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Subject Areas on Research
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A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions.
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Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.
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Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.
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An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells.
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Autologous bone marrow transplantation in acute myelogenous leukemia: in vitro treatment with myeloid-specific monoclonal antibodies and drugs in combination.
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CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.
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Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis.
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Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3).
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Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli.
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Conversion of Bcl-2 to a Bax-like death effector by caspases.
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Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3.
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Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13.
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Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand.
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Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.
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Cytokine-regulated expression of activated leukocyte cell adhesion molecule (CD166) on monocyte-lineage cells and in rheumatoid arthritis synovium.
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Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1.
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Effects of hematopoietic growth factors following myeloablation in a primate model.
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Effects of interleukin-3 on hematopoietic recovery after 5-fluorouracil or cyclophosphamide treatment of cynomolgus primates.
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Enhanced HIV-1 activity in bone marrow can lead to myelopoietic suppression partially contributed by gag p24.
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Enhanced expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors.
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Enrichment of peripheral blood stem cells in a primate model following administration of a single dose of rh-IL-1 beta.
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Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.
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Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines.
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Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.
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Granulocyte-macrophage colony-stimulating factor and interleukin-3 mRNAs are produced by a small fraction of blood mononuclear cells.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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Growth factors can influence cell growth and survival through effects on glucose metabolism.
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Hematopoietic growth factors: ESMO Clinical Practice Guidelines for the applications.
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High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains.
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Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU.
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Identification of a critical regulatory site in the human interleukin-3 promoter by in vivo footprinting.
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In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.
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Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal.
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Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and an octamer binding protein.
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Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
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Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.
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JAK2 is required for induction of the murine DUB-1 gene.
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Mechanism of differentiation of human erythroleukaemic cell line K562 by hemin.
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Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
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Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.
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Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia.
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Positive and negative elements regulate human interleukin 3 expression.
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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.
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Purification and partial characterization of a human hematopoietic precursor population.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Regulation of the human interleukin-3 gene.
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Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression.
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Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
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Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis.
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Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.
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The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells.
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The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells.
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The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell.
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The effect of PIXY-321 on 4-hydroperoxycyclophosphamide purged and CD34+ positively selected bone marrow.
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Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor.
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