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Subject Areas on Research
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A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2.
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A Phase II trial of Denileukin Diftitox in patients with previously treated advanced non-small cell lung cancer.
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A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization.
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A global approach to tumor immunology.
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A low rate of central nervous system progression in a phase II trial of outpatient chemobiologic therapy with cisplatin, temozolomide, interleukin-2, and interferon alfa 2-B for metastatic malignant melanoma.
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A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation.
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A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor-dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2.
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A phase II study of tamoxifen combined with cisplatin-interleukin 2 and alpha-interferon in metastatic melanoma.
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A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone.
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A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease.
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A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors.
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A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.
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A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor.
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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
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Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma.
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Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies.
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Activation of human B cells by phosphorothioate oligodeoxynucleotides.
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Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines.
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Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals.
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Active-specific immunization against melanoma: is the problem at the receiving end?
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Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens.
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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.
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Alteration of the CD34+ Tf-1 beta cell line profile in response to long-term exposure to IL-15.
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Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes.
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Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen.
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Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma.
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Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response.
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Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes.
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Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys.
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Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression.
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BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT.
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Biochemical and functional analysis of soluble human interleukin-2 receptor produced in rodent cells. Solid-phase reconstitution of a receptor-ligand binding reaction.
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CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade.
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CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδ T cell activation.
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CD19 expression in B cells is important for suppression of contact hypersensitivity.
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CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy strategies.
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CD28 costimulatory signal induces protein arginine methylation in T cells.
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CTLA-4-Mediated inhibition of early events of T cell proliferation.
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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
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Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling.
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Cellular anti-GP120 cytolytic reactivities in HIV-1 seropositive individuals.
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Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies.
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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
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Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection.
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Characterization of human interferon-gamma and human interleukin-2 from recombinant mammalian cell lines and peripheral blood lymphocytes.
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Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris.
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Chemoimmunotherapy of metastatic malignant melanoma. The Salpétrière Hospital (SOMPS) experience.
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Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma.
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Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation.
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Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype.
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Coadministration of zidovudine and interleukin-2 increases absolute CD4 cells in subjects with Walter Reed stage 2 human immunodeficiency virus infection: results of ACTG protocol 042.
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Cognitive and Affective Symptoms Experienced by Cancer Patients Receiving High-Dose Intravenous Interleukin 2 Therapy: An Integrative Literature Review.
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Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production.
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Combination gene therapy for liver metastasis of colon carcinoma in vivo.
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Combined immunodeficiency due to the selective absence of CD4 inducer T lymphocytes.
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Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness.
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Complete DiGeorge syndrome: persistence of profound immunodeficiency.
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Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer.
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Contemporary experience with high-dose interleukin-2 therapy and impact on survival in patients with metastatic melanoma and metastatic renal cell carcinoma.
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Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primates.
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Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
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Correlation of serum cytokine and adhesion molecule determinations with pregnancy outcome.
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Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.
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Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life.
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Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells.
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Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.
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Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13.
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Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6.
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Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.
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Cytokine therapy of cutaneous T-cell lymphoma: interferons, interleukin-12, and interleukin-2.
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Cytokine transcriptional events during helper T cell subset differentiation.
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Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium.
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Cytokines and immune response in the tumor microenvironment.
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DNA damage in peripheral blood mononuclear cells correlates with response to biochemotherapy in melanoma.
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DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memory.
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Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
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Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
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Denileukin diftitox for the treatment of CD25 low-expression mycosis fungoides and Sézary syndrome.
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Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.
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Depletion of human regulatory T cells.
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Development and use of SIV-based Integrase defective lentiviral vector for immunization.
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Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
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Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development.
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Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.
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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
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Does thalidomide affect IL-2 response and production?
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Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation.
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Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues.
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Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation.
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Effect of an intravitreal cyclosporine implant on experimental uveitis in horses.
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Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells.
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Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells.
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Effect of pregnancy and human immunodeficiency virus infection on intracellular interleukin-2 production patterns.
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Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets.
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Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation.
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Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer.
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Efficacy and safety of denileukin diftitox retreatment in patients with relapsed cutaneous T-cell lymphoma.
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Efficient gene transfer with adeno-associated virus-based plasmids complexed to cationic liposomes for gene therapy of human prostate cancer.
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Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies.
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Elevated levels of soluble interleukin-2 receptors in multiple sclerosis.
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
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Eradication of melanoma pulmonary metastases by immunotherapy with tumor cells engineered to secrete interleukin-2 or gamma interferon.
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Erythema nodosum in a patient with renal cell carcinoma treated with interleukin 2 and lymphokine-activated killer cells.
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Ex vivo expansion, maturation, and activation of umbilical cord blood-derived T lymphocytes with IL-2, IL-12, anti-CD3, and IL-7. Potential for adoptive cellular immunotherapy post-umbilical cord blood transplantation.
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Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.
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Expression of a cloned human interleukin-2 cDNA is enhanced by the substitution of a heterologous mRNA leader region.
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Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia.
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Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors.
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Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma.
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Follow up of soluble IL-2 receptor level in metastatic malignant melanoma patients treated by chemoimmunotherapy.
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FoxO-dependent regulation of diacylglycerol kinase α gene expression.
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Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.
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Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.
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Functional heterogeneity of vaccine-induced CD8(+) T cells.
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Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting.
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Gene expression signatures of interleukin-2 in vivo and in vitro and their relation to anticancer therapy.
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Gene modification of primary tumor cells for active immunotherapy of human breast and ovarian cancer.
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Gene profiling of immune responses against tumors.
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Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration.
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Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.
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Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells.
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Graves' disease after interleukin-2 therapy in a patient with human immunodeficiency virus infection.
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Growth-dependent regulation of cellular ceramides in human T-cells.
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HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.
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HLA-A2-restricted human CD8(+) cytotoxic T lymphocyte responses to a novel epitope in vaccinia virus that is conserved among orthopox viruses.
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Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors: G-CSF, GM-CSF, IL-1, IL-2, M-CSF.
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High-Dose Interleukin-2: Evaluation of a Standardized Order Set for Biotherapy in an Intensive Care Unit
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High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.
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High-dose interleukin-2 therapy related adverse events and implications on imaging.
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High-resolution, noninvasive longitudinal live imaging of immune responses.
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Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection.
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Human T cells specifically activated against autologous malignant melanoma.
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Human interleukin-2 and lymphoproliferative (T-helper cell) responses to soluble HLA class I antigens in vitro: I. Specificity for polymorphic domains.
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Human interleukin-2 production in insect (Trichoplusia ni) larvae: effects and partial control of proteolysis.
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Human melanoma-mediated inhibition of autologous CD4+ helper tumor-infiltrating lymphocyte growth in vitro.
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Human postnatal CD4- CD8- CD3- thymic T cell precursors differentiate in vitro into T cell receptor delta-bearing cells.
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Human thymic epithelial cells directly induce activation of autologous immature thymocytes.
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IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus.
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IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. Distinct requirement for costimulatory signals through adhesion molecules.
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IL-2-dependent adaptive control of NK cell homeostasis.
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IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells.
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IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation.
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IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
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Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa.
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Immune lymphocyte survival after chemotherapy and radiation.
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Immune status assay (ISA): a noninvasive procedure for studying allograft rejection.
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Immunobiology of human gliomas.
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Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells.
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Immunosuppressive effects of subglutinol derivatives.
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Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma.
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Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study.
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Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIMSM.
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Improved survival and tumor control with Interleukin-2 is associated with the development of immune-related adverse events: data from the PROCLAIMSM registry.
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In vitro and in vivo activity of murine lymphokine-activated killer cells after cryopreservation.
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In vitro and in vivo kinetics of recombinant vaccinia virus cancer-gene therapy.
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In vivo cytokine-associated responses to biomaterials.
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In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis.
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Increased immunogenicity of a DNA-launched Venezuelan equine encephalitis virus-based replicon DNA vaccine.
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Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression.
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Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia.
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Inflammatory protein profile during systemic high dose interleukin-2 administration.
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Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level.
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Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells.
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Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E.
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Inhibition of interleukin-2 and interferon-gamma by an HIV-1 Nef-encoded synthetic peptide.
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Inhibition of murine cytotoxic T lymphocyte activity by a synthetic retroviral peptide and abrogation of this activity by IL.
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Inhibition of the growth of human melanoma metastases in nude mice by melanoma-specific murine monoclonal antibody.
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Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage.
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Interleukin 2 produced by activated B lymphocytes acts as an autocrine proliferation-inducing lymphokine.
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Interleukin-10: An Immune-Activating Cytokine in Cancer Immunotherapy.
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Interleukin-15 augments superoxide production and microbicidal activity of human monocytes against Candida albicans.
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Interleukin-2 activity in patients with extensive small-cell lung cancer: a phase II trial of Cancer and Leukemia Group B.
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Interleukin-2 immunotherapy and AIDS-related cytomegalovirus retinitis.
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Interleukin-2 immunotherapy of murine cytomegalovirus retinitis during MAIDS correlates with increased intraocular CD8+ T-cell infiltration.
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Interleukin-2 receptor expression in peripheral blood lymphocytes from systemic lupus erythematosus patients: relationship to clinical activity.
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Interleukin-2 reverses CD8(+) T cell exhaustion in clinical malignant pleural effusion of lung cancer.
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Interleukin-2-induced dermatotoxicity resembling toxic epidermal necrolysis.
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Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.
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Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.
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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
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LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
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Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.
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Landscape of stimulation-responsive chromatin across diverse human immune cells.
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Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells.
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Long-term biopsychosocial effects of interleukin-2 therapy.
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Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells.
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Long-term killing of natural killer-resistant target cells by interferon-alpha-, interferon-gamma-, and interleukin-2-activated natural killer cells.
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Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: Cancer and Leukemia Group B Study 9720.
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Lymphokine-activated killer (LAK) cell anti-HIV-1 ADCC reactivity: a potential strategy for reduction of virus-infected cellular reservoirs.
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Lymphokine-activated killer cell activity after cryopreservation.
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Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.
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Measurement of cytokine release at the single cell level using the ELISPOT assay.
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Mechanism of immune response during immunotherapy.
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Mechanism of the anti-tumour effect of biochemotherapy in melanoma: preliminary results.
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Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy.
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Modulation of in vitro autologous melanoma-specific cytotoxic T-cell responses by phorbol dibutyrate and ionomycin.
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Modulation of specific active immunization against murine melanoma using recombinant cytokines.
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Molecular signals in B cell activation. I. Differential refractory effects of incomplete signaling by ionomycin or PMA relate to autocrine IL-2 production and IL-2R expression.
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Molecular signals in B cell activation. II. IL-2-mediated signals are required in late G1 for transition to S phase after ionomycin and PMA treatment.
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Mucosal melanoma.
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Murine cytomegalovirus retinitis during retrovirus-induced immunodeficiency (MAIDS) in mice: interleukin-2 immunotherapy correlates with increased intraocular levels of perforin mRNA.
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Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice.
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Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression.
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Mutation analysis of IL2RG in human X-linked severe combined immunodeficiency.
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Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
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NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system.
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Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy.
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Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.
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Overall survival by clinical risk category for high dose interleukin-2 (HD IL-2) treated patients with metastatic renal cell cancer (mRCC): data from the PROCLAIMSM registry.
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Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency.
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Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.
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Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
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Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.
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Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine.
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Pertussis toxin triggers rapid second messenger production in human T lymphocytes.
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Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100.
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Phase 2 study of the g209-2M melanoma peptide vaccine and low-dose interleukin-2 in advanced melanoma: Cancer and Leukemia Group B 509901.
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Phase I studies of interleukin (IL)-2 and rituximab in B-cell non-hodgkin's lymphoma: IL-2 mediated natural killer cell expansion correlations with clinical response.
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Phase I study of low-dose interleukin-2, fludarabine, and cyclophosphamide for previously untreated indolent lymphoma and chronic lymphocytic leukemia.
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Phase I trial of interleukin-2 plus doxorubicin.
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Phase I trial of interleukin-2 plus gamma-interferon.
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Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma.
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Phase I/II trial of intermittent subcutaneous IL-2 administration in pediatric patients with moderate immune suppression: results of Pediatric AIDS Clinical Trials Study 402.
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Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma.
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Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.
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Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma.
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Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.
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Positively selected Leu-11a (CD16+) cells require the presence of accessory cells or factors for the lysis of herpes simplex virus-infected fibroblasts but not herpes simplex virus-infected Raji.
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Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420.
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Predictors of complete responses with denileukin diftitox in cutaneous T-cell lymphoma.
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Preparative cytoreductive surgery in patients with metastatic renal cell carcinoma treated with adoptive immunotherapy with interleukin-2 or interleukin-2 plus lymphokine activated killer cells.
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Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
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Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.
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Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway.
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Quality-of-life improvements in cutaneous T-cell lymphoma patients treated with denileukin diftitox (ONTAK).
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RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.
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Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection.
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Recombinant interleukin-2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: results from Cancer and Leukemia Group B 19808.
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Reconstitution of high affinity IL-2 receptor expression in a human T-cell line using a retroviral cDNA expression vector.
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Regulation of transcription factor NFAT by ADP-ribosylation.
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Renal allograft-infiltrating lymphocytes. A prospective analysis of in vitro growth characteristics and clinical relevance.
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Renal cell carcinoma treated with continuous-infusion interleukin-2 with ex vivo-activated killer cells.
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Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells.
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Repression of interleukin-2 mRNA translation in primary human breast carcinoma tumor-infiltrating lymphocytes.
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Requirement for Abl kinases in T cell receptor signaling.
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Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
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Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.
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Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS.
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Retroviruses and human cancer: evaluation of T-lymphocyte transformation by human T-cell leukemia-lymphoma virus.
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Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection.
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Risk of bowel perforation in patients receiving interleukin-2 after therapy with anti-CTLA 4 monoclonal antibody.
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Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.
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Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2.
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Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor.
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Sequential chemoimmunotherapy with cisplatin, interleukin-2, and interferon alfa-2a for metastatic melanoma.
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Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity.
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Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice.
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Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable low-breadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2.
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Significance of cytokine gene polymorphism in renal transplantation.
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Solution structure of the core NFATC1/DNA complex.
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Specific activation strategies for amplification of low CTL signals.
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Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.
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Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.
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Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease.
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Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques.
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Subcutaneous interleukin-2 as initial therapy for patients with extensive small cell lung cancer: a phase II trial of Cancer and Leukemia Group B.
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Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.
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Subcutaneously administered recombinant human interleukin-2 and interferon alfa-2a for advanced breast cancer: a phase II study of the Cancer and Leukemia Group B (CALGB 9041).
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Surfactant protein A modulates induction of regulatory T cells via TGF-β.
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Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats.
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Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.
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Systemic cytokine immunotherapy for experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency.
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Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab.
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T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.
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T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.
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T-bet:Eomes balance, effector function, and proliferation of cytomegalovirus-specific CD8+ T cells during primary infection differentiates the capacity for durable immune control.
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TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
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TGF-beta inhibits the in vitro induction of lymphokine-activated killing activity.
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Targeting the IL-2 inducible kinase in melanoma; a phase 2 study of ibrutinib in systemic treatment-refractory distant metastatic cutaneous melanoma: preclinical rationale, biology, and clinical activity (NCI9922).
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Technology evaluation: gene therapy (IL-2), Valentis Inc.
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The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes.
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The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success.
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The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.
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The effect of AZT on in vitro lymphokine-activated killer (LAK) activity in human immunodeficiency virus type-1 (HIV-1) infected individuals.
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The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
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The importance of studying history: lessons learnt from a trial of tacrolimus in myasthenia gravis.
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The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
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The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell response.
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The pathway to biomarker discovery: carbonic anhydrase IX and the prediction of immune responsiveness.
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The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.
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The role of the L3T4 molecule in mitogen and antigen-activated signal transduction.
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The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
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The suppressive effect of a synthetic retroviral peptide on the human IFN gamma production is abrogated by the combined stimulation with IL-1 and IL-2.
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The virologic, immunologic, and clinical effects of interleukin 2 with potent antiretroviral therapy in patients with moderately advanced human immunodeficiency virus infection: a randomized controlled clinical trial--AIDS Clinical Trials Group 328.
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Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice.
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Thromboxane augmentation of alloreactive T cell function.
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Timing of plasmid cytokine (IL-2/Ig) administration affects HIV-1 vaccine immunogenicity in HIV-seronegative subjects.
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Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism.
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Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model.
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Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
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Treatment of advanced colorectal cancer.
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Treatment of human melanoma hepatic metastases in nude mice with human cytotoxic T lymphocytes.
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Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines.
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Tumor microenvironment: what have we learned studying the immune response in this puzzling battlefield?
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Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor.
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Two forms of NF-kappa B1 (p105/p50) in murine macrophages: differential regulation by lipopolysaccharide, interleukin-2, and interferon-gamma.
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Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
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Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy.
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Vaccine-elicited immune responses prevent clinical AIDS in SHIV(89.6P)-infected rhesus monkeys.
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Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1.
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[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis].
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p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
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Keywords of People
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Buckley, Rebecca Hatcher,
Professor Emeritus of Pediatrics,
Pediatrics, Allergy and Immunology
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Hemmers, Saskia,
Assistant Professor in Immunology,
Immunology
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Hoimes, Christopher,
Instructor in the Department of Medicine,
Medicine, Medical Oncology
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Lagoo, Anand Shreeram,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology