Immunity

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  Subject Areas on Research

  • A Commencement for Eye Commensals. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A guide to interrogating immunometabolism. 
  • A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. 
  • Abnormalities of leukocyte chemotaxis in human disease. 
  • Activation of interleukin 4- and interleukin 6-secreting cells by HIV-specific synthetic peptides. 
  • Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation. 
  • Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients. 
  • Adoptive transfer and specific active immunization of patients with malignant melanoma. 
  • Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health. 
  • Age cutoff in lymphoma diagnosis. 
  • Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. 
  • Altered immunologic reconstitution after standard-dose chemotherapy or high-dose chemotherapy with autologous bone marrow support. 
  • An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. 
  • Animal models of sudden unexplained death. 
  • Anti-DNA antibodies in systemic lupus erythematosus. 
  • Antibody responses to DNA in normal immunity and aberrant immunity. 
  • Aptamers in immunotherapy. 
  • B10 cell regulation of health and disease. 
  • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. 
  • BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression. 
  • Boosting high-intensity focused ultrasound-induced anti-tumor immunity using a sparse-scan strategy that can more effectively promote dendritic cell maturation. 
  • Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. 
  • Brain immunology and immunotherapy in brain tumours. 
  • Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides. 
  • Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs. 
  • Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives. 
  • Cell-Type-Specific Analysis of Molecular Pathology in Autism Identifies Common Genes and Pathways Affected Across Neocortical Regions. 
  • Changes in Nutritional Status Impact Immune Cell Metabolism and Function. 
  • Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. 
  • Clinical applications of a peptide-based vaccine for glioblastoma. 
  • Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. 
  • Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV. 
  • Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. 
  • Concise Review: Modulating Cancer Immunity with Hematopoietic Stem and Progenitor Cells. 
  • Conversations with Founders of the Field of Human Inborn Errors of Immunity. 
  • Cytokines and immune response in the tumor microenvironment. 
  • DNA vaccines and immunity to herpes simplex virus. 
  • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. 
  • Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Do macrophages destroy nascent tumors? 
  • Editorial: Nutritional Aspects of Immunity and Immunometabolism in Health and Disease. 
  • Effect of adriamycin and Corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. 
  • Enhanced macrophage tumoricidal activity and tumor suppression or regression caused by heat-killed Candida albicans. 
  • Enhancing immunogenicity by CpG DNA. 
  • Establishment of baseline cytology metrics in nestling American kestrels (Falco sparverius): Immunomodulatory effects of the flame retardant isopropylated triarylphosphate isomers. 
  • Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia. 
  • Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes. 
  • Evidence for an immune barrier after in utero hematopoietic-cell transplantation. 
  • Evolution of genes and genomes on the Drosophila phylogeny. 
  • Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets. 
  • Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses. 
  • Gene expression patterns that characterize advanced stage serous ovarian cancers. 
  • Gene expression profiling of anticancer immune responses. 
  • General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors. 
  • Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. 
  • Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation. 
  • Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 
  • HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. 
  • HSCT using carrier donors for CD40L deficiency results in excellent immune function and higher CD40L expression in cTfh. 
  • Harnessing the Immune Response to Fungal Pathogens for Vaccine Development. 
  • Host immune responses in the central nervous system during fungal infections. 
  • How do plants achieve immunity? Defence without specialized immune cells. 
  • Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice. 
  • IL-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis. 
  • Ig VH hypermutation is absent in the germinal centers of aged mice. 
  • Immune function during intravenous administration of a soybean oil emulsion. 
  • Immune function, cortisol, and cognitive decline & dementia in an aging latino population. 
  • Immune plexins and semaphorins: old proteins, new immune functions. 
  • Immune response to SARS-CoV-2 after a booster of mRNA-1273: an open-label phase 2 trial. 
  • Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. 
  • Immunobiology of primary intracranial tumors. Part 1: studies of the cellular and humoral general immune competence of brain-tumor patients. 
  • Immunodeficiency. 
  • Immunologic Consequences of Sequencing Cancer Radiotherapy and Surgery. 
  • Immunologic and hematopoietic alterations by 2,450-MHz electromagnetic radiation. 
  • Immunologic consequences of acute ethanol ingestion in rats. 
  • Immunologic consequences of nucleic acid therapy. 
  • Immunologic control of the ascites form of murine adenocarcinoma 755. II. Tumor immunity associated with a Friend--Moloney--Ra,scher-type virus. 
  • Immunologic control of the ascites of murine adenocarcinoma 755. I. Protection with syngeneic immune serum or lymphoid cells. 
  • Immunometabolism: From basic mechanisms to translation. 
  • Impact of breast cancer recurrence and cancer-specific stress on spouse health and immune function. 
  • Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres. 
  • Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity. 
  • Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review. 
  • Inhaled carbon nanotubes reach the subpleural tissue in mice. 
  • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. 
  • Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting. 
  • Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces ROS production. 
  • Introduction to the Special Issue of Brain, Behavior, and Immunity: Gender, Ethnicity and Immunity: the new frontier. 
  • Investigation of HIFU-induced anti-tumor immunity in a murine tumor model. 
  • Iron deficiency anemia: its relationship to infection susceptibility and host defense. 
  • Kinetics of cytokine expression in melanoma metastases classifies immune responsiveness. 
  • Laparoscopic surgery and the systemic immune response. 
  • Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques. 
  • Linking immune responses with fibrosis in allergic eye disease. 
  • Location, location, location: regional immune mechanisms critically influence rejection. 
  • M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer. 
  • Mast cells and basophils in innate immunity. 
  • Mast cells impair the development of protective anti-tumor immunity. 
  • Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses. 
  • Mediation of hyperacute rejection of rat hepatic allografts by RT-1 antigens. 
  • Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model. 
  • Metabolic and functional impairment of CD8+ T cells from the lungs of influenza-infected obese mice. 
  • Metabolic regulation of epigenetic remodeling in immune cells. 
  • Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development. 
  • Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. 
  • Modelling HIV immune response and validation with clinical data. 
  • Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. 
  • Mucosal immunity to infection with implications for vaccine development. 
  • NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection. 
  • Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. 
  • Nonurban male homosexuals: epidemiologic, immunologic and virologic characteristics. 
  • Nosocomial hepatitis A infection in a paediatric intensive care unit. 
  • Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection. 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Obesity Dysregulates the Immune Response to Influenza Infection and Vaccination Through Metabolic and Inflammatory Mechanisms. 
  • Ocular molecules and cells that regulate immune responses in situ. 
  • On sexual dimorphism in immune function. 
  • Oscillations in the immune system. 
  • Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning. 
  • PAMPs and DAMPs: signal 0s that spur autophagy and immunity. 
  • PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response. 
  • Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. 
  • Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential? 
  • Photoperiod influences the effects of exercise and food restriction on an antigen-specific immune response in Siberian hamsters. 
  • Platelet functions beyond hemostasis. 
  • Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart. 
  • Practical Considerations in the Design and Use of Immunologically Active Fibrillar Peptide Assemblies. 
  • Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees. 
  • Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques. 
  • Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. 
  • Pregnancy influences immune responses to SARS-CoV-2. 
  • Preliminary results in the analysis of the immune response after aneurysmal subarachnoid hemorrhage. 
  • Primary amyloidosis, pure red cell aplasia, and Kaposi's sarcoma in a single patient. 
  • Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. 
  • Protective plant immune responses are elicited by bacterial outer membrane vesicles. 
  • Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells. 
  • Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies. 
  • Reactive oxygen species: from health to disease. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Reprograming immunity to food allergens. 
  • Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. 
  • Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States. 
  • Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus challenge in Macaques. 
  • Rous sarcoma virus-induced tumours in mice. II. Contribution of H-2 and non-H-2 alloantigen barriers to tumour immunogenicity in vivo. 
  • Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation. 
  • Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses. 
  • Sex and gender in psychoneuroimmunology research: past, present and future. 
  • Sex difference in immune response to vaccination: A participant-level meta-analysis of randomized trials of IMVAMUNE smallpox vaccine. 
  • Sexual dimorphism in immunity across animals: a meta-analysis. 
  • Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. 
  • Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells. 
  • Six reference-quality genomes reveal evolution of bat adaptations. 
  • Stress and parental care in a wild Teleost fish: insights from exogenous supraphysiological cortisol implants. 
  • Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. 
  • Survival of allografted pancreatic islets in the subretinal space in rats. 
  • Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1. 
  • T cell metabolic fitness in antitumor immunity. 
  • TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance. 
  • The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood. 
  • The Immunology of Syncytialized Trophoblast. 
  • The Influence of the Pretreatment Immune State on Response to Radiation Therapy in High-Risk Prostate Cancer: A Validation Study From NRG/RTOG 0521. 
  • The brain's immune system. 
  • The clinical use and immunologic impact of thrombin in surgery. 
  • The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. 
  • The effects of nutrition and treatment of cancer on host immunocompetence. 
  • The immunologic constant of rejection. 
  • The kynurenine pathway and bipolar disorder: intersection of the monoaminergic and glutamatergic systems and immune response. 
  • The metabolic life and times of a T-cell. 
  • The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. 
  • Thinking outside the gate: single-cell assessments in multiple dimensions. 
  • Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients. 
  • To grow and to defend. 
  • Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor. 
  • Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases. 
  • Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration. 
  • What you and your patients need to know about vitamin D. 
  • Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial. 
  • Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. 
  • alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Donnelly, Christopher, Assistant Professor in Anesthesiology, Neurobiology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Khandelwal, Sanjay, Assistant Professor in Medicine, Medicine, Hematology
  • MacLeod, Amanda S, Adjunct Associate Professor in the Department of Dermatology, Integrative Immunobiology
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Staats, Herman Ford, Professor of Pathology, Integrative Immunobiology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology
  • Terrando, Niccolò, Associate Professor of Anesthesiology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology