Ion Channels

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  Subject Areas on Research

  • 5' exon replacement and repair by spliceosome-mediated RNA trans-splicing. 
  • A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. 
  • A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels. 
  • A novel, calcium-induced triphasic current response in silent, non-bursting Aplysia neurons. 
  • A possible role for TRPV4 receptors in asthma. 
  • A quantitative description of QX222 blockade of sodium channels in squid axons. 
  • A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime. 
  • A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain. 
  • Abnormal osmotic regulation in trpv4-/- mice. 
  • Activation by odorants of a multistate cation channel from olfactory cilia. 
  • Activators and inhibitors of the ion channel of the NMDA receptor. 
  • Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain. 
  • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • Aldosterone, ion channels, and sudden death: another piece of the circle? 
  • Altering the topology of gap junctions a major therapeutic target for atrial fibrillation. 
  • Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease. 
  • An upper limit for the electrogenic Na-K pump contribution to maximum diastolic potential in feline cardiac Purkinje fibers in steady state. 
  • Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. 
  • Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting. 
  • Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases. 
  • Ankyrins. 
  • Antiarrhythmic drug action. Blockade of the inward sodium current. 
  • Aquaporins and ion conductance. 
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. 
  • Astringent-tasting compounds alter ion transport across isolated canine lingual epithelia. 
  • Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. 
  • Barbiturate effects on acetylcholine-activated channels in Aplysia neurons. 
  • Basic concepts in cellular cardiac electrophysiology: Part I: Ion channels, membrane currents, and the action potential. 
  • Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Binding of 3H-phenamil, an irreversible amiloride analog, to toad urinary bladder: effects of aldosterone and vasopressin. 
  • Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel. 
  • Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel. 
  • Calcium-activated inward spike after-currents in bursting neurone R15 of Aplysia. 
  • Calmodulin and CaMKII as molecular switches for cardiac ion channels. 
  • Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. 
  • Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. 
  • Cardiac ion channels. 
  • Cationic selectivity and competition at the sodium entry site in frog skin. 
  • Cell Volume Regulation in the Proximal Tubule of Rat Kidney : Proximal Tubule Cell Volume Regulation. 
  • Cell biology and physiology of the uroepithelium. 
  • Channel shutdown: a response of hippocampal neurons to adverse environments. 
  • Channeling a new focus for heart failure: insights into ion channels. 
  • Characterization and property of DNA incorporated bilayer lipid membranes. 
  • Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro. 
  • Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins. 
  • Characterizing activity-dependent processes with a piecewise exponential model. 
  • Clinical relevance of defects in signalling pathways. 
  • Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. 
  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. 
  • Conditions for the triggering of spreading depression studied with computer simulations. 
  • Coupled sodium-calcium transport in cultured chick heart cells. 
  • Cultured human trabecular meshwork cells express aquaporin-1 water channels. 
  • Depression by calcium of spontaneous transmitter release at the mammalian neuromuscular junction. 
  • Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. 
  • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. 
  • Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. 
  • Diphenylhydantoin reduces the outward current of the action potential in Aplysia. 
  • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Divide, multitask, and conquer: Coordination in channel regulation. 
  • Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. 
  • Effect of exercise on cation transport in human red cells. 
  • Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo. 
  • Effects of hypertonia on voltage-gated ion currents in freshly isolated hippocampal neurons, and on synaptic currents in neurons in hippocampal slices. 
  • Effects of strongly anisosmotic and NaCl deficient solutions on muscimol- and glutamate evoked whole-cell currents in freshly dissociated hippocampal neurons. 
  • Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants. 
  • Electrocardiographic Early Repolarization: A Scientific Statement From the American Heart Association. 
  • Electrochemical study of ion channel behavior in incorporated poly L-glutamate bilayer lipid membranes. 
  • Electrophysiological correlates to the intrinsic optical signal in the rat neocortical slice. 
  • Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization. 
  • Energy metabolism in uncoupling protein 3 gene knockout mice. 
  • Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies. 
  • Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. 
  • Evidence against formation of A23187 dimers and oligomers in solution: photo-induced degradation of Ionophore A23187. 
  • Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum. 
  • Evidence for a junctional feet-ryanodine receptor complex from sarcoplasmic reticulum. 
  • Evidence for the role of cell stiffness in modulation of volume-regulated anion channels. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Factors modulating the sensitivity of the GABA receptor-gated chloride ion channel. 
  • Fate of antidiuretic hormone water channel proteins after retrieval from apical membrane. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Fluorescent epibatidine agonists for neuronal and muscle-type nicotinic acetylcholine receptors. 
  • Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. 
  • Forskolin stimulation of water and cation permeability in aquaporin 1 water channels. 
  • Frequency- and orientation-dependent effects of mexiletine and quinidine on conduction in the intact dog heart. 
  • Functional equivalence of monomeric (shark) and dimeric (bovine) cytochrome c oxidase. 
  • Functional reconstitution of purified human Hv1 H+ channels. 
  • G protein coupling of receptors to ionic channels and other effector systems. 
  • G protein coupling of receptors to ionic channels and other effector systems. 
  • Generation and customization of biosynthetic excitable tissues for electrophysiological studies and cell-based therapies. 
  • Genetic control of single lumen formation in the zebrafish gut. 
  • Genetics of cardiac repolarization. 
  • Genome-wide association study of sepsis in extremely premature infants. 
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes. 
  • High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. 
  • How many channels should there be in a gap junction? 
  • How noise affects the synchronization properties of recurrent networks of inhibitory neurons. 
  • Human pluripotent stem cells decouple respiration from energy production. 
  • Idealization and simulation of single ion channel data. 
  • Identification of G protein-gated and G protein-modulated ionic channels. Molecular basis for G protein action. 
  • Identification of two calcium channel receptor sites for [3H]nitrendipine in mammalian cardiac and smooth muscle membrane. 
  • Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix. 
  • Inactivation of the sodium current in squid giant axons by hydrocarbons. 
  • Increased vascular smooth muscle contractility in TRPC6-/- mice. 
  • Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. 
  • Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. 
  • Influence of the gamma subunit and expression system on acetylcholine receptor gating. 
  • Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent on depolarization via channel activation. 
  • Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel. 
  • Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. 
  • Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. 
  • Interstitial volume changes during spreading depression (SD) and SD-like hypoxic depolarization in hippocampal tissue slices. 
  • Intracellular potassium activity in rabbit sinoatrial node. Evaluation during spontaneous activity and arrest. 
  • Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy. 
  • Ion channel behavior of supported bilayer lipid membranes on a glassy carbon electrode. 
  • Ion channel involvement in hypoxia-induced spreading depression in hippocampal slices. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Ion channels in analgesia research. 
  • Ion channels under the sun. 
  • Ion regulation in the brain: implications for pathophysiology. 
  • Ion-channel sensing of ferricyanide anion based on a supported bilayer lipid membrane. 
  • Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. 
  • Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates. 
  • Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance. 
  • Localized force application reveals mechanically sensitive domains of Piezo1. 
  • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. 
  • Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. 
  • Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension. 
  • Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. 
  • Mechanisms of action of antiarrhythmic drugs: from ion channel blockage to arrhythmia termination. 
  • Mechanisms of apparent affinity variation of guarded receptors. 
  • Mechanisms of atrial fibrillation and action of drugs used in its management. 
  • Mechanisms of closure of cardiac sodium channels in rabbit ventricular myocytes: single-channel analysis. 
  • Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. 
  • Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors. 
  • Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. 
  • Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. 
  • Membrane currents underlying bursting pacemaker activity and spike frequency adaptation in invertebrates. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. 
  • Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control". 
  • Modeling ion channel blockade at guarded binding sites: application to tertiary drugs. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. 
  • Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. 
  • Multiple calcium-mediated effector mechanisms regulate chloride secretory responses in T84-cells. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex. 
  • NMR studies of combined lanthanide shift and relaxation agents for differential characterization of 23Na in a two-compartment model system. 
  • Nature of light-induced conductance changes in ventral photoreceptors of Limulus. 
  • Networking ionic channels by G proteins. 
  • Neurogenic inflammation and pancreatitis. 
  • Neurotrophins differentially regulate voltage-gated ion channels. 
  • Nitric oxide and differential effects of ATP on mitochondrial permeability transition. 
  • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. 
  • On the structure of the hemocyanin channel in lipid bilayers. 
  • Oxidants, antioxidants and the ischemic brain. 
  • PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. 
  • Phasic ion channel blockade. A kinetic model and parameter estimation procedure. 
  • Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder. 
  • Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Piezo proteins are pore-forming subunits of mechanically activated channels. 
  • Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. 
  • Pleiotropic function of TRPV4 ion channels in the central nervous system. 
  • Presynaptic calcium dynamics and transmitter release evoked by single action potentials at mammalian central synapses. 
  • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. 
  • Prolonged inhibition in burst firing neurons: synaptic inactivation of the slow regenerative inward current. 
  • Purification and reconstitution of the calcium release channel from skeletal muscle. 
  • ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. 
  • Radiohistochemical demonstration of NMDA/glycine-channel activation in rat hippocampus. 
  • Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro. 
  • Regulation of cation channels in liver cells by intracellular calcium and protein kinase C. 
  • Regulation of epithelial chloride channels by protein phosphatase. 
  • Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals. 
  • Regulation of ion channel structure and function by reactive oxygen-nitrogen species. 
  • Regulation of ionic channels by G proteins. 
  • Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines. 
  • Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid. 
  • Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cells. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Role of Piezo Channels in Joint Health and Injury. 
  • Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. 
  • Roles of bilayer material properties in function and distribution of membrane proteins. 
  • S-Nitrosylation of cardiac ion channels. 
  • Seizure-like afterdischarges simulated in a model neuron. 
  • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. 
  • Signal discretization: a source of error in histograms of ion channel events. 
  • Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. 
  • Simulation of use-dependent uptake of ion channel blocking agents by excitable membranes. 
  • Single cell transcriptome analysis of mouse carotid body glomus cells. 
  • Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. 
  • Steady state variables in the guarded receptor hypothesis. 
  • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. 
  • Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. 
  • Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. 
  • Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex. 
  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. 
  • Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • TRPV1b, a functional human vanilloid receptor splice variant. 
  • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. 
  • TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. 
  • Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report. 
  • The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function. 
  • The channel of death. 
  • The effects of bilayer thickness and tension on gramicidin single-channel lifetime. 
  • The genetics of the J wave patterns. 
  • The ionic mechanism of the slow outward current in Aplysia neurons. 
  • The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. 
  • The perplexing complexity of cardiac arrhythmias: beyond electrical remodeling. 
  • The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats. 
  • The salty and burning taste of capsaicin. 
  • Theoretical characterization of ion channel blockade. Competitive binding to periodically accessible receptors. 
  • Theoretical characterization of ion channel blockade: ligand binding to periodically accessible receptors. 
  • Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels. 
  • Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. 
  • Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels. 
  • Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. 
  • Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution. 
  • Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel. 
  • Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. 
  • Unitary sodium channels in isolated cardiac myocytes of rabbit. 
  • Use of ionic currents to identify and estimate parameters in models of channel blockade. 
  • Use of the single electrode voltage clamp to perform noise and relaxation studies of acetylcholine-activated channels in Aplysia neurons. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • [Bradykinin modulates ion channel in inflammatory pain]. 
  • beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase. 
  • gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. 
  • pKa does not predict pH potentiation of sodium channel blockade by lidocaine and W6211 in guinea pig ventricular myocardium. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Liu, Boyi, Adjunct Assistant Professor in the Department of Anesthesiology, Anesthesiology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Schwartz-Bloom, Rochelle D., Professor Emeritus of Pharmacology & Cancer Biology, Duke Science & Society
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology