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Subject Areas on Research
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A conserved family of enzymes that phosphorylate inositol hexakisphosphate.
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A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster.
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A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
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A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
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A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells.
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Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.
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Adrenergic receptors: recent insights into their mechanism of activation and desensitization.
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Alterations in an inositol phosphate code through synergistic activation of a G protein and inositol phosphate kinases.
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Aluminum is a weak agonist for the calcium-sensing receptor.
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An expanded view of inositol signaling.
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Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors.
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Biochemical analysis of inositol phosphate kinases.
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Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.
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Characteristics of GTP-mediated microsomal Ca2+ release.
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Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
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Characterization of mediators of insulin action.
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Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate.
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Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases.
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Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
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Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity.
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Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells.
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Cyclosporine augments receptor-mediated cellular Ca2+ fluxes in isolated hepatocytes.
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Cytochalasins enhance the proliferation of CD4 cells through the CD3-Ti antigen receptor complex or the CD2 molecule through an effect on early events of activation.
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Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
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Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.
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Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.
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Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.
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Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells.
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Evidence for a second alpha 2-macroglobulin receptor.
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Functional expression of human 5-HT1A receptors and differential coupling to second messengers in CHO cells.
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G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
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HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.
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High-performance liquid chromatographic analysis for a non-chromophore-containing phosphatidyl inositol analog, 1-((1-O-octadecyl-2-O-methyl-sn-glycero)phospho)-1D-3-deoxy-myo-inositol, using indirect UV detection.
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IP7 guards the CDK gate.
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Identification of a novel inositol bisphosphate isomer formed in chemoattractant stimulated human polymorphonuclear leukocytes.
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Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells.
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Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.
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Inositol diphosphate signaling regulates telomere length.
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Inositol phosphate metabolomics: merging genetic perturbation with modernized radiolabeling methods.
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Inositol phosphate multikinase dependent transcriptional control.
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Inositol phosphate synthesis and the nuclear processes they affect.
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Inositol polyphosphate kinases: regulators of nuclear function.
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Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae.
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Intracellular mediators of insulin action.
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Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
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Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.
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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
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Mas oncogene receptor coupling and peptide specificity in Balb 3T3 and vascular smooth muscle cells.
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Mastoparan, a wasp venom peptide, identifies two discrete mechanisms for elevating cytosolic calcium and inositol trisphosphates in human polymorphonuclear leukocytes.
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Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells.
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Modulation of thromboxane receptor activation in rat glomerular mesangial cells.
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Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
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Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in Mammalian cells.
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Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts.
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Nuclear inositol signaling: a structural and functional approach.
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Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
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Pertussis toxin triggers rapid second messenger production in human T lymphocytes.
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Phosphatidic acid modulates Cl- secretion in T84 cells: varying effects depending on mode of stimulation.
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Prostaglandin F2 alpha receptors in the human trabecular meshwork.
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Quantifying ligand bias at seven-transmembrane receptors.
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Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor.
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Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages.
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Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
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Reduced reperfusion-induced Ins(1,4,5)P3 generation and arrhythmias in hearts expressing constitutively active alpha1B-adrenergic receptors.
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Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.
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Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways.
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Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
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Regulation of inositol phosphate metabolism in chemoattractant-stimulated human polymorphonuclear leukocytes. Definition of distinct dephosphorylation pathways for IP3 isomers.
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Regulation of inositol phospholipid and inositol phosphate metabolism in chemoattractant-activated human polymorphonuclear leukocytes.
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Regulation of nuclear processes by inositol polyphosphates.
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Regulation of thromboxane receptor (TP) phosphorylation by protein phosphatase 1 (PP1) and PP2A.
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Regulator of G-protein signalling expression and function in ovarian cancer cell lines.
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Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor.
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Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
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Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor.
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Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.
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Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.
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Septohippocampal cholinergic changes after destruction of the A10-septal dopaminergic pathways.
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Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
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Signal transduction. Unexpected mediators of protein phosphorylation.
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SnapShot: Inositol phosphates.
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Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
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Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.
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Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
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The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.
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The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
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Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation.
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Thromboxane binding and signal transduction in rat glomerular mesangial cells.
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UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
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Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
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beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.