Immune Tolerance

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  Subject Areas on Research

  • 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity. 
  • A Race Against Time-Changing the Natural History of CRIM Negative Infantile Pompe Disease. 
  • A natural history of melanoma: serial gene expression analysis. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • A role for plasma cell targeting agents in immune tolerance induction in autoimmune disease and antibody responses to therapeutic proteins. 
  • A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model. 
  • AIDS/HIV. Host controls of HIV neutralizing antibodies. 
  • Acute and chronic graft-versus-host disease in man. 
  • Allogeneic microchimerism and donor antigen-specific hyporeactivity in lung transplant recipients. 
  • Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice. 
  • An expanded role of the tumor suppressor TSC1 in T cell tolerance. 
  • An immune tolerance approach using transient low-dose methotrexate in the ERT-naïve setting of patients treated with a therapeutic protein: experience in infantile-onset Pompe disease. 
  • Annual literature review for clinical transplants 2005. 
  • Anti-receptor antibody-induced H-Y-specific delayed-type hypersensitivity responses in nonresponder mice. 
  • Anti-tumor immunity: myeloid leukocytes control the immune landscape. 
  • Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer. 
  • Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. 
  • Apoptosis and B cell tolerance. 
  • Application of stem cell transplantation in autoimmune diseases. 
  • Aqueous humor factors and their effect on the immune response in the anterior chamber. 
  • Aspects of immunobiology and immunotherapy and uses of monoclonal antibodies and biologic immune modifiers in human gliomas. 
  • Aspergillus flavus: an unusual cause of chest wall inflammation in an immunocompetent host. 
  • Autologous tumor rejection in humans: trimming the myths. 
  • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. 
  • Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. 
  • B cell tolerance: putting the horse before the cart. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • Bacteria establish an aqueous living space in plants crucial for virulence. 
  • Behavioral, endocrine, and immunological correlates of immigration by an aggressive male into a natural primate group. 
  • Benefits of Prophylactic Short-Course Immune Tolerance Induction in Patients With Infantile Pompe Disease: Demonstration of Long-Term Safety and Efficacy in an Expanded Cohort. 
  • CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. 
  • CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • CD22 and Siglec-G in B cell function and tolerance. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. 
  • Candidal splenic abscesses. 
  • Cellular Therapies in Solid Organ Allotransplantation: Promise and Pitfalls. 
  • Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. 
  • Challenges in the pursuit of immune tolerance. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. 
  • Clinical applications of a peptide-based vaccine for glioblastoma. 
  • Clinical tolerance 2008. 
  • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. 
  • Colonic Diverticulitis in a 19-Year-Old Boy With Juvenile Idiopathic Arthritis: Surgical Implications of Chronic Immunosuppression. 
  • Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. 
  • Contemporary issues in the management of von Willebrand disease. 
  • Conversion of CD73hiFR4hi anergic T cells to IFN-γ-producing effector cells disrupts established immune tolerance. 
  • Costimulation, coinhibition and cancer. 
  • Countering tumor-induced immunosuppression during immunotherapy for pancreatic cancer. 
  • Creation and properties of histocompatibility antigen-cell conjugates. I. Preparation and immunological properties of rat histocompatibility antigens. 
  • Creation and properties of histocompatibility antigen-cell conjugates. II. Antibody tolerance after treatment with donor histocompatibility antigen chemically coupled to recipient spleen cells. 
  • Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. 
  • Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5. 
  • Crossing the bridge: large animal models in translational transplantation research. 
  • Cryptococcosis. 
  • Cryptosporidium species, a protean protozoan. 
  • Current status of bone marrow transplantation. 
  • Cutaneous manifestations of Corynebacterium group JK sepsis. 
  • Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies. 
  • Cytomegalovirus (CMV) shedding is highly correlated with markers of immunosuppression in CMV-seropositive women. 
  • Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma. 
  • Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway. 
  • Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice. 
  • Differentiation and tolerance of CD4+ T lymphocytes. 
  • Disseminated zygomycosis: report of four cases and review. 
  • Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population. 
  • Donor type natural killer cells after haploidentical T cell-depleted bone marrow stem cell transplantation in a patient with adenosine deaminase-deficient severe combined immunodeficiency. 
  • Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. 
  • Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype. 
  • Editorial: Viral Infection at the Maternal-Fetal Interface. 
  • Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model. 
  • Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. 
  • Enhanced response to enzyme replacement therapy in Pompe disease after the induction of immune tolerance. 
  • Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. 
  • Ethanol and complement hemolytic activity of selectively bred hypercholinergic rats. 
  • Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow. 
  • Exosomes in Pancreatic Cancer: from Early Detection to Treatment. 
  • Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. 
  • Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance. 
  • Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. 
  • Eye-derived cytokines and the immunosuppressive intraocular microenvironment: a review. 
  • FN18-CRM9 immunotoxin promotes tolerance in primate renal allografts. 
  • Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. 
  • Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease. 
  • First-trimester human chorionic villi express both immunoregulatory and inflammatory cytokines: a role for interleukin-10 in regulating the cytokine network of pregnancy. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • Frontiers in nephrology: immune tolerance to allografts in humans. 
  • Galectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis. 
  • Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses. 
  • Gene therapy in transplantation. 
  • Gene transfer to the thymus. A means of abrogating the immune response to recombinant adenovirus. 
  • Gold nanoparticles-mediated photothermal therapy and immunotherapy. 
  • Graft hyporeactivity induced by donor-derived dendritic cell progenitors. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development. 
  • HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes. 
  • HLA- and genotype-based risk assessment model to identify infantile onset pompe disease patients at high-risk of developing significant anti-drug antibodies (ADA). 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses. 
  • Hematopoietic chimerism achieved by in utero hematopoietic stem cell injection does not induce donor-specific tolerance for renal allografts in sheep. 
  • Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy. 
  • High dose IVIG successfully reduces high rhGAA IgG antibody titers in a CRIM-negative infantile Pompe disease patient. 
  • Hitting the reset button for immune tolerance. 
  • Host controls of HIV broadly neutralizing antibody development. 
  • Human B-cell lymphoma in severe combined immunodeficient mice after active infection with Epstein-Barr virus. 
  • Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy. 
  • Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro. 
  • Human intrathymic T cell differentiation. 
  • Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. 
  • Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells. 
  • Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors. 
  • IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. 
  • IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. 
  • Identification of a B cell signature associated with renal transplant tolerance in humans. 
  • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. 
  • Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy. 
  • Immune Modulation for Enzyme Replacement Therapy in A Female Patient With Hunter Syndrome. 
  • Immune Tolerance for Autoimmune Disease and Cell Transplantation. 
  • Immune Tolerance-Adjusted Personalized Immunogenicity Prediction for Pompe Disease. 
  • Immune heterogeneity in neuroinflammation: dendritic cells in the brain. 
  • Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction. 
  • Immune responses at the maternal-fetal interface. 
  • Immune signatures predict prognosis in localized cancer. 
  • Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease. 
  • Immunologic challenges of human reproduction: an evolving story. 
  • Immunologic tolerance. 
  • Immunological tolerance. 
  • Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy. 
  • Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. 
  • Immunoregulatory mechanisms of the eye. 
  • Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world. 
  • Immunotherapy of malignant brain tumors. 
  • Immunotherapy of type 1 diabetes: where are we and where should we be going? 
  • Impact of air filtration on nosocomial Aspergillus infections. Unique risk of bone marrow transplant recipients. 
  • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. 
  • Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. 
  • Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children. Pediatric Investigators Collaborative Network on Infections in Canada. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. 
  • In utero transplantation of rat hematopoietic stem cells induces xenogeneic chimerism in mice. 
  • Increased glomerular deposits of von Willebrand factor in chronic, but not acute, rejection of primate renal allografts. 
  • Induction of donor-specific tolerance to heart transplantation: From concept to clinical translation. 
  • Induction of maternal tolerance to fetal alloantigens by RANTES production. 
  • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. 
  • Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design. 
  • Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex. 
  • Induction of tolerance to parental parathyroid grafts using allogeneic thymus tissue in patients with DiGeorge anomaly. 
  • Induction of tolerance to solubilized rat histocompatibility antigens. 
  • Induction of type I IFN is required for overcoming tumor-specific T-cell tolerance after stem cell transplantation. 
  • Influence of changes in pretransplant sensitization on patient and graft survival in cadaver renal transplantation. 
  • Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. 
  • Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses. 
  • Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. 
  • Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression. 
  • Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. 
  • Introducing thymus for promoting transplantation tolerance. 
  • Introduction: Regulatory B Cell Special Issue-making all the pieces fit. 
  • Is the HScore useful in COVID-19? 
  • Is tolerance induction the answer to adolescent non-adherence? 
  • Joining Forces in Basic Science: ITS Meeting 2.0. 
  • JunB Controls Intestinal Effector Programs in Regulatory T Cells. 
  • Kupffer cells: another player in liver tolerance induction. 
  • Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. 
  • Less is more: maintenance minimization as a step toward tolerance. 
  • Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes. 
  • Loss of tolerance of anti-dsDNA B cells in mice overexpressing CD19. 
  • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. 
  • Lymphoma models for B cell activation and tolerance. V. Anti-Ig mediated growth inhibition is reversed by phorbol myristate acetate but does not involve changes in cytosolic free calcium. 
  • MHC class II alleles associated with clinical and immunological manifestations of HIV-1 infection among children in Catalonia, Spain. 
  • Management of the immunocompromised patient: impact of fungal infections. Introduction. 
  • Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. 
  • Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. 
  • Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment. 
  • Mechanisms of liver-induced tolerance. 
  • Mechanisms of peripheral T cell tolerance. 
  • Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. 
  • Metastable tolerance in nonhuman primates and humans. 
  • Microparticles as autoadjuvants in the pathogenesis of SLE. 
  • Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. 
  • Minding the gap: The impact of B-cell tolerance on the microbial antibody repertoire. 
  • Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine. 
  • Mitochondria, cell death, and B cell tolerance. 
  • Modified responses to recipient and donor B cells by genetically donor T cells from human haploidentical bone marrow chimeras. 
  • Murine cytomegalovirus dissemination but not reactivation in donor-positive/recipient-negative allogeneic kidney transplantation can be effectively prevented by transplant immune tolerance. 
  • Mycobacterial Evolution Intersects With Host Tolerance. 
  • Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. 
  • Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. 
  • Neonatal bacterial infection alters fever to live and simulated infections in adulthood. 
  • Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. 
  • New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency. 
  • New reagents on the horizon for immune tolerance. 
  • Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure. 
  • Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota. 
  • Novel immunosuppressive agents in tolerance induction. 
  • Novel targeted therapies for autoimmunity. 
  • Ocular molecules and cells that regulate immune responses in situ. 
  • Opportunistic infections and Kaposi's sarcoma in homosexual men. 
  • Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. 
  • Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. 
  • PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes. 
  • Packed red blood cells suppress T-cell proliferation through a process involving cell-cell contact. 
  • Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet⁺ B cells. 
  • Passive transfer of human myasthenia gravis to rats: 1. Electrophysiology of the developing neuromuscular block. 
  • Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading. 
  • Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions. 
  • Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. 
  • Physiology and therapeutics of vascular endothelial growth factor in tumor immunosuppression. 
  • Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design. 
  • Portal venous donor-specific transfusion in conjunction with sirolimus prolongs renal allograft survival in nonhuman primates. 
  • Possible production of immunosuppression in the host by exposure to microorganisms: observations in germfree rats. 
  • Pre-transplant analysis of accommodation in donor pigs. 
  • Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome. 
  • Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection. 
  • Pregnancy and rheumatoid arthritis: insights into the immunology of fetal tolerance and control of autoimmunity. 
  • Primate renal transplants using immunotoxin. 
  • Proline isomerases in microorganisms and small eukaryotes. 
  • Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. 
  • Purulent pericarditis caused by Candida: report of three cases and identification of high-risk populations as an aid to early diagnosis. 
  • Pyoderma gangrenosum. Occurrence with altered cellular immunity and a circulating serum factor. 
  • Qa-1 restriction of CD8+ suppressor T cells. 
  • Receptor signaling in immune cell development and function. 
  • Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease. 
  • Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice. 
  • RelB controls adaptive responses of astrocytes during sterile inflammation. 
  • Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. 
  • Retinoic acid signaling acts as a rheostat to balance Treg function. 
  • Risk of multiple sclerosis exacerbation during pregnancy and breast-feeding. 
  • Role of interleukin 12 and costimulators in T cell anergy in vivo. 
  • Role of transforming growth factor beta in human disease. 
  • SMAD4 is required for development of maximal endotoxin tolerance. 
  • Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. 
  • Self-discrepancy and natural killer cell activity: immunological consequences of negative self-evaluation. 
  • Self-tolerance curtails the B cell repertoire to microbial epitopes. 
  • Sensitization and Desensitization in Vascularized Composite Allotransplantation. 
  • Serological response following re-vaccination with Salmonella typhi Vi-capsular polysaccharide vaccines in healthy adult travellers. 
  • Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. 
  • Significance of regional draining lymph nodes in the development of tumor immunity: implications for cancer immunotherapy. 
  • Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice. 
  • Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. 
  • Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer. 
  • Specific association of retroviral envelope protein, p15E, with human cell surfaces. 
  • Split tolerance induced by immunotoxin in a rhesus kidney allograft model. 
  • Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients. 
  • Stability and function of regulatory T cells expressing the transcription factor T-bet. 
  • State-of-the-art of regulatory dendritic cells in cancer. 
  • Steps toward transplantation tolerance in the clinic. 
  • Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques. 
  • Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. 
  • Successful immune tolerance induction to enzyme replacement therapy in CRIM-negative infantile Pompe disease. 
  • Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses. 
  • Synergistic Efficacy from Gene Therapy with Coreceptor Blockade and a β2-Agonist in Murine Pompe Disease. 
  • T cell stemness and dysfunction in tumors are triggered by a common mechanism. 
  • T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis. 
  • T cells and B cells in lupus nephritis. 
  • T-cell Dysfunction in Glioblastoma: Applying a New Framework. 
  • T-cell-directed cancer vaccines: mechanisms of immune escape and immune tolerance. 
  • Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. 
  • Tempering allorecognition to induce transplant tolerance with chemically modified apoptotic donor cells. 
  • The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID. 
  • The Immune Tolerance Network at 10 years: tolerance research at the bedside. 
  • The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 
  • The contribution of macrophages to normal and pathological pregnancies. 
  • The cornea has "the nerve" to encourage immune rejection. 
  • The effector component of the cytotoxic T-lymphocyte response has a biphasic pattern after burn injury. 
  • The fetal allograft revisited: does the study of an ancient invertebrate species shed light on the role of natural killer cells at the maternal-fetal interface? 
  • The induction of tolerance and suppression in autoimmune MRL mice using hapten-modified self. 
  • The need for inducing tolerance in vascularized composite allotransplantation. 
  • The pathologic and clinical intersection of atopic and autoimmune disease. 
  • The pathophysiology and treatment of graft-versus-host disease. 
  • The potential impact of timing of IVIG administration on the efficacy of rituximab for immune tolerance induction for patients with Pompe disease. 
  • The road to tolerance: renal transplant tolerance induction in nonhuman primate studies and clinical trials. 
  • The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens. 
  • The role of tregs in glioma-mediated immunosuppression: potential target for intervention. 
  • Thoracic cryptococcosis: immunologic competence and radiologic appearance. 
  • Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor. 
  • Tolerance and the "Holy Grail" of transplantation. 
  • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. 
  • Tolerance mechanisms and recent progress. 
  • Tolerance: is it achievable in pediatric solid organ transplantation? 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania. 
  • Transforming the clinical outcome in CRIM-negative infantile Pompe disease identified via newborn screening: the benefits of early treatment with enzyme replacement therapy and immune tolerance induction. 
  • Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts. 
  • Transplant tolerance: converging on a moving target. 
  • Transplantation tolerance: a look at the nonhuman primate literature in the light of modern tolerance theories. 
  • Tumor necrosis factor-alpha and tumor growth factor-beta1 genotype: partial association with intragraft gene expression in two cases of long-term peripheral tolerance to a kidney transplant. 
  • Tumor suppressor TSC1 is critical for T-cell anergy. 
  • Universal antibiotic tolerance arising from antibiotic-triggered accumulation of pyocyanin in Pseudomonas aeruginosa. 
  • Uveitis and arthritis: experimental models and clinical correlates. 
  • Vaccination with mRNAs encoding tumor-associated antigens and granulocyte-macrophage colony-stimulating factor efficiently primes CTL responses, but is insufficient to overcome tolerance to a model tumor/self antigen. 
  • Vaccine Therapy, Oncolytic Viruses, and Gliomas. 
  • Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer. 
  • Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. 
  • [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis]. 
  • [IL-21 induces regulatory B cell differentiation and immunosuppressive effect through cognate interaction with T cells]. 
  • [Lymphocyte subpopulations in spleen and blood after early wound debridement and acute/chronic treatment with hyperbaric oxygen]. 
  • cDNA arrays and the enigma of melanoma immune responsiveness. 
  • mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. 
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  Keywords of People

  • Bilbo, Staci D., Haley Family Professor of Psycology and Neuroscience, Psychology & Neuroscience
  • Burt, Trevor Deon, Associate Professor of Pediatrics, Pediatrics, Neonatology
  • Case, Laura Elizabeth, Associate Professor in Orthopaedic Surgery, Pediatrics, Medical Genetics
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Gilner, Jennifer B, Assistant Professor of Obstetrics and Gynecology, Obstetrics and Gynecology, Maternal Fetal Medicine
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology