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Subject Areas on Research
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2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.
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A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
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A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
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A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation.
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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.
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Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.
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Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT.
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An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation.
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An integrated genomic analysis of human glioblastoma multiforme.
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Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma.
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Biological Role and Therapeutic Potential of IDH Mutations in Cancer.
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Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.
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CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
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CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
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Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
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Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
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Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases.
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Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.
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Culture kinetics of glycolytic enzyme induction, glucose utilization, and thymidine incorporation of extended-exposure phytohemagglutinin-stimulated human lymphocytes.
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Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
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Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
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Enzyme redesign guided by cancer-derived IDH1 mutations.
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Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.
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Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
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Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis.
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Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.
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Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.
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Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
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IDH1 and IDH2 hotspot mutations are not found in canine glioma.
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IDH1 and IDH2 mutations in gliomas.
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IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.
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IDH3α regulates one-carbon metabolism in glioblastoma.
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Improved grading of IDH-mutated astrocytic gliomas.
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Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.
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Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma.
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Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.
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Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.
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Isocitrate dehydrogenase mutations in gliomas.
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Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target.
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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
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Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia.
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Longitudinal molecular trajectories of diffuse glioma in adults.
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Management of glioblastoma: State of the art and future directions.
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Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
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Molecular profiling of different glioma specimens from an Ollier disease patient suggests a multifocal disease process in the setting of IDH mosaicism.
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Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas.
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Mutant IDH is sufficient to initiate enchondromatosis in mice.
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Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.
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Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process.
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Mutant IDH1 is required for IDH1 mutated tumor cell growth.
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Mutant metabolic enzymes are at the origin of gliomas.
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Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.
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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.
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Overcoming Resistance to Targeted Therapies in Gastrointestinal Cancers: Progress to Date and Progress to Come.
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Pattern of failure in anaplastic glioma patients with an IDH1/2 mutation.
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Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
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Radiogenomics of lower-grade glioma: algorithmically-assessed tumor shape is associated with tumor genomic subtypes and patient outcomes in a multi-institutional study with The Cancer Genome Atlas data.
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Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.
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Radioprotection of lipogenesis from glucose (U-14C) and activities of pyridine nucleotide dehydrogenases in liver of gamma-irradiated female rats by cystamine.
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Reflecting on survivorship outcomes to aid initial decision making in patients treated for IDH-mutated anaplastic glioma.
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Releasing the block: setting differentiation free with mutant IDH inhibitors.
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Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.
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Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.
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TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas.
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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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Vitamin A and biochemical development. II. Effect of postnatal excess vitamin-A administration on the activity of pyridine nucleotide-linked dehydrogenases.
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Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy.
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Keywords of People
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Immunology
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Yan, Hai,
Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine,
Pathology