Interleukins
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Subject Areas on Research
- A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.
- A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling.
- A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice.
- A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection.
- A vital role for interleukin-21 in the control of a chronic viral infection.
- APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy.
- Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts.
- Alterations in macrophage phenotypes in experimental venous thrombosis.
- An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response.
- Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients.
- Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.
- B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation.
- Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C.
- Biomarkers, mineralocorticoid receptor antagonism, and cardiorenal remodeling.
- CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis.
- Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C.
- Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants.
- Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-α-based regimens.
- Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.
- Cytokine mRNA expression in postischemic/reperfused myocardium.
- Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization.
- Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.
- Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein.
- Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
- Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: impaired viral kinetics and therapeutic response.
- Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques.
- Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
- Genetic variation in IL28B: impact on drug development for chronic hepatitis C infection.
- Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.
- Genome-wide association studies in asthma: what they really told us about pathogenesis.
- HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway.
- Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.
- Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype.
- Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling.
- High predictive accuracy of an unbiased proteomic profile for sustained virologic response in chronic hepatitis C patients.
- Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA.
- IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.
- IL-21 Biased Alemtuzumab Induced Chronic Antibody-Mediated Rejection Is Reversed by LFA-1 Costimulation Blockade.
- IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
- IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.
- IL-31 Inhibition as a Therapeutic Approach for the Management of Chronic Pruritic Dermatoses.
- IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
- IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin.
- IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: the future of personalized HCV therapies.
- IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C.
- IL28B in the era of direct-acting antivirals for hepatitis C.
- IL28B polymorphism is not associated with HCV protease diversity in patients co-infected with HIV and HCV treated with pegylated interferon and ribavirin.
- IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients.
- Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis.
- Immunopathogenesis of genital Chlamydia infection: insights from mouse models.
- Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.
- Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV.
- Implementation of Pharmacogenetic Testing Within the Veterans Health Administration From 2011 to 2013.
- Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans.
- Individualized therapy for hepatitis C infection: focus on the interleukin-28B polymorphism in directing therapy.
- Inflammation and cardiopulmonary bypass.
- Inflammation in coronary artery disease.
- Inflammatory response to cardiopulmonary bypass.
- Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats.
- Influence of interleukin-28B single-nucleotide polymorphisms on progression to liver cirrhosis in human immunodeficiency virus-hepatitis C virus-coinfected patients receiving antiretroviral therapy.
- Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men.
- Interferon lambda protects the female reproductive tract against Zika virus infection.
- Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.
- Interleukin 12 at the site of disease in tuberculosis.
- Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response.
- Interleukin-21: a multifunctional regulator of immunity to infections.
- Interleukin-27 promotes CD8+ T cell reconstitution following antibody-mediated lymphoablation.
- Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.
- Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus.
- Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia.
- Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.
- Lost in translation? IL28B's discovery and the journey back to the patient.
- Management of hepatitis C virus infection: the basics.
- Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV.
- Multiple gamma c-dependent cytokines regulate T-cell development.
- Perfluorocarbon administration during cardiopulmonary bypass in rats: an inflammatory link to adverse outcome?
- PharmGKB summary: peginterferon-α pathway.
- Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection.
- Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection.
- Predictors of consent to pharmacogenomics testing in the IDEAL study.
- Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization.
- Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
- Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.
- Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection.
- Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
- Sustained stress response after oxidative stress in trabecular meshwork cells.
- Systemic cytokine immunotherapy for experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency.
- The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity.
- The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection.
- The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.
- The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.
- The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.
- Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.
- Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection.
- Using biomarkers to assess risk and consider treatment strategies in non-ST-segment elevation acute coronary syndromes.
- [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis].
- [Antitumoral action of interferons and interleukins in combination with radiotherapy. Part II: radiobiological and immunologic strategies].
- [IL-21 induces regulatory B cell differentiation and immunosuppressive effect through cognate interaction with T cells].
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Keywords of People
- Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
- Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics