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Subject Areas on Research
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'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival.
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1 alpha,25 Dihydroxyvitamin D3 and mononuclear phagocytes: enhancement of mouse macrophage and human monocyte hydrogen peroxide production without alteration of tumor cytolysis.
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3-nitrotyrosine attenuates respiratory syncytial virus infection in human bronchial epithelial cell line.
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A Phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: monitoring the humoral immune response.
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A Potential Role of Interleukin 10 in COVID-19 Pathogenesis.
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A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys.
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A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.
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A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone.
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A multicenter trial of recombinant human interferon gamma in patients with systemic sclerosis: effects on cutaneous fibrosis and interleukin 2 receptor levels.
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A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization.
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A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling.
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A novel mutation in IFN-gamma receptor 2 with dominant negative activity: biological consequences of homozygous and heterozygous states.
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A nuclear factor-kappaB inhibitor BAY11-7082 inhibits interactions between human endothelial cells, T cells, and monocytes.
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A phase I trial of human gamma interferon transduced autologous tumor cells in patients with disseminated malignant melanoma.
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A phase II study of recombinant interferon-gamma following combination chemotherapy for patients with extensive small cell lung cancer. CALGB.
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A phase II trial of recombinant human interferon-gamma and recombinant tumor necrosis factor in patients with advanced gastrointestinal malignancies: results of a trial terminated by excessive toxicity.
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A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204).
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A possible coagulation-independent mechanism for pregnancy loss involving β(2) glycoprotein 1-dependent antiphospholipid antibodies and CD1d.
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A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation.
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A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment.
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A synthetic peptide homologous to retroviral envelope protein down-regulates TNF-alpha and IFN-gamma mRNA expression.
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AD2, a human molecule involved in the interaction of T cells with epidermal keratinocytes and thymic epithelial cells.
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ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers.
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Absence of interferon-gamma-inducible gene IGTP does not significantly alter the development of chagasic cardiomyopathy in mice infected with Trypanosoma cruzi (Brazil strain).
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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
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Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma.
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Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
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Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies.
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Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.
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Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system.
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Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines.
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Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice.
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Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma.
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Adjuvanticity and protective immunity of Plasmodium yoelii nigeriensis blood-stage soluble antigens encapsulated in fusogenic liposome.
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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism.
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Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease.
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Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways.
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Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon.
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Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.
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Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP.
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Analysis of erythropoietin and erythropoietin receptor genes expression in cattle during acute infection with Trypanosoma congolense.
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Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.
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Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells.
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Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye.
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Antifibrotic therapies: will we ever get there?
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Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.
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Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection.
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Antiviral activity of mismatched double-stranded RNA against human immunodeficiency virus in vitro.
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Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport.
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Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.
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Aspects of immunobiology and immunotherapy and uses of monoclonal antibodies and biologic immune modifiers in human gliomas.
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Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes.
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Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
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Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin.
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Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells.
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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.
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B cell depletion reduces the development of atherosclerosis in mice.
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BLyS and APRIL in rheumatoid arthritis.
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Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha.
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Balance of Irgm protein activities determines IFN-gamma-induced host defense.
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Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture.
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Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Trial.
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CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.
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CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.
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CD19 expression in B cells is important for suppression of contact hypersensitivity.
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CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis.
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CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells.
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Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
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Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy.
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Cell mediated immune responses following revaccination with an influenza A/H5N1 vaccine.
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Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
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Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.
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Characterization of human interferon-gamma and human interleukin-2 from recombinant mammalian cell lines and peripheral blood lymphocytes.
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Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes.
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Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris.
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Chemotactic peptide receptor-cytoskeletal interactions and functional correlations in differentiated HL-60 cells and human polymorphonuclear leukocytes.
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Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer.
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Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.
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Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.
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Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.
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Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.
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Clearance and distribution of recombinant murine gamma-interferon in mice.
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Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype.
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Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice.
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Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study.
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Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
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Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.
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Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy.
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Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost.
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Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV.
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Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals.
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Computational investigations into the origins of short-term biochemical memory in T cell activation.
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Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo.
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Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.
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Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).
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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
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Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.
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Cooperative effect of tumor necrosis factor and gamma-interferon on chemotactic peptide receptor expression and stimulus-induced actin polymerization in HL-60 cells.
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Cooperative effects of gamma interferon and 1-alpha,25-dihydroxyvitamin D3 in inducing differentiation of human promyelocytic leukemia (HL-60) cells.
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Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure.
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Correlation between interferon- gamma secretion and cytotoxicity, in virus-specific memory T cells.
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Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma.
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Correlation of serum cytokine and adhesion molecule determinations with pregnancy outcome.
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Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses.
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Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen.
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Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
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Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
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Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing.
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Cumulative exposure to gamma interferon-dependent chemokines CXCL9 and CXCL10 correlates with worse outcome after lung transplant.
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Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
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Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.
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Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique.
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Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant.
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Cytokine mRNA expression in postischemic/reperfused myocardium.
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Cytokine production at the site of disease in human tuberculosis.
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Cytokine profiles of preterm neonates with fungal and bacterial sepsis.
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Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization.
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Cytokine transcriptional events during helper T cell subset differentiation.
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Cytokines and immune response in the tumor microenvironment.
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Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain.
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Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.
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Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
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Defective antitumor responses in CX3CR1-deficient mice.
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Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
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Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis.
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Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription.
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Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response.
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Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
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Dendritic cells cultured in anti-CD40 antibody-immobilized plates elicit a highly efficient peptide-specific T-cell response.
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Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells.
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Dendritic epidermal T cells regulate skin antimicrobial barrier function.
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Dendritic-NK cell interactions in P. gingivalis-specific responses.
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Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients.
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Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.
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Development and use of SIV-based Integrase defective lentiviral vector for immunization.
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Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease.
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Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice.
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Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon production.
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Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein.
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Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1.
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Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy.
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Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
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Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
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Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells.
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Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers.
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ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.
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Editorial: A clear vision needs some balance.
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Effect of an intravitreal cyclosporine implant on experimental uveitis in horses.
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Effect of gamma interferon on the hypothalamic-pituitary-adrenal system.
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Effect of influenza virus vaccine on the expression of human immunodeficiency virus co-receptor CCR5.
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Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression.
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Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells.
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Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.
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Effect of modulating macrophage phenotype on peripheral nerve repair
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Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques.
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Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies.
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Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma.
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Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.
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Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection.
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Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells.
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Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ.
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Effects of gamma-interferon on the endocrine system: results from a phase I study.
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Efficacy and safety of entecavir plus carnitine complex (GODEX®) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: randomized, multicenter open-label trials. The GOAL study.
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Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates.
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Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus.
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Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis.
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Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.
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Enhanced dendritic cell antigen presentation in RNA-based immunotherapy.
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Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression.
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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
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Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis.
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Eradication of melanoma pulmonary metastases by immunotherapy with tumor cells engineered to secrete interleukin-2 or gamma interferon.
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Essential amino acid deprivation induces monocytic differentiation of the human HL-60 myeloid leukemia cell line.
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Ethnicity greatly influences cytokine gene polymorphism distribution.
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Evaluating cytokine production by flow cytometry using brefeldin A in mice.
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Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.
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Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus.
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Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice.
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Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects.
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Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation.
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Excellent safety and tolerability of the human immunodeficiency virus type 1 pGA2/JS2 plasmid DNA priming vector vaccine in HIV type 1 uninfected adults.
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Exercise mimetics and JAK inhibition attenuate IFN-γ-induced wasting in engineered human skeletal muscle.
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Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.
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Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
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Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines.
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Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall survival after immunizations with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine in late-stage colorectal cancer.
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Extracellular trafficking of myocilin in human trabecular meshwork cells.
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Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract.
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Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.
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Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression.
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Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes.
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Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques.
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Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.
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Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens.
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Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.
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Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
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Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.
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Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting.
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Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation.
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Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
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Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env.
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Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.
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Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture.
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Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells.
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Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.
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Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14.
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Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.
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Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo.
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Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
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Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.
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HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes.
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HIV-1 Infection Primes Macrophages Through STAT Signaling to Promote Enhanced Inflammation and Viral Replication.
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HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
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HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.
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HLA-A2-restricted human CD8(+) cytotoxic T lymphocyte responses to a novel epitope in vaccinia virus that is conserved among orthopox viruses.
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Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.
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Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.
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High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects.
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High-quality CMV-specific CD4+ memory is enriched in the lung allograft and is associated with mucosal viral control.
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High-resolution, noninvasive longitudinal live imaging of immune responses.
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How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens.
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Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein.
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Human IRGM induces autophagy to eliminate intracellular mycobacteria.
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Human alveolar and peritoneal macrophages mediate fungistasis independently of L-arginine oxidation to nitrite or nitrate.
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Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy.
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Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages.
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Human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs.
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Hyperexpansion of Functional Viral-Specific CD8+ T Cells in Lymphopenia-Associated MCMV Pneumonitis.
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IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
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IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection.
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IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.
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IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.
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IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.
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IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. Distinct requirement for costimulatory signals through adhesion molecules.
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IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.
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IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.
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IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR.
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IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila.
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IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.
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Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma.
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Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor.
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Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.
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Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
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Immune (gamma) interferon production by a murine T cell lymphoma: requirements for macromolecular synthesis and lack of relationship with cell cycle.
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Immune control of tuberculosis by IFN-gamma-inducible LRG-47.
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Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.
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Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice.
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Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.
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Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection.
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Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye.
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Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239.
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Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome.
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Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells.
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Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes.
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Immunological memory induced by genetically transduced tumor cells.
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Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma.
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Immunopathogenesis of genital Chlamydia infection: insights from mouse models.
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Immunostimulatory properties of genomic DNA from different bacterial species.
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Immunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon gamma.
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Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
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In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute Myeloid Leukemia.
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In vitro evaluation of mismatched double-stranded RNA (ampligen) for combination therapy in the treatment of acquired immunodeficiency syndrome.
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In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers.
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In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis.
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In-vivo impaired T helper 1 cell development in submandibular lymph nodes due to IL-12 deficiency following antigen injection into the anterior chamber of the eye.
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Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection.
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Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy.
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Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ.
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Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility.
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Induction of neutralizing antibodies and gag-specific cellular immune responses to an R5 primary isolate of human immunodeficiency virus type 1 in rhesus macaques.
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Induction of protective CTL responses in newborn mice by a murine retrovirus.
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Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response.
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Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
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Inflammation influences vascular remodeling through AT2 receptor expression and signaling.
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Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses.
-
Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level.
-
Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
-
Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide.
-
Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.
-
Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response.
-
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
-
Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.
-
Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine.
-
Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage.
-
Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.
-
Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC.
-
Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection.
-
Interferon in the treatment of cutaneous T-cell lymphoma.
-
Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells.
-
Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells.
-
Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.
-
Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection.
-
Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.
-
Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells.
-
Interferon-γ-secreting NK cells promote induction of dry eye disease.
-
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions.
-
Interleukin 12 at the site of disease in tuberculosis.
-
Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.
-
Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma.
-
Interleukin-15 enhances the secretion of IFN-gamma and CC chemokines by natural killer cells from HIV viremic and aviremic patients.
-
Interleukin-15 increases hepatic regenerative activity.
-
Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo.
-
Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells.
-
Interleukin-6: effects on and production by rat granulosa cells in vitro.
-
Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo.
-
Intradermal HIV-1 DNA Immunization Using Needle-Free Zetajet Injection Followed by HIV-Modified Vaccinia Virus Ankara Vaccination Is Safe and Immunogenic in Mozambican Young Adults: A Phase I Randomized Controlled Trial.
-
Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12.
-
Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.
-
Juvenile arthritis and autoimmunity to type II collagen.
-
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
-
Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.
-
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
-
LPS-sensory peptide communication in experimental cystitis.
-
Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.
-
Lessons from a multisite international trial in the Caribbean and South America of an HIV-1 Canarypox vaccine (ALVAC-HIV vCP1452) with or without boosting with MN rgp120.
-
Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.
-
Local secretion of IL-12 augments the therapeutic impact of dendritic cell-tumor cell fusion vaccination.
-
Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.
-
Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2.
-
Long-term killing of natural killer-resistant target cells by interferon-alpha-, interferon-gamma-, and interleukin-2-activated natural killer cells.
-
Loss of sarcomeric proteins via upregulation of JAK/STAT signaling underlies interferon-γ-induced contractile deficit in engineered human myocardium.
-
Low interleukin-12 activity in severe Plasmodium falciparum malaria.
-
Low sensitivity of T-cell based detection of tuberculosis among HIV co-infected Tanzanian in-patients.
-
Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients.
-
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major.
-
Macrophage activation downregulates the degradative capacity of the phagosome.
-
Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.
-
Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
-
Mast cells impair the development of protective anti-tumor immunity.
-
Measurement of cytokine release at the single cell level using the ELISPOT assay.
-
Mechanism of pokeweed mitogen inhibition of rhIL-4-induced human IgE synthesis.
-
Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.
-
Metabolic Signaling Drives IFN-γ.
-
Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.
-
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.
-
MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.
-
Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport.
-
Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.
-
Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.
-
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.
-
Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification.
-
Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x.
-
Modulation of mouse peritoneal macrophage Ia and human peritoneal macrophage HLA-DR expression by alpha 2-macroglobulin "fast" forms.
-
Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide.
-
Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine.
-
Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.
-
Monocyte-derived CD40 expression is regulated by interferon-γ/interferon-γ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells.
-
Mouse adenovirus type 1 infection of adipose tissue.
-
Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.
-
Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations.
-
Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.
-
Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3.
-
Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand.
-
Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice.
-
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
-
Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.
-
Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a.
-
Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.
-
Nasal immunization with a recombinant HIV gp120 and nanoemulsion adjuvant produces Th1 polarized responses and neutralizing antibodies to primary HIV type 1 isolates.
-
Nasal peanut+ CpG immunotherapy enhances peanut-specific IFN-γ in Th2 cells and IL-10 in non-Th2 cells in mice.
-
Nasal peptide vaccination elicits CD8 responses and reduces viral burden after challenge with virulent murine cytomegalovirus.
-
Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury.
-
Natural killer cell mobilization and egress following acute exercise in men with prostate cancer.
-
Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.
-
Neopterin production by HIV-1-infected mononuclear phagocytes.
-
Neural stem cell encapsulation and differentiation in strain promoted crosslinked polyethylene glycol-based hydrogels.
-
Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death.
-
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.
-
Nitric oxide-associated regulation of hepatocyte glutathione synthesis is a guanylyl cyclase-independent event.
-
Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis.
-
Novel Variants of ELP2 and PIAS1 in the Interferon Gamma Signaling Pathway Are Associated with Non-Small Cell Lung Cancer Survival.
-
Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients.
-
Optimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial.
-
Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma.
-
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.
-
Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages.
-
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
-
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.
-
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
-
Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.
-
Paradox of serial interferon-gamma release assays: variability width more important than specificity size.
-
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
-
Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.
-
Performance of serum-supplemented and serum-free media in IFNgamma Elispot Assays for human T cells.
-
Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles.
-
Peripheral blood dendritic cells, but not monocyte-derived dendritic cells, can augment human NK cell function.
-
Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice.
-
Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine.
-
Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial.
-
Phase I and II studies of the combination of recombinant human interferon-gamma and 5-fluorouracil in patients with advanced colorectal carcinoma.
-
Phase I studies of recombinant interferon-gamma.
-
Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma.
-
Phase I trial of interleukin-2 plus gamma-interferon.
-
Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer.
-
Phase I/II randomized trial of safety and immunogenicity of LIPO-5 alone, ALVAC-HIV (vCP1452) alone, and ALVAC-HIV (vCP1452) prime/LIPO-5 boost in healthy, HIV-1-uninfected adult participants.
-
Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma.
-
Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
-
Phenotypic characterization of gamma interferon-induced human monocyte polykaryons.
-
Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate.
-
Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease.
-
Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.
-
Polyribonucleotides induce nitric oxide production by human monocyte-derived macrophages.
-
Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate.
-
Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs.
-
Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens.
-
Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides.
-
Predicting tuberculosis: does the IGRA tell the tale?
-
Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.
-
Preexposure of resting B cells to interferon-gamma enhances their proliferative response to subsequent activation signals.
-
Preparation of peptide-loaded dendritic cells for cancer immunotherapy.
-
Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients.
-
Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.
-
Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.
-
Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis.
-
Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis.
-
Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma.
-
Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain.
-
Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory.
-
Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis.
-
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
-
Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma.
-
Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors.
-
Pulmonary immune-compartment-specific interferon gamma responses in HIV-infected individuals with active tuberculosis (TB) in an area of high TB prevalence.
-
RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss.
-
RNA-Modified T Cells Mediate Effective Delivery of Immunomodulatory Cytokines to Brain Tumors.
-
Ranitidine improves lymphocyte function after severe head injury: results of a randomized, double-blind study.
-
Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection.
-
Receptor-mediated monocytoid differentiation of human promyelocytic cells by tumor necrosis factor: synergistic actions with interferon-gamma and 1,25-dihydroxyvitamin D3.
-
Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer.
-
Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites.
-
Recombinant human gamma-interferon induces human monocyte polykaryon formation.
-
Recombinant varicella vaccines induce neutralizing antibodies and cellular immune responses to SIV and reduce viral loads in immunized rhesus macaques.
-
Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.
-
Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.
-
Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
-
Regulation of microglial function by interferons.
-
Regulation of myocilin-associated exosome release from human trabecular meshwork cells.
-
Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
-
Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
-
Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease.
-
Regulatory T cells decrease invariant natural killer T cell-mediated pregnancy loss in mice.
-
Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes.
-
Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials.
-
Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS.
-
RhCMV serostatus and vaccine adjuvant impact immunogenicity of RhCMV/SIV vaccines.
-
Role for hedgehog pathway in regulating growth and function of invariant NKT cells.
-
Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation.
-
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
-
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.
-
Role of interleukin 12 and costimulators in T cell anergy in vivo.
-
S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase
-
STAT1 drives tumor progression in serous papillary endometrial cancer.
-
STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection.
-
Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial.
-
Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults.
-
Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy.
-
Season and size of urban particulate matter differentially affect cytotoxicity and human immune responses to Mycobacterium tuberculosis.
-
Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage.
-
Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.
-
Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells.
-
Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.
-
Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection.
-
Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors.
-
Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2.
-
Significance of cytokine gene polymorphism in renal transplantation.
-
Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV.
-
Some characteristics of mouse immune (y) interferon produced by a T-lymphoma cell line.
-
Standardization and validation issues of the ELISPOT assay.
-
Staphylococcus aureus secretes immunomodulatory RNA and DNA via membrane vesicles.
-
Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process.
-
Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.
-
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.
-
Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.
-
Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.
-
Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques.
-
Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.
-
Substance P receptor mediated maintenance of chronic inflammation in EAE.
-
Superantigen enhanced protection against a weak tumor-specific melanoma antigen: implications for prophylactic vaccination against cancer.
-
Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.
-
Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet-derived growth factor B/c-sis gene.
-
Suppression of human interferon-gamma production by a 17 amino acid peptide homologous to the transmembrane envelope protein of retroviruses: evidence for a primary role played by monocytes.
-
Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine.
-
Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.
-
Susceptibility to acute mouse adenovirus type 1 respiratory infection and establishment of protective immunity in neonatal mice.
-
Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma.
-
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.
-
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
-
Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells.
-
T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.
-
T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.
-
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.
-
T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control.
-
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite.
-
TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells.
-
Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis.
-
Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma.
-
Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells.
-
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway.
-
The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.
-
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
-
The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-gamma.
-
The Immune Landscape of Cancer.
-
The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity.
-
The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation.
-
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.
-
The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.
-
The effect of interferon gamma on epidermal growth factor receptor expression in normal and malignant ovarian epithelial cells.
-
The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments.
-
The impact of caspase-12 on susceptibility to candidemia.
-
The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures.
-
The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors.
-
The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors.
-
The interleukin-2 receptor α chain (CD25) plays an important role in regulating monocyte-derived CD40 expression during anti-porcine cellular responses.
-
The intragraft CD8+ T cell response in renal allograft rejection in the mouse.
-
The lack of effect of tumor necrosis factor-alpha, interleukin-1-alpha, and interferon-gamma on human sperm motility in vitro.
-
The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.
-
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.
-
The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
-
The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis.
-
The role of leukocyte adhesion molecules in cellular interactions: implications for the pathogenesis of inflammatory synovitis.
-
The suppressive effect of a synthetic retroviral peptide on the human IFN gamma production is abrogated by the combined stimulation with IL-1 and IL-2.
-
The treatment of metastatic renal cell carcinoma patients with recombinant human gamma interferon.
-
Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice.
-
Three-Year Durability of Immune Responses Induced by HIV-DNA and HIV-Modified Vaccinia Virus Ankara and Effect of a Late HIV-Modified Vaccinia Virus Ankara Boost in Tanzanian Volunteers.
-
Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells.
-
Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells.
-
Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon.
-
Transcription interruption may be a common mechanism of c-myc regulation during HL-60 differentiation.
-
Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity.
-
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
-
Tumor cells cotransduced with B7.1 and gamma-IFN induce effective rejection of established parental tumor.
-
Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL.
-
Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes.
-
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.
-
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.
-
Two forms of NF-kappa B1 (p105/p50) in murine macrophages: differential regulation by lipopolysaccharide, interleukin-2, and interferon-gamma.
-
Type B CpG oligodeoxynucleotides induce Th1 responses to peanut antigens: modulation of sensitization and utility in a truncated immunotherapy regimen in mice.
-
Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients.
-
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour.
-
Unique aspects of IFN-γ/STAT1 signaling in neurons.
-
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.
-
Variability of the IFN-γ ELISpot assay in the context of proficiency testing and bridging studies.
-
Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus.
-
Viral Infection "Interferes" with Glucose Tolerance.
-
Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.
-
Viral-induced CD28 loss evokes costimulation independent alloimmunity.
-
[Characteristics of cells producing immune interferon].
-
[Study of immunoregulation of dendritic cells in allergic rhinitis].
-
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
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miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy.
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microRNA-142 guards against autoimmunity by controlling Treg cell homeostasis and function.
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p47 GTPases: regulators of immunity to intracellular pathogens.
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pp60v-src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor.
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Keywords of People
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Barker, Piers Christopher Andrew,
Professor of Pediatrics,
Pediatrics, Cardiology
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
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Cianciolo, George James,
Associate Professor Emeritus of Pathology,
Pathology
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Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
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Lee, Walter T,
Professor of Head and Neck Surgery & Communication Sciences,
Radiation Oncology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
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Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology
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Taylor, Gregory Alan,
Professor in Medicine,
Immunology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Immunology
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Yan, Hai,
Adjunct Professor of Pathology,
Pathology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology