Hypothermia, Induced

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  Subject Areas on Research

  • A clinical comparison of mitral valve repair versus valve replacement in ischemic mitral regurgitation. 
  • A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia. 
  • A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest. 
  • A structured educational intervention to improve targeted temperature management utilization after cardiac arrest. 
  • Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial. 
  • American Clinical Neurophysiology Society Guideline 5: Minimum Technical Standards for Pediatric Electroencephalography. 
  • An evidence-based review of the practice of cardiopulmonary bypass in adults: a focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response. 
  • Analysis of injury in complex organ preservation. 
  • Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping. 
  • Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest. 
  • Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state. 
  • Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest. 
  • Brain injury and protective effects of hypothermia using triphenyltetrazolium chloride in neonatal rat. 
  • Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy. 
  • Cardiopulmonary Bypass Strategy for a Cyanotic Child With Hemoglobin SC Disease. 
  • Cardiopulmonary bypass and the central nervous system: potential for cerebral protection. 
  • Cardiopulmonary bypass time does not affect cerebral blood flow. 
  • Case 4--1998. Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping. 
  • Cerebral blood flow values during cardiopulmonary bypass: relatively absolute or absolutely relative? 
  • Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. CNS Subgroup of McSPI. 
  • Cerebral protection. 
  • Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era. 
  • Childhood outcomes after hypothermia for neonatal encephalopathy. 
  • Clinical predictors of survival in patients treated with therapeutic hypothermia following cardiac arrest. 
  • Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. 
  • Communication Challenges in Neonatal Encephalopathy. 
  • Comparing two strategies of cardiopulmonary bypass cooling on jugular venous oxygen saturation in neonates and infants. 
  • Comparison of myocardial protection with nifedipine and potassium. 
  • Conduction block after cardioplegic arrest: prevention by augmented atrial hypothermia. 
  • Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database. 
  • Continuous jugular venous versus nasopharyngeal temperature monitoring during hypothermic cardiopulmonary bypass for cardiac surgery. 
  • Controlled Multifactorial Coagulopathy: Effects of Dilution, Hypothermia, and Acidosis on Thrombin Generation In Vitro. 
  • Corrected transposition with severe intracardiac deformities with Wolff-Parkinson-White syndrome in a child. Electrophysiologic investigation and surgical correction. 
  • Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy". 
  • Current advances in the use of therapeutic hypothermia. 
  • Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery. 
  • Discrete cerebral hypothermia in the management of traumatic brain injury: a randomized controlled trial. 
  • Does moderate hypothermia really carry less bleeding risk than deep hypothermia for circulatory arrest? A propensity-matched comparison in hemiarch replacement. 
  • Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. 
  • Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. 
  • Effect of deep hypothermia and circulatory arrest on cerebral blood flow and metabolism. 
  • Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. 
  • Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial. 
  • Effect of local hypothermia on early wound repair. 
  • Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. 
  • Effect of temperature on kainic acid-induced seizures. 
  • Effects of aortopulmonary collaterals on cerebral cooling and cerebral metabolic recovery after circulatory arrest. 
  • Effects of cold ischemia on reflow patterns in the rat cremaster muscle microcirculation. 
  • Effects of internal mammary artery dissection on phrenic nerve perfusion and function. 
  • Effects of moderate versus deep hypothermic circulatory arrest and selective cerebral perfusion on cerebrospinal fluid proteomic profiles in a piglet model of cardiopulmonary bypass. 
  • Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. 
  • Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. 
  • Feasibility and safety of combined percutaneous coronary intervention and therapeutic hypothermia following cardiac arrest. 
  • Feasibility and safety of moderate hypothermia after massive hemispheric infarction. 
  • Feasibility of autologous cord blood cells for infants with hypoxic-ischemic encephalopathy. 
  • Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study). 
  • Feeling the heat. 
  • Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary. 
  • Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats. 
  • Hyperammonemia in the ICU. 
  • Hyperglycaemia in infants with hypoxic-ischaemic encephalopathy is associated with improved outcomes after therapeutic hypothermia: a post hoc analysis of the CoolCap Study. 
  • Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy. 
  • Hypothermia and operative mortality during on-pump coronary artery bypass grafting. 
  • Hypothermia: comparing technology. 
  • Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. 
  • Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain. 
  • Impact of percutaneous coronary intervention performance reporting on cardiac resuscitation centers: a scientific statement from the American Heart Association. 
  • Induced hypothermia for neonates with hypoxic-ischemic encephalopathy. 
  • Induction of hypothermia after intraoperative hypoxic brain insult. 
  • Influence of hypothermic cardiopulmonary bypass on atrial natriuretic factor levels. 
  • Integrating neurocritical care approaches into neonatology: should all infants be treated equitably? 
  • Intermittent perfusion protects the brain during deep hypothermic circulatory arrest. 
  • Interrater reliability of the bedside shivering assessment scale. 
  • Interventional strategies associated with improvements in survival for out-of-hospital cardiac arrests in Singapore over 10 years. 
  • Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. 
  • Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]. 
  • Low-flow cardiopulmonary bypass produces greater pulmonary dysfunction than circulatory arrest. 
  • Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. 
  • Management of cardiogenic shock. 
  • Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. 
  • Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest due to acute ST-segment elevation myocardial infarction. 
  • Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons. 
  • Modified ultrafiltration improves cerebral metabolic recovery after circulatory arrest. 
  • Monitoring the brain during cardiac surgery in children. 
  • Monitoring the jugular-venous oxyhemoglobin saturation as a decision aid for normothermic cardiopulmonary bypass. 
  • Myocardial function is normal after rapid cooling of the in vivo neonatal heart. 
  • Myocardial reperfusion injury. 
  • Neurologic outcomes after coronary artery bypass grafting with and without cardiopulmonary bypass. 
  • No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. 
  • Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates. 
  • Organ protective mechanisms common to extremes of physiology: a window through hibernation biology. 
  • Outcome of term infants using apgar scores at 10 minutes following hypoxic-ischemic encephalopathy. 
  • Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy. 
  • Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. 
  • Parent Experience of Neonatal Encephalopathy. 
  • Patterns of use of targeted temperature management for acute myocardial infarction patients following out-of-hospital cardiac arrest: Insights from the National Cardiovascular Data Registry. 
  • Pediatric out-of-hospital cardiac arrest: Time to goal target temperature and outcomes. 
  • Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage. 
  • Perioperative hypothermia (33 degrees C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. 
  • Perioperative hypothermia: use and therapeutic implications. 
  • Perioperative temperature and cardiac surgery. 
  • Pharmacologic protection from ischemic neuronal injury. 
  • Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats. 
  • Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy. 
  • Plasma Glycoproteomic Study of Therapeutic Hypothermia Reveals Novel Markers Predicting Neurologic Outcome Post-cardiac Arrest. 
  • Post-myocardial infarction cardiogenic shock is a systemic illness in need of systemic treatment: is therapeutic hypothermia one possibility? 
  • Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. 
  • Predictive performance of a gentamicin population pharmacokinetic model in neonates receiving full-body hypothermia. 
  • Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery. 
  • Randomized clinical trial progress to inform care for out-of-hospital cardiac arrest. 
  • Recovery of cerebral metabolism and mitochondrial oxidation state is delayed after hypothermic circulatory arrest. 
  • Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat. 
  • Respiratory controversies in the critical care setting. Conference summary. 
  • Response to a different view concerning the NICHD neonatal research network late hypothermia trial. 
  • Right ventricular sensitivity to metabolic injury during cardiopulmonary bypass. 
  • Risk Prediction Model for Major Adverse Outcome in Proximal Thoracic Aortic Surgery. 
  • Safety of Moderate Hypothermia With Antegrade Cerebral Perfusion in Total Aortic Arch Replacement. 
  • Serum lactates correlate with mortality after operations for complex congenital heart disease. 
  • Stuck Between a Clot and a Cold Place: The Specter of Early In-Stent Thrombosis With Therapeutic Hypothermia. 
  • Supraventricular conduction abnormalities following cardiac operations. A complication of inadequate atrial preservation. 
  • Surgical treatment of supraventricular tachyarrhythmias. 
  • Temperature during coronary artery bypass surgery affects quality of life. 
  • Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. 
  • Temperatures achieved in human and canine neocortex during intraoperative passive or active focal cooling. 
  • The Use of Whole Body Cooling in the Treatment of Hypoxic-Ischemic Encephalopathy. 
  • The effect of duration of hypothermic cardioplegia on ventricular function. 
  • The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass. 
  • The electrophysiological effects of calcium channel blockade during standard hyperkalemic hypothermic cardioplegic arrest. 
  • The incidence of unacceptable movement with motor evoked potentials during craniotomy for aneurysm clipping. 
  • The relation between cerebral metabolic rate and ischemic depolarization. A comparison of the effects of hypothermia, pentobarbital, and isoflurane. 
  • The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery. 
  • The thermoresponsiveness of ventromedial hypothalamic (VMH) neurons following repeated scrotal thermal stimulation of rats maintained at normothermic or acutely hypothermic core temperatures. 
  • Therapeutic Hypothermia for Patients with Out-of-Hospital Cardiac Arrest in North Carolina. 
  • Therapeutic hypothermia in post-cardiac arrest. 
  • Transcranial Doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass. 
  • Translational research in acute central nervous system injury: lessons learned and the future. 
  • Traumatic brain injury and hypothermia. 
  • Treatment of chemotherapy-induced alopecia. 
  • Vancomycin pharmacokinetic parameters in patients with acute brain injury undergoing controlled normothermia, therapeutic hypothermia, or pentobarbital infusion. 
  • Variability in Postarrest Targeted Temperature Management Practice: Implications of the 2015 Guidelines. 
  • Volatile anesthetic sedation during therapeutic hypothermia after cardiac arrest in the ICU: a journey of a thousand miles begins with a single step. 
  • Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. 
  • Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. 
  • [Anatomical correction of transposition of the great arteries in 7 newborn infants]. 
  • pH-stat cooling improves cerebral metabolic recovery after circulatory arrest in a piglet model of aortopulmonary collaterals. 
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  Keywords of People

  • Berger, Miles, Associate Professor of Anesthesiology, Duke Science & Society
  • James, Michael Lucas, Associate Professor of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Muh, Carrie Rebecca, Adjunct Assistant Professor in the Department of Neurosurgery, Neurosurgery
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology