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Subject Areas on Research
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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).
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2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator.
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307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular Vessel.
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80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c.
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
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A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.
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A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice.
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A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes.
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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.
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A cluster randomised trial, cost-effectiveness analysis and psychosocial evaluation of insulin pump therapy compared with multiple injections during flexible intensive insulin therapy for type 1 diabetes: the REPOSE Trial.
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A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.
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A comparison of the structure of hamster pancreatic insulin and insulin extracted from a transplantable hamster islet-cell carcinoma.
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A controlled high-fat diet induces an obese syndrome in rats.
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A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
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A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals.
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A kinetic study of protein-protein interactions.
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A model of glucose-insulin homeostasis in man that incorporates the heterogeneous fast pool theory of pancreatic insulin release.
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A model system for the biochemical study of luteinizing hormone/chorionic gonadotropin receptor synthesis.
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A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase.
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A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
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A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling.
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A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.
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A physiologic role for somatostatin 28 as a regulator of insulin secretion.
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A primer on concentrated insulins: what an internist should know.
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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.
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A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women.
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A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
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A reliable method for isolation of viable porcine islet cells.
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A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding.
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A study of pituitary function in patients with idiopathic hemochromatosis.
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Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice.
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Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion.
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Abnormalities of carbohydrate and lipid metabolism in Dahl rats.
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Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses.
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Acetaminophen normalizes glucose homeostasis in mouse models for diabetes.
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Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.
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Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.
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Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
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Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen.
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Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
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Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.
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Active involvement of PKC for insulin-mediated rates of muscle protein synthesis in Zucker rats.
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Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.
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Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.
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Adenovirus-mediated expression of the catalytic subunit of glucose-6-phosphatase in INS-1 cells. Effects on glucose cycling, glucose usage, and insulin secretion.
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Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
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Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.
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Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration.
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Adiponectin is not altered with exercise training despite enhanced insulin action.
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Adrenal medullary storage vesicles of the spontaneously hypertensive rat.
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Adrenergic desensitization in left ventricle from streptozotocin diabetic swine.
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Adverse Cardiovascular Response to Aerobic Exercise Training: Is This a Concern?
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Adverse metabolic response to regular exercise: is it a rare or common occurrence?
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Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease.
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Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia.
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Alcohol-associated risks for young adults with Type 1 diabetes: a narrative review.
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All-or-none secretion of adrenal medullary storage vesicle contents in the rat.
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Alprazolam reduces stress hyperglycemia in ob/ob mice.
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Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse.
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Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones.
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Altered islet function and insulin clearance cause hyperinsulinemia in gastric bypass patients with symptoms of postprandial hypoglycemia.
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Alzheimer’s disease: the new promise.
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Analysis of myocardial function in orthotopic cardiac allografts after prolonged storage in UW solution.
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Analysis of sites phosphorylated on acetyl-CoA carboxylase in response to insulin in isolated adipocytes. Comparison with sites phosphorylated by casein kinase-2 and the calmodulin-dependent multiprotein kinase.
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Analysis of the role of E2A-encoded proteins in insulin gene transcription.
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Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.
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Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.
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Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation.
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Antidiabetic therapies affect risk of pancreatic cancer.
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Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
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Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.
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Are stress eaters at risk for the metabolic syndrome?
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Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness.
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Assessing the Impact of an Order Panel Utilizing Weight-Based Insulin and Standardized Monitoring of Blood Glucose for Patients With Hyperkalemia.
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Association between Bout Duration of Physical Activity and Health: Systematic Review.
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Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial.
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Association of Adverse Pregnancy Outcomes With Glyburide vs Insulin in Women With Gestational Diabetes.
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Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
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Association of muscle mass measured by D3-Creatine (D3Cr), sarcopenic obesity, and insulin-glucose homeostasis in postmenopausal women.
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Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes.
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Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure.
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Automated Insulin Delivery Systems: Hopes and Expectations of Family Members.
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Automated bolus advisor control and usability study (ABACUS): does use of an insulin bolus advisor improve glycaemic control in patients failing multiple daily insulin injection (MDI) therapy? [NCT01460446].
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BARI 2D: A Reanalysis Focusing on Cardiovascular Events.
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BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans.
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Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease.
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Baseline predictors of A1C reduction in adults using sensor-augmented pump therapy or multiple daily injection therapy: the STAR 3 experience.
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Be Careful What You Ask For: Effects of Benefit Descriptions on Diabetes Patients' Benefit-Risk Tradeoff Preferences.
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Bed rest worsens impairments in fat and glucose metabolism in older, overweight adults.
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Behavioral manipulation of the diabetic phenotype in ob/ob mice.
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Beta cell monoamines: further evidence for their role in modulating insulin secretion.
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Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.
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Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery.
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Big or fast: two strategies in the developmental control of body size.
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Biliary response to glucagon and insulin following hepatic transplantation in humans.
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Biliary response to glucagon in humans.
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Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.
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Biomedicine. Insulin resistance takes a trip through the ER.
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Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.
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Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.
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Bombyxin is a growth factor for wing imaginal disks in Lepidoptera.
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Both insulin and epidermal growth factor stimulate lipogenesis and acetyl-CoA carboxylase activity in isolated adipocytes. Importance of homogenization procedure in avoiding artefacts in acetyl-CoA carboxylase assay.
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Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats.
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Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.
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Branched-Chain Amino Acids and Insulin Metabolism: The Insulin Resistance Atherosclerosis Study (IRAS).
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Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents.
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C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice.
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CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger or satiety.
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Caffeine impairs glucose metabolism in type 2 diabetes.
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Calmodulin in endocrine cells and its multiple roles in hormone action.
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Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase.
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Calmodulin-induced early-onset diabetes in transgenic mice.
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Capsule Commentary on Min et al., Comparative Effectiveness of Insulin versus Combination Sulfonylurea and Insulin: a Cohort Study of Veterans with Type 2 Diabetes: How to Escalate Therapy for Patients who Fail Sulfonylureas.
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Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis.
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Cardiometabolic Health in Submariners Returning from a 3-Month Patrol.
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Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors' Expert Forum.
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Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.
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Cellular engineering and gene therapy strategies for insulin replacement in diabetes.
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Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens.
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Central and sympatho-adrenal responses to insulin in adult and neonatal rats.
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Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.
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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
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ChREBP regulates fructose-induced glucose production independently of insulin signaling.
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Changes in depressive symptoms and glycemic control in diabetes mellitus.
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Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.
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Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin.
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Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates.
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Characterization of mediators of insulin action.
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Characterization of the insulinotropic potency of polyunsaturated fatty acids.
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Cholinergic augmentation of insulin release requires ankyrin-B.
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Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
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Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.
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Clinical Effects of Balanced Crystalloids vs Saline in Adults With Diabetic Ketoacidosis: A Subgroup Analysis of Cluster Randomized Clinical Trials.
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Clinical Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.
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Clinical Phenotypes in Patients With Type 2 Diabetes Mellitus: Characteristics, Cardiovascular Outcomes and Treatment Strategies.
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Clinical pearls and strategies to optimize patient outcomes.
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Clinical pharmacology of insulin confounds stroke trials.
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Clinical uses of gut peptides.
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Clinical, Hormonal, and Metabolic Parameters in Women with Subclinical Hypothyroidism and Polycystic Ovary Syndrome: A Cross-Sectional Study.
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Cloned mice have an obese phenotype not transmitted to their offspring.
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Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy.
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Cocaine-exposed preterm neonates show behavioral and hormonal differences.
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Cognitive function and anticoagulation control in patients with atrial fibrillation.
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Combination insulin and sulfonylurea therapy in insulin-requiring type 2 diabetes mellitus.
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Comparison of an Electronic Glycemic Management System Versus Provider-Managed Subcutaneous Basal Bolus Insulin Therapy in the Hospital Setting.
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Comparison of one-year outcomes following coronary artery stenting in diabetic versus nondiabetic patients (from the Enhanced Suppression of the Platelet IIb/IIIa Receptor With Integrilin Therapy [ESPRIT] Trial).
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Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion.
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Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models.
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Complexation hydrogels for oral protein delivery: an in vitro assessment of the insulin transport-enhancing effects following dissolution in simulated digestive fluids.
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Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.
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Computerized knowledge management in diabetes care.
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Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression.
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Consumption of a high-fat diet alters the homeostatic regulation of energy balance.
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Consumption of a high-fat diet induces central insulin resistance independent of adiposity.
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Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.
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Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism.
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Contributions of fat and protein to the incretin effect of a mixed meal.
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Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice.
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
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Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin.
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Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.
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Controlled release of biologics for the treatment of type 2 diabetes.
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Cooperation between brain and islet in glucose homeostasis and diabetes.
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Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin.
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Cost-effectiveness of sensor-augmented pump therapy in adults with type 1 diabetes in the United States.
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Critical appraisal of four IL-6 immunoassays.
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Current practices in gestational diabetes mellitus diagnosis and management in the United States: survey of maternal-fetal medicine specialists.
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Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance.
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Day-and-Night Closed-Loop Insulin Delivery in a Broad Population of Pregnant Women With Type 1 Diabetes: A Randomized Controlled Crossover Trial.
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Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice.
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Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
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Deintensification of Treatment With Sulfonylurea and Insulin After Severe Hypoglycemia Among Older Adults With Diabetes.
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Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.
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Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.
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Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.
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Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia.
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Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
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Depression in persons with diabetes by age and antidiabetic treatment: a cross-sectional analysis with data from the Hordaland Health Study.
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Determinants of successful glycemic control among participants in the BARI 2D trial: a post-hoc analysis.
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Development of postglucoprivic insulin-induced suckling and feeding in rats.
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Developmental mechanisms of body size and wing-body scaling in insects.
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Diabetes Technology and the Human Factor.
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Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
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Diabetes mellitus and insulin therapy in infective endocarditis.
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Diabetic biomarkers and the risk of proximal or distal gastric cancer.
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Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells.
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Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes.
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Diet-induced type II diabetes in C57BL/6J mice.
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Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803 (Alliance).
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Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
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Dietary regulation of glucose-dependent insulinotropic peptide (GIP) gene expression in rat small intestine.
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Dietary treatment of diabetes mellitus in the pre-insulin era (1914-1922).
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Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.
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Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans.
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Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.
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Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling.
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Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. Evidence for functional segregation of the high and low Km enzymes.
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Differential glycemic effects of morphine in diabetic and normal mice.
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Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information
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Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.
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Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.
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Disinhibited eating and weight-related insulin mismanagement among individuals with type 1 diabetes.
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Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction.
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Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
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Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
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Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus?
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Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion.
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Dynamic changes in retinal vessel diameter during acute hyperglycemia in type 1 diabetes.
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Early pregnancy insulin resistance and subsequent gestational diabetes mellitus.
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Early-life starvation alters lipid metabolism in adults to cause developmental pathology in Caenorhabditis elegans.
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Early-onset repeated dieting reduces food intake and body weight but not adiposity in dietary-obese female rats.
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Education on the glycemic index of foods fails to improve treatment outcomes in a behavioral weight loss program.
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Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial.
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Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling.
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Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.
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Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin.
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Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes.
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Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity.
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Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation.
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Effect of fatty acids on insulin release: role of chain length and degree of unsaturation.
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Effect of glucagon and insulin upon biliary lipid secretion.
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Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test.
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Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. II. Effect of serum and insulin.
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Effect of intracerebroventricular infusion of insulin on glucose-dependent insulinotropic peptide in dogs.
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Effect of predicted low suspend pump treatment on improving glycaemic control and quality of sleep in children with type 1 diabetes and their caregivers: the QUEST randomized crossover study.
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Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.
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Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas.
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Effect of the volume and intensity of exercise training on insulin sensitivity.
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Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11beta-HSD1 in the Syrian hamster.
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Effectively identifying the inpatient with hyperglycemia to increase patient care and lower costs.
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Effects of Extended-Release Niacin Added to Simvastatin/Ezetimibe on Glucose and Insulin Values in AIM-HIGH.
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Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis.
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Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans.
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Effects of Roux-en-Y gastric bypass or diabetes support and education on insulin sensitivity and insulin secretion in morbidly obese patients with type 2 diabetes.
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Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.
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Effects of aerobic training with and without weight loss on insulin sensitivity and lipids.
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Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs.
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Effects of an ad libitum, high carbohydrate diet and aerobic exercise training on insulin action and muscle metabolism in older men and women.
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Effects of bombesin on fasting bile formation.
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Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study.
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Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial.
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Effects of experimental diabetes on adrenergic and cholinergic receptors of rat myocardium.
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Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.
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Effects of glucagon-like peptide 1 on the hepatic glucose metabolism.
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Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures.
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Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line.
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Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors.
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Effects of leukocyte depleted blood on renal reperfusion injury in a porcine model.
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Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials.
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Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials.
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Effects of moderate and high glycemic index meals on metabolism and exercise performance.
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Effects of modulation of glycerol kinase expression on lipid and carbohydrate metabolism in human muscle cells.
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Effects of morphine on the rat adrenal medulla.
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Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial.
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Effects of relaxation therapy on patients with type I diabetes mellitus.
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Effects of reserpine on the content and properties of rat adrenal medullary storage vesicles.
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Effects of short-term very low-calorie diet on intramyocellular lipid and insulin sensitivity in nondiabetic and type 2 diabetic subjects.
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Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.
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Efficacy and safety of acarbose in metformin-treated patients with type 2 diabetes.
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Efficacy and safety of dapagliflozin in acute heart failure: Rationale and design of the DICTATE-AHF trial.
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Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.
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Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice.
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Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.
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Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.
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Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis.
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Engineered cell lines for insulin replacement in diabetes: current status and future prospects.
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Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.
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Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.
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Enhanced Glucose Control Following Vertical Sleeve Gastrectomy Does Not Require a β-Cell Glucagon-Like Peptide 1 Receptor.
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Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13).
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Enhanced cardiac preservation with oxygenated University of Wisconsin solution.
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Enhancement of endocrine pancreatic secretions by essential fatty acids.
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Enhancing insulin-use safety in hospitals: Practical recommendations from an ASHP Foundation expert consensus panel.
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Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I.
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Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism.
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Epidermal growth factor enhances [125I]iodo-follicle-stimulating hormone binding by cultured porcine granulosa cells.
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Epidermal growth factor stimulates glycogen synthesis in fetal rat hepatocytes: comparison with the glycogenic effects of insulin-like growth factor I and insulin.
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Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
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Evaluation of solutions for small intestinal preservation. Biochemical changes as a function of storage time.
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Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts.
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Evidence for metabolic and endocrine abnormalities in subjects recovered from anorexia nervosa.
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Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway.
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Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion.
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Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells.
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Evidence that activation of acetyl-CoA carboxylase by insulin in adipocytes is mediated by a low-Mr effector and not by increased phosphorylation.
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Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.
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Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by administration of caffeine in coffee.
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Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.
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Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance.
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Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect.
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Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
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Experience with combined hepatic, pancreaticoduodenal, and renal procurement with UW solution.
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Experiences of closed-loop insulin delivery among pregnant women with Type 1 diabetes.
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Exploring the Role of Insulin Signaling in Relative Growth: A Case Study on Wing-Body Scaling in Lepidoptera.
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Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.
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Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage.
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Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.
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Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass.
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Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines.
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Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
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Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.
-
Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis.
-
Factors associated with non-adherence to insulin and non-insulin medications in patients with poorly controlled diabetes.
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Factors associated with persistent poorly controlled diabetes mellitus: clues to improving management in patients with resistant poor control.
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Failure of 2-deoxy-D-glucose to stimulate feeding in deermice.
-
Failure of genetically selected miniature swine to model NIDDM.
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Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators.
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Fasting and postprandial concentrations of somatostatin-28 and somatostatin-14 in type II diabetes in men.
-
Fatty acid oxidation and insulin action: when less is more.
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Fear of hypoglycaemia in parents of young children with type 1 diabetes: a systematic review.
-
Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression.
-
Follicle-stimulating hormone-mediated induction of functional luteinizing hormone/human chorionic gonadotropin receptors during monolayer culture of porcine granulosa cells.
-
Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism.
-
Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans.
-
Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.
-
Function of microtubules under inadequate protein diet.
-
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
-
Functional photoacoustic microscopy of diabetic vasculature.
-
G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.
-
GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1.
-
GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study.
-
GLP-1 and energy balance: an integrated model of short-term and long-term control.
-
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
-
GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model.
-
Galphaz negatively regulates insulin secretion and glucose clearance.
-
Gastric bypass alters both glucose-dependent and glucose-independent regulation of islet hormone secretion.
-
Gastric bypass significantly improves quality of life in morbidly obese patients with type 2 diabetes.
-
Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans.
-
Gastric emptying, glucose tolerance, and insulin response after duodenojejunostomy.
-
Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans.
-
Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
-
Genetic studies of body mass index yield new insights for obesity biology.
-
Genetic variation in aldosterone synthase predicts plasma glucose levels.
-
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
-
Genomewide search for type 2 diabetes susceptibility genes in four American populations.
-
Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1.
-
Ghrelin regulation of glucose metabolism.
-
Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans.
-
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.
-
Giant two-dimensional gel electrophoresis: methodological update and comparison with intermediate-format gel systems.
-
Glucagon in insulin coma therapy: its use in a small psychiatric unit of a general hospital.
-
Glucagon lowers glycemia when β-cells are active.
-
Glucagon or insulin suppressed biliary lipid excretion in dog and man.
-
Glucagon-like peptide 1 (GLP-1).
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Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal.
-
Glucagon-like peptide 1: continued advances, new targets and expanding promise as a model therapeutic.
-
Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes.
-
Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis.
-
Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.
-
Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice.
-
Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle.
-
Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin.
-
Glucose control in hospitalized patients.
-
Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.
-
Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell.
-
Glucose tolerance, insulin secretion, and insulin sensitivity in children and adolescents with cystic fibrosis and no prior history of diabetes.
-
Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.
-
Glycemic Variability and Its Impact on Quality of Life in Adults With Type 1 Diabetes.
-
Glycemic response to stress is altered in euglycemic Pima Indians.
-
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance.
-
Glycogen synthase: a putative locus for diet-induced hyperglycemia.
-
Glycophase glass revisited: protein adsorption and cell growth on glass surfaces bearing immobilized glycerol monosaccharides.
-
Granulosa cell differentiation in vitro: effect of insulin on growth and functional integrity.
-
Growth retardation in the Lesch-Nyhan syndrome.
-
Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies.
-
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
-
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
-
Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease.
-
Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism.
-
Higher high-density lipoprotein cholesterol in African-American women with polycystic ovary syndrome compared with Caucasian counterparts.
-
Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.
-
History of and factors associated with diabetic foot ulcers in Norway: the Nord-Trøndelag Health Study.
-
History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium.
-
Holistic Impact of Closed-Loop Technology on People With Type 1 Diabetes.
-
Home Use of an Artificial Beta Cell in Type 1 Diabetes.
-
Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study.
-
Hormonal activation of ornithine decarboxylase in embryonic chick pelvic cartilage.
-
Hormonal and metabolic effects of carbohydrate restriction in children with Prader-Willi syndrome.
-
Hormonal control of growth in the wing imaginal disks of Junonia coenia: the relative contributions of insulin and ecdysone.
-
Hormonal stimulation of avian embryonic cartilage growth in vitro: histologic and ultrastructural features.
-
Hormone receptor complexes and their modulation of membrane function.
-
Hostility and fasting glucose in African American women.
-
Hostility, race, and glucose metabolism in nondiabetic individuals.
-
How are we going to understand (dys)regulation of glucose metabolism?
-
Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia.
-
Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin.
-
Hyperacidity and hypergastrinemia following extensive intestinal resection.
-
Hyperandrogenemia in human immunodeficiency virus-infected women with the lipodystrophy syndrome.
-
Hyperglycaemia associated with lactic acidaemia in a renal allograft recipient with type I glycogen storage disease.
-
Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells.
-
Hyperinsulinemia in the pregnant C57BL/6J mouse.
-
Hyperkalemia: treatment options.
-
Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus.
-
Hypoglycemia Communication in Primary Care Visits for Patients with Diabetes.
-
Hypothalamic CaMKK2 contributes to the regulation of energy balance.
-
Hypothalamic and pituitary function in hypogonadotropic hypogonadism.
-
INSPstI polymorphism and prostate cancer in African-American men.
-
ISPAD Guidelines. Managing diabetes in preschool children.
-
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
-
Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.
-
Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways.
-
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
-
Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia.
-
Impact of Chronic Sleep Disturbance for People Living With T1 Diabetes.
-
Impact of Standardized Simulated Patients on First-Year Pharmacy Students' Knowledge Retention of Insulin Injection Technique and Counseling Skills.
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Impact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients.
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Impact of baseline insulin regimen on glycemic response to a group medical clinic intervention.
-
Impact of donor factors and preservation on function and survival after liver transplantation.
-
Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults.
-
Impact of insulin reduction on glycemic control in children attending a residential diabetes camp.
-
Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose.
-
Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes.
-
Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients.
-
Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice.
-
Impaired proinsulin processing is a characteristic of transplanted islets.
-
Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.
-
Implementation of a new intravenous insulin method on intermediate-care units in hospitalized patients.
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Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program.
-
Improved glycemic control enhances the incretin effect in patients with type 2 diabetes.
-
Improved insulin sensitivity after gastric bypass correlates with decreased total body fat, but not with changes in free fatty acids.
-
Inaccurate Estimates of Negotiated Reimbursement Prices for Insulin-Reply.
-
Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells.
-
Increased Ia-antigen-bearing T cells in type I diabetes mellitus.
-
Increased Risk of Severe Hypoglycemic Events Before and After Cardiovascular Outcomes in TECOS Suggests an At-Risk Type 2 Diabetes Frail Patient Phenotype.
-
Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus.
-
Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII.
-
Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.
-
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
-
Increases in stimulated secretion of proinflammatory cytokines by blood monocytes following arousal of negative affect: the role of insulin resistance as moderator.
-
Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes.
-
Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1.
-
Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.
-
Influence of fasting on carbohydrate and fat metabolism during rest and exercise in men.
-
Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
-
Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
-
Inhibition of basal and meal-stimulated choleresis by somatostatin.
-
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
-
Initial injectable therapy in type 2 diabetes: Key considerations when choosing between glucagon-like peptide 1 receptor agonists and insulin.
-
Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest.
-
Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin.
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Insulin Growth Factor Phenotypes in Heart Failure With Preserved Ejection Fraction, an INSPIRE Registry and CATHGEN Study.
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Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents.
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Insulin Therapy and Stroke Risk in Patients With Diabetes and Atrial Fibrillation: Guilty by Association?
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Insulin Use and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery.
-
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.
-
Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf.
-
Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle.
-
Insulin and glucagon choleresis during normoglycemia.
-
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo.
-
Insulin and glucose homeostasis in childhood cancer survivors treated with abdominal radiation: A pilot study.
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Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy.
-
Insulin and longevity: antidiabetic biguanides as geroprotectors.
-
Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C.
-
Insulin can make diabetes worse: the smoldering Somogyi effect.
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Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen.
-
Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats.
-
Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
-
Insulin inhibits dexamethasone effect on angiotensinogen gene expression and induction of hypertrophy in rat kidney proximal tubular cells in high glucose.
-
Insulin or glucagon choleresis in the isolated perfused guinea pig liver.
-
Insulin pump therapy in toddlers and preschool children with type 1 diabetes mellitus.
-
Insulin receptor of fat cells in insulin-resistant metabolic states.
-
Insulin replacement therapy in diabetic rats using an osmotic pump normalizes expression of enzymes key to hepatic carbohydrate metabolism.
-
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.
-
Insulin resistance independently predicts the progression of coronary artery calcification.
-
Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men.
-
Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients.
-
Insulin resistance syndrome and cardiovascular disease: genetics and connections to skeletal muscle function.
-
Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease.
-
Insulin therapy for ketolactic acidosis complicating malignancy.
-
Insulin treatment and clinical outcomes in patients with diabetes and heart failure with preserved ejection fraction.
-
Insulin, Hyperglycemia, and Severe Retinopathy of Prematurity in Extremely Low-Birth-Weight Infants.
-
Insulin-like signalling to the maternal germline controls progeny response to osmotic stress.
-
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.
-
Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling.
-
Insulin/IGF Signaling and Vitellogenin Provisioning Mediate Intergenerational Adaptation to Nutrient Stress.
-
Insulin/IGF-dependent Wnt signaling promotes formation of germline tumors and other developmental abnormalities following early-life starvation in Caenorhabditis elegans.
-
Intensive insulin therapy and mortality in critically ill patients.
-
Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes.
-
Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.
-
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
-
Interventions for Diabetic Retinopathy in Type 1 Diabetes: Systematic Review and Meta-Analysis.
-
Intestinal transplantation: the University of Wisconsin experience.
-
Intra-Target Microdosing - A Novel Drug Development Approach: Proof of Concept, Safety, and Feasibility Study in Humans.
-
Intraarterial Microdosing: A Novel Drug Development Approach, Proof-of-Concept PET Study in Rats.
-
Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.
-
Intracellular mediators of insulin action.
-
Intracerebroventricular infusion of bombesin modulates GIP secretion in conscious dogs.
-
Intracerebroventricular neuropeptide Y increases gastric and pancreatic secretion in the dog.
-
Intrahepatic glucose: a requirement for neonatal ODC induction by specific hormones.
-
Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice.
-
Intraoperative hyperglycemia and cognitive decline after CABG.
-
Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors.
-
Investigation of the mechanisms contributing to the compensatory increase in insulin secretion during dexamethasone-induced insulin resistance in rhesus macaques.
-
Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
-
Ionic basis of phenytoin sodium inhibition of insulin secretion in pancreatic islets.
-
Is GLP-1 a hormone: Whether and When?
-
Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data.
-
Is iatrogenic sleep disturbance worth the effort in Type 1 diabetes?
-
Is there a glycemic threshold for impaired autonomic control?
-
Is there a role for a low-carbohydrate ketogenic diet in the management of prostate cancer?
-
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
-
Islet cell transplantation for the treatment of diabetes mellitus.
-
Islet α cells and glucagon--critical regulators of energy homeostasis.
-
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
-
Isolated hormone receptors: physiologic and clinical implications.
-
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
-
Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.
-
Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.
-
L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.
-
L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice.
-
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
-
Leptin directly alters lipid partitioning in skeletal muscle.
-
Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice.
-
Leptin therapy in insulin-deficient type I diabetes.
-
Letter: Insulin activity: the solid matrix.
-
Leveraging leptin for type I diabetes?
-
Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression.
-
Lipid-induced mitochondrial stress and insulin action in muscle.
-
Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.
-
Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.
-
Long-lived implanted silastic drum glucose sensors.
-
Long-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance.
-
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
-
Longitudinal multi-omics of host-microbe dynamics in prediabetes.
-
Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.
-
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
-
Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects.
-
Management of Preexisting Diabetes in Pregnancy: A Review.
-
Management of Type 1 Diabetes With a Very Low-Carbohydrate Diet.
-
Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).
-
Manipulation of insulin signaling phenocopies evolution of a host-associated polyphenism.
-
Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.
-
Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring.
-
Maturation of the adrenal medulla. II. Content and properties of catecholamine storage vesicles of the rat.
-
Meal feeding improves oral glucose tolerance in male rats and causes adaptations in postprandial islet hormone secretion that are independent of plasma incretins or glycemia.
-
Meal-anticipatory glucagon-like peptide-1 secretion in rats.
-
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
-
Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding.
-
Mechanism of postgastrectomy hypoglycemia.
-
Mechanisms by which smoothelin-like protein 1 reverses insulin resistance in myotubules and mice.
-
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes.
-
Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor-Maybe.
-
Membrane receptors as general markers for plasma membrane isolation procedures. The use of 125-I-labeled wheat germ agglutinin, insulin, and cholera toxin.
-
Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.
-
Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients.
-
Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus).
-
Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy.
-
Metabolic coupling factors in pancreatic beta-cell signal transduction.
-
Metabolic cycling in control of glucose-stimulated insulin secretion.
-
Metabolic effects and efficacy of a triphasic oral contraceptive (norgestimate/ethinyl estradiol).
-
Metabolic effects of dietary lactose in adult female rats.
-
Metabolic profiling in Prader-Willi syndrome and nonsyndromic obesity: sex differences and the role of growth hormone.
-
Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.
-
Metabolomics applied to islet nutrient sensing mechanisms.
-
Metabolomics reveals unexpected responses to oral glucose.
-
Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics.
-
Methylprednisolone for Heart Surgery in Infants - A Randomized, Controlled Trial.
-
Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes.
-
Minimal versus umbilical waist circumference measures as indicators of cardiovascular disease risk.
-
Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome.
-
Mitochondrial dysfunction and insulin resistance: a matter of lifestyle?
-
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.
-
Modification of postprandial hyperglycemia with insulin lispro improves glucose control in patients with type 2 diabetes.
-
Modulation of pancreatic exocrine and endocrine secretion.
-
Molecular engineering of the pancreatic beta-cell.
-
Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.
-
Momentary Predictors of Insulin Restriction Among Adults With Type 1 Diabetes and Eating Disorder Symptomatology.
-
Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
-
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
-
Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.
-
Muscle atrophy in transgenic mice expressing a human TSC1 transgene.
-
Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation.
-
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.
-
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
-
Need for insulin therapy in type II diabetes mellitus. A randomized trial.
-
Nephrogenic diabetes insipidus with new onset diabetic ketoacidosis in a child - challenges in fluid and electrolyte management.
-
Neural ensemble coding of satiety states.
-
Neurogenic differentiation of murine and human adipose-derived stromal cells.
-
Neurohormonal regulation of pancreatic secretion.
-
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
-
Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.
-
New genetic loci link adipose and insulin biology to body fat distribution.
-
New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system.
-
New ways in which GLP-1 can regulate glucose homeostasis.
-
Nitrogen-sparing intravenous fluids in postperative patients.
-
Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species.
-
Nonalcoholic steatohepatitis and nonalcoholic Fatty liver disease in young women with polycystic ovary syndrome.
-
Nondialytic management of hyperkalemia and pulmonary edema among end-stage renal disease patients: an evaluation of the evidence.
-
Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.
-
Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin.
-
Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.
-
Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
-
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
-
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.
-
Nutrition for the diabetic pregnant woman.
-
Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.
-
Olanzapine, new-onset diabetes mellitus, and risk for insulin overdose.
-
One-year results from the first US-based enhanced recovery after cardiac surgery (ERAS Cardiac) program.
-
Ontogenesis of prolactin receptors in the human fetus: roles in fetal development.
-
Ontogeny of adrenomedullary responses to hypoxia and hypoglycemia: role of splanchnic innervation.
-
Open Source Closed-Loop Insulin Delivery Systems: A Clash of Cultures or Merging of Diverse Approaches?
-
Optimizing hospital use of intravenous insulin therapy: improved management of hyperglycemia and error reduction with a new nomogram.
-
Optimizing perioperative glycemic control.
-
Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.
-
Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.
-
Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.
-
Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
-
Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.
-
Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
-
Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms.
-
Ovine placental lactogen inhibits glucagon-induced glycogenolysis in fetal rat hepatocytes.
-
Ovine placental lactogen, but not growth hormone, stimulates amino acid transport in fetal rat diaphragm.
-
Oxidative and nonoxidative macronutrient disposal in lean and obese men after mixed meals.
-
PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation.
-
PHAS-I as a link between mitogen-activated protein kinase and translation initiation.
-
PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
-
Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids.
-
Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse.
-
Pancreatic hormone response to neuropeptide Y (NPY) perifusion in vitro.
-
Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.
-
Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
-
Parents' experiences of managing their child's diabetes using an insulin pump: a qualitative study.
-
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
-
Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading.
-
Patient Self-Management of Diabetes Care in the Inpatient Setting: Pro.
-
Patient time costs associated with sensor-augmented insulin pump therapy for type 1 diabetes: results from the STAR 3 randomized trial.
-
Perceptions and experiences of using automated bolus advisors amongst people with type 1 diabetes: a longitudinal qualitative investigation.
-
Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial: Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT).
-
Peripheral metabolic actions of leptin.
-
Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity.
-
Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization.
-
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.
-
Pharmacologic Treatment of Diabetes in Pregnancy.
-
Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
-
Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes.
-
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug.
-
Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.
-
Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity.
-
Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.
-
Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
-
Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
-
Physical activity and NIDDM in African-Americans. The Pitt County Study.
-
Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans.
-
Physiological concentrations of cholecystokinin stimulate amino acid-induced insulin release in humans.
-
Physiological receptors as physicochemical entities.
-
Physiological role for cholecystokinin in reducing postprandial hyperglycemia in humans.
-
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
-
Placental hormones and the control of maternal metabolism and fetal growth.
-
Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men.
-
Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction.
-
Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients.
-
Plasma glucose response to recreational diving in novice teenage divers with insulin-requiring diabetes mellitus.
-
Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.
-
Polycystic ovary syndrome and severe nonalcoholic steatohepatitis: beneficial effect of modest weight loss and exercise on liver biopsy findings.
-
Polyvinyl Pyrrolidone: A Novel Cryoprotectant in Islet Cell Cryopreservation.
-
Positive Impact of Continuous-Flow Left Ventricular Assist Device Implantation on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Advanced Chronic Systolic Heart Failure.
-
Postoperative hyperglycemia after 4- vs 8-10-mg dexamethasone for postoperative nausea and vomiting prophylaxis in patients with type II diabetes mellitus: a retrospective database analysis.
-
Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction.
-
Potassium and glucose measures in older adults: the Cardiovascular Health Study.
-
Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.
-
Pre-existing, Concurrent/Early-Onset, and Late-Onset Diabetes in Chronic Pancreatitis: Do Outcomes Differ?
-
Precocious development of sympatho-adrenal function in rats whose mothers received methadone.
-
Predictors of target organ damage in hypertensive blacks and whites.
-
Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance.
-
Premature development of cardiac sympathetic neurotransmission in the fetal alcohol syndrome.
-
Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner.
-
Preparation of inverted plasma membrane vesicles from isolated adipocytes.
-
Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort.
-
Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III.
-
Prevalences of type 2 diabetes, the insulin resistance syndrome, and coronary heart disease in an elderly, biethnic population.
-
Procurement, preservation, and transport of cadaver kidneys.
-
Progesterone inhibits human infragenicular arterial smooth muscle cell proliferation induced by high glucose and insulin concentrations.
-
Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2.
-
Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5.
-
Prolongation of normoglycemia in patients with type I glycogen storage disease.
-
Prospective association between fasting NEFA and type 2 diabetes: impact of post-load glucose.
-
Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.
-
Protein nutrition and resistance exercise.
-
Protein nutrition, exercise and aging.
-
Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting.
-
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.
-
Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.
-
Race differences in the relation of vitamins A, C, E, and β-carotene to metabolic and inflammatory biomarkers.
-
Randomized nutrition education intervention to improve carbohydrate counting in adolescents with type 1 diabetes study: is more intensive education needed?
-
Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR Therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14.
-
Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
-
Rapid deterioration of insulin secretion in obese adolescents preceding the onset of type 2 diabetes.
-
Rationale, design, and organization of a randomized, controlled Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) in patients with type 2 diabetes and established cardiovascular disease.
-
Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.
-
Recent advances in pancreatic endocrine and exocrine secretion.
-
Recent advances in the regulation of pancreatic secretion.
-
Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.
-
Recovery of rat adrenal amine stores after insulin administration.
-
Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.
-
Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.
-
Regulation of Glucose Production in the Pathogenesis of Type 2 Diabetes.
-
Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: potential role of immediate-early genes.
-
Regulation of adrenal chromaffin cell development by the central monoaminergic system: differential control of norepinephrine and epinephrine levels and secretory responses.
-
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.
-
Regulation of cerebral glucose metabolism.
-
Regulation of expression of transcobalamin II receptor in the rat.
-
Regulation of hepatic biliary secretion.
-
Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A. Evidence for discrete classes of insulin binding sites.
-
Regulation of insulin secretion from novel engineered insulinoma cell lines.
-
Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion.
-
Regulation of pancreatic endocrine function by cholecystokinin: studies with MK-329, a nonpeptide cholecystokinin receptor antagonist.
-
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
-
Relation between sulfonylurea therapy, complications, and outcome for elderly patients with acute myocardial infarction.
-
Relation of severe coronary artery narrowing to insulin or thiazolidinedione use in patients with type 2 diabetes mellitus (from the Bypass Angioplasty Revascularization Investigation 2 Diabetes Study).
-
Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia.
-
Relations of insulin sensitivity to longitudinal blood pressure tracking: variations with baseline age, body mass index, and blood pressure.
-
Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.
-
Relationship between insulin-mediated turnover of glucosamine-labeled lipids and activity of the insulin receptor tyrosine kinase.
-
Relationships of plasma C-peptide and gender to the urinary excretion of inositols in older people.
-
Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.
-
Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes.
-
Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.
-
Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.
-
Response to: 'Pharmacokinetic/pharmacodynamic properties and efficacy/safety of U-500R from randomized clinical studies'.
-
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.
-
Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways.
-
Reversal of diet-induced obesity and diabetes in C57BL/6J mice.
-
Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats.
-
Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward?
-
Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road.
-
Risking health to avoid injections: preferences of Canadians with type 2 diabetes.
-
Role of transcription factor NFAT in glucose and insulin homeostasis.
-
Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycaemia.
-
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes.
-
Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency.
-
SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control.
-
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
-
SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.
-
Safe and Efficacious Use of Automated Bolus Advisors in Individuals Treated With Multiple Daily Insulin Injection (MDI) Therapy: Lessons Learned From the Automated Bolus Advisor Control and Usability Study (ABACUS).
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Safely Converting an Entire Academic Medical Center From Sliding Scale to Basal Bolus Insulin via Implementation of the eGlycemic Management System.
-
Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.
-
Selective upregulated expression of the alpha2-macroglobulin signaling receptor in highly metastatic 1-LN prostate carcinoma cells.
-
Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.
-
Self-management practices of Chinese Americans with type 2 diabetes.
-
Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity.
-
Sensitive and precise quantification of insulin-like mRNA expression in Caenorhabditis elegans.
-
Sequential Multiple Assignment Randomized Trial (SMART) to identify optimal sequences of telemedicine interventions for improving initiation of insulin therapy: A simulation study.
-
Serum and dietary potassium and risk of incident type 2 diabetes mellitus: The Atherosclerosis Risk in Communities (ARIC) study.
-
Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon.
-
Severe insulin resistance in a patient with type 1 diabetes and stiff-man syndrome treated with insulin lispro.
-
Sex differences in the amount of insulin extractable from diabetic human pancreas.
-
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
-
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.
-
Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats.
-
Simplifying therapy to assure glycemic control and engagement (STAGE) in poorly-controlled diabetes: A pilot study.
-
Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.
-
Sitagliptin and risk of fractures in type 2 diabetes: Results from the TECOS trial.
-
Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats.
-
Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.
-
Sleeve gastrectomy rapidly enhances islet function independently of body weight.
-
Standardization of the single-breath diffusing capacity in a multicenter clinical trial.
-
Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells.
-
Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
-
Stimulation of insulin secretion by a rapid intravenous calcium infusion in patients with beta-cell neoplasms of the pancreas.
-
Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.
-
Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice.
-
Stress and autonomic nervous system in type II diabetes. A hypothesis.
-
Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis.
-
Suitability of capillary blood glucose analysis in patients receiving vasopressors.
-
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
-
Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect.
-
Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus.
-
Survival of allografted pancreatic islets in the subretinal space in rats.
-
Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats.
-
Sympatho-adrenal development in perinatally addicted rats.
-
Synergistic effect of insulin and follicle-stimulating hormone on biochemical and morphological differentiation of porcine granulosa cells in vitro.
-
Synergistic effects of oPL and insulin on glycogen metabolism in fetal rat hepatocytes.
-
Systematic literature review: quality of life associated with insulin pump use in Type 1 diabetes.
-
Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors.
-
Systemic administration of HVJ viral coat-liposome complex containing human insulin vector decreases glucose level in diabetic mouse: A model of gene therapy.
-
TCF1 links GIPR signaling to the control of beta cell function and survival.
-
Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target?
-
Tamoxifen Improves Glucose Tolerance in a Delivery-, Sex-, and Strain-Dependent Manner in Mice.
-
Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance.
-
Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia.
-
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.
-
Technical problems with agarose-hormone linkage.
-
Technosphere insulin: inhaled prandial insulin.
-
Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery.
-
Tempol therapy attenuates medial smooth muscle cell apoptosis and neointima formation after balloon catheter injury in carotid artery of diabetic rats.
-
Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control.
-
Testing a very low-carbohydrate adaption of the Diabetes Prevention Program among adults with prediabetes: study protocol for the Lifestyle Education about prediabetes (LEAP) trial.
-
Tetrahydroindenoindole inhibits the progression of diabetes in mice.
-
The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.
-
The 24-hour average concentration of cortisol is elevated in obese African-American youth with type 2 diabetes.
-
The Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE) Schizophrenia Trial: clinical comparison of subgroups with and without the metabolic syndrome.
-
The Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action.
-
The Enigma of Glucose and Lipid Metabolism.
-
The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans.
-
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.
-
The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides.
-
The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition.
-
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
-
The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy.
-
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
-
The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.
-
The Relation of Light-to-Moderate Alcohol Consumption to Glucose Metabolism and Insulin Resistance in Nondiabetic Adults: the Moderating Effects of Depressive Symptom Severity, Adiposity, and Sex.
-
The Relative Effectiveness of Pumps Over MDI and Structured Education (REPOSE): study protocol for a cluster randomised controlled trial.
-
The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.
-
The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.
-
The beta-adrenergic receptor.
-
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.
-
The constitutive secretory pathway is a major route for islet amyloid polypeptide secretion in neonatal but not adult rat islet cells.
-
The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.
-
The control of body size in insects.
-
The control of growth.
-
The developmental control of size in insects.
-
The distinct roles of insulin signaling in polyphenic development.
-
The effect of abdominal evisceration or adrenalectomy on insulin choleresis.
-
The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model.
-
The effect of chronic twice daily exenatide treatment on β-cell function in new onset type 2 diabetes.
-
The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats.
-
The effect of intraocular irrigating solutions on lens clarity in normal and diabetic rabbits.
-
The effect of membrane filtration upon protein conformation.
-
The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers.
-
The effect of octreotide on hepatic regeneration in rats.
-
The effect of plating density on granulosa cell growth and differentiation in vitro.
-
The effect of the PREMIER interventions on insulin sensitivity.
-
The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from STRRIDE AT/RT: a randomized trial.
-
The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes.
-
The effects of relaxations on glucose tolerance in non-insulin-dependent diabetes.
-
The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.
-
The enteroinsular axis revisited. A novel role for an incretin.
-
The hepatic extraction of gastric inhibitory polypeptide and insulin.
-
The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity.
-
The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?
-
The incretins and beta-cell health: contrasting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 as a path to understand islet function in diabetes.
-
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
-
The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays.
-
The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.
-
The intravenous insulin tolerance test in type I diabetes.
-
The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.
-
The mitochondrial 2-oxoglutarate carrier is part of a metabolic pathway that mediates glucose- and glutamine-stimulated insulin secretion.
-
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
-
The past, present, and future physiology and pharmacology of glucagon.
-
The pathogenesis of insulin resistance in children: metabolic complications and the roles of diet, exercise and pharmacotherapy in the prevention of type 2 diabetes.
-
The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase.
-
The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.
-
The placental lactogen receptor in maternal and fetal sheep liver: regulation by glucose and role in the pathogenesis of fasting during pregnancy.
-
The predictive value of donor liver biopsies on the development of primary nonfunction after orthotopic liver transplantation.
-
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
-
The relationship of insulin secretion and GAD65 antibody levels at diagnosis on glycemic control in type 2 diabetes.
-
The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
-
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.
-
The role of energy expenditure in the differential weight loss in obese women on low-fat and low-carbohydrate diets.
-
The role of motor activity in diet-induced obesity in C57BL/6J mice.
-
The role of protein kinase C in laminin-mediated neurite outgrowth.
-
The role of the transcription factor ETV5 in insulin exocytosis.
-
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
-
The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
-
The use of UW solution in clinical transplantation. A 4-year experience.
-
Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray.
-
Time of Day When Type 1 Diabetes Patients With Eating Disorder Symptoms Most Commonly Restrict Insulin.
-
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
-
Tissue norepinephrine concentration in spontaneously diabetic Chinese hamsters.
-
To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest.
-
Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts.
-
Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.
-
Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.
-
Transdermal delivery of macromolecules by erbium:YAG laser.
-
Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.
-
Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.
-
Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro.
-
Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.
-
Treatment with incretins does not increase the risk of pancreatic diseases compared to older anti-hyperglycaemic drugs, when added to metformin: real world evidence in people with Type 2 diabetes.
-
Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.
-
Trends in Insulin Out-of-Pocket Costs and Reimbursement Price Among US Patients With Private Health Insurance, 2006-2017.
-
Triglyceride Induced Metabolic Inflammation: Potential Connection of Insulin Resistance and Recurrent Pregnancy Loss.
-
Two insulin receptors determine alternative wing morphs in planthoppers.
-
Type 1 Diabetes Mellitus.
-
Type III Hypersensitivity Reaction to Subcutaneous Insulin Preparations in a Type 1 Diabetic.
-
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.
-
Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes.
-
Understanding of basic mechanisms of beta-cell function and survival: prelude to new diabetes therapies.
-
Unsupervised home use of an overnight closed-loop system over 3-4 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes.
-
Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin.
-
Update on preservation of liver grafts.
-
Use of an automated bolus calculator reduces fear of hypoglycemia and improves confidence in dosage accuracy in patients with type 1 diabetes mellitus treated with multiple daily insulin injections.
-
Use of an insulin bolus advisor facilitates earlier and more frequent changes in insulin therapy parameters in suboptimally controlled patients with diabetes treated with multiple daily insulin injection therapy: results of the ABACUS trial.
-
Use of an insulin bolus advisor improves glycemic control in multiple daily insulin injection (MDI) therapy patients with suboptimal glycemic control: first results from the ABACUS trial.
-
Use of automated bolus advisors may improve adherence to multiple daily insulin injection therapy.
-
Using insulin to prevent hyperglycemia in surgical patients.
-
Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans
.
-
Uterine leiomyomata in relation to insulin-like growth factor-I, insulin, and diabetes.
-
Utility of Continuous Glucose Monitoring vs Meal Study in Detecting Hypoglycemia After Gastric Bypass.
-
Utilization of pediatric donors for pancreas transplantation.
-
Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.
-
Veterans' Interpretation of Diabetes Distress in Diabetes Self-Management: Findings From Cognitive Interviews.
-
Viral Infection "Interferes" with Glucose Tolerance.
-
Visceral fat and adiponectin: associations with insulin resistance are tissue-specific in women.
-
Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats.
-
What End Users and Stakeholders Want From Automated Insulin Delivery Systems.
-
While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001.
-
Workshop IX--Lipids, insulin, diabetes.
-
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.
-
[Insulin producing cells as therapy in diabetes mellitus].
-
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
-
beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy.
-
dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest
-
β Cell tone is defined by proglucagon peptides through cAMP signaling.
-
β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes.
-
β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.
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β-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity.
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β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus.
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Keywords of People
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Baugh, L. Ryan,
Associate Professor of Biology,
Biology
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Carbrey, Jennifer Mehlman,
Assistant Research Professor of Cell Biology,
Cell Biology
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Freemark, Michael Scott,
Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine,
Pediatrics, Endocrinology
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Grambow, Steven C.,
Associate Professor of Biostatistics & Bioinformatics,
Biostatistics & Bioinformatics
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Humphreys, Margaret Ellen,
Josiah Charles Trent Distinguished Professor of the History of Medicine, in the School of Medicine,
Duke Science & Society
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Muir, Kelly Walton,
Associate Professor of Ophthalmology,
Ophthalmology, Glaucoma
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Soderling, Scott Haydn,
George Barth Geller Distinguished Professor of Molecular Biology,
Cell Biology
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Yancy Jr., William Samuel,
Professor of Medicine,
Medicine, General Internal Medicine