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Subject Areas on Research
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4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro.
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A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
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A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization.
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A comparative study of monoclonal gammopathies and immunoglobulin levels in Japanese and United States elderly.
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A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group.
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A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol.
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A human CD46 transgenic pig model system for the study of discordant xenotransplantation.
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A monoclonal IgM with antibodylike specificity for phospholipids in a patient with lymphoma.
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A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group.
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A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis.
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Aberrant IgM on T cells: biomarker or pathogenic factor in childhood nephrotic syndrome?
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Abrogation of baboon natural xenoantibody to pig splenocytes by DL-penicillamine.
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Absence of hyperacute rejection in newborn pig-to-baboon cardiac xenografts.
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Absence of hyperacute rejection in pig-to-primate orthotopic pulmonary xenografts.
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Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function.
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Acute hepatitis due to epstein-barr virus in an immunocompetent patient.
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Age-related development of human anti-pig xenoantibody.
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Agglutination of Naegleria fowleri and Naegleria gruberi by antibodies in human serum.
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Alteration of T-lymphocyte subpopulations in sarcoidosis.
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Alteration of human erythrocyte membrane properties by complement fixation.
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An accidental laboratory infection with African trypanosomes of a defined stock. I. The clinical course of the infection.
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An in vitro analogue of immune dysfunction with altered immunoglobulin production in the aged.
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An outbreak of Rift Valley fever in Northeastern Kenya, 1997-98.
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Analysis of Japanese encephalitis epidemic in Western Nepal in 1997.
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Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency.
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Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.
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Antibodies reactive with class II antigens encoded for by the major histocompatibility complex inhibit human B cell activation.
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Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response.
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Antibody alone does not prevent experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency (MAIDS).
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Antibody inhibitors of nonmuscle myosin function and assembly.
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Antibody-dependent cellular cytotoxicity in primary immunodeficiency diseases and with normal leukocyte subpopulations. Importance of the type of target.
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Anticardiolipin antibodies and osteonecrosis of the femoral head.
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Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers.
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B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
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B cell depletion reduces the development of atherosclerosis in mice.
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B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates.
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B-cell lymphopenia and hypogammaglobulinemia in thymoma patients.
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B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.
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Binding of polyreactive antibodies to self versus foreign antigens.
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Blast cell leukemia with IgM monoclonal gammopathy and intracytoplasmic vacuoles and Auer-body-like inclusions.
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Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques.
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CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
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CD19 can regulate B lymphocyte signal transduction independent of complement activation.
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CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.
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CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.
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CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
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CD22 serves as a receptor for soluble IgM.
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COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors.
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Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection.
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Cell surface reactive human monoclonal antibody directed to human melanoma-associated gangliosides.
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Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA.
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Characterization of human anti-porcine "natural antibodies" recovered from ex vivo perfused hearts--predominance of IgM and IgG2.
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Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency.
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Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus-induced infectious mononucleosis.
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Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.
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Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants.
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Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.
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Clinical and immunologic features of selective IgA deficiency.
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Comparison of cytomegalovirus polymerase chain reaction and serology for screening umbilical cord blood components.
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Comparison of the intestinal and serum antibody response in patients with dermatitis herpetiformis.
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Concomitant Waldenstrom macroglobulinemia and IgA plasmablastic myeloma in a patient with untreated IgM paraproteinemia: sequential development of biclonal B-cell neoplasms over a 10-year period in a single individual.
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Correlation of milk precipitins with IgA deficiency.
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Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women.
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Cytomegalovirus pericarditis: a case series and review of the literature.
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D6.1, a murine antimelanoma monoclonal antibody from congenitally athymic nude mice immunized with purified melanoma tumor-associated antigen.
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Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
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Depression of cell-mediated immunity in atopic eczema.
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Development of IgA and IgG2 subclass deficiency after sulfasalazine therapy.
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Development of multiple monoclonal serum immunoglobulins (multiclonal gammopathy) following both HLA-identical unfractionated and T cell-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency.
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Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
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Differential effects of donor-specific alloantibody.
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Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease.
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Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
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Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces.
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Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.
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Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice.
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Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain.
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Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency.
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Effect of soluble complement receptor type 1 on natural antibody levels during xenograft rejection.
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Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis.
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Effects of bursectomy and rat skin xenografts on natural antibodies in chickens.
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Elevated IgA concentration in milk produced by mothers delivered of preterm infants.
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Evaluation of hyperviscosity in monoclonal gammopathies.
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Evaluation of serum immunoglobulin concentrations in the perinatal period by use of a standardized method of measurement.
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Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation?
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Expanding the Spectrum of EBV-positive Marginal Zone Lymphomas: A Lesion Associated With Diverse Immunodeficiency Settings.
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Experimental transfusion reactions in monkeys: haemolytic, coagulant and renal effects of transfused isoimmune IgG and IgM.
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Exploring the basis of peptide-carbohydrate crossreactivity: evidence for discrimination by peptides between closely related anti-carbohydrate antibodies.
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Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus.
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Expression of newborn pig endothelial cell xenoantigens recognized by baboon natural xenoantibody.
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False Positive Lyme Disease IgM Immunoblots in Children.
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Flow cytometric analysis of immunoglobulin heavy chain expression in B-cell lymphoma and reactive lymphoid hyperplasia.
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Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma.
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Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient.
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Genetic control of inflammatory arthritis and glomerulonephritis in congenic lpr mice and their F1 hybrids.
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Granulomatous hepatitis associated with acute cytomegalovirus infection.
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Heavy and light chain utilization in autoantibodies of elderly patients with systemic lupus erythematosus.
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Hereditary alterations in the immune response: coexistence of "agammaglobulinemia", acquired hypogammaglobulinemia and selective immunoglobulin deficiency in a sibship.
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Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency. Evidence against a stem cell defect.
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Host regulation of MOPC 104E plasmacytoma after reduction of tumor burden by total body irradiation.
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Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans.
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Human T lymphocyte antigens as defined by monoclonal antibodies.
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Human herpesvirus 6 polymerase chain reaction findings in human immunodeficiency virus associated neurological disease and multiple sclerosis.
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Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells May Lead to Impaired Antibody Immune Reconstitution.
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Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors.
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Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.
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Humoral immunodeficiency.
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Hyper IgM syndrome associated with defective CD40-mediated B cell activation.
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I and i antigens on normal and leukemic leukocytes.
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IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.
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Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
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Idiotypic regulation by isologous monoclonal anti-idiotope antibodies.
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IgA immune complexes in patients with dermatitis herpetiformis occur in the absence of IgA rheumatoid factor.
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IgA-containing circulating immune complexes in gluten-sensitive enteropathy.
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IgG and IgM anticardiolipin antibodies following treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis.
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IgG is a prominent component of cynomolgus antiporcine natural xenoantibody.
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Immune recognition of DNA in SLE.
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Immunobiology of primary intracranial tumors. Part 1: studies of the cellular and humoral general immune competence of brain-tumor patients.
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Immunodeficiency.
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Immunofluorescent studies of the eye in Waldenström's macroglobulinemia.
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Immunofluorescent studies on the trabecular meshwork in open-angle glaucoma.
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Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis.
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Immunoglobulin localization in benign and malignant lesions of the human mammary gland.
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Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle.
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Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation.
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Immunoradiometric assay for examination and quantitation of Brucella abortus-specific antibodies reactive with the antigen(s) used in the indirect hemolysis test.
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In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.
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In vitro autoantibody production by normal adult and cord blood B cells.
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In vitro evaluation of neonatal human immunity against the pig.
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Incidence of Hepatitis E Infection in American Patients With Suspected Drug-Induced Liver Injury Is Low and Declining: The DILIN Prospective Study.
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Incompatible bone-marrow transplantation in lymphopenic immunologic deficiency. Circumvention of fatal graft-versus-host disease by immunologic enhancement.
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Increased efficiency of binding of nascent C3b to the erythrocytes of chronic cold agglutinin disease.
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Inhibition of in vitro NZB antibody responses by cyclosporine.
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Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia.
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Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.
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Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood.
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Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.
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Ipr gene control of the anti-DNA antibody response.
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Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways.
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Long term use of intravenous immune globulin in patients with primary immunodeficiency diseases: inadequacy of current dosage practices and approaches to the problem.
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Longitudinal changes in serum immunoglobulin levels in older humans.
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Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19.
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Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.
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Lyme disease: authentic imitator or wishful imitation?
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MYD88 L265P Mutation in Lymphoid Malignancies.
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Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure.
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Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency.
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Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
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Molecular and genetic biomarkers implemented from next-generation sequencing provide treatment insights in clinical practice for Waldenström macroglobulinemia.
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Monoclonal antibodies to uveal melanoma.
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Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease.
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Mouse CD20 expression and function.
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Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion.
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Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome.
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Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
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Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
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Natural anti-carbohydrate IgM in mice: dependence on age and strain.
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Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity.
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Natural antipig xenoantibody is absent in neonatal human serum.
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Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies.
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Newborn baboon immunity: lessons in cross-species transplantation.
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Newborn baboon serum lacks natural anti-pig xenoantibody.
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Newborn discordant cardiac xenotransplantation in primates: a model of natural antibody depletion.
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Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation.
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Partial splenectomy but not total splenectomy preserves immunoglobulin M memory B cells in mice.
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Patterns of autoantibody expression in pediatric and adult systemic lupus erythematosus.
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Peripheral polyneuropathy, high and low molecular weight IgM, and amyloidosis.
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Peripubertal immune challenges attenuate reproductive development in male Siberian hamsters (Phodopus sungorus).
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Plasma therapy in immunodeficiency diseases.
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Plasma therapy in immunodeficiency diseases.
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Platelet factor 4/heparin antibody (IgG/M/A) in healthy subjects: a literature analysis of commercial immunoassay results.
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Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.
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Polyspecific reactivity of a murine monoclonal antibody that binds to nuclear matrix-associated, chromatin-bound autoantigens.
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Prevalence of antibodies to rotavirus in different age-groups of infants in Bochum, West Germany.
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Prevention of hyperacute xenograft rejection by intravenous immunoglobulin.
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Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens.
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Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract.
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Prolonged survival of pig cardiac xenografts in unmodified newborn baboons.
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Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates.
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Race-related differences in antibody responses to the inactivated influenza vaccine are linked to distinct pre-vaccination gene expression profiles in blood.
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Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels.
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Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.
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Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.
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Regulation of the tyrosine kinase-dependent adhesion pathway in human lymphocytes through CD45.
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Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.
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Relationship of antiphospholipid antibodies to cardiovascular manifestations of systemic lupus erythematosus.
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Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery.
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Seroconversion patterns to four human rotavirus serotypes in hospitalized infants with acute rotavirus gastroenteritis.
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Seroepidemiology of Rickettsia typhi, spotted fever group rickettsiae, and Coxiella burnetti infection in pregnant women from urban Tanzania.
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Serum IgD and IgE concentrations in immunodeficiency diseases.
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Serum immunogbulin cocentrations during normal pregnancy.
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Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial.
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Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
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Spatiotemporal Heterogeneity of Zika Virus Transmission in Indonesia: Serosurveillance Data from a Pediatric Population.
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Species differences in natural xenoantibody to swine.
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Spectrum of humoral rejection after pediatric heart transplantation.
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Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
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Successful pyrimethamine-sulfadiazine therapy of pneumocystis pneumonia in infants with X-linked immunodeficiency with hyper-IgM.
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Suppressor function of T lymphocytes in the acquired immunodeficiency syndrome as assessed by allogeneic mixed lymphocyte culture.
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The United States National Prospective Hemolytic Uremic Syndrome Study: microbiologic, serologic, clinical, and epidemiologic findings.
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The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
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The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells.
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The differential effect of in vivo hydrocortisone on the kinetics of subpopulations of human peripheral blood thymus-derived lymphocytes.
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The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA.
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The footprint of antibody bound to pig cells: evidence of complex surface topology.
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The human antibody response to the surface of Mycobacterium tuberculosis.
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The humoral immune response in humans following cross-perfusion of porcine organs.
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The humoral immune response in humans following ex vivo perfusion of porcine livers.
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The influence of Yaa on anti-DNA responses of B6-lpr mice.
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The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains.
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The intravenous insulin tolerance test in type I diabetes.
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The nephrotic syndrome in congenital syphilis: an immunopathy.
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The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus.
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The relationship of anticardiolipin antibodies to disease manifestations in pediatric systemic lupus erythematosus.
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The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotides.
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Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis.
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Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.
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Transient hypogammaglobulinemia of infancy: review of the literature, clinical and immunologic features of 11 new cases, and long-term follow-up.
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Use of a human plaque-forming cell assay to study peripheral blood bursa-equivalent cell activation and excessive suppressor cell activity in humoral immunodeficiency.
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Variability in B cell maturation and differentiation in X-linked agammaglobulinemia.
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Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma, version 2.2013.
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West Nile virus among hospitalized, febrile patients: a case for expanding diagnostic testing.
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West Nile virus infection in blood donors in the New York City area during the 2010 seasonal epidemic.
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When you hear hoof beats...do not forget the zebras.
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Xanthogranulomatous pyelonephritis in renal transplant recipient.
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Xenoreactive natural antibodies and isohemagglutinins: a distinct class of antibodies.
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Xenoreactivity of fetal and neonatal baboon intracellular antibody against the pig.
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[Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism].
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β1-integrin-matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability.
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Keywords of People
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Buckley, Rebecca Hatcher,
James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine,
Pediatrics, Allergy and Immunology
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Kelsoe, Garnett H.,
James B. Duke Distinguished Professor of Immunology,
Integrative Immunobiology
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Khandelwal, Sanjay,
Assistant Professor in Medicine,
Medicine, Hematology
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Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
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O'Connor, Christopher Michael,
Adjunct Professor in the Department of Medicine,
Medicine, Clinical Pharmacology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Integrative Immunobiology