Intervertebral Disc

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  Subject Areas on Research

  • A linear material model for fiber-induced anisotropy of the anulus fibrosus. 
  • A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape. 
  • A nonlinear hyperelastic mixture theory model for anisotropy, transport, and swelling of annulus fibrosus. 
  • Alterations in the mechanical behavior of the human lumbar nucleus pulposus with degeneration and aging. 
  • Anisotropic and inhomogeneous tensile behavior of the human anulus fibrosus: experimental measurement and material model predictions. 
  • Annulus cells release ATP in response to vibratory loading in vitro. 
  • Anterior disc excision and interbody spinal fusion for chronic low back pain. 
  • Anterior intervertebral discectomy and arthrodesis for treatment of low back pain with or without radiculopathy. 
  • Assessment of apparent diffusion coefficient in normal and degenerated intervertebral lumbar disks: initial experience. 
  • Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project. 
  • Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist. 
  • Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project. 
  • Biomaterials for intervertebral disc regeneration and repair. 
  • Cell mechanics and mechanobiology in the intervertebral disc. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging. 
  • Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures. 
  • Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. 
  • Degeneration affects the anisotropic and nonlinear behaviors of human anulus fibrosus in compression. 
  • Degeneration and aging affect the tensile behavior of human lumbar anulus fibrosus. 
  • Degenerative adult onset scoliosis. 
  • Degenerative disease of the lumbar spine. Role of CT-myelography in the MR era. 
  • Degenerative lumbar scoliosis. 
  • Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. 
  • Diagnostic findings in painful adult scoliosis. 
  • Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc. 
  • Diffusion tensor microscopy of the intervertebral disc anulus fibrosus. 
  • Directions for future research. 
  • Does smoking have an impact on fusion rate in single-level anterior cervical discectomy and fusion with allograft and rigid plate fixation? Clinical article. 
  • Dynamic responses of the head and cervical spine to axial impact loading. 
  • Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen. 
  • Endplate changes following discectomy: natural history and associations between imaging and clinical data. 
  • Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc. 
  • Extracellular matrix ligand and stiffness modulate immature nucleus pulposus cell-cell interactions. 
  • Extreme lateral interbody fusion with posterior instrumentation for spondylodiscitis. 
  • Frequency, risk factors, and treatment of distal adjacent segment pathology after long thoracolumbar fusion: a systematic review. 
  • Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. 
  • Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. 
  • High-resolution determination of soft tissue deformations using MRI and first-order texture correlation. 
  • Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system. 
  • Hyperconcavity of the lumbar vertebral endplates in the elite football lineman. 
  • Hyperosmotically induced volume change and calcium signaling in intervertebral disk cells: the role of the actin cytoskeleton. 
  • IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress. 
  • Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration. 
  • Integrin expression in cells of the intervertebral disc. 
  • Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. 
  • Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis. 
  • Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells. 
  • Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture. 
  • Intervertebral disc degeneration. Proceedings of a workshop organized by the American Academy of Orthopaedic Surgeons, the National Institutes of Health, and the Orthopaedic Research Society. September 15-18, 2005. 
  • Intervertebral disc degeneration. Summary of an AAOS/NIH/ORS workshop, September 2005. 
  • Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. 
  • Introduction: disc degeneration: summary. 
  • Is the nucleus pulposus a solid or a fluid? Mechanical behaviors of the nucleus pulposus of the human intervertebral disc. 
  • Lumbar disc excision in children and adolescents. 
  • Male and Female Cervical Spine Biomechanics and Anatomy: Implication for Scaling Injury Criteria. 
  • Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity. 
  • Measurement of intracellular strain on deformable substrates with texture correlation. 
  • Mechanobiology of the intervertebral disc and relevance to disc degeneration. 
  • Minimally invasive transforaminal lumbar interbody fusion with expandable versus static interbody devices: radiographic assessment of sagittal segmental and pelvic parameters. 
  • Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. 
  • Nucleus pulposus cell-matrix interactions with laminins. 
  • Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR. 
  • Pathologic quiz case: acute-onset paraplegia in a 60-year-old woman. Spinal cord infarction secondary to fibrocartilaginous (intervertebral disk) embolism. 
  • Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration. 
  • Rat spinal motion segment in organ culture: a cell viability study. 
  • Regulation of human nucleus pulposus cells by peptide-coupled substrates. 
  • Replacement of intervertebral discs in chimpanzees by silicone-dacron implants: a preliminary report. 
  • Role of computed tomography in the radiological evaluation of painful radiculopathy after negative myelography: foraminal neural entrapment. 
  • Sagittal cervical alignment after cervical disc arthroplasty and anterior cervical discectomy and fusion: results of a prospective, randomized, controlled trial. 
  • Scaffolding in tissue engineering: general approaches and tissue-specific considerations. 
  • Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis. 
  • Segmental contribution toward total lumbar range of motion in disc replacement and fusions: a comparison of operative and adjacent levels. 
  • Self-report of depressive symptoms in low back pain patients. 
  • Significant new observations on cervical spine trauma. 
  • Simple method for determining the need for sternotomy/manubriotomy with the anterior approach to the cervicothoracic junction. 
  • Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration. 
  • Small intestinal submucosa for anular defect closure: long-term response in an in vivo sheep model. 
  • Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro. 
  • Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells. 
  • Tensile properties of nondegenerate human lumbar anulus fibrosus. 
  • The association between lumbar spine radiographic features and low back pain: a systematic review and meta-analysis. 
  • The effects of bone density and disc degeneration on the structural property distributions in the lower lumbar vertebral endplates. 
  • The future of spinal arthroplasty: a biomaterial perspective. 
  • The impact of coronal alignment of device on radiographic degeneration in the case of total disc replacement. 
  • The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. 
  • The micromechanical environment of intervertebral disc cells: effect of matrix anisotropy and cell geometry predicted by a linear model. 
  • The relative value of lumbar roentgenograms, metrizamide myelography, and discography in the assessment of patients with chronic low-back syndrome. 
  • The role of F-actin in hypo-osmotically induced cell volume change and calcium signaling in anulus fibrosus cells. 
  • The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review. 
  • The viscoelastic behavior of the non-degenerate human lumbar nucleus pulposus in shear. 
  • Thoracolumbar deformity arthrodesis to L5 in adults: the fate of the L5-S1 disc. 
  • Three-dimensional culture of rabbit nucleus pulposus cells in collagen microspheres. 
  • Three-dimensional morphology of the pericellular matrix of intervertebral disc cells in the rat. 
  • Traumatic burst fracture in a patient with a lumbar artificial disc. 
  • Vibratory loading decreases extracellular matrix and matrix metalloproteinase gene expression in rabbit annulus cells. 
  • Viscoelastic properties of intervertebral disc cells. Identification of two biomechanically distinct cell populations. 
  • [Observations on the transabdominal approach in excision of diseased intervertebral disks]. 
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  Keywords of People

  • Nightingale, Roger W, Adjunct Associate Professor of Biomedical Engineering, Biomedical Engineering