Isoantigens

• 

  Subject Areas on Research

  • A comparison of the leukocyte agglutination and mixed agglutination techniques for detecting human tissue isoantigens. 
  • Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. 
  • Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. 
  • Allogeneic microchimerism and donor antigen-specific hyporeactivity in lung transplant recipients. 
  • Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • Anaemia in early infancy. 
  • Analysis of Fc gamma receptors on human peripheral blood leukocytes by flow microfluorometry. I. Receptor distributions on monocytes, T gamma cells and cells labeled with the 3Al anti-T cell monoclonal antibody. 
  • Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice. 
  • Blocking of autologous and homologous leukocyte responses by human alloimmune plasmas: a possible in vitro correlate of enhancement. 
  • Cellular immunology markers postransplantation predictive of long-term graft outcome. 
  • Characterization of chimpanzee leukocyte alloantisera. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Chronic rejection of mouse kidney allografts. 
  • Circulating donor antigen and response to donor antigen as predictors of long-term lung and kidney transplant success. 
  • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. 
  • Coordinator's report--section 2D3. 
  • Cross-reactivity of primate alloantigens: absorption of anti-HL-A reactivity from human alloantisera by chimpanzee lymphocytes. 
  • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. 
  • Cytotoxicity reactions of chimpanzee antisera with human lymphocyte donors phenotyped or genotyped for HL-A. 
  • Detection of both T-cell and Ia-like antigens on cells from patients with acute myelomonocytic leukemia and chronic myelogenous leukemia in blast crisis. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • EL-4 metastases in spleen and bone marrow suppress the NK activity generated in these organs. 
  • Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance. 
  • Gamma-irradiation reduces the allogenicity of donor corneas. 
  • Graft-versus-leukemia in the rat--the antileukemic efficacy of syngeneic and allogeneic graft-versus-host disease. 
  • HL-A antigenic loss in malignant transformation. 
  • Hepatic allograft-derived Kupffer cells regulate T cell response in rats. 
  • Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. 
  • Histocompatibility testing and mixed lymphocyte culture responses in chimpanzee families. 
  • Human B cell alloantigens: expression of MB and MT determinants. 
  • Human B cell alloantigens; alpha subunit variability. 
  • Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. 
  • Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. 
  • Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity. 
  • Human red cell antigens. IV. The abnormal sialoglycoprotein of Gerbich-negative red cells. 
  • Identification of human erythrocyte blood group antigens on the C3b/C4b receptor. 
  • Immune status assay (ISA): a noninvasive procedure for studying allograft rejection. 
  • Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules. 
  • Implications of leukoregulin to autologous tumor-specific human T-cell populations. 
  • Improved renal function in mouse kidney allografts lacking MHC class I antigens. 
  • Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Intragraft CD11b(+) IDO(+) cells mediate cardiac allograft tolerance by ECDI-fixed donor splenocyte infusions. 
  • Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression. 
  • JMH variants: serologic, clinical, and biochemical analyses in two cases. 
  • Joint report of first histocompatibility workshop on primates. 
  • Lymphocyte activation markers may predict the presence of donor specific alloreactivity in pediatric living related liver transplant recipients. 
  • MHC-restricted recognition of autologous melanoma by tumor-specific cytotoxic T cells. Evidence for restriction by a dominant HLA-A allele. 
  • Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. 
  • Metastatic potential of colon carcinoma. Expression of ABO/Lewis-related antigens. 
  • Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. 
  • Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo. 
  • Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice. 
  • Organ-specific patterns of donor antigen-specific hyporeactivity and peripheral blood allogeneic microchimerism in lung, kidney, and liver transplant recipients. 
  • Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. 
  • Portal venous donor-specific transfusion in conjunction with sirolimus prolongs renal allograft survival in nonhuman primates. 
  • Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients. 
  • Reactions of human HL-A sera with orangutan and gorilla lymphocytes. 
  • Reduced antigenicity of formaldehyde-fixed arterial allografts and their potential clinical application. 
  • Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. 
  • SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. 
  • Sensitization to endothelial cell antigens: Unraveling the cause or effect paradox. 
  • Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity. 
  • Skin graft rejection between subjects genotyped for HL-A. 
  • T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients. 
  • The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. 
  • The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success. 
  • The clinical application of monoclonal antibody therapies in renal transplantation. 
  • The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. 
  • The immunogenetics of the major histocompatibility chromosomal region in man. 
  • The role of ACAID and CD4+CD25+FOXP3+ regulatory T cells on CTL function against MHC alloantigens. 
  • The role of hyaluronan degradation products as innate alloimmune agonists. 
  • The tumor dormant state. Quantitation of L5178Y cells and host immune responses during the establishment and course of dormancy in syngeneic DBA/2 mice. 
  • Tissue antigens of man and chimpanzees; their role in xenografting. 
  • Tolerance mechanisms and recent progress. 
  • Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. 
  • Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease. 
  • Visualization of Immune Responses in the Cornea. 
  • [Characteristics of cells producing immune interferon]. 
• 

  Keywords of People

  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology