Iron

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  Subject Areas on Research

  • 2002 E. Mead Johnson Award for Research in Pediatrics Lecture: the molecular biology of the anemia of chronic disease: a hypothesis. 
  • 57Fe and 1H electron-nuclear double resonance of three doubly reduced states Escherichia coli sulfite reductase. 
  • A general map of iron metabolism and tissue-specific subnetworks. 
  • A genetic view of iron homeostasis. 
  • A hot-vent gastropod with iron sulfide dermal sclerites. 
  • A molybdopterin-free form of xanthine oxidase. 
  • A mouse model of familial porphyria cutanea tarda. 
  • A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia. 
  • A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A new MRI ratio method for in-vivo estimation of signal hypointensity in aging and Alzheimer's disease. 
  • A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. 
  • A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. 
  • A perspective essay on the use of Ga³⁺ as a proxy for Fe³⁺ in bioinorganic model studies and its successful use for therapeutic purposes. 
  • A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation. 
  • A randomized trial of blood donor iron repletion on red cell quality for transfusion and donor cognition and well-being. 
  • A review of the environmental implications of in situ remediation by nanoscale zero valent iron (nZVI): Behavior, transport and impacts on microbial communities. 
  • A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea. 
  • ABCs of erythroid mitochondrial iron uptake. 
  • AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia. 
  • Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration. 
  • Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures. 
  • Acid mucopolysaccharides in the outflow apparatus. 
  • Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. 
  • Adherence to Iron Chelation Therapy with Deferasirox Formulations among Patients with Sickle Cell Disease and β-thalassemia. 
  • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. 
  • An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins--From superoxide dismutation to H2O2-driven pathways. 
  • An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Analysis of the E399D mutation in SLC11A2. 
  • Anemia of inflammation: the cytokine-hepcidin link. 
  • Anemia of inflammation: the hepcidin link. 
  • Animal models of hereditary iron transport disorders. 
  • Antioxidant enzyme expression in clinical isolates of Pseudomonas aeruginosa: identification of an atypical form of manganese superoxide dismutase. 
  • Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Aqueous solution speciation of Fe(III) complexes with dihydroxamate siderophores alcaligin and rhodotorulic acid and synthetic analogues using electrospray ionization mass spectrometry. 
  • Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model. 
  • Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. 
  • Assessing abnormal iron content in the deep gray matter of patients with multiple sclerosis versus healthy controls. 
  • Assessing global and regional iron content in deep gray matter as a function of age using susceptibility mapping. 
  • Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults. 
  • At the Crossroads for Intravenous Iron Dosing. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Balancing acts: molecular control of mammalian iron metabolism. 
  • Baleen whale prey consumption based on high-resolution foraging measurements. 
  • Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis. 
  • Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Borate as a synergistic anion for Marinobacter algicola ferric binding protein, FbpA: a role for boron in iron transport in marine life. 
  • Brain Iron Assessment after Ferumoxytol-enhanced MRI in Children and Young Adults with Arteriovenous Malformations: A Case-Control Study. 
  • Calcineurin is required for Candida albicans to survive calcium stress in serum. 
  • Calcium oxalate and iron accumulation in sarcoidosis. 
  • Carbohydrate histochemistry of surface epithelium of rat trachea: backscatter and x-ray imaging. 
  • Carbon monoxide binding by simple heme proteins under photodissociating conditions. 
  • Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function. 
  • Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury. 
  • Carrier-facilitated bulk liquid membrane transport of iron(III)-siderophore complexes utilizing first coordination sphere recognition. 
  • Cases from the Osler Medical Service at Johns Hopkins University. Diffuse colonic angiodysplasia with chronic iron deficiency anemia. 
  • Cell identity mediates the response of Arabidopsis roots to abiotic stress. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Changes in streptonigrin lethality during adaptation of Escherichia coli to picolinic acid. Correlation with intracellular picolinate and iron uptake. 
  • Characterization and pathogenesis of anemia in glycogen storage disease type Ia and Ib. 
  • Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria. 
  • Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products. 
  • Characterizing reactive oxygen generation and bacterial inactivation by a zerovalent iron-fullerene nano-composite device at neutral pH under UV-A illumination. 
  • Chemical aspects of siderophore mediated iron transport. 
  • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. 
  • Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis. 
  • Closing the iron gate. 
  • Commentary on: ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption. 
  • Comparative effectiveness studies to improve clinical outcomes in end stage renal disease: the DEcIDE patient outcomes in end stage renal disease study. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism. 
  • Comprehensive Survey of ChIP-Seq Datasets to Identify Candidate Iron Homeostasis Genes Regulated by Chromatin Modifications. 
  • Computational studies of small carbon and iron-carbon systems relevant to carbon nanotube growth. 
  • Construction of a catalytically active iron superoxide dismutase by rational protein design. 
  • Construction of a novel redox protein by rational design: conversion of a disulfide bridge into a mononuclear iron-sulfur center. 
  • Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. 
  • Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. 
  • Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release. 
  • Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates. 
  • Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. 
  • Cortical iron mediates age-related decline in fluid cognition. 
  • Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Crystal structure of ferrioxamine B: a comparative analysis and implications for molecular recognition. 
  • Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. 
  • Current status of metals as therapeutic targets in Alzheimer's disease. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Deficiency of α-1-antitrypsin influences systemic iron homeostasis. 
  • Deposition of silver nanoparticles in geochemically heterogeneous porous media: predicting affinity from surface composition analysis. 
  • Detection of hepatic lesions in candidates for surgery: comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT. 
  • Detection of iron deficiency in children with Down syndrome. 
  • Determination of the stoichiometry of electron uptake and the midpoint reduction potentials of milk xanthine oxidase at 25 degrees C by microcoulometry. 
  • Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. 
  • Diacetyl exposure disrupts iron homeostasis in animals and cells. 
  • Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging. 
  • Disorders of iron metabolism. 
  • Disorders of iron metabolism. 
  • Disorders of iron metabolism. 
  • Disorders of iron metabolism. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Disruption of iron homeostasis in mesothelial cells after talc pleurodesis. 
  • Disruption of iron homeostasis in the lungs of transplant patients. 
  • Distribution of brain iron accrual in adolescence: Evidence from cross-sectional and longitudinal analysis. 
  • Distribution of transferrin saturations in the African-American population. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Divalent metal transporter-1 decreases metal-related injury in the lung. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • Drusen of the optic disc. A retrospective study in cadaver eyes. 
  • Dual contrast enhancement of both T1- and T2-weighted sequences using ultrasmall superparamagnetic iron oxide. 
  • Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. 
  • ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY). 
  • Editorial: awareness and prevention of intravenous iron-induced hypophosphataemia. 
  • Effect of a Low-Rank Denoising Algorithm on Quantitative Magnetic Resonance Imaging-Based Measures of Liver Fat and Iron. 
  • Effects of a single bout of ultraendurance exercise on lipid levels and susceptibility of lipids to peroxidation in triathletes. 
  • Effects of anthropogenic disturbance on indri (Indri indri) health in Madagascar. 
  • Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. 
  • Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial. 
  • Efficacy of iron-supplement bars to reduce anemia in urban Indian women: a cluster-randomized controlled trial. 
  • Electron paramagnetic resonance and optical evidence for interaction between siroheme and Fe4S4 prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands. 
  • Electron paramagnetic resonance studies of iron reduction and semiquinone formation in metalloflavoproteins. 
  • Elucidation of a [4Fe-4S] cluster degradation pathway: rapid kinetic studies of the degradation of Chromatium vinosum HiPIP. 
  • Emerging mechanistic targets in lung injury induced by combustion-generated particles. 
  • Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect. 
  • Energy Transduction in Nitrogenase. 
  • Enhanced mobilization of iron from body stores in malnourished patients during intravenous nutritional support. 
  • Ethyne-bridged (porphinato)zinc(II)-(porphinato)iron(III) complexes: phenomenological dependence of excited-state dynamics upon (porphinato)iron electronic structure. 
  • Evidence for a low Km transporter for non-transferrin-bound iron in isolated rat hepatocytes. 
  • Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport. 
  • Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine. 
  • Examination of the relationship between iron status and cognitive function among healthy young women with and without a recent history of blood donation. 
  • Experimental detection of iron overload in liver through neutron stimulated emission spectroscopy. 
  • Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • FGF23 at the crossroads of phosphate, iron economy and erythropoiesis. 
  • Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study. 
  • Factors that influence siderophoremediated iron bioavailability: catalysis of interligand iron (III) transfer from ferrioxamine B to EDTA by hydroxamic acids. 
  • FbpA--a bacterial transferrin with more to offer. 
  • Fe(III) coordination properties of a new saccharide-based exocyclic trihydroxamate analogue of ferrichrome. 
  • Fe(III) coordination properties of two new saccharide-based enterobactin analogues: methyl 2,3,4-tris-O-[N-[2,3-di(hydroxy)benzoyl-glycyl]-aminopropyl]-alpha-D-glucopyranoside and methyl 2,3,4-tris-O-[N-[2,3-di-(hydroxy)-benzoyl]-aminopropyl]-alpha-D-glucopyranoside. 
  • Fe(III)-complexes of the tripodal trishydroxamate siderophore basidiochrome: potential biological implications. 
  • Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. 
  • Fe3+ coordination and redox properties of a bacterial transferrin. 
  • Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial. 
  • Ferritin and increased vs upper reference interval tibc saturation to identify increased iron stores in African Americans. 
  • Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. 
  • Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. 
  • Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. 
  • Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. 
  • Focal nodular hyperplasia: intraindividual comparison of dynamic gadobenate dimeglumine- and ferucarbotran-enhanced magnetic resonance imaging. 
  • Folding dynamics of phenylalanine hydroxylase depends on the enzyme's metallation state: the native metal, iron, protects against aggregate intermediates. 
  • Forging a field: the golden age of iron biology. 
  • Four-decade responses of soil trace elements to an aggrading old-field forest: B, Mn, Zn, Cu, and Fe. 
  • GI Evaluation of Iron Deficiency Anemia: Clinical Decision Support Tool. 
  • Generation of hydroxyl radical by crocidolite asbestos is proportional to surface [Fe3+]. 
  • Genes determining blood cell traits. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Groundwater Chemistry Has a Greater Influence on the Mobility of Nanoparticles Used for Remediation than the Chemical Heterogeneity of Aquifer Media. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Haptoglobin modifies the hemochromatosis phenotype in mice. 
  • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 
  • Heme oxygenase 1 is required for mammalian iron reutilization. 
  • Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. 
  • Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort. 
  • Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease. 
  • Hepatic iron concentration does not influence response to therapy with interferon plus ribavirin in chronic HCV infection. 
  • Hepatic iron overload: diagnosis and quantification by noninvasive imaging. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Hepcidin and disordered mineral metabolism in chronic kidney disease. 
  • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. 
  • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. 
  • Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. 
  • High-dose IV iron for anemia correction in chronic kidney disease. 
  • Hijacking transferrin bound iron: protein-receptor interactions involved in iron transport in N. gonorrhoeae. 
  • Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. 
  • Household food insecurity is a risk factor for iron-deficiency anaemia in a multi-ethnic, low-income sample of infants and toddlers. 
  • How catalysts affect the growth of single-walled carbon nanotubes on substrates. 
  • How do I develop a process to effectively treat parturients with iron deficiency anemia? 
  • Hungry irony. 
  • Hybrid resonant phenomena in a SRR/YIG metamaterial structure. 
  • Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose in patients with iron deficiency anaemia due to inflammatory bowel disease (PHOSPHARE-IBD): a randomised clinical trial. 
  • Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management. 
  • Hypothesis: iron chelation plays a vital role in neutrophilic inflammation. 
  • Identification of a novel mutation (C321X) in HJV. 
  • Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection. 
  • Impact of Sodium Humate Coating on Collector Surfaces on Deposition of Polymer-Coated Nanoiron Particles. 
  • Implementation of a Preoperative Anemia Clinic Utilizing a Minimal Staffing Model. 
  • Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron. 
  • Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes. 
  • In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. 
  • In vitro preparation of nonenzymatically glucosylated human transferrin, alpha 2-macroglobulin, and fibrinogen with preservation of function. 
  • In vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber. 
  • Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. 
  • Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. 
  • Influence of iron manipulation on hypoxic pulmonary vasoconstriction and pulmonary reactivity during ascent and acclimatization to 5050 m. 
  • Inhibitor of marrow thymidine incorporation from sera of patients with uremia. 
  • Interexamination repeatability and spatial heterogeneity of liver iron and fat quantification using MRI-based multistep adaptive fitting algorithm. 
  • Intestinal iron absorption: current concepts circa 2000. 
  • Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. 
  • Intravenous Iron-Induced Hypophosphatemia: An Emerging Syndrome. 
  • Intravenous iron administration strategies and anemia management in hemodialysis patients. 
  • Intravenous iron exposure and mortality in patients on hemodialysis. 
  • Iron Deficiency Anemia in Pregnancy. 
  • Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients. 
  • Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport. 
  • Iron accumulation in lung allografts after transplantation. 
  • Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. 
  • Iron and Iron-Related Proteins in Asbestosis. 
  • Iron and copper in mitochondrial diseases. 
  • Iron deficiency and hair loss: the jury is still out. 
  • Iron deficiency: lessons from anemic mice. 
  • Iron enhances the bactericidal action of streptonigrin. 
  • Iron homeostasis and erythropoiesis. 
  • Iron homeostasis and eye disease. 
  • Iron homeostasis and inherited iron overload disorders: an overview. 
  • Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. 
  • Iron homeostasis in the lung. 
  • Iron homeostasis. 
  • Iron homeostasis: insights from genetics and animal models. 
  • Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels. 
  • Iron in skin of mice with three etiologies of systemic iron overload. 
  • Iron increases expression of iron-export protein MTP1 in lung cells. 
  • Iron insufficiency and hypovitaminosis D in adolescents with chronic fatigue and orthostatic intolerance. 
  • Iron is essential for neuron development and memory function in mouse hippocampus. 
  • Iron is hot: an update on the pathophysiology of hemochromatosis. 
  • Iron metabolism and cell membranes. I. Relation between ferritin and hemosiderin in bile and biliary excretion of lysosome contents. 
  • Iron metabolism and cell membranes. II. The relationship of ferritin to the cytocavitary network in rat hepatic parenchymal cells. 
  • Iron metabolism and cell membranes. III. Iron-induced alterations in HeLa cells. 
  • Iron metabolism in mice with partial frataxin deficiency. 
  • Iron metabolism: iron deficiency and iron overload. 
  • Iron negative foci and nodules in safrole-exposed mouse liver made siderotic by iron-dextran injection. 
  • Iron overload due to X-linked sideroblastic anemia in an African American man. 
  • Iron overload following red blood cell transfusion and its impact on disease severity. 
  • Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. 
  • Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide. 
  • Iron requirement in the bactericidal mechanism of streptonigrin. 
  • Iron status, fibroblast growth factor 23 and cardiovascular and kidney outcomes in chronic kidney disease. 
  • Iron stores and cerebral veins in MS studied by susceptibility weighted imaging. 
  • Iron supplementation decreases severity of allergic inflammation in murine lung. 
  • Iron transport across biologic membranes. 
  • Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. 
  • Iron-dependent regulation of the divalent metal ion transporter. 
  • Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin. 
  • Is weekly iron and folic acid supplementation as effective as daily supplementation for decreasing incidence of anemia in adolescent girls? 
  • Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus). 
  • Joint effects of dietary trace metals and DNA repair capacity in lung cancer risk. 
  • Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis. 
  • Kinetics and mechanism of iron release from the bacterial ferric binding protein nFbp: exogenous anion influence and comparison with mammalian transferrin. 
  • Kinetics and mechanism of iron(III) complexation by ferric binding protein: the role of phosphate. 
  • Kinetics and mechanism of iron(III) dissociation from the dihydroxamate siderophores alcaligin and rhodotorulic acid. 
  • Kinetics of iron release from ferric binding protein (FbpA): mechanistic implications in bacterial periplasm-to-cytosol Fe3+ transport. 
  • Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism. 
  • Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. 
  • Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. 
  • Letter: inconsistency in reporting of hypophosphatemia after intravenous iron. 
  • Low serum iron levels. 
  • Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations. 
  • Lung injury after ozone exposure is iron dependent. 
  • MR Imaging of Diffuse Liver Disease. 
  • MR microscopy at 7.0 T: effects of brain iron. 
  • MRI of brain iron. 
  • Magnetic interactions in milk xanthine oxidase. 
  • Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects. 
  • Magnetic resonance imaging in hemochromatosis: extrahepatic iron deposition. 
  • Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients. 
  • Magnetic susceptibility of brain iron is associated with childhood spatial IQ. 
  • Mammalian iron transport: an unexpected link between metal homeostasis and host defense. 
  • Mapping oxidative DNA damage at nucleotide level. 
  • Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues. 
  • Marginal structural models for analyzing causal effects of time-dependent treatments: an application in perinatal epidemiology. 
  • Marine diatom proteorhodopsins and their potential role in coping with low iron availability. 
  • Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. 
  • Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. 
  • Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. 
  • Metabolic capacity regulates iron homeostasis in endothelial cells. 
  • Metal ion-dependent hydrogen peroxide-induced DNA damage is more sequence specific than metal specific. 
  • Metal transporters and disease. 
  • Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE. 
  • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. 
  • Mimosine, a novel inhibitor of DNA replication, binds to a 50 kDa protein in Chinese hamster cells. 
  • Mining copper transport genes. 
  • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. 
  • Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. 
  • Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. 
  • Molecular control of iron metabolism. 
  • Molecular insights into mechanisms of iron transport. 
  • Monomeric yeast frataxin is an iron-binding protein. 
  • Motility-indole-lysine-sulfide medium. 
  • Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. 
  • Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure. 
  • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). 
  • Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity. 
  • Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups. 
  • NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia. 
  • Near-infrared excited state dynamics of melanins: the effects of iron content, photo-damage, chemical oxidation, and aggregate size. 
  • Neonatal E. coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron. 
  • Neutrophil elastase increases airway epithelial nonheme iron levels. 
  • Nitration of tyrosine by hydrogen peroxide and nitrite. 
  • Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron. 
  • Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. 
  • Novel forms of structural integration between microbes and a hydrothermal vent gastropod from the Indian Ocean. 
  • Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Optimization of the lariat ether carboxylic acid host structure for ferrioxamine B: demonstration of a second coordination shell chelate effect. 
  • Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial. 
  • Oxalate deposition on asbestos bodies. 
  • Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. 
  • Oxidation-reduction potentials of molybdenum, flavin, and iron-sulfur centers in milk xanthine oxidase: variation with pH. 
  • Oxidative iron species and ocean challenges: a perspective. 
  • Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. 
  • Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. 
  • Pathophysiologic mechanisms of anemia of chronic disease. 
  • Patient Blood Management: Recommendations From the 2018 Frankfurt Consensus Conference. 
  • Perchlorate reduction by autotrophic bacteria attached to zerovalent iron in a flow-through reactor. 
  • Perchlorate reduction by autotrophic bacteria in the presence of zero-valent iron. 
  • Perioperative Anemia: Prevention, Diagnosis, and Management Throughout the Spectrum of Perioperative Care. 
  • Phenotypic characterization of murine models of cerebral cavernous malformations. 
  • Phenotyping heart failure patients for iron deficiency and use of intravenous iron therapy: data from the Swedish Heart Failure Registry. 
  • Phosphate ester hydrolysis is catalyzed by a bacterial transferrin: potential implications for in vivo iron transport mechanisms. 
  • Photosynthetic maximum quantum yield increases are an essential component of the Southern Ocean phytoplankton response to iron 
  • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. 
  • Potential impacts of leakage from deep CO2 geosequestration on overlying freshwater aquifers. 
  • Potential role of increased iron stores in diabetes. 
  • Prenatal stress perturbs fetal iron homeostasis in a sex specific manner. 
  • Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. 
  • Prevalence of heterozygotes for hemochromatosis in the white population of the United States. 
  • Prevalence of iron deficiency in children with Down syndrome. 
  • Probing the iron pool. Focus on "Detection of intracellular iron by its regulatory effect". 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Progressive improvement in wound healing with increased therapy in haemophilia B mice. 
  • Prolonged red cell storage before transfusion increases extravascular hemolysis. 
  • Promoting awareness of donation-related iron depletion among high risk blood donors. 
  • Protease cleavage of iron-transferrin augments pyocyanin-mediated endothelial cell injury via promotion of hydroxyl radical formation. 
  • Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. 
  • Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. 
  • Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. 
  • Pulmonary oxalate deposition associated with Aspergillus niger infection. An oxidant hypothesis of toxicity. 
  • Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles. 
  • Purification and properties of chicken liver xanthine dehydrogenase. 
  • Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase. 
  • Purification and properties of xanthine dehydroganase from Micrococcus lactilyticus. 
  • Quadruplex DNA formation in a region of the tRNA gene supF associated with hydrogen peroxide mediated mutations. 
  • Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, R2 and R2. 
  • Quantitative analysis of T2 signal intensities in Alzheimer's disease. 
  • Quantitative magnetic susceptibility of the developing mouse brain reveals microstructural changes in the white matter. 
  • Radiation synovectomy with 165Dy-FHMA: lymph node uptake and radiation dosimetry calculations. 
  • Randomised clinical trial of ferric citrate hydrate on anaemia management in haemodialysis patients with hyperphosphataemia: ASTRIO study. 
  • Randomized trial of intravenous iron-induced hypophosphatemia. 
  • Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. 
  • Reactive oxygen species produced by liver mitochondria of rats in sepsis. 
  • Real-world diagnostic testing patterns for assessment of ring sideroblasts and SF3B1 mutations in patients with newly diagnosed lower-risk myelodysplastic syndromes. 
  • Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers. 
  • Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humans. 
  • Redox potential determines the reaction mechanism of HNO donors with Mn and Fe porphyrins: defining the better traps. 
  • Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. VI. The reaction of carbon monoxide with the Escherichia coli holoenzyme, the hemoprotein, and free siroheme. 
  • Reduced stress defense in heme oxygenase 1-deficient cells. 
  • Regulation of iron absorption in Hfe mutant mice. 
  • Regulation of iron transport related genes by boron in the marine bacterium Marinobacter algicola DG893. 
  • Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli. 
  • Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey. 
  • Relationships between hepatic iron content and virologic response in chronic hepatitis C patients treated with interferon and ribavirin. 
  • Relative Reactivity and Bioavailability of Mercury Sorbed to or Coprecipitated with Aged Iron Sulfides. 
  • Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival of Haemophilus influenzae. 
  • Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 2. Fe4S4 cluster vibrational modes. 
  • Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. 
  • Review: In HF with iron deficiency, iron supplementation reduces HF admissions and improves cardiac function. 
  • Risk Factors for and Effects of Persistent and Severe Hypophosphatemia Following Ferric Carboxymaltose. 
  • Risk factors for mortality in patients with mucormycosis. 
  • Role of citrate and phosphate anions in the mechanism of iron(III) sequestration by ferric binding protein: kinetic studies of the formation of the holoprotein of wild-type FbpA and its engineered mutants. 
  • Role of oxidants in microbial pathophysiology. 
  • Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates. 
  • STRUCTURE AND FUNCTION OF IRON-FLAVOPROTEINS. 
  • Scara5 is a ferritin receptor mediating non-transferrin iron delivery. 
  • Sequestration of mitochondrial iron by silica particle initiates a biological effect. 
  • Short day lengths attenuate the symptoms of infection in Siberian hamsters. 
  • Sickle cell disease is associated with iron mediated hypercoagulability. 
  • Simultaneous and completely automated methods for serum iron and iron-binding capacity determinations. 
  • Siroheme and sirohydrochlorin. The basis for a new type of porphyrin-related prosthetic group common to both assimilatory and dissimilatory sulfite reductases. 
  • Siroheme: a prosthetic group of the Neurospora crassa assimilatory nitrite reductase. 
  • Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • Solving the problem at the source: controlling Mn release at the sediment-water interface via hypolimnetic oxygenation 
  • Southern Ocean Iron Enrichment Experiment: Carbon Cycling in High- and Low-Si Waters 
  • Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. 
  • Splenic magnetic resonance imaging using particulate agents. 
  • Spotlight: Gastrointestinal Evaluation of Iron Deficiency Anemia. 
  • Stream transport of iron and phosphorus by authigenic nanoparticles in the Southern Piedmont of the U.S. 
  • Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. I. Spectra at equilibrium states. 
  • Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy. II. Kinetic studies by rapid freezing. 
  • Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA: the origins and effects of anion promiscuity. 
  • Superoxide-dependent iron uptake: a new role for anion exchange protein 2. 
  • Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice. 
  • Superparamagnetic iron oxide particles (SH U 555 A): evaluation of efficacy in three doses for hepatic MR imaging. 
  • Surface-bound iron: a metal ion buffer in the marine brown alga Ectocarpus siliculosus? 
  • Synthesis and iron sequestration equilibria of novel exocyclic 3-hydroxy-2-pyridinone donor group siderophore mimics. 
  • Synthesis of Double-walled Carbon Nanotubes Using Iron Disilicide as Catalyst 
  • THE ABSORPTION SPECTRA OF IRON-FLAVOPROTEINS. 
  • TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells. 
  • Technical Note: On maximizing Cherenkov emissions from medical linear accelerators. 
  • Ternary complex formation facilitates a redox mechanism for iron release from a siderophore. 
  • The ASCEND-ND trial: study design and participant characteristics. 
  • The G185R mutation disrupts function of the iron transporter Nramp2. 
  • The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. 
  • The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans. 
  • The Southern Ocean biological response to aeolian iron deposition 
  • The association between intravenous iron for antenatal anemia and postnatal depression: a retrospective cohort study. 
  • The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. 
  • The core control system of intracellular iron homeostasis: a mathematical model. 
  • The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation. 
  • The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. 
  • The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. 
  • The ins and outs of iron homeostasis. 
  • The iron cycle and oxidative stress in the lung. 
  • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. 
  • The iron status of children and youth in a community mental health clinic is lower than that of a national sample. 
  • The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies. 
  • The molecular regulation of iron metabolism. 
  • The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease. 
  • The physics and neurobiology of magnetoreception. 
  • The redox hypothesis in siderophore-mediated iron uptake. 
  • The release of iron from different asbestos structures by hydrogen peroxide with concomitant O2 generation. 
  • The role of duodenal cytochrome b in intestinal iron absorption remains unclear. 
  • The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. 
  • The role of soluble components in ambient fine particles-induced changes in human lungs and blood. 
  • The role of zinc and iron-folic acid supplementation on early child temperament and eating behaviors in rural Nepal: a randomized controlled trial. 
  • The selection and evaluation of new chelating agents for the treatment of iron overload. 
  • The surface oxidation potential of melanosomes measured by free electron laser-photoelectron emission microscopy. 
  • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. 
  • Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients: ASCEND-TD: A Phase 3 Randomized, Double-Blind, Noninferiority Trial. 
  • Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. 
  • Transcriptomics in the wild: Hibernation physiology in free-ranging dwarf lemurs. 
  • Transferrin is required for early T-cell differentiation. 
  • Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. 
  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. 
  • Transfusion-related biologic effects and free hemoglobin, heme, and iron. 
  • Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development. 
  • Treatment of iron deficiency anemia: are monomeric iron compounds suitable for parenteral administration? 
  • Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates. 
  • Treatment patterns and outcomes in the management of anaemia in cancer patients in Europe: findings from the Anaemia Cancer Treatment (ACT) study. 
  • Treatment strategies for myeloid growth factors and intravenous iron: when, what, and how? 
  • Trends in anemia care in older patients approaching end-stage renal disease in the United States (1995-2010). 
  • Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. 
  • Under-mining health: environmental justice and mining in India. 
  • Understanding heme transport. 
  • Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study. 
  • Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda. 
  • Use of SDS micelles to stabilize a ternary intermediate in the reaction of ferrioxamine B and 1,10-phenanthroline. 
  • Vascular release of nonheme iron in perfused rabbit lungs. 
  • [Spontaneous motor activity in mice overloaded with iron-dextran]. 
  • pH-dependent conformational changes of ferricytochrome c induced by electrode surface microstructure. 
• 

  Keywords of People

  • Blum, Volker, Associate Professor in the Department of Mechanical Engineering and Materials Science, Nicholas Institute-Energy Initiative
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Schmid, Amy K., David M. Goodner Associate Professor, Duke Science & Society