Inositol Phosphates
-
Subject Areas on Research
- A conserved family of enzymes that phosphorylate inositol hexakisphosphate.
- A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.
- A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
- A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
- A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.
- Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.
- Adrenergic receptors: recent insights into their mechanism of activation and desensitization.
- Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.
- Aluminum is a weak agonist for the calcium-sensing receptor.
- An expanded view of inositol signaling.
- Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
- Biochemical analysis of inositol phosphate kinases.
- Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.
- Characteristics of GTP-mediated microsomal Ca2+ release.
- Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
- Characterization of mediators of insulin action.
- Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate.
- Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.
- Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
- Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity.
- Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells.
- Cyclosporine augments receptor-mediated cellular Ca2+ fluxes in isolated hepatocytes.
- Cytochalasins enhance the proliferation of CD4 cells through the CD3-Ti antigen receptor complex or the CD2 molecule through an effect on early events of activation.
- Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.
- Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.
- Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.
- Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells.
- Evidence for a second alpha 2-macroglobulin receptor.
- Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells.
- G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
- HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.
- High-performance liquid chromatographic analysis for a non-chromophore-containing phosphatidyl inositol analog, 1-((1-O-octadecyl-2-O-methyl-sn-glycero)phospho)-1D-3-deoxy-myo-inositol, using indirect UV detection.
- IP7 guards the CDK gate.
- Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes.
- Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells.
- Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.
- Inositol diphosphate signaling regulates telomere length.
- Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods.
- Inositol phosphate multikinase dependent transcriptional control.
- Inositol phosphate synthesis and the nuclear processes they affect.
- Inositol polyphosphate kinases: regulators of nuclear function.
- Intracellular mediators of insulin action.
- Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.
- MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
- Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells.
- Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes.
- Modulation of thromboxane receptor activation in rat glomerular mesangial cells.
- Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
- Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells.
- Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts.
- Nuclear inositol signaling: a structural and functional approach.
- Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
- Pertussis toxin triggers rapid second messenger production in human T lymphocytes.
- Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
- Prostaglandin F2 alpha receptors in the human trabecular meshwork.
- Quantifying ligand bias at seven-transmembrane receptors.
- Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor.
- Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.
- Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
- Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.
- Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways.
- Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
- Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers.
- Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes.
- Regulation of nuclear processes by inositol polyphosphates.
- Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A.
- Regulator of G-protein signalling expression and function in ovarian cancer cell lines.
- Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.
- Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
- Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor.
- Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.
- Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.
- Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.
- Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
- Signal transduction. Unexpected mediators of protein phosphorylation.
- SnapShot: Inositol phosphates.
- Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
- Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
- The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.
- The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
- Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation.
- Thromboxane binding and signal transduction in rat glomerular mesangial cells.
- UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
- beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.