Subject Areas on Research
- Branhamella catarrhalis activates human B lymphocytes following interactions with surface IgD and class I major histocompatibility complex antigens.
- CD19 can regulate B lymphocyte signal transduction independent of complement activation.
- CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
- CD20 deficiency in humans results in impaired T cell-independent antibody responses.
- CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
- Clinical and immunologic features of selective IgA deficiency.
- Depression of cell-mediated immunity in atopic eczema.
- Flow cytometric analysis of immunoglobulin heavy chain expression in B-cell lymphoma and reactive lymphoid hyperplasia.
- Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect.
- Humoral immunodeficiency.
- Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion.
- Purification of glycopeptides of human plasma proteins by high-performance liquid chromatography.
- RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.
- Serum IgD and IgE concentrations in immunodeficiency diseases.
- Serum IgD concentrations in normal infants, children, and adults and in patients with elevated IgE.
- Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
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