Interneurons

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  Subject Areas on Research

  • A bird's eye view: top down intracellular analyses of auditory selectivity for learned vocalizations. 
  • A circuit for motor cortical modulation of auditory cortical activity. 
  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. 
  • A striatal interneuron circuit for continuous target pursuit. 
  • Activation of specific interneurons improves V1 feature selectivity and visual perception. 
  • Acute restraint stress redirects prefrontal cortex circuit function through mGlu₅ receptor plasticity on somatostatin-expressing interneurons. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS. 
  • BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. 
  • Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch. 
  • Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties. 
  • Biochemical plasticity of short-axon interneurons: increased glutamate decarboxylase activity in the denervated area of rat dentate gyrus following entorhinal lesion. 
  • Calcium-binding proteins define interneurons in HVC of the zebra finch (Taeniopygia guttata). 
  • Calcium-dependent gamma-aminobutyrate release by interneurons of rat hippocampal regions: lesion-induced plasticity. 
  • Cellular and Synaptic Properties of Local Inhibitory Circuits. 
  • Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. 
  • Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala. 
  • Cholecystokinin excites interneurons in rat basolateral amygdala. 
  • Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. 
  • Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. 
  • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. 
  • Cortical interneurons that specialize in disinhibitory control. 
  • Dendrites of classes of hippocampal neurons differ in structural complexity and branching patterns. 
  • Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia. 
  • Development of GABA innervation in the cerebral and cerebellar cortices. 
  • Developmental differences in the sensitivity of spontaneous and miniature IPSCs to ethanol. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Different subthreshold mechanisms underlie song selectivity in identified HVc neurons of the zebra finch. 
  • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. 
  • Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses. 
  • Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. 
  • Differential sensitivity of hippocampal interneurons to ethanol in adolescent and adult rats. 
  • Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. 
  • Disinhibition in rat superior colliculus mediated by GABAc receptors. 
  • Dissociation of Unit Activity and Gamma Oscillations during Vocalization in Primate Auditory Cortex. 
  • Distinct behavioural and network correlates of two interneuron types in prefrontal cortex. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. 
  • Distinct recruitment of feedforward and recurrent pathways across higher-order areas of mouse visual cortex. 
  • Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. 
  • Dynamics of networks of randomly connected excitatory and inhibitory spiking neurons. 
  • Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons. 
  • Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus. 
  • Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network. 
  • Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus. 
  • Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures. 
  • Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period. 
  • Feed-forward inhibitory potentials and excitatory interactions in guinea-pig hippocampal pyramidal cells. 
  • Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy. 
  • Forever young: Neoteny, neurogenesis and a critique of critical periods in olfaction. 
  • From subthreshold to firing-rate resonance. 
  • Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans. 
  • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. 
  • GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons. 
  • GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border. 
  • Gain modulation by nicotine in macaque v1. 
  • Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells. 
  • Glutamic acid decarboxylase-67-positive hippocampal interneurons undergo a permanent reduction in number following kainic acid-induced degeneration of ca3 pyramidal neurons. 
  • High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors. 
  • Hippocampal interneurons expressing glutamic acid decarboxylase and calcium-binding proteins decrease with aging in Fischer 344 rats. 
  • Hub GABA neurons mediate gamma-frequency oscillations at ictal-like event onset in the immature hippocampus. 
  • Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells. 
  • Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. 
  • Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging. 
  • Identifying local and descending inputs for primary sensory neurons. 
  • Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. 
  • Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. 
  • Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. 
  • Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia. 
  • Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. 
  • Inhibition stabilization is a widespread property of cortical networks. 
  • Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition. 
  • Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy. 
  • Interneurons from embryonic development to cell-based therapy. 
  • Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis. 
  • Interneurons of the dentate-hilus border of the rat dentate gyrus: morphological and electrophysiological heterogeneity. 
  • Intrinsically determined cell death of developing cortical interneurons. 
  • LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system. 
  • LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling. 
  • Lineage-specific laminar organization of cortical GABAergic interneurons. 
  • Long-range inhibition within the zebra finch song nucleus RA can coordinate the firing of multiple projection neurons. 
  • Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood. 
  • MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. 
  • Mechanisms of increased hippocampal excitability in the Mashl+/- mouse model of Na+ /K+ -ATPase dysfunction. 
  • Modeling effects of spinal cord stimulation on wide-dynamic range dorsal horn neurons: influence of stimulation frequency and GABAergic inhibition. 
  • Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists. 
  • Morphological features of the entorhinal-hippocampal connection. 
  • Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons. 
  • Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission. 
  • Muscarinic acetylcholine receptors in macaque V1 are most frequently expressed by parvalbumin-immunoreactive neurons. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. 
  • Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. 
  • Neural basis for motor learning in the vestibuloocular reflex of primates. I. Changes in the responses of brain stem neurons. 
  • Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex. 
  • Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. 
  • Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. 
  • New insights into the classification and nomenclature of cortical GABAergic interneurons. 
  • Non-monotonic effects of GABAergic synaptic inputs on neuronal firing. 
  • Nonlinear signal transfer from mouse rods to bipolar cells and implications for visual sensitivity. 
  • Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell. 
  • Numb antagonizes Notch signaling to specify sibling neuron cell fates. 
  • Olfactory Bulb Deep Short-Axon Cells Mediate Widespread Inhibition of Tufted Cell Apical Dendrites. 
  • Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia. 
  • PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons. 
  • Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. 
  • Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. 
  • Persistent activity and the single-cell frequency-current curve in a cortical network model. 
  • Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. 
  • Presynaptic inhibition of spinal sensory feedback ensures smooth movement. 
  • Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity. 
  • Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. 
  • Recurrent circuitry dynamically shapes the activation of piriform cortex. 
  • Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. 
  • Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex. 
  • Responses during eye movements of brain stem neurons that receive monosynaptic inhibition from the flocculus and ventral paraflocculus in monkeys. 
  • Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons. 
  • SEMA3A signaling controls layer-specific interneuron branching in the cerebellum. 
  • Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells. 
  • Sparing of Descending Axons Rescues Interneuron Plasticity in the Lumbar Cord to Allow Adaptive Learning After Thoracic Spinal Cord Injury. 
  • Spatial and temporal scales of neuronal correlation in visual area V4. 
  • Steady-state electrotonic analysis of intracellularly stained hippocampal neurons. 
  • Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior. 
  • Striatal mechanisms of turning behaviour following unilateral dopamine depletion in mice. 
  • Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. 
  • Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. 
  • Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. 
  • Synaptic organization and acetylcholine sensitivity of multiply innervated autonomic ganglion cells. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • Targeting cells with single vectors using multiple-feature Boolean logic. 
  • The HVC microcircuit: the synaptic basis for interactions between song motor and vocal plasticity pathways. 
  • The diversity of GABAergic neurons and neural communication elements. 
  • The spatial and temporal origin of chandelier cells in mouse neocortex. 
  • Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. 
  • Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. 
  • Transitions between sleep and feeding states in rat ventral striatum neurons. 
  • Visual identification of two kinds of nerve cells and their synaptic contacts in a living autonomic ganglion of the mudpuppy (Necturus maculosus). 
  • What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance. 
  • Working memory: The real VIP. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
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  Keywords of People

  • Field, Greg D., Associate Professor of Neurobiology, Neurobiology
  • Schmehl, Meredith, Student, Neurobiology
  • Sommer, Marc A., Associate Professor of Biomedical Engineering, Duke Science & Society
  • Tsalik, Ephraim, Adjunct Associate Professor in the Department of Medicine, Medicine, Infectious Diseases
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering