Intermediate Filaments

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  Subject Areas on Research

  • A maturational model for the study of airway smooth muscle adaptation to mechanical oscillation. 
  • A model for slow axonal transport and its application to neurofilamentous neuropathies. 
  • A structural comparison of tryptic fragments of three types of intermediate filaments. 
  • An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. 
  • Ca(2+)-regulated serine protease associated with the nuclear scaffold. 
  • Increased calmodulin affects cell morphology and mRNA levels of cytoskeletal protein genes. 
  • Intermediate filament associated proteins. 
  • Intronic NEFH variant is associated with reduced risk for sporadic ALS and later age of disease onset. 
  • Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit. 
  • Organized deposits in the kidney and look-alikes. 
  • Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. 
  • Roles for Ndel1 in keratin organization and desmosome function. 
  • Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. 
  • Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. 
  • Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments. 
  • Structural characteristics of the desmin protofilament. 
  • The human keratin genes and their differential expression. 
  • Ultrastructural features of diffuse malignant mesotheliomas. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute