Intestines

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  Subject Areas on Research

  • A 25-year experience with postresection short-bowel syndrome secondary to radiation therapy. 
  • A Neural Circuit for Gut-Induced Reward. 
  • A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities. 
  • A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. 
  • A decade of experience with a single dose of rabbit antithymocyte globulin or alemtuzumab pretreatment for intestinal and multivisceral transplantation. 
  • A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites. 
  • A mathematical model to evaluate the routine use of fecal microbiota transplantation to prevent incident and recurrent Clostridium difficile infection. 
  • A mouse model of juvenile hemochromatosis. 
  • A multidisciplinary approach to the treatment of intestinal failure. 
  • A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. 
  • Adenine nucleotides of ischemic intestine do not reflect injury. 
  • Agent-Based Modelling to Delineate Spatiotemporal Control Mechanisms of the Stem Cell Niche. 
  • Analysis of results of radiation therapy for stage IB carcinoma of the cervix. 
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. 
  • Aquacultured rainbow trout (Oncorhynchus mykiss) possess a large core intestinal microbiota that is resistant to variation in diet and rearing density. 
  • Ascaris suum, an intestinal parasite, produces morphine. 
  • Assessment of quality of life after pediatric intestinal transplantation by parents and pediatric recipients using the child health questionnaire. 
  • Atypical presentation of inflammatory bowel disease in the elderly. 
  • Autologous gastrointestinal reconstruction: review of the optimal nontransplant surgical options for adults and children with short bowel syndrome. 
  • B cells contribute to ischemia/reperfusion-mediated tissue injury. 
  • Basiliximab decreases the incidence of acute rejection after intestinal transplantation. 
  • Bipolar sealing increases mesenteric reach during bowel transection compared with stapled division: clinical evidence and laboratory support in a porcine model. 
  • Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice. 
  • Bmp signaling is required for intestinal growth and morphogenesis. 
  • CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells. 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Campath-1H in intestinal and multivisceral transplantation: preliminary data. 
  • Can Glycine Mitigate COVID-19 Associated Tissue Damage and Cytokine Storm? 
  • Cell biology: A guardian angel of cell integrity. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines. 
  • Clinical intestinal transplantation: new perspectives and immunologic considerations. 
  • Combination regimens with statin, niacin, and intestinally active LDL-lowering drugs: alternatives to high-dose statin therapy? 
  • Comparison of fecal biota from specific pathogen free and feral mice. 
  • Comparison of short bowel syndrome acquired early in life and during adolescence. 
  • Comparison of the intestinal and serum antibody response in patients with dermatitis herpetiformis. 
  • Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir. 
  • Contribution of neutral processes to the assembly of gut microbial communities in the zebrafish over host development. 
  • Control of ingestion in 6-day-old rat pups: termination of intake by gastric fill alone? 
  • Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge. 
  • Corroborating evidence refutes batch effect as explanation for fetal bacteria. 
  • Cost and quality of life after intestinal transplantation. 
  • Current status of intestinal transplantation in children. 
  • Cytomegalovirus infection after intestinal transplantation in children. 
  • Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes. 
  • Deciphering the tête-à-tête between the microbiota and the immune system. 
  • Decompression sickness risk reduced by native intestinal flora in pigs after H2 dives. 
  • Degeneration of the central nervous system associated with celiac disease. 
  • Detection of intestinal dysplasia using angle-resolved low coherence interferometry. 
  • Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. 
  • Disaccharidase activities and fat assimilation in pediatric patients after intestinal transplantation. 
  • Distal ventriculoperitoneal shunt failure secondary to Clostridium difficile colitis. 
  • Does the intestinal microflora synthesize pyrroloquinoline quinone? 
  • Effects of dietary pectin and cellulose on hepatic and intestinal mixed-function oxidations and hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the rat. 
  • Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. 
  • Electrical stimulation of the conus medullaris to control the bladder in the paraplegic patient. A 10-year review. 
  • Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif. 
  • Enteric conversion of bladder-drained pancreas allografts: experience in 95 patients. 
  • Enteroaggregative Escherichia coli Subclinical Infection and Coinfections and Impaired Child Growth in the MAL-ED Cohort Study. 
  • Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. 
  • Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells. 
  • Estimation of liver and intestine lipids of rat by silicic acid column chromatography. 
  • Evaluating outcomes of enterocystoplasty in patients with spina bifida: a review of the literature. 
  • Evidence for a core gut microbiota in the zebrafish. 
  • Experience with the duodenal switch operation in the presence of intestinal malrotation. 
  • Experiences with bladder reconstruction in children. 
  • Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells. 
  • Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. 
  • Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges. 
  • Frailty in liver transplantation: An expert opinion statement from the American Society of Transplantation Liver and Intestinal Community of Practice. 
  • Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. 
  • Gastrointestinal dysfunction in the critically ill: nutritional implications. 
  • Genetic control of single lumen formation in the zebrafish gut. 
  • Genetically induced microtubule disruption in the mouse intestine impairs intracellular organization and transport. 
  • Glafenine-induced intestinal injury in zebrafish is ameliorated by μ-opioid signaling via enhancement of Atf6-dependent cellular stress responses. 
  • Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans. 
  • Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models. 
  • Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. 
  • Gut flora-based therapy in liver disease? The liver cares about the gut. 
  • Gut immune maturation depends on colonization with a host-specific microbiota. 
  • Gut microbes out of control in HIV infection. 
  • HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. 
  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. 
  • Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. 
  • Human syngeneic intestinal transplantation: evaluation of enterocyte viability with serum levels of intestinal fatty acid binding protein. 
  • Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. 
  • IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. 
  • IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model. 
  • Identification of nonsulfated cholecystokinin-58 in canine intestinal extracts and its biological properties. 
  • Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. 
  • Implication of gut microbiota in nonalcoholic fatty liver disease. 
  • Implications of hypoxia on mucosal barrier function. 
  • In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. 
  • Incidence and risk factors associated with the development of cytomegalovirus disease after intestinal transplantation. 
  • Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys. 
  • Inflammasome, Inflammation, and Tissue Homeostasis. 
  • Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88. 
  • Influence of donor criteria on early outcome after intestinal transplantation. 
  • Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. 
  • Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols. 
  • Inhibition of gastric emptying in response to intestinal lipid is dependent on chylomicron formation. 
  • Initial experience using rapamycin immunosuppression in pediatric intestinal transplant recipients. 
  • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. 
  • Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. 
  • Interaction of ethanol and acute hypoxia (7620 m) on vitamin A distribution in rat organs. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice. 
  • Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia. 
  • Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. 
  • Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. 
  • Intestinal and hepatic complications of human bone marrow transplantation. Part II. 
  • Intestinal knockout of Nedd4 enhances growth of Apc^min tumors. 
  • Intestinal lengthening for short bowel syndrome. 
  • Intestinal lengthening in adult patients with short bowel syndrome. 
  • Intestinal malrotation in neonates with nonbilious emesis. 
  • Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. 
  • Intestinal transplantation: a single-center experience. 
  • Intestinal transplantation: the University of Wisconsin experience. 
  • Intestine Transplantation Across a Positive Crossmatch With Preformed Donor-Specific Antibodies. 
  • Isolated intestinal transplantation for intestinal failure. 
  • L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells. 
  • Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). 
  • Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection. 
  • Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. 
  • Lactose drives Enterococcus expansion to promote graft-versus-host disease. 
  • Late graft loss and long-term outcome after isolated intestinal transplantation in children. 
  • Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain. 
  • Liver and intestine transplantation in the United States 1998-2007. 
  • Liver and intestine transplantation in the United States, 1997-2006. 
  • Long-term outcomes and quality of life after intestine transplantation. 
  • Long-term results of intestinal transplantation for pseudo-obstruction in children. 
  • Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. 
  • Magnetic resonance imaging for detection of arterial and venous occlusion in canine muscle flaps and bowel segments. 
  • Management of the bladder outlet in patients requiring enterocystoplasty. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. 
  • Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine. 
  • Metabolic Teamwork in the Stem Cell Niche. 
  • Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. 
  • Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function. 
  • Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. 
  • Microbiota of Inflammatory Bowel Disease Models. 
  • Microbiota regulate intestinal absorption and metabolism of fatty acids in the zebrafish. 
  • Modulation of decompression sickness risk in pigs with caffeine during H(2) biochemical decompression. 
  • Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. 
  • Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae. 
  • Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Moving beyond microbiome-wide associations to causal microbe identification. 
  • NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. 
  • Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium. 
  • Non-alcoholic fatty liver disease: lumen-liver interactions and possible role for probiotics. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells. 
  • Novel mechanism of rapamycin in GVHD: increase in interstitial regulatory T cells. 
  • Nutrient tasting and signaling mechanisms in the gut. IV. There is more to taste than meets the tongue. 
  • Omeprozole therapy in pediatric patients after liver and intestinal transplantation. 
  • On the likelihood of decompression sickness during H(2) biochemical decompression in pigs. 
  • Organ uptake and release of inorganic nitrate and nitrite in the pig. 
  • P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury. 
  • PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock. 
  • Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome. 
  • Pathologic features of enteric infection with Yersinia enterocolitica. 
  • Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas. 
  • Pneumatosis intestinalis. Surgical management and clinical outcome. 
  • Postoperative short bowel syndrome. 
  • Posttransplant infection in enteric versus bladder-drained simultaneous pancreas-kidney transplant recipients. 
  • Predicting outcome of procedures to slow intestinal transit. 
  • Predictors of Enteral Autonomy in Children with Intestinal Failure: A Multicenter Cohort Study. 
  • Preformed and de novo donor specific antibodies in visceral transplantation: long-term outcome with special reference to the liver. 
  • Pregnancy with prolonged fetal exposure to an angiotensin-converting enzyme inhibitor. 
  • Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery. 
  • Prenatal ultrasonographic findings associated with short bowel syndrome in two fetuses with gastroschisis. 
  • Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. 
  • Prospective evaluation of Peristeen® transanal irrigation system with the validated neurogenic bowel dysfunction score sheet in the pediatric population. 
  • Quality of life after intestinal transplantation. 
  • Quality of life after pediatric intestinal transplantation: the perception of pediatric recipients and their parents. 
  • Race affects outcome among infants with intestinal failure. 
  • Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis. 
  • Rapid changes in the gut microbiome during human evolution. 
  • Recent advances in hepatic transplantation at the University of Pittsburgh. 
  • Regulation of cholecystokinin synthesis and secretion in rat intestine. 
  • Regulation of expression of transcobalamin II receptor in the rat. 
  • Regulation of intestinal cholecystokinin and somatostatin mRNA by bombesin in rats. 
  • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. 
  • Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification. 
  • Results of solitary pancreas transplantation with enteric drainage: is there a benefit from monitoring urinary amylase levels? 
  • Role of an intestinal rehabilitation program in the treatment of advanced intestinal failure. 
  • Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection. 
  • Role of platelet activating factor in the inflammatory and secretory effects of Clostridium difficile toxin A. 
  • Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice. 
  • Short bowel syndrome after laparoscopic procedures. 
  • Short bowel syndrome after trauma. 
  • Short bowel syndrome following bariatric surgical procedures. 
  • Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. 
  • Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Studies on the epidemiology of antibiotic-associated Clostridium difficile colitis. 
  • Study of host-microbe interactions in zebrafish. 
  • Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors. 
  • Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration. 
  • Swirl Sign - Intestinal Volvulus after Roux-en-Y Gastric Bypass. 
  • Terry Lechler: the cytoskeleton is skin deep. Interview by Nicole LeBrasseur. 
  • The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis. 
  • The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. 
  • The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems. 
  • The composition of the zebrafish intestinal microbial community varies across development. 
  • The intestinal lymph fistula model--a novel approach to study ghrelin secretion. 
  • The intestinal tuft cell nanostructure in 3D. 
  • The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. 
  • The structure of a molybdopterin precursor. Characterization of a stable, oxidized derivative. 
  • The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA. 
  • Thresholds for thermal damage to normal tissues: an update. 
  • Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. 
  • Toxic effect of the roasted and unroasted beans of Cassia occidentalis in goats. 
  • Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. 
  • Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium. 
  • Treatment of intestinal failure: intestinal transplantation. 
  • Urinary diversion in the genitourinary cancer survivor. 
  • Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases. 
  • Use of L-glutamine in total parenteral nutrition. 
  • Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose. 
  • Viable bacterial colonization is highly limited in the human intestine in utero. 
  • Viscera affectum anno: the gut beyond eating behaviours. 
  • Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment. 
  • [A case of congenital malabsorption of lactose]. 
  • c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. 
  • mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium. 
  • n-3 Canola oil effectively replaces fish oil as a new safe dietary source of DHA in feed for juvenile Atlantic salmon. 
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  Keywords of People

  • Bradford, William Dalton, Professor of Pathology, Pathology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Karhausen, Jorn, Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering