Immunoglobulin A

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  Subject Areas on Research

  • A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques. 
  • A comparative study of monoclonal gammopathies and immunoglobulin levels in Japanese and United States elderly. 
  • A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia. 
  • Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function. 
  • Agglutination of Naegleria fowleri and Naegleria gruberi by antibodies in human serum. 
  • Aggregate complexes of HIV-1 induced by multimeric antibodies. 
  • Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound. 
  • Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. 
  • Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. 
  • Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells. 
  • An in vitro analogue of immune dysfunction with altered immunoglobulin production in the aged. 
  • Analysis of autoantibodies to plasminogen in the serum of patients with rheumatoid arthritis. 
  • Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. 
  • Anaphylactic reactions after gamma globulin administration in patients with hypogammaglobulinemia. Detection of IgE antibodies to IgA. 
  • Anaphylactic reactions to plasma infusions in patients with hypogammaglobulinemia and anti-IgA antibodies. 
  • Anaphylaxis after administration of gamma globulin for hypogammaglobulinemia. 
  • Anti-EBV serologic tests for nasopharyngeal carcinoma. 
  • Antibody Profiling by Proteome Microarray with Multiplex Isotype Detection Reveals Overlap between Human and Aotus nancymaae Controlled Malaria Infections. 
  • Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women. 
  • Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. 
  • Anticardiolipin antibodies and osteonecrosis of the femoral head. 
  • Anticardiolipin antibodies in an unselected stroke population. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma. 
  • Application of Epstein-Barr virus serology to the diagnosis and staging of North American patients with nasopharyngeal carcinoma. 
  • Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1. 
  • B-cell lymphopenia and hypogammaglobulinemia in thymoma patients. 
  • Biofilms in the large bowel suggest an apparent function of the human vermiform appendix. 
  • Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CD28 is required for germinal center formation. 
  • COMPASS identifies T-cell subsets correlated with clinical outcomes. 
  • Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. 
  • Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis. 
  • Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis. 
  • Circulating IgA immune complexes in patients with psoriasis. 
  • Clinical application of whole-genome sequencing in patients with primary immunodeficiency. 
  • Clinicopathologic features and outcomes of lymphoplasmacytic lymphoma patients with monoclonal IgG or IgA paraprotein expression. 
  • Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk. 
  • Comparison of the intestinal and serum antibody response in patients with dermatitis herpetiformis. 
  • Concomitant Waldenstrom macroglobulinemia and IgA plasmablastic myeloma in a patient with untreated IgM paraproteinemia: sequential development of biclonal B-cell neoplasms over a 10-year period in a single individual. 
  • Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primates. 
  • Correction of severe combined immunodeficiency by fetal liver cells. 
  • Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaques. 
  • Cost-effectiveness analysis of strategies for diagnosing celiac disease. 
  • Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques. 
  • Cutaneous endothelial cell activation in normal skin of patients with dermatitis herpetiformis associated with increased serum levels of IL-8, sE-Selectin, and TNF-alpha. 
  • Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. 
  • DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial. 
  • DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memory. 
  • Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency. 
  • Definition of distinct compartments in polarized Madin-Darby canine kidney (MDCK) cells for membrane-volume sorting, polarized sorting and apical recycling. 
  • Depression of cell-mediated immunity in atopic eczema. 
  • Dermatitis herpetiformis and the mucosal immune response. 
  • Dermatitis herpetiformis. 
  • Dermatitis herpetiformis. 
  • Dermatitis herpetiformis: the skin and the gut. 
  • Dermatomyositis associated with IgA deposition. 
  • Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) following both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency. 
  • Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel. 
  • Does chronic Chlamydia pneumoniae infection increase the risk of myocardial injury? Insights from patients with non-ST-elevation acute coronary syndromes. 
  • Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time. 
  • Effect of bismuth salts on systemic and mucosal immune responses to orally administered cholera toxin. 
  • Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis. 
  • Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. 
  • Elevated IgA concentration in milk produced by mothers delivered of preterm infants. 
  • Elevated serum secretory immunoglobulin A levels in patients with head and neck carcinoma. 
  • Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome. 
  • Enzyme immunoassay for detection of human immunodeficiency virus-specific immunoglobulin A antibodies. 
  • Evaluation of hyperviscosity in monoclonal gammopathies. 
  • Evidence for immune-mediated reduction of viral replication in Macaca nemestrina mucosally immunized with inactivated SHIV(89.6). 
  • Fate of four cadaveric donor renal allografts with mesangial IgA deposits. 
  • Frequency of celiac disease in individuals with Down syndrome in the United States. 
  • Function of the secretory immune system in bronchogenic carcinoma. Immunoglobulin A levels in respiratory secretions. 
  • GM-CSF DNA: an adjuvant for higher avidity IgG, rectal IgA, and increased protection against the acute phase of a SHIV-89.6P challenge by a DNA/MVA immunodeficiency virus vaccine. 
  • Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient. 
  • Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva. 
  • HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. 
  • HIV-1 specific IgA detected in vaginal secretions of HIV uninfected women participating in a microbicide trial in Southern Africa are primarily directed toward gp120 and gp140 specificities. 
  • HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge. 
  • HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis. 
  • HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine. 
  • HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. 
  • HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. 
  • Heavy-chain receptor editing unbound. 
  • Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. 
  • Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect. 
  • Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. 
  • Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses. 
  • IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. 
  • Identification and characterization of a novel regulatory factor: IgA-inducing protein. 
  • Identification of selective immunoglobulin a deficiency by renal biopsy. 
  • Idiopathic monoclonal (IgA) gammopathy in a dog. 
  • IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. 
  • IgA antibodies against reticulin and endomysium in the serum and gastrointestinal secretions of patients with dermatitis herpetiformis. 
  • IgA immune complexes in patients with dermatitis herpetiformis occur in the absence of IgA rheumatoid factor. 
  • IgA in saliva of breast-fed and bottle-fed infants. 
  • IgA-binding structures in dermatitis herpetiformis skin are independent of elastic-microfibrillar bundles. 
  • IgA-containing circulating immune complexes in dermatitis herpetiformis, Henoch-Schönlein purpura, systemic lupus erythematosus and other diseases. 
  • IgA-containing circulating immune complexes in gluten-sensitive enteropathy. 
  • IgA-containing circulating immune complexes in patients with igA nephropathy. 
  • IgA-containing immune complexes in patients with psoriatic arthritis. 
  • Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses. 
  • Immune-correlates analysis of an HIV-1 vaccine efficacy trial. 
  • Immunization with Haemophilus influenzae Hap adhesin protects against nasopharyngeal colonization in experimental mice. 
  • Immunization with Salmonella enterica serovar Typhimurium-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae. 
  • Immunobiology of primary intracranial tumors. Part 1: studies of the cellular and humoral general immune competence of brain-tumor patients. 
  • Immunoblot analysis of anti-Ureaplasma urealyticum antibody in pregnant women and newborn infants. 
  • Immunofluorescent studies on the trabecular meshwork in open-angle glaucoma. 
  • Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes. 
  • Immunoglobulin levels in haemophiliacs at HIV seroconversion and during follow up. 
  • Immunoglobulin localization in benign and malignant lesions of the human mammary gland. 
  • Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle. 
  • Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. 
  • Immunoregulatory disorders associated with hereditary angioedema. II. Serologic and cellular abnormalities. 
  • Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. 
  • In-vitro infection of chronic lymphocytic leukemia cells by Epstein-Barr virus (EBV). 
  • Incompatible bone-marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement. 
  • Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. 
  • Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine. 
  • Intraepidermal neutrophilic IgA dermatosis in an HIV-infected patient. 
  • Kernel-based logistic regression model for protein sequence without vectorialization. 
  • Lessons learned from HIV-1 vaccine trials: new priorities and directions. 
  • Leukocytoclastic vasculitis as the presenting feature of dermatitis herpetiformis. 
  • Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys. 
  • Long term use of intravenous immune globulin in patients with primary immunodeficiency diseases: inadequacy of current dosage practices and approaches to the problem. 
  • Longitudinal changes in serum immunoglobulin levels in older humans. 
  • Management of dermatitis herpetiformis. 
  • Maternal Humoral Immune Responses Do Not Predict Postnatal HIV-1 Transmission Risk in Antiretroviral-Treated Mothers from the IMPAACT PROMISE Study. 
  • Maternal cholera immunisation and scecretory IgA in breast milk. 
  • Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. 
  • Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency. 
  • Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh. 
  • Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining. 
  • Mid-life stress is associated with both up- and down-regulation of markers of humoral and cellular immunity. 
  • Mucosal and systemic adjuvant activity of alphavirus replicon particles. 
  • Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk. 
  • Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates. 
  • Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease--dermatitis herpetiformis. 
  • Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection. 
  • Neutrophil CD11b, L-selectin and Fc IgA receptors in patients with dermatitis herpetiformis. 
  • No prognostic significance of chronic infection with Chlamydia pneumoniae in acute coronary syndromes: insights from the Global Utilization of Strategies to Open Occluded Arteries IV Acute Coronary Syndromes trial. 
  • Non-specific and specific immunotherapy in patients with melanoma. 
  • Noninvasive measurement of mucosal immunity in a free-ranging baboon population. 
  • Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. 
  • Novel directions in HIV-1 vaccines revealed from clinical trials. 
  • Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. 
  • Ocular cicatricial pemphigoid with granular IgA and complement deposition. 
  • Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector. 
  • Oral immunogenicity of the plant proteinase bromelain. 
  • Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection. 
  • Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection. 
  • Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. 
  • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. 
  • Plasma therapy in immunodeficiency diseases. 
  • Plasma therapy in immunodeficiency diseases. 
  • Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results. 
  • Preexisting vaccinia virus immunity decreases SIV-specific cellular immunity but does not diminish humoral immunity and efficacy of a DNA/MVA vaccine. 
  • Present status of pyoderma gangrenosum. Review of 21 cases. 
  • Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany. 
  • Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. 
  • Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C. 
  • Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Randomized trial comparing the safety and antibody responses to live attenuated versus inactivated influenza vaccine when administered to breastfeeding women. 
  • Randomized, Double-Blind Evaluation of Late Boost Strategies for HIV-Uninfected Vaccine Recipients in the RV144 HIV Vaccine Efficacy Trial. 
  • Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1. 
  • Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. 
  • Regulation of complement activity by immunoglobulin. I. Effect of immunoglobulin isotype on C4 uptake on antibody-sensitized sheep erythrocytes and solid phase immune complexes. 
  • Response of the secretory immune system to bronchogenic carcinoma of the lung. 
  • RhoB-dependent modulation of postendocytic traffic in polarized Madin-Darby canine kidney cells. 
  • SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses. 
  • Salt-split human skin substrate for the immunofluorescent screening of serum from patients with cicatricial pemphigoid and a new method of immunoprecipitation with IgA antibodies. 
  • Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women. 
  • Secretory immune response in patients with oropharyngeal carcinoma. 
  • Selective IgA deficiency. 
  • Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis. 
  • Seroprevalence of antibodies to Chlamydia pneumoniae in women with preeclampsia. 
  • Serum IL-8 in patients with dermatitis herpetiformis is produced in response to dietary gluten. 
  • Serum IgD and IgE concentrations in immunodeficiency diseases. 
  • Serum concentrations of four immunoglobulins in non-immunized and immunized athymic ('nude') mice. 
  • Serum immunogbulin cocentrations during normal pregnancy. 
  • Severe combined immunodeficiency with leukopenia (reticular dysgenesis) in siblings: immunologic and histopathologic findings. 
  • Soluble interleukin-2 receptor levels in patients with dermatitis herpetiformis. 
  • Streptokinase promotes development of dipeptidyl peptidase IV (CD26) autoantibodies after fibrinolytic therapy in myocardial infarction patients. 
  • Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell Responses. 
  • The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. 
  • The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. 
  • The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. 
  • The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. 
  • The glomerular complement receptor in immunologically mediated renal glomerular injury. 
  • The nephrotic syndrome in congenital syphilis: an immunopathy. 
  • The pathogenesis of dermatitis herpetiformis. 
  • The pathogenesis of dermatitis herpetiformis: recent advances. 
  • The pathogenesis of nontypable Haemophilus influenzae otitis media. 
  • The role of bacterial infections in asthma. 
  • Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up. 
  • Transplantation outcomes for severe combined immunodeficiency, 2000-2009. 
  • Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. 
  • Value of day 100 screening studies for predicting the development of chronic graft-versus-host disease after allogeneic bone marrow transplantation. 
  • Vancomycin-associated linear IgA dermatosis. A report of three cases. 
  • [IgA pemphigus. Successful treatment with mycophenolate mofetil]. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology