Immunoglobulin Isotypes

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  Subject Areas on Research

  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Anticardiolipin antibodies and osteonecrosis of the femoral head. 
  • B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • Chronic cicatrizing conjunctivitis in a patient with epidermolysis bullosa acquisita. 
  • Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis. 
  • Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis. 
  • Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. 
  • Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient. 
  • Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus. 
  • Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. 
  • Immunochemical properties of anti-DNA antibodies in the sera of patients with Escherichia coli bacteremia. 
  • Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. 
  • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. 
  • Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes. 
  • Low Serum IgE Is a Sensitive and Specific Marker for Common Variable Immunodeficiency (CVID). 
  • Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. 
  • Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions. 
  • Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines. 
  • Preparation and characterization of an intravenous solution of IgG from human immunodeficiency virus-seropositive donors. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. 
  • Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire. 
  • VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology