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Subject Areas on Research
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A clinical comparison of mitral valve repair versus valve replacement in ischemic mitral regurgitation.
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A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia.
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A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest.
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A structured educational intervention to improve targeted temperature management utilization after cardiac arrest.
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Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial.
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American Clinical Neurophysiology Society Guideline 5: Minimum Technical Standards for Pediatric Electroencephalography.
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An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response.
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Analysis of injury in complex organ preservation.
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Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping.
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Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest.
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Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state.
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Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest.
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Brain injury and protective effects of hypothermia using triphenyltetrazolium chloride in neonatal rat.
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Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy.
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Cardiopulmonary Bypass Strategy for a Cyanotic Child With Hemoglobin SC Disease.
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Cardiopulmonary bypass and the central nervous system: potential for cerebral protection.
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Cardiopulmonary bypass time does not affect cerebral blood flow.
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Case 4--1998. Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping.
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Cerebral blood flow values during cardiopulmonary bypass: relatively absolute or absolutely relative?
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Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. CNS Subgroup of McSPI.
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Cerebral protection.
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Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.
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Childhood outcomes after hypothermia for neonatal encephalopathy.
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Clinical predictors of survival in patients treated with therapeutic hypothermia following cardiac arrest.
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Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial.
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Communication Challenges in Neonatal Encephalopathy.
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Comparing two strategies of cardiopulmonary bypass cooling on jugular venous oxygen saturation in neonates and infants.
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Comparison of myocardial protection with nifedipine and potassium.
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Conduction block after cardioplegic arrest: prevention by augmented atrial hypothermia.
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Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database.
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Continuous jugular venous versus nasopharyngeal temperature monitoring during hypothermic cardiopulmonary bypass for cardiac surgery.
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Controlled Multifactorial Coagulopathy: Effects of Dilution, Hypothermia, and Acidosis on Thrombin Generation In Vitro.
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Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy".
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Current advances in the use of therapeutic hypothermia.
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Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery.
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Discrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial.
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Does moderate hypothermia really carry less bleeding risk than deep hypothermia for circulatory arrest? A propensity-matched comparison in hemiarch replacement.
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Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.
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Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial.
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Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial.
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Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial.
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Effect of local hypothermia on early wound repair.
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Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion.
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Effect of temperature on kainic acid-induced seizures.
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Effects of aortopulmonary collaterals on cerebral cooling and cerebral metabolic recovery after circulatory arrest.
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Effects of cold ischemia on reflow patterns in the rat cremaster muscle microcirculation.
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Effects of internal mammary artery dissection on phrenic nerve perfusion and function.
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Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes.
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Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.
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Feasibility and safety of moderate hypothermia after massive hemispheric infarction.
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Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy.
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Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study).
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Feeling the heat.
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Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.
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Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats.
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Hyperammonemia in the ICU.
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Hyperglycaemia in infants with hypoxic-ischaemic encephalopathy is associated with improved outcomes after therapeutic hypothermia: a post hoc analysis of the CoolCap Study.
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Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy.
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Hypothermia: comparing technology.
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Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation.
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Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain.
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Impact of percutaneous coronary intervention performance reporting on cardiac resuscitation centers: a scientific statement from the American Heart Association.
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Induced hypothermia for neonates with hypoxic-ischemic encephalopathy.
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Induction of hypothermia after intraoperative hypoxic brain insult.
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Influence of hypothermic cardiopulmonary bypass on atrial natriuretic factor levels.
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Integrating neurocritical care approaches into neonatology: should all infants be treated equitably?
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Intermittent perfusion protects the brain during deep hypothermic circulatory arrest.
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Interrater reliability of the bedside shivering assessment scale.
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Interventional strategies associated with improvements in survival for out-of-hospital cardiac arrests in Singapore over 10 years.
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Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest.
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Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected].
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Low-flow cardiopulmonary bypass produces greater pulmonary dysfunction than circulatory arrest.
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Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.
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Management of cardiogenic shock.
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Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats.
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Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.
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Modified ultrafiltration improves cerebral metabolic recovery after circulatory arrest.
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Monitoring the jugular-venous oxyhemoglobin saturation as a decision aid for normothermic cardiopulmonary bypass.
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Myocardial function is normal after rapid cooling of the in vivo neonatal heart.
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Neurologic outcomes after coronary artery bypass grafting with and without cardiopulmonary bypass.
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No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial.
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Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.
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Organ protective mechanisms common to extremes of physiology: a window through hibernation biology.
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Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy.
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Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy.
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Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy.
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Parent Experience of Neonatal Encephalopathy.
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Patterns of use of targeted temperature management for acute myocardial infarction patients following out-of-hospital cardiac arrest: Insights from the National Cardiovascular Data Registry.
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Pediatric out-of-hospital cardiac arrest: Time to goal target temperature and outcomes.
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Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.
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Perioperative hypothermia (33 degrees C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial.
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Perioperative hypothermia: use and therapeutic implications.
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Perioperative temperature and cardiac surgery.
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Pharmacologic protection from ischemic neuronal injury.
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Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats.
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Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy.
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Post-myocardial infarction cardiogenic shock is a systemic illness in need of systemic treatment: is therapeutic hypothermia one possibility?
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Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery.
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Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia.
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Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
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Randomized clinical trial progress to inform care for out-of-hospital cardiac arrest.
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Recovery of cerebral metabolism and mitochondrial oxidation state is delayed after hypothermic circulatory arrest.
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Respiratory controversies in the critical care setting. Conference summary.
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Response to a different view concerning the NICHD neonatal research network late hypothermia trial.
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Right ventricular sensitivity to metabolic injury during cardiopulmonary bypass.
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Risk Prediction Model for Major Adverse Outcome in Proximal Thoracic Aortic Surgery.
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Safety of Moderate Hypothermia With Antegrade Cerebral Perfusion in Total Aortic Arch Replacement.
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Stuck Between a Clot and a Cold Place: The Specter of Early In-Stent Thrombosis With Therapeutic Hypothermia.
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Supraventricular conduction abnormalities following cardiac operations. A complication of inadequate atrial preservation.
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Surgical treatment of supraventricular tachyarrhythmias.
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Temperature during coronary artery bypass surgery affects quality of life.
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Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy.
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Temperatures achieved in human and canine neocortex during intraoperative passive or active focal cooling.
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The effect of duration of hypothermic cardioplegia on ventricular function.
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The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass.
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The electrophysiological effects of calcium channel blockade during standard hyperkalemic hypothermic cardioplegic arrest.
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The incidence of unacceptable movement with motor evoked potentials during craniotomy for aneurysm clipping.
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The relation between cerebral metabolic rate and ischemic depolarization. A comparison of the effects of hypothermia, pentobarbital, and isoflurane.
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The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.
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Therapeutic Hypothermia for Patients with Out-of-Hospital Cardiac Arrest in North Carolina.
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Therapeutic hypothermia in post-cardiac arrest.
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Transcranial Doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass.
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Translational research in acute central nervous system injury: lessons learned and the future.
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Traumatic brain injury and hypothermia.
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Treatment of chemotherapy-induced alopecia.
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Vancomycin pharmacokinetic parameters in patients with acute brain injury undergoing controlled normothermia, therapeutic hypothermia, or pentobarbital infusion.
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Variability in Postarrest Targeted Temperature Management Practice: Implications of the 2015 Guidelines.
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Volatile anesthetic sedation during therapeutic hypothermia after cardiac arrest in the ICU: a journey of a thousand miles begins with a single step.
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Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.
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Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.
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[Anatomical correction of transposition of the great arteries in 7 newborn infants].
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pH-stat cooling improves cerebral metabolic recovery after circulatory arrest in a piglet model of aortopulmonary collaterals.
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Keywords of People
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Berger, Miles,
Associate Professor of Anesthesiology,
Duke Science & Society
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James, Michael Lucas,
Associate Professor of Anesthesiology,
Anesthesiology, Neuroanesthesia
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Milano, Carmelo Alessio,
Professor of Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Muh, Carrie Rebecca,
Adjunct Assistant Professor in the Department of Neurosurgery,
Neurosurgery
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Nielsen, Karen Cristina,
Associate Professor of Anesthesiology,
Anesthesiology, Ambulatory
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Swaminathan, Madhav,
Professor of Anesthesiology,
Anesthesiology, Cardiothoracic
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Warner, David Samuel,
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine,
Neurobiology