastric Bypass. 
  • Variability of disease spectrum in children with liver phosphorylase kinase deficiency caused by mutations in the PHKG2 gene. 
  • Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. 
  • Weight change in patients with type 2 diabetes starting basal insulin therapy: correlates and impact on outcomes. 
  • Who gains clinical benefit from using insulin pump therapy? A qualitative study of the perceptions and views of health professionals involved in the Relative Effectiveness of Pumps over MDI and Structured Education (REPOSE) trial. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hirschey, Matthew, Associate Professor of Medicine, Cell Biology