Insecticides

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  Subject Areas on Research

  • A Voucher System To Speed Review Could Promote A New Generation Of Insecticides To Fight Vector-Borne Diseases. 
  • A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance. 
  • A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. 
  • A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania. 
  • A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides. 
  • A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids. 
  • Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes. 
  • Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish. 
  • Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. 
  • Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids. 
  • Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. 
  • Analysis of the action of lidocaine on insect sodium channels. 
  • Anti-Müllerian hormone and lifestyle, reproductive, and environmental factors among women in rural South Africa. 
  • Bayesian isotonic regression and trend analysis. 
  • Bayesian multivariate logistic regression. 
  • Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. 
  • Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. 
  • Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. 
  • Chlordanes in the indoor and outdoor air of three U.S. cities. 
  • Chlorpyrifos accumulation patterns for child-accessible surfaces and objects and urinary metabolite excretion by children for 2 weeks after crack-and-crevice application. 
  • Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. 
  • Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. 
  • Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes. 
  • Chlorpyrifos targets developing glia: effects on glial fibrillary acidic protein. 
  • Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti. 
  • Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. 
  • Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. 
  • Comparative field evaluation of combinations of long-lasting insecticide treated nets and indoor residual spraying, relative to either method alone, for malaria prevention in an area where the main vector is Anopheles arabiensis. 
  • Comparative toxicities of selected compounds to nauplii of Balanus amphitrite amphitrite Darwin and Artemia sp. 
  • Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. 
  • Contact toxicity of permethrin-impregnated fabric to Hyalomma anatolicum excavatum (Acari: Ixodidae): effects of laundering and exposure and recovery times. 
  • Contamination of rural surface and ground water by endosulfan in farming areas of the Western Cape, South Africa. 
  • Cost of microbial larviciding for malaria control in rural Tanzania. 
  • Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. 
  • Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort. 
  • DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster. 
  • Detection of endocrine disrupting chemicals in samples of second trimester human amniotic fluid. 
  • Development of a methyl bromide collection system for fumigated farmland. 
  • Developmental cholinotoxicants: nicotine and chlorpyrifos. 
  • Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. 
  • Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. 
  • Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. 
  • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. 
  • Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. 
  • Developmental exposure to terbutaline and chlorpyrifos, separately or sequentially, elicits presynaptic serotonergic hyperactivity in juvenile and adolescent rats. 
  • Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. 
  • Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. 
  • Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target? 
  • Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: effects on neurospecific proteins indicate changing vulnerabilities. 
  • Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. 
  • Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. 
  • Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period? 
  • Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. 
  • Developmental neurotoxicity of succeeding generations of insecticides. 
  • Diazinon and parathion diverge in their effects on development of noradrenergic systems. 
  • Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides. 
  • Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. 
  • Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. 
  • Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity? 
  • Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. 
  • Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. 
  • Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos? 
  • Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging. 
  • Effect of a fluvalinate-resistance-associated sodium channel mutation from varroa mites on cockroach sodium channel sensitivity to fluvalinate, a pyrethroid insecticide. 
  • Effects of an insecticidal dip containing d-limonene in the cat. 
  • Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats. 
  • Effects of dietary exposure to the pyrethroid pesticide esfenvalerate on medaka (Oryzias latipes). 
  • Effects of permethrin-impregnated bed nets on malaria vectors of northern Guatemala. 
  • Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects. 
  • Efficacy of permethrin-treated bed nets in the prevention of mortality in young children in an area of high perennial malaria transmission in western Kenya. 
  • Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel. 
  • Environmental contaminants and body fat distribution. 
  • Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. 
  • Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes. 
  • Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood. 
  • Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood. 
  • Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. 
  • Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. 
  • Fine scale spatial investigation of multiple insecticide resistance and underlying target-site and metabolic mechanisms in Anopheles gambiae in central Côte d'Ivoire. 
  • Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides. 
  • Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro. 
  • Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the rat. 
  • Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. 
  • Household perceptions and subjective valuations of indoor residual spraying programmes to control malaria in northern Uganda. 
  • Identification and expression of the ecdysone receptor in the harpacticoid copepod, Amphiascus tenuiremis, in response to fipronil. 
  • Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. 
  • Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. 
  • Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. 
  • Impregnated bed nets for malaria control: biological success and social responsibility. 
  • Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). 
  • Index of suspicion. 
  • Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. 
  • Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. 
  • Insect sodium channels and insecticide resistance. 
  • Insight into the Mode of Action of Haedoxan A from Phryma leptostachya. 
  • Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Isolation and insecticidal activity of mellamide from Aspergillus melleus. 
  • Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species. 
  • Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein. 
  • Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies. 
  • Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. 
  • Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. 
  • Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides. 
  • Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. 
  • Molecular basis of selective resistance of the bumblebee BiNav1 sodium channel to tau-fluvalinate. 
  • Molecular biology of insect sodium channels and pyrethroid resistance. 
  • Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. 
  • Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti. 
  • Monitoring community response to malaria control using insecticide-impregnated bed nets, curtains and residual spray at Nsukka, Nigeria. 
  • More than a Mite Contagious: Crusted Scabies. 
  • Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. 
  • Mosquito coil emissions and health implications. 
  • Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus. 
  • Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. 
  • Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance. 
  • Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems. 
  • Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. 
  • Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish. 
  • Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. 
  • Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. 
  • Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. 
  • Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. 
  • Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. 
  • Organophosphate-induced acetylcholinesterase inhibition and embryonic retinal cell necrosis in vivo in the teleost (Oryzias latipes). 
  • Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. 
  • Parasites and progress: ethical decision-making and the Santee-Cooper Malaria study, 1944-1949. 
  • Perinatal diazinon exposure compromises the development of acetylcholine and serotonin systems. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Permethrin-impregnated bed nets for malaria control in northern Guatemala: epidemiologic impact and community acceptance. 
  • Permethrin-impregnated curtains and bed-nets prevent malaria in western Kenya. 
  • Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. 
  • Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. 
  • Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure. 
  • Persistent organic pollutants in two dolphin species with focus on toxaphene and polybrominated diphenyl ethers. 
  • Potency of combined estrogenic pesticides. 
  • Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb. 
  • Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. 
  • Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor. 
  • Prenatal dexamethasone, as used in preterm labor, worsens the impact of postnatal chlorpyrifos exposure on serotonergic pathways. 
  • Prospective surveillance of semen quality in the workplace. 
  • Pthiriasis capitis. 
  • Pyridostigmine bromide intake during the Persian Gulf War is not associated with postwar handgrip strength. 
  • Recent declines in PAH, PCB, and toxaphene levels in the northern Great Lakes as determined from high resolution sediment cores. 
  • Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis. 
  • Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation. 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Semi-field evaluation of the cumulative effects of a "Lethal House Lure" on malaria mosquito mortality. 
  • Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. 
  • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. 
  • Stage sensitivity of medaka (Oryzias latipes) eggs and embryos to permethrin. 
  • Stage-dependent differences in effects of carbaryl on population growth rate in Japanese medaka (Oryzias latipes). 
  • Stage-specific toxicity of cypermethrin to medaka (Oryzias latipes) eggs and embryos using a refined methodology for an in vitro fertilization bioassay. 
  • Suppression of a P450 hydroxylase gene in plant trichome glands enhances natural-product-based aphid resistance. 
  • Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. 
  • Synergism of chlorpyrifos against the German cockroach, Blattella germanica. 
  • Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide. 
  • Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. 
  • The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. 
  • The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides. 
  • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. 
  • The effectiveness of insecticide-impregnated bed nets in reducing cases of malaria infection: a meta-analysis of published results. 
  • The influence of individual preventive measures on the clinical severity of malaria among Nigerian children. 
  • The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. 
  • Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids. 
  • Thyroid toxicity due to subchronic exposure to a complex mixture of 16 organochlorines, lead, and cadmium. 
  • Toxicity of a formulation of the insecticide indoxacarb to the tarnished plant bug, Lygus lineolaris (Hemiptera: Miridae), and the big-eyed bug, Geocoris punctipes (Hemiptera: Lygaeidae). 
  • Toxicity of stormwater runoff after dormant spray application of diazinon and esfenvalerate (Asana) in a French prune orchard, Glenn county, California, USA. 
  • Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics. 
  • Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Ultraviolet photolysis of chlorpyrifos: developmental neurotoxicity modeled in PC12 cells. 
  • Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model. 
  • Use of alternative bioassays to explore the impact of pyrethroid resistance on LLIN efficacy. 
  • Use of non-mammalian alternative models for neurotoxicological study. 
  • Use of protein phosphatase inhibitors. 
  • Using charcoal as base material reduces mosquito coil emissions of toxins. 
  • Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze. 
  • Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Duke Innovation & Entrepreneurship