Immunoglobulin Light Chains
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Subject Areas on Research
- A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries.
- A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries.
- Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.
- Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.
- Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry.
- Can We Cure Light Chain Deposition Disease of the Kidneys?-A Review and Case Report of a Patient Treated With a Triple Transplant Approach.
- Chronic myopathy due to immunoglobulin light chain amyloidosis.
- Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling.
- Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. I. A description of the technique and of methods for the analysis of colonies.
- Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics.
- Construction of polyclonal antibody libraries using phage display.
- Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice.
- Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.
- Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature.
- Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains.
- Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells.
- Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
- Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum.
- Genotypic divergence precedes clinical dissemination in a case of synchronous bilateral B-cell malignant lymphoma of the testes.
- Immunochemical properties of anti-DNA antibodies in the sera of patients with Escherichia coli bacteremia.
- Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.
- In situ studies of the germinal center reaction.
- Lambda light chain deposition disease in a renal allograft.
- Mantle zone lymphoma in a gastric glomus tumor.
- Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions.
- Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
- Myeloma light chains are ligands for cubilin (gp280).
- Patterns of heavy and light chain utilization in the antibody response to single-stranded bacterial DNA in normal human subjects and patients with systemic lupus erythematosus.
- Pinch Purpura: A Cutaneous Manifestation of Systemic Amyloidosis.
- Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification.
- Rearrangement and expression of the human psi C lambda 6 gene segment results in a surface Ig receptor with a truncated light chain constant region.
- λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies.
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Keywords of People
- Kelsoe, Garnett H., James B. Duke Professor of Immunology, Immunology