Insulin-Like Growth Factor II

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  Subject Areas on Research

  • Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. 
  • An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor. 
  • Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. 
  • Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. 
  • Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children. 
  • Cell death and control of cell survival in the oligodendrocyte lineage. 
  • Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. 
  • Development of a Grp94 inhibitor. 
  • Developmental regulation of insulin-like growth factor binding protein production: studies in fetal, postnatal, and pregnant sheep. 
  • Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling. 
  • Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations. 
  • Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling. 
  • Effects of insulin-like growth factors I and II and insulin on the immortalized hypothalamic GTI-7 cell line. 
  • Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts. 
  • Expression of insulin-like growth factor II in spontaneously immortalized rat mesothelial and spontaneous mesothelioma cells: a potential autocrine role of insulin-like growth factor II. 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. 
  • Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. 
  • High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer. 
  • IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. 
  • IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites. 
  • In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. 
  • Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. 
  • Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma. 
  • Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma. 
  • Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice. 
  • Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. 
  • Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. 
  • Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. 
  • PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. 
  • Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. 
  • Phylogenetic footprint analysis of IGF2 in extant mammals. 
  • Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2. 
  • Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. 
  • Secretion of a large molecular-weight form of insulin-like growth factor by a primary renal tumor. 
  • Selective expression of insulin-like growth factor II in the songbird brain. 
  • Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute