Isoleucine

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  Subject Areas on Research

  • 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: a new inborn error of L-isoleucine metabolism. 
  • A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein. 
  • A past mutation at isoleucine 397 is now a common cause of moderate/mild haemophilia B. 
  • An inner activation gate controls TMEM16F phospholipid scrambling. 
  • Calmodulin supports both inactivation and facilitation of L-type calcium channels. 
  • Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin. 
  • Force-induced prolyl cis-trans isomerization in elastin-like polypeptides. 
  • Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 
  • Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling. 
  • JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. 
  • Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. 
  • Living related versus deceased donor liver transplantation for maple syrup urine disease. 
  • Mutational analysis of the function of Met137 and Ile197, two amino acids implicated in sequence-specific DNA recognition by the EcoRI endonuclease. 
  • Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein. 
  • Myotilin is mutated in limb girdle muscular dystrophy 1A. 
  • Myotilin overexpression enhances myopathology in the LGMD1A mouse model. 
  • Rapid diagnosis of homocystinuria and other hypermethioninemias from newborns' blood spots by tandem mass spectrometry. 
  • Rapid diagnosis of maple syrup urine disease in blood spots from newborns by tandem mass spectrometry. 
  • Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties. 
  • Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. 
  • Thrombin-catalyzed activation of recombinant human factor V. 
  • Transport interactions of cystine and dibasic amino acids in isolated rat renal tubules. 
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  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology