Hypothalamo-Hypophyseal System

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  Subject Areas on Research

  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A functional polymorphism in the HTR2C gene associated with stress responses: a validation study. 
  • Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm. 
  • Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity. 
  • Amenorrhea: observations based on the analysis of luteinizing hormone-releasing hormone testing. 
  • Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation. 
  • Association of Epidemiologic Factors and Genetic Variants Influencing Hypothalamic-Pituitary-Adrenocortical Axis Function With Postconcussive Symptoms After Minor Motor Vehicle Collision. 
  • Association of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan. 
  • CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. 
  • CSF CRH in abstinent cocaine-dependent patients. 
  • Caffeine affects cardiovascular and neuroendocrine activation at work and home. 
  • Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression. 
  • Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. 
  • Child abuse, disruptive behavior disorders, depression, and salivary cortisol levels among institutionalized and community-residing boys in Mongolia. 
  • Chronic administration of U50,488H fails to produce hypothalamo-pituitary-adrenal axis tolerance in neonatal rats. 
  • Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats. 
  • Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis. 
  • Cortisol awakening response and developmental outcomes at 6-7 years in children born extremely preterm. 
  • Cortisol levels and responses to mammography screening in breast cancer survivors: a pilot study. 
  • D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. 
  • DNA methylation in former extremely low birth weight newborns: association with cardiovascular and endocrine function. 
  • Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. 
  • Depression and cardiovascular disease: mechanisms of interaction. 
  • Depression, smoking abstinence and HPA function in women smokers. 
  • Depressogenic vulnerability and gender-specific patterns of neuro-immune dysregulation: What the ratio of cortisol to C-reactive protein can tell us about loss of normal regulatory control. 
  • Dexamethasone suppression test identifies a subset of elderly depressed patients with reduced platelet serotonin transport and resistance to imipramine inhibition of transport. 
  • Diagnosis and treatment of hypothyroidism in the elderly. 
  • Differential sensitivity to dexamethasone suppression in an animal model of the DST. 
  • Disordered control of thirst in hypothalamic-pituitary sarcoidosis. 
  • Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress. 
  • Diurnal dynamic range as index of dysregulation of system dynamics. A cortisol examplar using data from the Study of Midlife in the United States. 
  • Dominance rank causally affects personality and glucocorticoid regulation in female rhesus macaques. 
  • Effect of gamma interferon on the hypothalamic-pituitary-adrenal system. 
  • Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine. 
  • Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats. 
  • Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat. 
  • Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial. 
  • Endocrine consequences of perinatal methadone exposure. 
  • Epigenetic Programming by Maternal Behavior in the Human Infant. 
  • Facial expressions of emotion reveal neuroendocrine and cardiovascular stress responses. 
  • Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG. 
  • GBR12909 stimulates hypothalamo-pituitary-adrenal activity by inhibition of uptake at hypothalamic dopamine neurons. 
  • Gender difference in cocaine-induced HPA axis activation. 
  • Genetic Moderation of Stress Effects on Corticolimbic Circuitry. 
  • Glucocorticoid exposure predicts survival in female baboons. 
  • HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children. 
  • Hypothalamic-pituitary dysfunction in alternating hemiplegia of childhood. 
  • Hypothalamic-pituitary-adrenal axis dysfunction in non-clinical psychosis. 
  • Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function. 
  • In vivo assessment of pituitary volume with magnetic resonance imaging and systematic stereology: relationship to dexamethasone suppression test results in patients. 
  • Increased hypothalamic [3H]flunitrazepam binding in hypothalamic-pituitary-adrenal axis hyporesponsive Lewis rats. 
  • Inhibiting cortisol response accelerates recovery from a photic phase shift. 
  • Integrating the female masculinization and challenge hypotheses: Female dominance, male deference, and seasonal hormone fluctuations in adult blue-eyed black lemurs (Eulemur flavifrons). 
  • Maternal psychological distress, prenatal cortisol, and fetal weight. 
  • Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor. 
  • Modeling endocrine control of the pituitary-ovarian axis: androgenic influence and chaotic dynamics. 
  • Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation. 
  • Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. 
  • Non-invasive biomarkers of fetal brain development reflecting prenatal stress: An integrative multi-scale multi-species perspective on data collection and analysis. 
  • Ontogenetic studies of tolerance development: effects of chronic morphine on the hypothalamic-pituitary-adrenal axis. 
  • Pathophysiology of hypercortisolism in depression. 
  • Perinatal factors, parenting behavior, and reactive aggression: does cortisol reactivity mediate this developmental risk process? 
  • Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. 
  • Post-traumatic stress disorder in women: current concepts and treatments. 
  • Profiling retrospective thyroid function data in complete thyroidectomy patients to investigate the HPT axis set point (PREDICT-IT). 
  • Psychoneuroendocrinology and brain imaging in depression. 
  • Psychosocial and biobehavioral factors and their interplay in coronary heart disease. 
  • Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. 
  • Relational victimization, friendship, and adolescents' hypothalamic-pituitary-adrenal axis responses to an in vivo social stressor. 
  • Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress. 
  • Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression. 
  • Serotonin transporter expression in rat brain regions and blood platelets: aging and glucocorticoid effects. 
  • Sex and gender in psychoneuroimmunology research: past, present and future. 
  • Special Issue: the neuroendocrine-immune axis in health and disease. 
  • Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. 
  • Stress, cortisol, and externalizing behavior in adolescent males: an examination in the context of multisystemic therapy. 
  • Suppression of cortisol following dexamethasone in demented patients. 
  • Tactile-kinesthetic stimulation effects on sympathetic and adrenocortical function in preterm infants. 
  • The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function. 
  • The dissociation of catecholamine and hypothalamic-pituitary-adrenal responses to daily stressors using dexamethasone. 
  • The effects of child maltreatment on the hypothalamic-pituitary-adrenal axis. 
  • The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. 
  • The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. 
  • The prism of reactivity: Concordance between biobehavioral domains of infant stress reactivity. 
  • The roles of steroidogenic factor-1 in reproductive function. 
  • Therapeutic implications of HPA axis abnormalities in Alzheimer's disease: review and update. 
  • Topical clobetasol-17-propionate: review of its clinical efficacy and safety. 
  • Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training. 
  • Weight change and the dexamethasone suppression test. 
  • What does the dexamethasone suppression test identify? 
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  Keywords of People

  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology