Immunoglobulins

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  Subject Areas on Research

  • A comparative evaluation of nasal and parenteral vaccine adjuvants to elicit systemic and mucosal HIV-1 peptide-specific humoral immune responses in cynomolgus macaques. 
  • A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. 
  • A human immunodeficiency virus type 1 (HIV-1) infection-enhancing factor in seropositive sera. 
  • A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. 
  • A program for eradication of hepatitis B from Taiwan by a 10-year, four-dose vaccination program. 
  • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. 
  • A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. 
  • A successful unrelated peripheral blood stem cell transplantation with reduced intensity-conditioning regimen in a patient with late-onset purine nucleoside phosphorylase deficiency. 
  • A whole blood immunoassay using gold nanoshells. 
  • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. 
  • Accelerated development of immunity following transplantation of maternal marrow stem cells into infants with severe combined immunodeficiency and transplacentally acquired lymphoid chimerism. 
  • Activation of human B cells by phosphorothioate oligodeoxynucleotides. 
  • Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function. 
  • Adenosine deaminase and purine nucleoside phosphorylase deficiencies: evaluation of therapeutic interventions in eight patients. 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Algorithm for the early diagnosis and treatment of patients with cross reactive immunologic material-negative classic infantile pompe disease: a step towards improving the efficacy of ERT. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • An in vitro analogue of immune dysfunction with altered immunoglobulin production in the aged. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells. 
  • Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. 
  • Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. 
  • Antibody-dependent enhancement of human immunodeficiency virus type 1 infection. 
  • B-cell reconstitution for SCID: should a conditioning regimen be used in SCID treatment? 
  • CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. 
  • CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • CD83: a regulatory molecule of the immune system with great potential for therapeutic application. 
  • CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Cellular events in the differentiation of antibody-secreting cells. 
  • Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. 
  • Circulating anticoagulants to factor VIII. Immunochemical studies and clinical response to factor VIII concentrates. 
  • Clinical and physiological abnormalities in hepatic function. 
  • Clinical utility of erythrocyte sedimentation rate and plasma protein analysis in the elderly. 
  • Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. 
  • Coagulation abnormalities in patients with hip osteonecrosis. 
  • Colonic nodular lymphoid hyperplasia in a child with antibody deficiency and near-normal immunoglobulins. 
  • Complete DiGeorge syndrome: persistence of profound immunodeficiency. 
  • Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. 
  • Concurrent administration of inactivated hepatitis A vaccine with immune globulin in healthy adults. 
  • Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. 
  • Controversies in the Management of Isolated Congenital Atrioventricular Block. 
  • Crystal-storing histiocytosis: a clinicopathological study of 13 cases. 
  • Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis. 
  • Dendritic cell CD83: a therapeutic target or innocent bystander? 
  • Dendritic cells cultured in anti-CD40 antibody-immobilized plates elicit a highly efficient peptide-specific T-cell response. 
  • Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. 
  • Developmental allometry and paediatric malaria. 
  • Diagnosis and antenatal management of congenital cytomegalovirus infection. 
  • Direct measurement of peptide-specific CD8+ T cells using HLA-A2:Ig dimer for monitoring the in vivo immune response to a HER2/neu vaccine in breast and prostate cancer patients. 
  • Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. 
  • Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice. 
  • Disulfide-mediated dimerization of L1 Ig domains. 
  • Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Effect of therapeutic plasma exchange on immunoglobulins in myasthenia gravis. 
  • Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. 
  • Effects of photoperiod history on immune responses to intermediate day lengths in Siberian hamsters (Phodopus sungorus). 
  • Efficacy and tolerability of 16% subcutaneous immunoglobulin compared with 20% subcutaneous immunoglobulin in primary antibody deficiency. 
  • Electron microscopic virus-like material in systemic lupus erythematosus: with preliminary immunologic observations on presence of measles antigen. 
  • Emergence of suppressor cells of immunoglobulin synthesis during acute Epstein-Barr virus-induced infectious mononucleosis. 
  • Emerging paradigms, platforms, and unifying themes in biomarker science. 
  • Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus. 
  • Evaluation of lymphocyte differentiation in primary and secondary immunodeficiency diseases. 
  • Evaluation of recurrent glomerulonephritis in kidney allografts. 
  • Evaluation of serum immunoglobulins by protein electrophoresis and rate nephelometry before and after therapeutic plasma exchange. 
  • Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. 
  • Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor-alpha for use in cancer immunotherapy. 
  • Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. 
  • Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages. 
  • Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection. 
  • High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. 
  • High-dose intravenous immunoglobulin for severe platelet alloimmunization. 
  • Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. 
  • Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemic lymphocytes. 
  • Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants. 
  • Humoral immune responses in L-selectin-deficient mice. 
  • Humoral immunodeficiency. 
  • Hyper IgM syndrome associated with defective CD40-mediated B cell activation. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Idiopathic autoimmune thrombocytopenic purpura. 
  • Immune function during intravenous administration of a soybean oil emulsion. 
  • Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy. 
  • Immunoglobulin Deficiency and the Unified Airway. 
  • Immunoglobulin G subclass deficiency: fact or fancy? 
  • Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. 
  • Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies. 
  • Immunoglobulin localization in benign and malignant lesions of the human mammary gland. 
  • Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle. 
  • Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies. 
  • Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits. 
  • Immunological abnormalities in the tears of multiple sclerosis patients. 
  • Immunological recovery in 48 patients following syngeneic marrow transplantation or hematological malignancy. 
  • Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation. 
  • Immunoreconstitution. 
  • Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. 
  • Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. 
  • Impaired antibody response to polysaccharides in association with functional asplenia. 
  • Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. 
  • In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma. 
  • Inactivation of murine xenotropic oncornavirus by normal mouse sera is not immunoglobulin-mediated. 
  • Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies. 
  • Increased biodiversity in the environment improves the humoral response of rats. 
  • Influence of Killer Immunoglobulin-Like Receptors and Somatic Mutations on Transplant Outcomes in Acute Myeloid Leukemia. 
  • Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. 
  • Integrins and other cell adhesion molecules in endometrium and endometriosis. 
  • Kinetics of immunoglobulin synthesis and secretion by resting and pokeweed mitogen-transformed human lymphocytes. 
  • Leprosy in a mangabey monkey--naturally acquired infection. 
  • Long term use of intravenous immune globulin in patients with primary immunodeficiency diseases: inadequacy of current dosage practices and approaches to the problem. 
  • Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). 
  • Longitudinal changes in serum immunoglobulin levels in older humans. 
  • Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin. 
  • Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. 
  • Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells. 
  • Mechanism of Epstein-Barr virus-induced human B-lymphocyte activation. 
  • Meningeal mycosis fungoides: clinical and cellular characteristics. 
  • Molecular biology. Enhancers, chromosome position effects, and transgenic mice. 
  • Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus. 
  • Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration. 
  • Monoclonal gammopathies and aging. 
  • Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity. 
  • Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. 
  • Mucosal plasma cells are required to protect the upper airway and brain from infection. 
  • Multiple Myeloma, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. 
  • Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. 
  • Myelomatous pleural effusion: clinical course and immunologic characterization of the pleural fluid cells. 
  • Neurological disorders with abnormalities of immunoglobulin metabolism. 
  • Neutralization of sensitized virus by purified components of complement. 
  • Next-generation approaches to advancing eco-immunogenomic research in critically endangered primates. 
  • Novel type of proliferating lymphoplasmacytoid cell with a characteristic spotted immunofluorescence pattern. 
  • Ocular manifestations of multiple myeloma, Waldenström's macroglobulinemia and benign monoclonal gammopathy. 
  • Performance evaluation of the Helena V8 capillary electrophoresis system. 
  • Peroxide detoxification affecting the production of immunoglobulin by mouse myeloma tumor cells in vitro. 
  • Phase I study of recombinant human endostatin in patients with advanced solid tumors. 
  • Phase II, randomized, multicenter, double-blind, placebo-controlled trial of a polyclonal anti-Staphylococcus aureus capsular polysaccharide immune globulin in treatment of Staphylococcus aureus bacteremia. 
  • Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis. 
  • Point mutations alter the mechanical stability of immunoglobulin modules. 
  • Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans. 
  • Positive Family History, Infection, Low Absolute Lymphocyte Count (ALC), and Absent Thymic Shadow: Diagnostic Clues for All Molecular Forms of Severe Combined Immunodeficiency (SCID). 
  • Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees. 
  • Prevalence of non-A,non-B hepatitis/hepatitis C virus antibody in human immunoglobulins. 
  • Production of chemotactic activity by guinea pig immunoglobulins following activation of the C3 complement shunt pathway. 
  • Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model. 
  • Pseudo-Gaucher cells in multiple myeloma. 
  • Pulse therapy. Therapeutic efficacy in the treatment of pyoderma gangrenosum. 
  • Pyoderma gangrenosum, altered delayed hypersensitivity and polyarthritis. 
  • Randomised trial of plasma exchange in mild systemic lupus erythematosus. 
  • Recognition molecules and immunoglobulin domains in invertebrates. 
  • Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. 
  • Relapse in Guillain-Barré syndrome after treatment with human immune globulin. 
  • Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. 
  • Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. 
  • Robo functions as an attractive cue for glial migration through SYG-1/Neph. 
  • Safety and patient acceptability of intravenous immune globulin in 10% maltose. 
  • Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. 
  • Seroconversion for hepatitis C virus antibody in bone marrow recipients treated with immune globulin. 
  • Serum immunoglobulin levels in systemic lupus erythematosus: the effects of age, sex, race and disease duration. 
  • Similarity of three-dimensional structure between the immunoglobulin domain and the copper, zinc superoxide dismutase subunit. 
  • Single protein misfolding events captured by atomic force microscopy. 
  • Single-Cell-Based High-Throughput Ig and TCR Repertoire Sequencing Analysis in Rhesus Macaques. 
  • Statin, a protein specifically present in nonproliferating cells, is a phosphoprotein and forms a complex with a 45-kilodalton serine/threonine kinase. 
  • Stretching single protein molecules: titin is a weird spring. 
  • Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial. 
  • Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. 
  • Symptomatic giardiasis in three patients with X-linked agammaglobulinemia. 
  • Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity. 
  • Systemic lupus erythematosus. 
  • T-cell-independent stimulation of immunoglobulin secretion in resting human B lymphocytes by the mannose-specific adhesin of Escherichia coli type 1 fimbriae. 
  • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. 
  • Tandem mass spectrometry, but not T-cell receptor excision circle analysis, identifies newborns with late-onset adenosine deaminase deficiency. 
  • Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. 
  • The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. 
  • The Ties that Bind (the Igh Locus). 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The essential role of L-glutamine in lymphocyte differentiation in vitro. 
  • The kinetics of immunoglobulin synthesis by pokeweed mitogen stimulated peripheral blood lymphocytes in multiple myeloma. 
  • The macrophage as an antineoplastic surveillance cell: biological perspectives. 
  • The mouse Cd83 gene: structure, domain organization, and chromosome localization. 
  • The nephrotic syndrome in congenital syphilis: an immunopathy. 
  • The structural basis of repertoire shift in an immune response to phosphocholine. 
  • The tyrosine corner: a feature of most Greek key beta-barrel proteins. 
  • The use of intravenous immune globulin in immunodeficiency diseases. 
  • Thromboxane receptor blockade reduces renal injury in murine lupus nephritis. 
  • Topology of cell adhesion molecules. 
  • Transcription factor NF-kappaB regulates inducible CD83 gene expression in activated T lymphocytes. 
  • Use of intravenous gamma-globulin in antibody immunodeficiency: results of a multicenter controlled trial. 
  • Variability in B cell maturation and differentiation in X-linked agammaglobulinemia. 
  • Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci. 
  • Varicella in a susceptible pregnant woman. 
  • Virologic and clinical outcomes of hepatitis B virus infection in HIV-HBV coinfected transplant recipients. 
  • What is blood and what is not? Caring for the Jehovah's Witness patient undergoing cardiac surgery. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology