Immune Sera

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  Subject Areas on Research

  • A comparison of the leukocyte agglutination and mixed agglutination techniques for detecting human tissue isoantigens. 
  • A complement-resistant HeLa cell line (T638) is blocked at the step of C3 deposition. 
  • A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin. 
  • A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement. 
  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • Abnormalities of leukotaxis in atopic dermatitis. 
  • Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Alternative translation initiation site usage results in two structurally distinct forms of Pit-1. 
  • An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies. 
  • Analysis of complement-dependent antibody-mediated lysis of target cells acutely infected with measles. 
  • Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. 
  • Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. 
  • Antibody-dependent lymphoid cell-mediated cytotoxicity: role of complement. 
  • Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins. 
  • Antigenicity of a recombinant Ro (SS-A) fusion protein. 
  • Appearance of a ribonucleic acid polymerase-binding protein in asporogenous mutants of Bacillus subtilis. 
  • Bactericidal and opsonic properties of C4-deficient guinea pig serum. 
  • Binding of human immunodeficiency virus type 1 to the C3b/C4b receptor CR1 (CD35) and red blood cells in the presence of envelope-specific antibodies and complement. National Institutes of Health AIDS Vaccine Clinical Trials Networks. 
  • Biochemical and immunological properties of dog brain isorenin. 
  • Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain. 
  • Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1. 
  • C-terminal region of human T cell lymphotropic virus type I (HTLVI) p19 core protein is immunogenic in humans and contains an HTLVI-specific epitope. 
  • Ca2+-dependent regulator. Production and characterization of a monospecific antibody. 
  • Cathepsin D of rabbit skin: an immunoenzymic study. 
  • Cell surface differentiation antigens of the malignant T cell in Sezary syndrome and mycosis fungoides. 
  • Cerebral physiology in dogs after brain-tumor induction with Schmidt-Ruppin Rous sarcoma virus: experiences with radioiodinated normal and antiviral immunoglobulin G. 
  • Characterization of a chimpanzee anti-human melanoma antiserum. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of antigens in SSV nonproducer cells. 
  • Characterization of chimpanzee leukocyte alloantisera. 
  • Characterization of melanoma cell membrane tumor-associated antigens using xenoserum, alloserum, and autoserum: I. immunofluorescence. 
  • Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency. 
  • Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. 
  • Clinical and immunologic features of selective IgA deficiency. 
  • Comparative immunogenicity of HIV-1 clade C envelope proteins for prime/boost studies. 
  • Comparison of anti-HIV-1 ADCC reactivities in infected humans and chimpanzees. 
  • Comparison of glycoproteins isolated by phenol-water partition of human erythrocyte membranes. 
  • Comparison of the hydrophobic properties of Candida albicans and Candida dubliniensis. 
  • Complement fixation by a single molecule of gamma G hemolysin. 
  • Complement-mediated tissue damage: contribution of the classical and alternate complement pathways in the Forssman reaction. 
  • Cross-reactivity of primate alloantigens: absorption of anti-HL-A reactivity from human alloantisera by chimpanzee lymphocytes. 
  • Cytotoxicity reactions of chimpanzee antisera with human lymphocyte donors phenotyped or genotyped for HL-A. 
  • Deficiency of the homologous restriction factor in paroxysmal nocturnal hemoglobinuria. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Demonstration of abnormalities in expression of thymic epithelial surface antigens in severe cellular immunodeficiency diseases. 
  • Detection and partial characterization of human thymus-leukemia antigens. 
  • Detection of anti-human cell antibodies in sera from macaques immunized with whole inactivated virus. 
  • Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate. 
  • Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply. 
  • Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. II. Effect of serum and insulin. 
  • Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity. 
  • Embryonic development of human transplantation antigens. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Epithelial cell adherence mediated by the enterotoxigenic Escherichia coli tia protein. 
  • Erythrocyte Webb-type glycophorin C variant lacks N-glycosylation due to an asparagine to serine substitution. 
  • Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity. 
  • Experimental transfusion reactions in monkeys: haemolytic, coagulant and renal effects of transfused isoimmune IgG and IgM. 
  • Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids. 
  • Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. 
  • Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles. 
  • Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. 
  • Further characterization of a factor from endotoxin-treated serum which releases histamine and heparin from mast cells. 
  • Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa. 
  • Generation of chemotactic factors in guinea pig serum via activation of the classical and alternate complement pathways. 
  • Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes. 
  • GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins. 
  • H-2K molecules have two different C-termini, one of which is K-region specific. 
  • Hemolysis of sheep erythrocytes in guinea pig serum deficient in the fourth component of complement. I. Antibody and serum requirements. 
  • Hemolysis of sheep erythrocytes in guinea pig serum deficient in the fourth component of complement. II. Evidence for involvement of C1 and components of the alternate complement pathway. 
  • Hemolytic transfusion reactions caused by failure of commercial antiglobulin reagents to detect complement. 
  • Hereditary C6 deficiency in man. 
  • Histocompatibility testing and mixed lymphocyte culture responses in chimpanzee families. 
  • Human B cell alloantigens: expression of MB and MT determinants. 
  • Human acute leukemia cells with membrane-bound immunoglobulin. 
  • Human histocompatibility antigen mutants immunoselected in vitro. Biochemical analysis of a mutant which synthesizes an altered HLA-A2 heavy chain. 
  • Human leukemia antigens: partial isolation and characterization. 
  • Human melanoma and leukemia associated antigens difined by nonhuman primate antisera. 
  • Humoral immunostimulation. IV. Role of complement. 
  • Humoral mediators of chemotaxis of mononuclear leukocytes. 
  • Humoral rejection of rat hepatic transplants by passive transfer of serum. 
  • Identification of a 20,000-dalton protein in SSV-transformed nonproducer cells. 
  • Ig-positive lymphocytes in Hodgkin's disease. 
  • Immune fever in the rabbit: responses of the hematologic and complement systems. 
  • Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA with adjuvant monophosphoryl lipid A protects swine from a homologous but not a heterologous challenge. 
  • Immunization with the Haemophilus ducreyi trimeric autotransporter adhesin DsrA with alum, CpG or imiquimod generates a persistent humoral immune response that recognizes the bacterial surface. 
  • Immunoblot analyses of Candida albicans-associated antigens and antibodies in human sera. 
  • Immunocytochemical localization of cathepsin D in rabbit skin. 
  • Immunodiagnosis of melanoma using chimpanzee antihuman melanoma antiserum. 
  • Immunogenicity of constrained monoclonal antibody A32-human immunodeficiency virus (HIV) Env gp120 complexes compared to that of recombinant HIV type 1 gp120 envelope glycoproteins. 
  • Immunologic control of a retrovirus-associated murine adenocarcinoma. VIII. Corynebacterium parvum-activated natural killer cells as potent antibody-dependent cell-mediated cytotoxicity effectors. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. IV. Characterization of the protective antibody in hyperimmune serum. 
  • In vitro selection of RNA epitopes using autoimmune patient serum. 
  • In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. 
  • In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. 
  • Inactivation of murine xenotropic oncornavirus by normal mouse sera is not immunoglobulin-mediated. 
  • Induction and characterization of neutralizing antibodies against a human immunodeficiency virus type 1 primary isolate. 
  • Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. 
  • Influence of antisera to oncornavirus glycoprotein (gp71) on infections of cats with feline leukemia virus. 
  • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. 
  • Interspecies determinants of Friend leukemia virus antigens involved in cytolysis of virus-pfoducing cells. 
  • Isolation and characterization of a novel plasma protein which binds to activated C4 of the classical complement pathway. 
  • Isolation and characterization of two group-specific antigens from feline leukemia virus. 
  • Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses. 
  • Isolation of the nuclear gene encoding a subunit of the yeast mitochondrial RNA polymerase. 
  • Kinetic analysis of chemotactic factor generation in human serum via activation of the classical and alternate complement pathways. 
  • Localization of fibronectin, laminin-entactin, and entactin in Reichert's membrane by immunoelectron microscopy. 
  • Mapping of homologous, amino-terminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins. 
  • Mapping of immunogenic regions of human T cell leukemia virus type I (HTLV-I) gp46 and gp21 envelope glycoproteins with env-encoded synthetic peptides and a monoclonal antibody to gp46. 
  • Measurement of the third component of complement bound to red blood cells in patients with the cold agglutinin syndrome. 
  • Mechanism of therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-dependent immune damage in a guinea pig model. 
  • Neutralization of homologous and heterologous oncornaviruses by antisera against the p15(E) and gp71 polypeptides of Friend murine leukemia virus. 
  • Neutralization of sensitized virus by purified components of complement. 
  • Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4. 
  • Nuclear spreads: I. Visualization of bipartite ribosomal RNA domains. 
  • Observations on the mechanism of immune hemolysis: importance of immunoglobulin class and source of complement on the extent of damage. 
  • Oligomeric structure and tissue distribution of ficolins from mouse, pig and human. 
  • Outer membrane of avian myeloblastosis virus. 
  • Ovalbumin messenger RNA of chick oviduct: partial characterization, estrogen dependence, and translation in vitro. 
  • Pancreatic islet cell carcinoma associated with multiple hormone secretion and pancytopenia. Evidence of a serum factor suppressing hematopoiesis. 
  • Passive infusion of immune serum into simian immunodeficiency virus-infected rhesus macaques undergoing a rapid disease course has minimal effect on plasma viremia. 
  • Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts. 
  • Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells. 
  • Plasma therapy in immunodeficiency diseases. 
  • Polypeptides of avian RNA tumor viruses. II. Serological characterization. 
  • Polypeptides of avian RNA tumor viruses. IV. Components of the viral envelope. 
  • Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses. 
  • Polypeptides of mammalian oncornaviruses. III. Localization of p 15 and reactivity with natural antibody. 
  • Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes. 
  • Production of chemotactic activity by guinea pig immunoglobulins following activation of the C3 complement shunt pathway. 
  • Production of congenital malformations using tissueantisera. 8. Effectiveness of reduced, alkylated and digested anti-kidney antibodies. 
  • Properties of mouse leukemia viruses. II. Isolation of viral components. 
  • Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. 
  • Purification and serological characterization of the major envelope glycoprotein from AKR murine leukemia virus and its reactivity with autogenous immune sera from mice. 
  • Reactions of human HL-A sera with orangutan and gorilla lymphocytes. 
  • Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • Role of antibody and complement in the immune clearance and destruction of erythrocytes. I. In vivo effects of IgG and IgM complement-fixing sites. 
  • Safety and patient acceptability of intravenous immune globulin in 10% maltose. 
  • Selection of donors for kidney transplantation. 
  • Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy. 
  • Site of deposition of C3 in Arthus reactions of C4 deficient guinea pigs. 
  • Spatial relationships between specific sites on reconstituted chloroplast proton adenosinetriphosphatase and the phospholipid vesicle surface. 
  • Specificity, cross-reactivity, and affinity of 125I-labeled antiglioma antibodies for monolayers of cultured glioma cells. 
  • Studies of complement-mediated membrane damage: the influence of erythrocyte storage on susceptibility to cytolysis. 
  • Synthesis and secretion of gamma-globulin by lymph node cells. VI. Characteristics of the structure of immunoglobulin A and its pattern of secretion by appendix cell suspensions. 
  • The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid. 
  • The ability of certain SIV vaccines to provoke reactions against normal cells. 
  • The binding of sera of patients with SLE to bacterial and mammalian DNA. 
  • The effect of temperature on the reactivity of guinea-pig complement with gamma G and gamma M haemolytic antibodies. 
  • The immunohistochemical application of three anti-GFAP monoclonal antibodies to formalin-fixed, paraffin-embedded, normal and neoplastic brain tissues. 
  • The nature of allergy. 
  • The relationship of complement consumption to immune fever. 
  • The requirement of specific anticapsular IgG for killing of Haemophilus influenzae by the alternative pathway of complement activation. 
  • The responses of atrial natriuretic factor concentrations to acute volume changes in conscious rats. 
  • The subunit structure of normal and hemophilic factor VIII. 
  • Tissue antigens of man and chimpanzees; their role in xenografting. 
  • Transplantation in miniature swine. 
  • Type-specific neutralization of the human immunodeficiency virus with antibodies to env-encoded synthetic peptides. 
  • Use of antisera for identification of enterotoxigenic Escherichia coli. 
  • [Basis for a specific-active immunotherapy in malignant melanoma]. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology