Immunoglobulin Heavy Chains
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Subject Areas on Research
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A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries.
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A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries.
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A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia.
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Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth.
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Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.
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Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.
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Anti-idiotypic monoclonal Ig specific for an anti-laminin Ig heavy chain transgene variable region.
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Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.
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Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.
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Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice.
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Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance.
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Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding.
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Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia.
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Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.
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Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling.
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Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.
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Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study.
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Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life.
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Construction of polyclonal antibody libraries using phage display.
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Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice.
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Critical analysis and diagnostic usefulness of limited immunophenotyping of B-cell non-Hodgkin lymphomas by flow cytometry.
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Deconstructing B cell tolerance to basement membranes.
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Delineation of immunologically and biochemically distinct HLA-A2 antigens.
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Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis.
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Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
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Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.
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Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL.
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Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.
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Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.
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Flow cytometric analysis of immunoglobulin heavy chain expression in B-cell lymphoma and reactive lymphoid hyperplasia.
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Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
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Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay.
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Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.
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GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
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Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.
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Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum.
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Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus.
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Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia.
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Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.
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Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.
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Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution.
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HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.
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HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.
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Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
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Heavy-chain receptor editing unbound.
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High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas.
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Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a 'transdifferentiation' during the clonal evolution.
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Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors.
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IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.
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Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with chronic lymphocytic leukaemia: a single-arm, multicentre, phase 2 trial.
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Ig VH hypermutation is absent in the germinal centers of aged mice.
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Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.
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Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.
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Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1.
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In situ studies of the germinal center reaction.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.
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In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains.
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In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.
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Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences.
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Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.
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Influence of heavy chain constant regions on antigen binding and HIV-1 neutralization by a human monoclonal antibody.
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Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.
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Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig.
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Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
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Lupus-like nephrotropic autoantibodies in non-autoimmune mice harboring an anti-basement membrane/anti-DNA Ig heavy chain transgene.
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Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions.
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Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
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Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse.
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Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
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Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.
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Molecular composition of an antigen-specific, Ly-1 T suppressor inducer factor. One molecule binds antigen and is I-J-; another is I-J+, does not bind antigen, and imparts an Igh-variable region-linked restriction.
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Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A.
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Murine V kappa gene expression does not follow the VH paradigm.
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New presentation of alpha heavy chain disease: North American polypoid gastrointestinal lymphoma. Clinical and cellular studies.
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Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.
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Pairing of VH gene families with the lambda 1 light chain: evidence for a non-stochastic association.
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Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus.
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Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.
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Prominent Dutcher body formation in a case of follicular lymphoma with BCL6 gene rearrangement and intact BCL2 gene.
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Reduced thymic output, increased spontaneous apoptosis and oligoclonal B cells in polyethylene glycol-adenosine deaminase-treated patients.
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Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice.
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Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women.
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Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies.
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Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis.
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Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice.
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Stochastic pairing of heavy-chain and kappa light-chain variable gene families occurs in polyclonally activated B cells.
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Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes.
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Structural properties of a subset of nephritogenic anti-DNA antibodies.
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The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage.
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The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance.
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The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors.
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The nude mutation results in impaired primary antibody repertoire.
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The primary antibody repertoire: the somatic genotype and paratopic phenotype of B-cell populations.
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Topology of an amiloride-binding protein.
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Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.
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Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII.
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VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies.
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Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced.
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Viral receptor-binding site antibodies with diverse germline origins.
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Keywords of People