Insulin-Like Growth Factor I

• 

  Subject Areas on Research

  • A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemia. 
  • Acanthosis nigricans: a practical approach to evaluation and management. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Alzheimer’s disease: the new promise. 
  • Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. 
  • Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment. 
  • Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty. 
  • Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. 
  • BRCA1 expression is not directly responsive to estrogen. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. 
  • Biological basis of bone formation, remodeling, and repair-part I: biochemical signaling molecules. 
  • Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. 
  • Cell death and control of cell survival in the oligodendrocyte lineage. 
  • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. 
  • Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. 
  • Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. 
  • Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation. 
  • Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma. 
  • Developmental regulation of insulin-like growth factor binding protein production: studies in fetal, postnatal, and pregnant sheep. 
  • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. 
  • Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. 
  • Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling. 
  • Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. 
  • Directed axonal outgrowth using a propagating gradient of IGF-1. 
  • Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • Echocardiographic assessment of cardiac morphology and function in mutant dwarf rats. 
  • Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling. 
  • Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. 
  • Effects of an oral growth hormone secretagogue in older adults. 
  • Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice. 
  • Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line. 
  • Efficacy and safety of CyberKnife radiosurgery for acromegaly. 
  • Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 
  • Elevated neonatal insulin-like growth factor I is associated with fetal hypertrophic cardiomyopathy in diabetic women. 
  • Embryonic chick cartilage produces its own somatomedin-like peptide to stimulate cartilage growth in vitro. 
  • Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. 
  • Epidermal growth factor stimulates glycogen synthesis in fetal rat hepatocytes: comparison with the glycogenic effects of insulin-like growth factor I and insulin. 
  • Evaluation of antihypertensive drugs in combination with enzyme replacement therapy in mice with Pompe disease. 
  • Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts. 
  • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. 
  • Exogenously administered growth hormone and insulin-like growth factor-I alter intracellular Ca2+ handling and enhance cardiac performance. In vitro evaluation in the isolated isovolumic buffer-perfused rat heart. 
  • Expression of insulin-like growth factor II in spontaneously immortalized rat mesothelial and spontaneous mesothelioma cells: a potential autocrine role of insulin-like growth factor II. 
  • Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. 
  • Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. 
  • Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. 
  • Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study. 
  • Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. 
  • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. 
  • Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. 
  • Growth hormone attenuates early left ventricular remodeling and improves cardiac function in rats with large myocardial infarction. 
  • Homologous and heterologous growth hormones fail to stimulate avian cartilage growth in vitro. 
  • I-CLIP: improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP score. 
  • IGF-1 predicts survival in chronic heart failure. Insights from the T.O.S.CA. (Trattamento Ormonale Nello Scompenso CArdiaco) registry. 
  • IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405. 
  • IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men. 
  • IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. 
  • IPLEX and the telephone game: the difficulty in separating myth from reality on the internet. 
  • Importance of an intact growth hormone/insulin-like growth factor 1 axis for normal post-infarction healing: studies in dwarf rats. 
  • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. 
  • Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps. 
  • Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. 
  • Influence of vitamin A injection before mating on oocyte development, follicular hormones, and ovulation in gilts fed high-energy diets. 
  • Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy. 
  • Insulin-like growth factor 1 and delirium. 
  • Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation. 
  • Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. 
  • Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells. 
  • Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles. 
  • Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. 
  • Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma. 
  • Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical correlates of prostate volume among Black men. 
  • Insulin-like growth factor-I gene expression in the tibial epiphyseal growth plate of growth hormone-treated uremic rats. 
  • Insulin-like growth factor-I is a serum component stimulating growth of human neuroblastoma. 
  • Insulin-like growth factor-I is expressed by avian flexor tendon cells. 
  • Intrinsic cardiac muscle function, calcium handling and beta -adrenergic responsiveness is impaired in rats with growth hormone deficiency. 
  • Is there a role for a low-carbohydrate ketogenic diet in the management of prostate cancer? 
  • Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study. 
  • Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. 
  • Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. 
  • MicroRNAs both promote and antagonize longevity in C. elegans. 
  • Molecular biology of gastrointestinal peptides and growth factors: relevance to intestinal adaptation. 
  • Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells. 
  • Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. 
  • Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6. 
  • PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro. 
  • Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia. 
  • Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation. 
  • Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. 
  • Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. 
  • Randomized trial of tamoxifen versus combined tamoxifen and octreotide LAR Therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14. 
  • Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. 
  • Reduced prostate branching morphogenesis in stromal fibroblast, but not in epithelial, estrogen receptor α knockout mice. 
  • Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status. 
  • Relationship Between Serum IGF-1 and BMI Differs by Age. 
  • Secretion of a large molecular-weight form of insulin-like growth factor by a primary renal tumor. 
  • Serum insulin-like growth factor-1 and its binding protein-7: potential novel biomarkers for heart failure with preserved ejection fraction. 
  • Short stature, growth hormone deficiency, and social anxiety. 
  • Somatomedin-C stimulates glycogen synthesis in fetal rat hepatocytes. 
  • Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. 
  • Stimulation of brain hexokinase gene expression by recombinant brain insulin-like growth factor in C6 glial cells. 
  • Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis. 
  • Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle. 
  • The 25-kilodalton insulin-like growth factor (IGF)-binding protein inhibits both basal and IGF-I-mediated growth of chick embryo pelvic cartilage in vitro. 
  • The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain. 
  • The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model. 
  • The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. 
  • The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway. 
  • The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse. 
  • The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. 
  • Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. 
  • Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density. 
  • Triiodothyronine stimulates cartilage growth and maturation by different mechanisms. 
  • Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. 
  • Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. 
  • [Recent advances in atherothrombotic diseases]. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute