Injections, Spinal

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  Subject Areas on Research

  • A reappraisal of the results of stopping therapy in childhood leukemia. 
  • Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. 
  • Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis. 
  • Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. 
  • Advantages of the combined spinal epidural (CSE) technique. 
  • An unusual presentation of chronic myelogenous leukemia: a review of isolated central nervous system relapse. 
  • Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. 
  • Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201. 
  • Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat. 
  • Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron. 
  • CSF distribution of morphine, methadone and sucrose after intrathecal injection. 
  • CSF distribution of opioids in animals and man. 
  • CT-guided cervical transforaminal steroid injections: where should the needle tip be located? 
  • Central nervous system treatment in childhood acute lymphoblastic leukemia. Long-term follow-up of patients diagnosed between 1973 and 1985. 
  • Chronic CSF leak into the peritoneal cavity shown by radionuclide cisternography. Successful treatment with an epidural blood patch. 
  • Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. 
  • Comparison of Tc99m-DTPA and indium-111 DTPA studies of baclofen pump function. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Cytokinetically based induction chemotherapy and splenectomy for childhood acute nonlymphocytic leukemia. 
  • Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy. 
  • Dexamethasone for the prophylaxis of postoperative nausea and vomiting associated with neuraxial morphine administration: a systematic review and meta-analysis. 
  • Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study. 
  • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. 
  • Effect of administration of high dose intrathecal clonidine or morphine prior to sciatic nerve section on c-Fos expression in rat lumbar spinal cord. 
  • Effects of cranial radiation in children with high risk T cell acute lymphoblastic leukemia: a Pediatric Oncology Group report. 
  • Fluoroscopy procedure and equipment changes to reduce staff radiation exposure in the interventional spine suite. 
  • Gabapentin attenuates morphine tolerance through interleukin-10. 
  • Immunoreactivity, pharmacokinetics and bone marrow dosimetry of intrathecal radioimmunoconjugates. 
  • In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: effect of ischemia and intrathecal hyperbaric 5% lidocaine. 
  • Inadvertent Intrafacet Injection during Lumbar Interlaminar Epidural Steroid Injection: A Comparison of CT Fluoroscopic and Conventional Fluoroscopic Guidance. 
  • Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. 
  • Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. 
  • Intramedullary contrast injection in the setting of a split spinal cord. 
  • Intrathecal PLC(β3) oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance. 
  • Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis. 
  • Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury. 
  • Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice. 
  • Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model. 
  • Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats. 
  • Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. 
  • Intrathecal endotoxin: Intrathecal endotoxin: the role of the central nervous system in septic shock. 
  • Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. 
  • Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats. 
  • Intrathecal morphine for analgesia after postpartum bilateral tubal ligation. 
  • Intrathecal morphine for postpartum bilateral tubal ligation. 
  • Intrathecal morphine suppresses immune function in rats with inflammatory-induced pain. 
  • Intrathecal sufentanil for extracorporeal shock wave lithotripsy provides earlier discharge of the outpatient than intrathecal lidocaine. 
  • Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. 
  • Low-dose naloxone infusion for the treatment of intractable nausea and vomiting after intrathecal morphine in a parturient. 
  • Maculopathy as a complication of blood-brain barrier disruption in patients with central nervous system lymphoma. 
  • Meningitis due to Mycobacterium bovis BCG--reactivation or accidental intrathecal inoculation? 
  • Modified LSA2-L2 treatment in 53 children with E-rosette-positive T-cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study). 
  • Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy. 
  • Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. 
  • Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. 
  • Novel intrathecal and subcutaneous catheter delivery systems in the mouse. 
  • Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. 
  • Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia. 
  • Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors. 
  • Persistent pain associated with long-term intrathecal morphine administration. 
  • Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors: a pediatric brain tumor consortium study (PBTC-001). 
  • Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). 
  • Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion. 
  • Pilot study of systemic and intrathecal mafosfamide followed by conformal radiation for infants with intracranial central nervous system tumors: a pediatric brain tumor consortium study (PBTC-001). 
  • Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. 
  • Prevention and management of intrathecal drug delivery and spinal cord stimulation system infections. 
  • Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. 
  • Pupillary response in patients receiving intrathecal sufentanil. 
  • Radiation dose exposure for lumbar spine epidural steroid injections: a comparison of conventional fluoroscopy data and CT fluoroscopy techniques. 
  • Re: Toxicity of intrathecal melphalan. 
  • Reducing Patient Radiation Exposure From CT Fluoroscopy-Guided Lumbar Spine Pain Injections by Targeting the Planning CT. 
  • Refractory status epilepticus after inadvertent intrathecal injection of tranexamic acid treated by magnesium sulfate. 
  • Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1. 
  • Regulation of murine arthritis by systemic, spinal, and intra-articular adrenoceptors. 
  • Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. 
  • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 
  • Role of epidural and intrathecal narcotics and peptides in the management of cancer pain. 
  • Safety and side-effect profile of intrathecal morphine in a diverse patient population undergoing total knee and hip arthroplasty. 
  • Second central nervous system prophylaxis in children with acute lymphoblastic leukemia who relapse after elective cessation of therapy. 
  • Seesaw nystagmus following whole brain irradiation and intrathecal methotrexate. 
  • Self-extraction of intrathecal pump opioid. 
  • Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: a systematic review and meta-analysis. 
  • Short small-interfering RNAs produce interferon-α-mediated analgesia. 
  • Small-dose intrathecal lidocaine versus ropivacaine for anorectal surgery in an ambulatory setting. 
  • Spinal anesthesia for orthopedic surgery: a detailed video assessment of quality. 
  • Spinal cord neural anatomy in rats examined by in vivo magnetic resonance microscopy. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury. 
  • Standardization of health care provider competencies for intrathecal access procedures. 
  • Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. 
  • Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus. 
  • Tetanus neonatorum: clinico-epidemiological profile. 
  • The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats. 
  • The effect of intrathecal neuropeptide Y on the flexor reflex in rats after carrageenan-induced inflammation. 
  • The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat. 
  • The use of an intrathecal pump to manage intractable cancer pain in a pediatric patient: a case report. 
  • The use of nalmefene for intrathecal opioid-associated nausea in postpartum patients. 
  • Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury. 
  • Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. 
  • Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate. 
  • Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice. 
  • Transversus abdominis plane block for analgesia after Cesarean delivery: a systematic review and meta-analysis. 
  • Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of alpha-particle-emitting (211)At-labeled trastuzumab. 
  • Treatment of neoplastic meningitis with intrathecal 9-nitro-camptothecin. 
  • Use of external ventriculostomy and intrathecal anti-fungal treatment in cerebral mucormycotic abscess. 
  • Use of neostigmine in the management of acute postoperative pain and labour pain: a review. 
  • [Analgesic effect of intrathecal injection of Herpes simplex virus type I amplicon vector-mediated human preproenkephalin gene on chronic neuropathic pain: experiment with rats]. 
  • [Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain]. 
  • [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. 
  • [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. 
  • [Intrathecal administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin pain]. 
  • p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. 
  • β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Siriwetchadarak, Rapipen, Assistant Professor of Neurosurgery, Neurosurgery
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology
  • Wiggins, Walter, Assistant Professor of Radiology, Radiology, Neuroradiology