Immunoglobulin Isotypes
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Subject Areas on Research
- Antibody response to a T-dependent antigen requires B cell expression of complement receptors.
- Anticardiolipin antibodies and osteonecrosis of the femoral head.
- B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.
- CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
- Chronic cicatrizing conjunctivitis in a patient with epidermolysis bullosa acquisita.
- Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis.
- Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis.
- Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
- Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.
- Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient.
- Homotypic antibody responses to fresh clinical isolates of human immunodeficiency virus.
- Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.
- Immunochemical properties of anti-DNA antibodies in the sera of patients with Escherichia coli bacteremia.
- Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies.
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
- Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes.
- Isohemagglutinins and xenoreactive antibodies: members of a distinct family of natural antibodies.
- Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.
- Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions.
- Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.
- Preparation and characterization of an intravenous solution of IgG from human immunodeficiency virus-seropositive donors.
- Regulation of complement activity by immunoglobulin. I. Effect of immunoglobulin isotype on C4 uptake on antibody-sensitized sheep erythrocytes and solid phase immune complexes.
- Role of JAK3 in CD40-mediated signaling.
- Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant.
- Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
- The mechanism of autoantibody production in an autoimmune MRL/lpr mouse.
- Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire.
- VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies.
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Keywords of People
- Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
- Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology