Inositol Phosphates

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  Subject Areas on Research

  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate. 
  • A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. 
  • A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. 
  • A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. 
  • A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Adrenergic receptors: recent insights into their mechanism of activation and desensitization. 
  • Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases. 
  • Aluminum is a weak agonist for the calcium-sensing receptor. 
  • An expanded view of inositol signaling. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Biochemical analysis of inositol phosphate kinases. 
  • Bradykinin stimulation of inositol polyphosphate production in porcine aortic endothelial cells. 
  • Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants. 
  • Characteristics of GTP-mediated microsomal Ca2+ release. 
  • Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. 
  • Characterization of mediators of insulin action. 
  • Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. 
  • Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. 
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. 
  • Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity. 
  • Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells. 
  • Cyclosporine augments receptor-mediated cellular Ca2+ fluxes in isolated hepatocytes. 
  • Cytochalasins enhance the proliferation of CD4 cells through the CD3-Ti antigen receptor complex or the CD2 molecule through an effect on early events of activation. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. 
  • Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals. 
  • Effect of temperature on bradykinin-induced arachidonate release and calcium mobilization in vascular endothelial cells. 
  • Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts. 
  • High-performance liquid chromatographic analysis for a non-chromophore-containing phosphatidyl inositol analog, 1-((1-O-octadecyl-2-O-methyl-sn-glycero)phospho)-1D-3-deoxy-myo-inositol, using indirect UV detection. 
  • IP7 guards the CDK gate. 
  • Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes. 
  • Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods. 
  • Inositol phosphate multikinase dependent transcriptional control. 
  • Inositol phosphate synthesis and the nuclear processes they affect. 
  • Inositol polyphosphate kinases: regulators of nuclear function. 
  • Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae. 
  • Intracellular mediators of insulin action. 
  • Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium. 
  • Lipid rafts constrain basal alpha(1A)-adrenergic receptor signaling by maintaining receptor in an inactive conformation. 
  • MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. 
  • Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells. 
  • Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes. 
  • Modulation of thromboxane receptor activation in rat glomerular mesangial cells. 
  • Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. 
  • Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells. 
  • Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts. 
  • Nuclear inositol signaling: a structural and functional approach. 
  • Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion. 
  • Pertussis toxin triggers rapid second messenger production in human T lymphocytes. 
  • Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation. 
  • Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells. 
  • Prostaglandin F2 alpha receptors in the human trabecular meshwork. 
  • Purification and analysis of proteinase-resistant mutants of recombinant platelet-derived growth factor-BB exhibiting improved biological activity. 
  • Quantifying ligand bias at seven-transmembrane receptors. 
  • Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. 
  • Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages. 
  • Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. 
  • Reduced reperfusion-induced Ins(1,4,5)P3 generation and arrhythmias in hearts expressing constitutively active alpha1B-adrenergic receptors. 
  • Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. 
  • Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways. 
  • Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. 
  • Regulation of endothelin-induced Ca2+ mobilization in smooth muscle cells by protein kinase C. 
  • Regulation of endothelin-mediated calcium mobilization in vascular smooth muscle cells by isoproterenol. 
  • Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers. 
  • Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes. 
  • Regulation of nuclear processes by inositol polyphosphates. 
  • Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. 
  • Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A. 
  • Regulator of G-protein signalling expression and function in ovarian cancer cell lines. 
  • Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor. 
  • Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. 
  • Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. 
  • Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology. 
  • Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. 
  • Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Signal transduction. Unexpected mediators of protein phosphorylation. 
  • SnapShot: Inositol phosphates. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. 
  • Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. 
  • Thapsigargin stimulates Ca2+ entry in vascular smooth muscle cells: nicardipine-sensitive and -insensitive pathways. 
  • The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. 
  • The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. 
  • Thromboxane binding and signal transduction in rat glomerular mesangial cells. 
  • Tunicamycin increases intracellular calcium levels in bovine aortic endothelial cells. 
  • UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors. 
  • beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.