Immunoglobulin mu-Chains

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  Subject Areas on Research

  • A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice. 
  • A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. 
  • An analysis of clinical and laboratory features of acute lymphocytic leukemias with emphasis on 35 children with pre-B leukemia. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain. 
  • Identification of an activity in B-cell extracts that selectively impairs the formation of an immunoglobulin mu s poly(A) site processing complex. 
  • Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. 
  • Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. 
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  Keywords of People

  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology