Intracellular Membranes

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  Subject Areas on Research

  • A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. 
  • Adaptation of cat motoneurons to sustained and intermittent extracellular activation. 
  • Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Assays for characterizing URF13, the pathotoxin and methomyl receptor of cms-T maize. 
  • Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. 
  • Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. 
  • CD9 plays a role in Schwann cell migration in vitro. 
  • COPII and secretory cargo capture into transport vesicles. 
  • Calcium- and polyphosphate-containing acidocalcisomes in chicken egg yolk. 
  • Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes. 
  • Central regulation of photosensitive membrane turnover in the lateral eye of Limulus, II: octopamine acts via adenylate cyclase/cAMP-dependent protein kinase to prime the retina for transient rhabdom shedding. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Comparison of human growth hormone binding to rat liver plasma and Golgi membranes. 
  • Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0. 
  • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. 
  • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. 
  • Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus. 
  • Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis. 
  • Dystonia with and without deafness is caused by TIMM8A mutation. 
  • Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. 
  • Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium. 
  • Effect of spermine on membranolytic effect of vitamin A in rats. 
  • Electrical characteristics of dendrites and dendritic spines in intracellularly stained CA3 and dentate hippocampal neurons. 
  • Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. 
  • Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins. 
  • Energy transfer assays of rat renal cortical endosomal fusion: evidence for superfusion. 
  • Evidence for a junctional feet-ryanodine receptor complex from sarcoplasmic reticulum. 
  • Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion. 
  • Exogenously administered growth hormone and insulin-like growth factor-I alter intracellular Ca2+ handling and enhance cardiac performance. In vitro evaluation in the isolated isovolumic buffer-perfused rat heart. 
  • Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes. 
  • Extracellular trafficking of myocilin in human trabecular meshwork cells. 
  • Function of tightly bound nucleotides on membrane-bound chloroplast coupling factor. 
  • Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. 
  • Human trabecular meshwork cell volume regulation. 
  • Hydrogen peroxide production by alveolar type II cells, alveolar macrophages, and endothelial cells. 
  • Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. 
  • Identification of a novel stage of ribosome/nascent chain association with the endoplasmic reticulum membrane. 
  • Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. 
  • Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells. 
  • In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. 
  • Ion beam etching effects in biological microanalysis. 
  • Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Membrane potential mediates H(+)-ATPase dependence of "degradative pathway" endosomal fusion. 
  • Membrane topology and biogenesis of eukaryotic signal peptidase. 
  • Membrane translocation and regulation of uridine diphosphate-glucuronic acid uptake in rat liver microsomal vesicles. 
  • Membranous cytochrome c oxidase. A freeze-fracture electron microscopic analysis. 
  • Methods to Visualize MAVS Subcellular Localization. 
  • Microsomal membranes contain a high affinity binding site for prenylated peptides. 
  • Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. 
  • Modulation of thromboxane receptor activation in rat glomerular mesangial cells. 
  • NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Nucleotide receptors regulate membrane ion transport in renal epithelial cells. 
  • Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. 
  • Oxidative stress and adenine nucleotide control of mitochondrial permeability transition. 
  • Paracrystalline inclusions associated with the disk membranes of frog retinal rod outer segments. 
  • Placental lactogen receptors in maternal sheep liver: effects of fasting and refeeding. 
  • Prenylated peptides in identification of specific binding proteins. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Proteolytic domains of the epidermal growth factor receptor of human placenta. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Reconstitution of secretory protein translocation from detergent-solubilized rough microsomes. 
  • Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates. 
  • Regulation of cation channels in liver cells by intracellular calcium and protein kinase C. 
  • Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool. 
  • Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. 
  • Retrospective diagnosis of carnitine-acylcarnitine translocase deficiency by acylcarnitine analysis in the proband Guthrie card and enzymatic studies in the parents. 
  • Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. 
  • Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Snare protein expression and adenoviral transfection of amphicrine AR42J. 
  • Subcellular organelle lipidomics in TLR-4-activated macrophages. 
  • Sweet host revenge: Galectins and GBPs join forces at broken membranes. 
  • TRANSPORTER OF IBA1 Links Auxin and Cytokinin to Influence Root Architecture. 
  • The channel of death. 
  • The chromaffin granule as a model for membrane fusion: implications for exocytosis. 
  • The localization of the light-harvesting complexes in the intracytoplasmic membranes of Rhodopseudomonas capsulata [proceedings]. 
  • The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. 
  • The secretory granule matrix-electrolyte interface: a homologue of the p-n rectifying junction. 
  • Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. 
  • URF13, a ligand-gated, pore-forming receptor for T-toxin in the inner membrane of cms-T mitochondria. 
  • URF13, a maize mitochondrial pore-forming protein, is oligomeric and has a mixed orientation in Escherichia coli plasma membranes. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma